ψ 
Isoquinolines 
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lucifer yellow  77944-88-8 1H-Benz(de)isoquinoline-2(3H)-carboxylic acid, 6-amino-1,3-dioxo-5,8-disulfo-, 2-hydrazide, dilithium salt  *Isoquinolines. 
Pharma Action Fluorescent Dyes 		CELL 14(3):741;1978
H 89  127243-85-0   *Isoquinolines *Sulfonamides Protein Kinases/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. 
Pharma Action Protein Kinase Inhibitors 		J Biol Chem 1990;265(9):5267
PK 11195  85340-56-3   *Isoquinolines. 
Pharma Action Antineoplastic Agents 		Neurosci Lett 1983;35(1):93
mivacurium  106791-40-6   *Isoquinolines. 
Pharma Action Neuromuscular Nondepolarizing Agents 		Can Anaesth Soc J 1986;33(3 Pt 2):S1MIVACRON; MIVACRON IN DEXTROSE 5% IN PLASTIC CONTAINER
sanguinarine  2447-54-3   *Alkaloids *Isoquinolines *Benzophenanthridines. 
Pharma Action Anti-Infective Agents ; Cardiotonic Agents 		Am J Clin Nutr 28(8):883;1975; Biochem Pharmacol 27(21):2555;1978; Biochim Biophys Acta 511(2):251;1978; Cancer Treat Rep 60(8):1178;1976; Eur J Pharmacol 1979;60(4):373; Farm Zh 3:40;1977; J Chromatogr 132(2):359;1977; J Physiol 1979;295:1; J Trop Med Hyg 80(7):149;1977; Lloydia 41(2):145;1978
N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide  84478-11-5   *Isoquinolines Protein Kinase C/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. 
Pharma Action Enzyme Inhibitors 		Biochem Biophys Res Commun 1987;145(3):1315
N-(2-guanidinoethyl)-5-isoquinolinesulfonamide  91742-10-8   *Isoquinolines *Sulfonamides Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. 
Pharma Action Calcium Channel Blockers ; Protein Kinase Inhibitors 		J Pharmacol Exp Ther 1984;231(1):141
salsolinol  525-72-4   *Isoquinolines.  J Pharmacol Exp Ther 1983;224(1):193
laudanosine  2688-77-9   *Isoquinolines Opium. 
Pharma Action Central Nervous System Agents 		J Org Chem 41(15):2548;1976; J Pharm Sci 60(11):1672;1971
amonafide  69408-81-7 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)  *Imides *Isoquinolines *Naphthalimides. 
Pharma Action Antineoplastic Agents ; Antiviral Agents ; Enzyme Inhibitors ; Intercalating Agents 		Arch Virol 1982;74(2-3):157
doxacurium  106819-53-8   *Isoquinolines. 
Pharma Action Neuromuscular Nondepolarizing Agents 		Can Anaesth Soc J 1986;33(3 Pt 2):S1NUROMAX
isoquinoline  119-65-3   *Isoquinolines.  Carcinogenesis 1983;4(9):1169
6-(2-(1H-tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid  150131-78-5   *Isoquinolines *Tetrazoles Receptors, AMPA/antagonists & inhibitors.  J Med Chem 1993 Jul 9;36(14):2046-8
McN 5652  96795-90-3   *Isoquinolines. 
Pharma Action Serotonin Antagonists 		J Pharmacol Exp Ther 1988;247(3):1032
LOE 908  149759-26-2 1-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-alpha-phenyl-N,N-bis(2-(2,3,4-trimethoxyphenyl)ethyl)-, (+-)  *Acetamides *Isoquinolines Ion Channels/drug effects.  Mol Pharmacol 1993 May;43(5):655-9
LY 235959  137433-06-8   *Isoquinolines. 
Pharma Action Antiparkinson Agents ; Excitatory Amino Acid Antagonists 		Neurosci Lett 1994 Mar 14;169(1-2):105-8
palonosetron  135729-61-2   *Isoquinolines *Quinuclidines. 
Pharma Action Serotonin Antagonists 		J Med Chem 1993 Sep 3;36(18):2645-57ALOXI
AR-C239  67339-62-2 1,3(2H,4H)-Isoquinolinedione, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-4,4-dimethyl  *Isoquinolines *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists 		J Cardiovasc Pharmacol 1980;2(2):175
tritoqualine  14504-73-5 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)iso quinolin-5-yl)-1(3H)-isobenzofuranone  *Isoquinolines. 
Pharma Action Cholagogues and Choleretics ; Histamine H1 Antagonists 		Arch Int Pharmacodyn Ther 196:155;1972; C R Soc Biol (Paris) 171(6):1284;1977; Gastroenterol Jpn 13(2):105;1978; Pol Tyg Lek 33(3):107;1978
pancratistatin  96281-31-1 Pancratistatin  *Isoquinolines *Amaryllidaceae Alkaloids.  J Nat Prod 1984;47(6):1018
N-(2-aminoethyl)-5-isoquinolinesulfonamide  84468-17-7   *Isoquinolines *Sulfonamides Protein Kinase C. 
Pharma Action Protein Kinase Inhibitors 		J Biol Chem 1985;260(5):2922
PK 14105  107257-28-3   *Isoquinolines. 
Pharma Action Affinity Labels 		Mol Pharmacol 1987;31(1):42
saframycin A  66082-27-7   Isoquinolines. 
Pharma Action Anti-Bacterial Agents ; Antibiotics, Antineoplastic 		Experientia 1980;36(9):1025
alrestatin  51411-04-2 1,3-dioxo-1H-benz(de)isoquinoline-2(3H)- acetate  *Isoquinolines. 
Pharma Action Enzyme Inhibitors ; Parasympatholytics 		Digestion 18(1-2):35;1978; Experientia 34(4):441;1978; Horm Metab Res 10(4):273;1978; Science 182(4117):1146;1973
tilisolol  85136-71-6 1(2H)-Isoquinolinone, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-2-methyl  *Isoquinolines. 
Pharma Action Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents 		J Pharmacol Exp Ther 1982;223(3):801
LY 274614  136109-04-1 3-Isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3alpha,4aalpha,6beta,8aalpha)  *Isoquinolines.  Eur J Pharmacol 1991;197(1):9
mitonafide  54824-17-8 2-(2-(dimethylamino)ethyl)-5-nitro-1H-benz(de)isoquinoline-1,3(2H)-dione  *Imides *Isoquinolines *Naphthalimides. 
Pharma Action Antineoplastic Agents ; Antiviral Agents ; Intercalating Agents 		Arch Framacol Toxicol 5(1):17;1979; Cancer Chemother Pharmacol 1980;4(1):61; Chemotherapy 25(2):83;1979; Nucleic Acids Res1979;7(1):217
Ro 22-1319  78541-97-6 4H-Pyrrolo(2,3-g)isoquinolin-4-one, 3-ethyl-1,4a,5,6,7,8,8a,9-octahydro-2,6-dimethyl-, trans-(+-)  *Isoquinolines. 
Pharma Action Antipsychotic Agents 		J Med Chem 1981;24(9):1026
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  120615-25-0   *Isoquinolines.  J Biol Chem 1989;264(9):4924
quinocarcin  84573-33-1 3,6-Imino-1H-2-oxa-11c-azanaphth(1,2,3-cd)azulene-5-carboxylic acid, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-, (2aalpha,3alpha,5alpha,6alpha,6aalpha,11balpha)-(-)  *Isoquinolines.  J Antibiot (Tokyo) 1983;36(5):463; J Antibiot (Tokyo) 1983;36(5):468
oracine  148317-76-4   *Ethanolamines *Isoquinolines.  J Chromatogr B Biomed Appl 1996 May 31;681(1):169-75
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide  31404-61-2 7-Isoquinolinesulfonamide, 1,2,3,4-tetrahydro  *Isoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors.  J Pharmacol 208(1):24;1979
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone  59261-39-1   *Isoquinolines Ribonucleotide Reductases/antagonists & inhibitors.  Cancer Res 1979;39(11):4600; Cancer Res 37:1692;1977; Cancer Treat Rep 63(3):449;1979; J Med Chem 19(7):970;1976
pazelliptine  65222-35-7 N,N-diethyl-N'-(6-methyl-5H-pyrido(3',4'-4,5)pyrrolo(2,3-g)isoquinolin-10-yl)-1,3-propanediamine  *Indoles *Isoquinolines.  Bull Cancer (Paris) 1980;67(1):1
fredericamycin A  80455-68-1 Spiro(2H-benz(f)indene-2,8'-(8H)cyclopent(g)isoquinoline)-1,1',3,5,8(2'H)-pentone, 6',7'-dihydro-4,9,9'-trihydroxy-6-methoxy-3'-(1,3-pentadienyl)-, (E,E)  Isoquinolines Spiro Compounds.  J Antibiot (Tokyo) 1981;34(11):1389
diclofensine  67165-56-4   *Isoquinolines.  J Int Med Res 1981;9(5):324
jadomycin B  149633-99-8   Isoquinolines Streptomyces.  J Antibiot (Tokyo) 1993 May;46(5):869-71
bisnafide  145124-30-7 1H-Benz(de)isoquinoline-1,3(2H)-dione, 2,2'-(1,2-ethanediylbis(imino(1-methyl-2,1-ethanediyl)))bis(5-nitro-, (R-(R*,R*)))-, dimethanesulfonate  *Isoquinolines *Mesylates.  Cancer Res 1994 Jan 1;54(1):159-64
pixantrone  144510-96-3   *Isoquinolines DNA Topoisomerases, Type II/antagonists & inhibitors.  J Med Chem 1994 Mar 18;37(6):828-37
RS 79948-197  0   *Isoquinolines *Naphthyridines Ligands.  Eur J Pharmacol 1996 Dec 12;317(1):67-73
1,5-dihydroxyisoquinoline  5154-02-9   *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors.  Int J Immunopharmacol 1995 Apr;17(4):265-71
LY382884  0   *Isoquinolines Receptors, Kainic Acid/antagonists & inhibitors.  Nature 1999 Nov 18;402(6759):297-301
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone  0   *Isoquinolines *Piperidines Poly(ADP-ribose) Polymerases/antagonists & inhibitors.  Nat Med 1997 Oct;3(10):1089-95
5-aminoisoquinolinone  0   Poly(ADP-ribose) Polymerases/antagonists & inhibitors *Isoquinolines.  Br J Pharmacol 2000 Jun;130(4):843-50
michellamine A  137793-81-8   *Isoquinolines *Naphthalenes Stereoisomerism.  J Med Chem 1991;34(12):3402
3,4-dihydro-3,3-dimethylisoquinoline-N-oxide  0   *Isoquinolines Spin Labels.  Ann N Y Acad Sci 1994 Nov 17;738:243-9
T 1032  0   *Isoquinolines *Pyridines.  J Pharmacol Exp Ther 2000 Sep;294(3):870-5
3,4-dihydro-5-methyl-1(2H)-isoquinolinone  129075-56-5 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl  *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors.  Radiat Res 1991;126(3):367
fosquidone  114517-02-1   *Isoquinolines *Organophosphorus Compounds.  Br J Cancer 1990 May:61(5):709-11
GPI 6150  0   Poly(ADP-ribose) Polymerases/antagonists & inhibitors *Benzopyrans *Isoquinolines.  Biochem Biophys Res Commun 2000 Nov 30;278(3):590-8
STO 609  0   *Benzimidazoles *Isoquinolines *Naphthalimides.  J Biol Chem 2002 May 3;277(18):15813-8
cycleanine  518-94-5 8,11:20,23-Dietheno-1H,12H-(1,10)dioxacyclooctadecino(2,3,4-ij:11,12,13-i'j')diisoquinoline, 2,3,12a,13,14,15,24,24a-octahydro-1,13-dimethyl-5,6,17,18-tetramethoxy-, (12aR-(12aR*,24aR*))  *Alkaloids *Isoquinolines Menispermaceae.  Masui 1982;31(9):1016
5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine  119813-87-5   *Isoquinolines *Naphthyridines.  J Med Chem 1989;32(9):2034
tetrahydropapaverine  13074-31-2   *Isoquinolines.  Pharmacol Biochem Behav 1990;35(1):29
DX 52-1  96251-59-1   Isoquinolines.  Cancer Res 1995 Feb 15;55(4):862-7
LU 79553  0   *Amides *Isoquinolines.  Cancer Res 1995 Mar 1;55(5):1176-80
GW280430A  0   *Isoquinolines.  Int J Pharm 2002 Mar 2;234(1-2):19-23
lamellarin D  0   *Coumarins *Heterocyclic Compounds with 4 or More Rings *Isoquinolines.  J Nat Prod 2002 Apr;65(4):500-4
L 11204  55308-64-0 (1,2,4)triazolo(5,1-a)isoquinoline, 2-(3-ethoxyphenyl)-5,6-dihydro  *Isoquinolines.  Fertil Steril 28(9):992;1977; Prostaglandins 15(3):525;1978
dimethylcycleanine  75846-14-9   *Alkaloids *Isoquinolines Menispermaceae.  Chung-Kuo Yao Li Hseuh Pao 1980;1(1):26
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