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Poly(ADP-ribose) Polymerases

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Definition: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.     
Examples Tankyrases 		Other names Poly(ADP-ribose) Polymerase; Poly(ADP-Ribose) Synthase; Poly ADP Ribose Polymerase; ADP-Ribosyltransferase, Nuclear; ADP-Ribosyltransferase (Polymerizing); Synthase, Poly ADP-Ribose; Polymerase, PARP; Poly ADP Ribose Synthase; Nuclear NAD+ ADP Ribosyltransferase; Nuclear ADP Ribosyltransferase; NAD+ ADP-Ribosyltransferase, Nuclear; Diphosphoribosyltransferase, Nuclear Adenosine; Adenosine Diphosphoribosyltransferase, Nuclear; ADPRT, Nuclear; ADP-Ribosyltransferase, Nuclear NAD+; ADP Ribosyltransferase, Nuclear; Poly(ADPribose) Polymerase; Poly(ADPR) Polymerase; Poly(ADP-Ribose) Transferase; Poly ADP-Ribose Synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MP 124  0   *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Brain Res 2011 May 10;1389:169-76
PARP3 protein, zebrafish  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Zebrafish Proteins. PLoS One 2011;6(1):e15834
10-((4-hydroxypiperidin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one  0   *Benzopyrans *Phthalazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Drug Metab Dispos 2011 Jan;39(1):61-70
PARP-13 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Nat Immunol 2011 Jan;12(1):37-44
PARP-2 protein, rat  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Neurochem Res 2010 Dec;35(12):2144-53
PARP2 protein, mouse  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Biol Reprod 2011 Feb;84(2):218-28
2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide  0   *Benzimidazoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2010 Apr 22;53(8):3142-53
2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide  0   *Indazoles *Piperidines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2009 Nov 26;52(22):7170-85
2-(4-(pyridin-2-yl)phenyl)-1H-benzo(d)imidazole-4-carboxamide  0   *Benzimidazoles *Pyridines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6803-13
2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-1H-benzo(d)imidazole-4-carboxamide  0   *Benzimidazoles *Oxadiazoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6803-13
2-(methoxycarbonyl(4-methoxyphenyl)methylsulfanyl)-1H-benzimidazole-4-carboxylic acid amide  0   *Benzimidazoles *Phenylacetates Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Jan;328(1):10-8
4-(3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl)-2H-phthalazin-1-one  0   *Phthalazines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2008 Oct 23;51(20):6581-91
AZD 2281  0   *Phthalazines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Clin Cancer Res 2008 Jun 15;14(12):3916-25
AG 014699  0   *Indoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Curr Opin Pharmacol 2006 Aug;6(4):364-8
Parp-9 protein, mouse  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Dev Dyn 2008 Jan;237(1):209-15
PARP1 protein, Drosophila  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Drosophila Proteins. J Biol Chem 2007 Nov 2;282(44):32511-9
Coast6 protein, mouse  0   *Poly(ADP-ribose) Polymerases. Proc Natl Acad Sci U S A 2006 Mar 14;103(11):4210-5
HO 3089  0   *Benzimidazoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Cardiovasc Pharmacol 2004 Mar;43(3):423-31
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one  0   *Piperidines *Quinazolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Oct;315(1):273-82
GPI 15427  0   *Organic Chemicals Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Clin Cancer Res 2003 Nov 1;9(14):5370-9
PARP10 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Proto-Oncogene Proteins. Oncogene. 2005 Mar 17;24(12):1982-93
Adprt protein, rat  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases.
Parp1 protein, mouse  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases.
PARP1 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases.
2-(4-chlorophenyl)-5-quinoxalinecarboxamide  0   *Quinoxalines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2004 Sep;310(3):1114-24
INO 1001  0   *Indoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2004 Aug;310(2):498-504
poly(ADP-ribose)polymerase-1, mouse  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Exp Gerontol 2004 May;39(5):775-88
poly(ADP-ribose)polymerase-2, rat  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Biochim Biophys Acta. 2004 May 28;1692(1):35-44
PARP2 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. J Biol Chem 2004 Feb 13;279(7):5244-8
PARP3 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Cell Cycle Proteins. Genomics 1999 May 1;57(3):442-5
1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one  0   *Benzodiazepines Azulenes Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Cancer Res 2003 Sep 15;63(18):6008-15
N-(6-oxo-5,6-dihydrobenzo(c)(1,5)naphthyridin-2-yl)-2-(4-pyrrolidin-1-ylpiperidin-1-yl)acetamide  0   *Naphthyridines *Piperidines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2003 Jul 3;46(14):3138-51
2-(4-cyclopropylmethylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one  0   *Naphthyridines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2003 Jul 3;46(14):3138-51
2-(4-methylpiperazin-1-yl)-5H-benzo(c)(1,5)naphthyridin-6-one  0   *Naphthyridines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2003 Jul 3;46(14):3138-51
3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone  0   *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Jun;305(3):943-9
thieno(2,3-c)isoquinolin-5-one  0   *Isoquinolines *Thiophenes Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Jun;305(3):943-9
poly(ADP-ribose) polymerase 3, mouse  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases. Folia Biol (Praha) 2002;48(5):182-91
poly(ADP-ribose) polymerase-2, mouse  EC 2.4.2.30.   *Poly(ADP-ribose) Polymerases. J Biol Chem 2002 Jun 21;277(25):23028-36
1,5-dihydroisoquinoline  0   *Isoquinolines Poly(ADP-ribose) Polymerases. Arch Biochem Biophys 2002 Jun 15;402(2):227-32
vault poly(ADP-ribose) polymerase  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Vault Ribonucleoprotein Particles.
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride  0 2-dimethylamino-N-(6-oxo-5H-phenanthridin-2-yl)-acetamide  *Phenanthrenes Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Int J Mol Med 2001 Mar;7(3):255-60
GPI 6150  0   *Benzopyrans *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Nov 30;278(3):590-8
NU 1085  0   *Benzimidazoles Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4084-97
5-aminoisoquinolinone  0   *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Br J Pharmacol 2000 Jun;130(4):843-50
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone  0   *Isoquinolines *Piperidines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Nat Med 1997 Oct;3(10):1089-95
cofpropamine  0   Caffeine/*analogs & derivatives Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Gen Pharmacol 1996 Oct;27(7):1215-8
botulinum toxin type C  0   *Botulinum Toxins Poly(ADP-ribose) Polymerases. Electrophoresis 1996 Nov;17(11):1776-80
1,5-dihydroxyisoquinoline  5154-02-9   *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Int J Immunopharmacol 1995 Apr;17(4):265-71
4-iodo-3-nitrobenzamide  0   *Benzamides Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Proc West Pharmacol Soc 1994;37:117-9
4-amino-1,8-naphthalimide  1742-95-6   *Quinolones *Naphthalimides 1-Naphthylamine/*analogs & derivatives Poly(ADP-ribose) Polymerases. Biochem Biophys Res Commun 1994 Mar 30;199(3):1270-7
3-nitrosobenzamide  144189-66-2   *Benzamides *Nitroso Compounds Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Proc Natl Acad Sci U S A 1992 Aug 15;89(16):7703-7
5-iodo-6-amino-1,2-benzopyrone  137881-27-7   *Coumarins Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Biochem Biophys Res Commun 1991;180(2):504
6-nitroso-1,2-benzopyrone  130506-22-8   *Coumarins Poly(ADP-ribose) Polymerases/antagonists & inhibitors. FEBS Lett 1991;290(1-2):181
3,4-dihydro-5-methyl-1(2H)-isoquinolinone  129075-56-5 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl  *Isoquinolines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Radiat Res 1991;126(3):367
2-methyl-4(3H)-quinazolinone  1769-24-0   *Quinazolinones Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Antibiot (Tokyo) 1991;44(1):111
6-amino-1,2-benzopyrone  14415-44-2   *Coumarins Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Exp Cell Res 1991;193(1):1
epidermal cell differentiation inhibitor, Staphylococcus aureus  134773-77-6   *Bacterial Proteins Poly(ADP-ribose) Polymerases Staphylococcus aureus. Biochem Biophys Res Commun 1991;174(2):459
benadrostin  117241-60-8 2H-1,3-Benzoxazine-2,4(3H)-dione, 8-hydroxy  *Oxazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Antibiot (Tokyo) 1988;41(8):1009
4-carbamoylbenzenediazonium  58441-07-9   Diazonium Compounds Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Biochemistry 1987;26(8):2226
3-aminobenzoic acid  99-05-8   *Aminobenzoic Acids Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Exp Cell Res 1985;157(1):271
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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