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Isoquinolines
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Definition
: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Examples
Benzylisoquinolines
;
Debrisoquin
;
Emetine
;
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
;
Naphthalimides
;
Nelfinavir
;
Nomifensine
;
Noscapine
;
Praziquantel
;
Saquinavir
;
Tetrahydroisoquinolines
Substance
CAS Registry & name
Categories
Source
Drugs
*
1-
(3,4-
dihydro-
6,7-
dimethoxy-
2(1H)-
isoquinolinyl)-
3,3-
dimethyl-
2-
((4-
pyridinylmethyl)amino)-
1-
butanone
0
*Isoquinolines
*Pyridines.
J Pharmacol Exp Ther. 2010 Aug;334(2):522-9.
2-
(2,4-
hexadienoyl)-
7-
(2-
(5-
methyl-
2-
(5-
methylhexen-
1-
yl)oxazol-
4-
yl)ethoxy)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxylic acid
0
*Isoquinolines
*Oxazoles
PPAR gamma/agonists.
Bioorg Med Chem. 2012 Jan 15;20(2):1060-75.
asunaprevir
0
*Isoquinolines
*Sulfonamides.
Hepatology. 2012 Mar;55(3):742-8.
5-
(3-
biphenyl-
4-
yl-
5-
ethyl-
4H-
1,2,4-
triazol-
4-
yl)isoquinoline
0
*Biphenyl Compounds
*Isoquinolines.
Bioorg Med Chem. 2012 Jan 1;20(1):34-41
1-
(7-
(2-
amino-
6-
(4-
methylpiperazin-
1-
yl)pyrimidin-
4-
yl)-
3,4-
dihydroisoquinolin-
2(1H)-
yl)-
2-
cyclopentylethanone
0
*Isoquinolines
*Pyrimidines
Histamine Antagonists.
Eur J Pharmacol. 2012 Jan 30;675(1-3):47-56.
N-
(6-
amino-
1-
(2,2-
diphenylethylamino)-
1-
oxohexan-
2-
yl)-
2-
(4-
oxo-
4-
phenylbutanoyl)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxamide
0
*Isoquinolines
Receptors, CXCR3/agonists.
Biochem Biophys Res Commun. 2012 Mar 9;419(2):412-8.
methyl 2'-
(7,8-
dihydrosanguinarine-
8-
yl)acetate
0
*Isoquinolines
*Benzophenanthridines
Alkaloids.
Bioorg Med Chem Lett. 2011 Dec 1;21(23):6960-3
BRD-
8899
0
*Isoquinolines.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5
2-
((3-
(aminomethyl)-
2-
(2-
methylpropyl)-
1-
oxo-
4-
phenyl-
1,2-
dihydroisoquinolin-
6-
yl)oxy)acetamide
0
*Isoquinolines
Hypoglycemic Agents
Dipeptidyl-Peptidase IV Inhibitors.
Bioorg Med Chem. 2011 Aug 15;19(16):4953-70
3-
(4-
(ethylthio)-
1H-
benzimidazol-
2-
yl)isoquinoline
0
*Benzimidazoles
*Isoquinolines
Adrenergic alpha-1 Receptor Antagonists.
ChemMedChem. 2011 Oct 4;6(10):1909-18.
IQ-
143 compound
0
*Isoquinolines
*Naphthalenes.
Genome Biol. 2011;12(3):R24
1-
(7-
methoxy-
2-
methyl-
1,2,3,4-
tetrahydro-
isoquinolin-
4-
yl)cyclohexanol
0
*Cyclohexanols
*Isoquinolines
Antidepressive Agents.
Neurosci Lett. 2011 Oct 3;503(2):120-4
benzo(3,4)azepino(1,2-
b)-
isoquinolinone
0
*Benzazepines
*Isoquinolines.
Chem Pharm Bull (Tokyo). 2011;59(9):1169-73
benzo(3,4)azepino(1,2-
b)isoquinolin-
9-
one
0
*Azepines
*Isoquinolines.
Chem Pharm Bull (Tokyo). 2011;59(9):1169-73
5-
(3-
(2-
(2-
hydroxy-
1-
(hydroxymethyl)ethyl)-
5-
methyl-
1,2,3,4-
tetrahydro-
6-
isoquinolinyl)-
1,2,4-
oxadiazol-
5-
yl)-
2-
((1-
methylethyl)oxy)benzonitrile
0
*Isoquinolines
*Oxadiazoles
Receptors, Lysosphingolipid/agonists.
J Med Chem. 2011 Oct 13;54(19):6724-33.
jasisoquinoline B
0
*Isoquinolines.
Org Lett. 2011 Sep 16;13(18):4798-801
jasisoquinoline A
0
*Isoquinolines.
Org Lett. 2011 Sep 16;13(18):4798-801
2-
(2-
(3,3-
dimethylbutanamido)-
3-
methylpentanoyl)-
7-
(2-
(hydroxyamino)-
2-
oxoethoxy)-
N-
(4-
methoxyphenyl)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxamide
0
*Hydroxamic Acids
*Isoquinolines
Histone Deacetylase Inhibitors.
J Med Chem 2011 Aug 11;54(15):5532-9
U63A05
0
*Imidazoles
*Isoquinolines.
J Pharmacol Sci. 2011;115(4):500-8
MP 124
0
*Isoquinolines
Poly(ADP-ribose) Polymerases/antagonists & inhibitors.
Brain Res 2011 May 10;1389:169-76
pyrrolo(2,1-
a)isoquinoline
0
*Isoquinolines
*Pyrroles.
J Org Chem. 2011 May 6;76(9):3296-305
quinolino-
benzo-
(5, 6)-
dihydroisoquindolium
0
*Isoquinolines.
Eur J Med Chem. 2011 May;46(5):1906-13
6-
(4'-
trifluoromethyl-
6-
methoxybiphenyl-
2-
ylcarboxamido)-
1,2,3,4-
tetrahydroisoquinoline-
2-
carboxylic acid phenyl ester
0
*Benzamides
*Isoquinolines.
J Pharmacol Exp Ther 2011 Jun;337(3):775-85
3-
amino-
6-
(3-
aminopropyl)-
5,6-
dihydro-
5,11-
dioxo-
11H-
indeno(1,2-
c)isoquinoline
0
*Indenes
*Isoquinolines
Cyclooxygenase Inhibitors
Cyclooxygenase 2.
Cancer Prev Res (Phila) 2011 Apr;4(4):592-607
5-
piperazin-
1-
ylindeno(1,2-
c)isoquinolin-
11-
one
0
*Isoquinolines
*Piperazines
DNA Topoisomerases, Type I.
Bioorg Med Chem 2011 Mar 15;19(6):1924-9
5-
bromo-
N-
(4-
(6,7-
dimethoxy-
3,4-
dihydro-
1H-
isoquinolin-
2-
yl)butyl)-
2,3-
dimethoxybenzamide
0
*Benzamides
*Isoquinolines
Ligands.
Bioorg Med Chem 2011 Mar 15;19(6):1852-9
(1,2,4)triazolo(3,4-
a)thienotetrahydroisoquinoline
0
*Isoquinolines
*Triazoles.
Eur J Med Chem. 2011 Feb;46(2):567-78
2-
hydroxyisoquinoline-
1,3(2H,4H)-
dione
0
*Isoquinolines.
Eur J Med Chem. 2011 Feb;46(2):535-46
SR 8278
0
*Isoquinolines
*Thiophenes
Nuclear Receptor Subfamily 1, Group D, Member 1/antagonists & inhibitors.
ACS Chem Biol 2011 Feb 18;6(2):131-4
1-
cyclopropyl-