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Emetine

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Definition: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.     
Pharmacological Action Amebicides; Antinematodal Agents; Cathartics; Emetics; Protein Synthesis Inhibitors 		Other names Hydrochloride, Emetine; Dihydrochloride, Emetine; Emetine Hydrochloride; Emetine Dihydrochloride; Methylcephaeline; Ipecine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1',2'-dehydrotubulosine  0   Emetine/*analogs & derivatives. J Nat Prod 2000 May;63(5):723-5
1',2',3',4'-tetradehydrotubulosine  0   Emetine/*analogs & derivatives. J Nat Prod 1999 Sep;62(9):1346-8
psychotrine  0   Emetine/*analogs & derivatives. J Comput Aided Mol Des 1998 Sep;12(5):411-8
dehydroemetine  4914-30-1   Emetine/*analogs & derivatives.
O-methylpsychotrine  523-01-3   Emetine/*analogs & derivatives. J Biol Chem 1991;266(35):23529
dihydroemetine  0   Emetine/*analogs & derivatives. J Infect 1984;9(1):101
pseudotubulosine  64091-47-0 17-Norcorynan, 16-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl)  Emetine/*analogs & derivatives. C R Acad Sci (D)(Paris) 288(14):1095;1979
tubulosine  2632-29-3 10,11-dimethoxytubulosan-8'-ol  Emetine/*analogs & derivatives. Biochemistry 16(14):3209;1977; C R Soc Biol (Paris) 170(1):15;1976; Cell Tissue Kinet 8(1):67;1975; Mol Gen Genet 156(3):319;1977
O-methyltubulosine  5263-31-0   Emetine/*analogs & derivatives. Biochem J 140(1):87;1974
cephaelin  483-17-0   Emetine/*analogs & derivatives. Biochemistry 16(14):3209;1977; C R Soc Biol (Paris) 170(1):15;1976
O-methylpsychotrine oxylate  14637-07-1   Emetine/*analogs & derivatives. Mol Pharmacol 7(2):122;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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