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Hydroxamic Acids

More information in Books or onNLM PubMed
Definition: A class of weak acids with the general formula R-CONHOH.     
Examples Bufexamac; Deferoxamine; Ferrichrome 		Other names Acids, Hydroxamic; Acid, Hydroxamic; Hydroxamic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
JBIR-111  0   *Hydroxamic Acids. J Nat Prod. 2012 Feb 24;75(2):285-9
JBIR-110  0   *Hydroxamic Acids. J Nat Prod. 2012 Feb 24;75(2):285-9
JBIR-109  0   *Hydroxamic Acids. J Nat Prod. 2012 Feb 24;75(2):285-9
N8-hydroxy-2-(1H-indole-2-carboxamido)-N1-(quinolin-8-yl)octanediamide  0   *Aminoquinolines *Hydroxamic Acids Histone Deacetylase Inhibitors. J Periodontal Res. 2011 Dec;46(6):697-703.
dehydroxytrichostatin A  0   *Hydroxamic Acids. Molecules. 2011;16(9) (dup#20):7183-98
6-(4-chlorophenylsulfanyl)-2,4-hexadienoic acid hydroxyamide  0   *Hydroxamic Acids *Sulfides Histone Deacetylase Inhibitors. Apoptosis. 2011 Sep;16(9):914-23.
N1-(4-(2-fluoroethyl)phenyl)-N8-hydroxyoctanediamide  0   *Anilides *Hydroxamic Acids Fluorine Radioisotopes. Nucl Med Biol 2011 Jul;38(5):683-96
2-(2-(3,3-dimethylbutanamido)-3-methylpentanoyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylase Inhibitors. J Med Chem 2011 Aug 11;54(15):5532-9
desferrioxamine E  0   *Hydroxamic Acids *Lactams. Biol Pharm Bull 2011;34(6):917-20
N-hydroxy-3-(4-((2-(2-methylpyrazolo(1,5-a)pyridin-3-yl)ethylamino)methyl)phenyl)acrylamide  0   *Acrylamides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4752-72
N-hydroxy-3-(4-(((2-(2-(1-hydroxy-1-methylethyl)-1H-indol-3-yl)ethyl)isopropylamino)methyl)phenyl)acrylamide  0   *Acrylamides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4752-72
octanedioic acid (1-(3-azido-5-azidomethylbenzyl)-1H-pyrazol-4-yl)amide hydroxyamide  0   *Azides *Hydroxamic Acids Histone Deacetylase Inhibitors. J Med Chem 2011 Jul 14;54(13):4350-64
2,3-dihydrotrichostatin A  0   *Hydroxamic Acids. J Nat Prod. 2011 May 27;74(5):1272-4
CHR-79888  0   *Hydroxamic Acids Glycine/*analogs & derivatives. Leuk Res. 2011 May;35(5):677-81
2-(2-(1-(4-chlorobenzoyl)-2-methyl-5-methoxyl-1H-indoyl-3-yl)acetoxy)ethanesulfonyl hydroxamic acid  0   *Hydroxamic Acids Indomethacin/*analogs & derivatives. J Med Chem 2011 Mar 10;54(5):1356-64
N-hydroxy-6-(((adamantan-1-ylamino)carbonyl)amino)hexamide  0   *Hydroxamic Acids Adamantane/*analogs & derivatives Histone Deacetylase Inhibitors. Int J Radiat Oncol Biol Phys 2011 Apr 1;79(5):1541-8
3-(2-(4-quinolin-3-yl)benzyl-1-oxoisoindolin-6-yl)-N-hydroxy-acrylamide  0   *Hydroxamic Acids *Isoindoles Histone Deacetylase Inhibitors. PLoS One 2010;5(11):e13834
3-(2-(4-pyridin-4-yl)benzyl-1-oxoisoindolin-6-yl)-N-hydroxyacrylamide  0   *Hydroxamic Acids *Isoindoles Histone Deacetylase Inhibitors. PLoS One 2010;5(11):e13834
4-(2,2-dimethyl-4-phenylbutyrylamino)-N-hydroxybenzamide  0   *Benzamides *Hydroxamic Acids Histone Deacetylase Inhibitors. PLoS One 2010;5(9):e12417
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide  0   *Dipeptides *Hydroxamic Acids ADAM Proteins/antagonists & inhibitors. Blood 2003 Aug 15;102(4):1186-95
4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide  0   *Hydroxamic Acids. Mol Cancer Ther 2010 Jan;9(1):246-56
tubastatin A  0   *Indoles *Hydroxamic Acids Histone Deacetylases. J Am Chem Soc 2010 Aug 11;132(31):10842-6
ethyl acetohydroximate  0   *Hydroxamic Acids. J Am Chem Soc 2010 Jul 28;132(29):9990-1
N-hydroxy-7-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)heptanamide  0   *Hydroxamic Acids *Thiophenes Histone Deacetylases. Bioorg Med Chem 2010 Jun 15;18(12):4187-94
N-hydroxy-5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)pentanamide  0   *Hydroxamic Acids *Thiophenes Histone Deacetylases. Bioorg Med Chem 2010 Jun 15;18(12):4187-94
1-cyclopropyl-N-hydroxy-4-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)piperidine-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
N-hydroxy-1-(2-methoxyethyl)-4-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)piperidine-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
N-hydroxy-4-((4-(4-(trifluoromethyl)phenoxy)phenyl)sulfonyl)tetrahydro-2H-pyran-4-carboxamide  0   *Hydroxamic Acids *Sulfones Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6653-80
dimerumic acid  0   *Hydroxamic Acids *Diketopiperazines. Free Radic Biol Med 2000 Mar 15;28(6):999-1004
methyl 3-((9-(dimethylamino)nonanoyl)(methoxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
methyl 3-((9-(dimethylamino)nonanoyl)(hydroxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
ABS 130  0   *Cinnamates *Hydroxamic Acids. Neuropharmacology 2010 Jun;58(8):1189-98
2,4-dichlorocinnamic acid hydroxamate  0   *Cinnamates *Hydroxamic Acids. Neuropharmacology 2010 Jun;58(8):1189-98
N-hydroxy-4-(2-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)ethoxy)cinnamide  0   *Coumarins *Hydroxamic Acids. ChemMedChem 2010 Apr 6;5(4):598-607
N-hydroxy-3-(3-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)propoxy)cinnamide  0   *Coumarins *Hydroxamic Acids. ChemMedChem 2010 Apr 6;5(4):598-607
N-hydroxy-3-(2-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)ethoxy)cinnamide  0   *Coumarins *Hydroxamic Acids. ChemMedChem 2010 Apr 6;5(4):598-607
resminostat  0   *Hydroxamic Acids *Sulfonamides. Br J Haematol 2010 May;149(4):518-28
benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylases. Bioorg Med Chem 2010 Mar 1;18(5):1761-72
tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate  0   *Hydroxamic Acids *Isoquinolines Histone Deacetylases. Bioorg Med Chem 2010 Mar 1;18(5):1761-72
7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide  0   *Hydroxamic Acids *Quinazolines Histone Deacetylases. J Med Chem 2010 Mar 11;53(5):2000-9
N-1-(1'-naphthyl)ethyl-O-tert-butylhydroxamate  0   *Hydroxamic Acids *Naphthalenes. J Org Chem. 2010 Feb 19;75(4):1214-27
2-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)-N-hydroxybutanamide  0   *Hydroxamic Acids *Sulfonamides. J Med Chem 2010 Mar 25;53(6):2622-35
benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate  0   *Hydroxamic Acids *Sulfonamides. J Med Chem 2010 Mar 25;53(6):2622-35
Y 41654  0   *Hydroxamic Acids *Succinates. Shock 2009 Nov;32(5):535-40
N-hydroxy-3-((4-methoxyphenyl)sulfonyl)-2-(((4-methoxyphenyl)sulfonyl)methyl)propanamide  0   *Hydroxamic Acids *Sulfones. Biomol NMR Assign. 2009 Dec;3(2):183-6
lauryl hydroxamic acid  0   *Hydroxamic Acids. J Org Chem. 2009 Nov 6;74(21):8254-60
CG 0006  0   *Hydroxamic Acids *Piperidines Histone Deacetylases. Anticancer Drugs 2009 Oct;20(9):815-21
1-naphthylacetohydroxamic acid  0   *Hydroxamic Acids *Naphthalenes. Luminescence 2009 Jul-Aug;24(4):203-8
1-naphthylhydroxamic acid  0   *Hydroxamic Acids *Naphthalenes. Luminescence 2009 Jul-Aug;24(4):203-8
N-hydroxy-9H-xanthene-9-carboxamide  0   *Hydroxamic Acids *Xanthenes Histone Deacetylases. Bioorg Med Chem Lett 2009 Oct 1;19(19):5684-8
N-hydroxy-2,2-diphenylacetamide  0   *Diphenylacetic Acids *Hydroxamic Acids Histone Deacetylases. Bioorg Med Chem Lett 2009 Oct 1;19(19):5684-8
10-undecanhydroxamic acid  0   *Hydroxamic Acids. FEMS Microbiol Lett. 2009 May;294(1); 61-7
JNJ 26481585  0   *Hydroxamic Acids. Anticancer Drugs 20090 Jun;20(5):321-33
kendine 91  0   *Hydroxamic Acids *Pyrroles Histone Deacetylase Inhibitors. Cancer Chemother Pharmacol 2009 Jun;64(1):153-9
5-bromo-1H-indole-3-acetohydroxamic acid  0   *Hydroxamic Acids *Indoles. ChemMedChem 2009 Feb;4(2):261-75
3-(1-cinnamyl-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide  0   *Hydroxamic Acids *Triazoles Histone Deacetylases/antagonists & inhibitors. J Med Chem 2008 Dec 11;51(23):7417-27
KBH A42  0   *Hydroxamic Acids *Piperidones Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 1;16(15):4068-70
5-phenylvaleric hydroxamic acid  0   *Hydroxamic Acids. J Enzyme Inhib Med Chem. 2008 Aug;23(4):549-55
4-benzoylbutyric hydroxamic acid  0   *Hydroxamic Acids. J Enzyme Inhib Med Chem. 2008 Aug;23(4):549-55
4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide  0   *Hydroxamic Acids *Sulfonamides Matrix Metalloproteinase 13/antagonists & inhibitors. Drug Metab Dispos 2008 Sep;36(9):1869-83
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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