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Piperazines 
     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
imatinib  152459-95-5   *Piperazines *Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors. 
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		Cancer Res 1996 Jan 1;56(1):100-4GLEEVEC
sildenafil  139755-83-2   *Piperazines Impotence 3',5'-Cyclic-GMP Phosphodiesterase/antagonists & inhibitors. 
Pharma Action Phosphodiesterase Inhibitors ; Vasodilator Agents 		Br J Urol 1996 Aug;78(2):257-61REVATIO; VIAGRA
WAY 100635  146714-97-8 Cyclohexanecarboxamide, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinyl-, trihydrochloride  *Piperazines *Pyridines Carbon Radioisotopes. 
Pharma Action Serotonin Antagonists 		Life Sci 1994;55(20):PL403-7
1-(3-chlorophenyl)piperazine  6640-24-0   *Piperazines. 
Pharma Action Serotonin Agonists 		Eur J Pharmacol 1980;61(2):203; J Neural Transm 44(3):237;1979; Naunyn Schmiedebergs Arch Pharmacol 1979;308(2):159; Res Commun Chem Pathol Pharmacol 17(3):551;1977
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid  100828-16-8   *Piperazines. 
Pharma Action Anticonvulsants ; Excitatory Amino Acid Antagonists 		Brain Res 1986;382(1):169
eszopiclone  0 (+)-(5S)-6(chloropyridine-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)-pyrazin-5-yl-4-methyl-piperazine-1-carboxylate  Sleep Initiation and Maintenance Disorders *Piperazines. 
Pharma Action Hypnotics and Sedatives ; Hypnotics and Sedatives 		LUNESTA
urapidil  34661-75-1 6-((3-(4- (2-methoxyphenyl)-1-piperazinyl)propyl)amino)- 1,3-dimethyl-2,4(1H,3H)-pyrimidinedione  *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists ; Antihypertensive Agents ; Vasodilator Agents ; Serotonin Agonists 		Arzneim Forsch 27(10):1895;1977; Arzneim Forsch 27(11):2075;1977; Arzneim Forsch 27(11):2077;1977; Arzneim Forsch 27(12):2406;1977; Eur J Pharmacol 1979;59(1-2):1
vanoxerine  67469-78-7   *Piperazines. 
Pharma Action Dopamine Uptake Inhibitors 		Eur J Pharmacol 1984;103(3-4):241
ziprasidone  146939-27-7   *Piperazines *Thiazoles. 
Pharma Action Serotonin Antagonists ; Antipsychotic Agents ; Dopamine Antagonists 		Psychopharmacology (Berl) 1993;112(2-3):308-14GEODON
aripiprazole  129722-12-9   *Piperazines *Quinolones Hyperglycemia. 
Pharma Action Antipsychotic Agents 		J Pharmacol Exp Ther 1995 Jul;274(1):329-36ABILIFY
vardenafil  224785-90-4   Impotence Vasodilator Agents *Imidazoles *Piperazines Sulfones Triazines. 
Pharma Action Phosphodiesterase Inhibitors 		J Urol.2001 Apr;165(4):1316-8LEVITRA
1-(3-trifluoromethylphenyl)piperazine  15532-75-9 1-(3-(trifluoromethyl)phenyl)piperazine  *Piperazines. 
Pharma Action Serotonin Agonists 		Eur J Pharmacol 52(1):11;1978
piperazine  110-85-0   *Piperazines. 
Pharma Action Antinematodal Agents 		Am J Clin Nutr 1982;36(1):80
histidyl-proline diketopiperazine  4257-92-5 Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S-trans)  *Peptides, Cyclic *Piperazines. 
Pharma Action Antioxidants ; Neurotransmitter Uptake Inhibitors 		Biochem Biophys Res Commun 85(4):1582;1978; Eur J Pharmacol l979;58(1):97; Nature 268(5616):142;1977; Nature 274(5667):174;1978
GBR 12935  76778-22-8   *Piperazines Ligands.  Eur J Pharmacol 1985;107(2):289
oxatomide  60607-34-3 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one  *Piperazines. 
Pharma Action Histamine H1 Antagonists ; Anti-Allergic Agents ; Anti-Asthmatic Agents 		Acta Allergol 32(4):278;1977; Agents Actions 8(6):568;1978; Arch Int Pharm 232(2):217;1978; Arch Int Pharm 234(1):164;1978; Curr Med Res Opin 1980;6(6):380; Experientia 33(12):1657;1977; Int Arch Allergy Appl Immunol 56(6):507;1978; Laryngoscope 1980;90(1):145
BMY 7378  21102-94-3   *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists 		Eur J Pharmacol 1987;137(2-3):293
grepafloxacin  119914-60-2   *Piperazines *Fluoroquinolones. 
Pharma Action Anti-Bacterial Agents 		Antimicrob Agents Chemother 1992 Mar 36(3):573-9RAXAR
1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine  115338-32-4   *Piperazines. 
Pharma Action Serotonin Antagonists 		Eur J Pharmacol 1988;154(3):339
GR 127935  148672-13-3 01,1'-Biphenyl-4-carboxamide, N-04-methoxy-3-((4-methyl-1-piperazinyl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)  *Oxadiazoles *Piperazines. 
Pharma Action Serotonin Antagonists 		Neuropharmacology 1994 Mar-Apr;33(3-4):393-402
5-methylurapidil  34661-85-3   *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists 		Eur J Pharmacol 1988;151(2):333
flesinoxan  98206-10-1   *Piperazines. 
Pharma Action Antidepressive Agents ; Antihypertensive Agents ; Anti-Anxiety Agents ; Serotonin Agonists 		Eur J Pharmacol 1988;149(3):213
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide  156727-74-1   *Benzamides *Piperazines Receptors, Opioid, delta.  J Med Chem 1994 Jul 9;37(14):2125-8
ranolazine  110445-25-5   *Piperazines Angina Pectoris/drug therapy. 
Pharma Action Enzyme Inhibitors 		Br J Pharmacol 1988;93(2):375RANEXA
U 78517F  133681-84-2   *Chromans *Piperazines. 
Pharma Action Antioxidants ; Neuroprotective Agents ; Anti-Asthmatic Agents 		Stroke 1990;21 Suppl:III-83
azimilide  149888-94-8   *Piperazines *Imidazolidines. 
Pharma Action Anti-Arrhythmia Agents ; Calcium Channel Blockers 		J Cardiovasc Pharmacol 1993 Dec;22(6):810-8
SDZ EAA 494  137424-80-7   *Piperazines. 
Pharma Action Excitatory Amino Acid Antagonists 		Neurosci Lett 1990;113(3):315
tandospirone  112457-95-1 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (3aalpha,4beta,7beta,7aalpha)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)  *Piperazines *Pyrimidines. 
Pharma Action Anti-Anxiety Agents ; Serotonin Agonists 		Jpn J Pharmacol 1987;45(4):493
ICRF 193  21416-68-2   *Piperazines DNA Topoisomerases, Type II/antagonists & inhibitors. 
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Cancer Res 1991;51(18):4903
WAY 100135  133025-23-7 1-Piperazinepropanamide, N-(1,1-dimethylethyl)-4-(2-methoxyphenyl)-alpha-phenyl  *Piperazines. 
Pharma Action Serotonin Antagonists 		J Med Chem 1993 May 14;36(10):1509-10
DPI 201-106  97730-95-5   *Piperazines. 
Pharma Action Cardiotonic Agents 		Naunyn Schmiedebergs Arch Pharmacol 1985;329(3):316
diketopiperazine  29990-68-9   *Piperazines. 
Pharma Action Anti-Bacterial Agents 		J Mol Evol 1980;16(1):1
amperozide  75558-90-6   *Piperazines. 
Pharma Action Psychotropic Drugs ; Serotonin Antagonists ; Antipsychotic Agents 		Acta Vet Scand 1986;27(1):141
triethylenediamine  280-57-9 1,4-diazabicyclo(2.2.2)octane  *Piperazines. 
Pharma Action Radiation-Protective Agents 		Biochem Biophys Res Commun 76(2):391;1977; Biochem Biophys Res Commun 88(2):676;1979; Biochem J 158(1):113;1976; Biul Eksp Biol Med 83(2):147;1977; Chem Biol Interact 7(3):143;1973; Gerontology 1980;26(1):17; Photochem Photobiol 28(4/5):881;1978
dapiprazole  72822-12-9 1,2,4-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)  *Piperazines *Triazoles. 
Pharma Action Adrenergic alpha-Antagonists ; Antipsychotic Agents 		Arzneimittelforsch 1982;32(6):668REV-EYES
BW 373U86  150428-54-9 Benzamide, 4-((2,5-dimethyl-4-(2-propenyl)-1-piperazinyl)(3-hydroxyphenyl)methyl)-N,N-diethyl-, (1(S*),2alpha,5beta)-(+-)  *Benzamides *Piperazines.  Mol Pharmacol 1993 Oct;44(4):827-34
trimazosin  35795-16-5 4-(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazinecarboxylic acid, 2-hydroxy-2- methylpropyl ester  *Piperazines. 
Pharma Action Antihypertensive Agents ; Vasodilator Agents 		Am J Cardiol 40(5):789;1977; Am J Cardiol 44(1):126;1979; Am J Med 65(1):155;1978; Clin Pharmacol Ther 22(4):425;1977; Clin Pharmacol Ther 23(1):11;1978; Clin Pharmacol Ther 24(5):531;1978; Curr Ther Res 15(7):339;1973; Curr Ther Res 17(6):564;1975
naftopidil  57149-07-2   *Naphthalenes *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists ; Antihypertensive Agents ; Calcium Channel Blockers ; Platelet Aggregation Inhibitors 		Arzneimittelforschung 1990;40(3):253
1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine  67469-57-2 Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)  *Piperazines. 
Pharma Action Dopamine Agonists ; Dopamine Uptake Inhibitors 		Brain Res 1983;277(1):47
levocetirizine  130018-77-8   *Piperazines *Cetirizine. 
Pharma Action Histamine H1 Antagonists, Non-Sedating 		Biochem Pharm 2003 Oct; 66(7) 1123-6; Clin Exp Allergy 2002 Aug;32(8):1187-92
KB 2796  101477-54-7   *Piperazines Migraine Disorders. 
Pharma Action Calcium Channel Blockers 		Nippon Geka Hokan 1986;55(5):682
draflazine  120770-34-5 1-Piperazineacetamide, 2-(aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-(5,5-bis(4-fluorophenyl)pentyl)  *Piperazines. 
Pharma Action Cardiotonic Agents ; Platelet Aggregation Inhibitors 		Ann Thorac Surg 1991;52(6):1300
prulifloxacin  123447-62-1 1H,4H-(1,3)Thiazeto(3,2-a)quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-1-piperazinyl)-4-oxo  *Dioxolanes *Piperazines *Quinolones *Fluoroquinolones.  Antimicrob Agents Chemother 1991 Dec;35(12):2496-9
BIBN 4096BS  0   Calcitonin Gene-Related Peptide/analogs & derivatives *Piperazines *Quinazolines.  Br J Pharmacol 2000 Feb;129(3):420-3
SA 4503  0   *Piperazines Carbon Radioisotopes Receptors, sigma/agonists. 
Pharma Action Nootropic Agents 		J Pharmacol Exp Ther 1996 Oct;279(1):106-13
phenylpiperazine  92-54-6   *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists ; Psychotropic Drugs 		Pol J Pharmacol 1980;32(4):495
tiaramide  32527-55-2 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)- 1-piperazineethanol  *Piperazines *Benzothiazoles. 
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Bronchodilator Agents 		Allergy 33(2):76;1978; Arzneim Forsch 22(4):716;1972; Arzneim Forsch 29(6):903;1979; Experientia 34(8):1063;1978; J Pharmacol Exp Ther 200(1):25;1977; Jpn J Pharmacol 26:593;1976; Pharmacol Res Commun 1979;11(8):703; Prostaglandins 13(1):153;1977; Res Commun Chem Pathol Pharmacol 24(3):501;1979; Xenobiotica 7(8):491;1977
eltoprazine  98224-03-4   *Piperazines. 
Pharma Action Serotonin Agonists 		J Pharmacol Exp Ther 1990;253(1):284
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine  155204-23-2   *Aminopyridines *Piperazines Iodine Radioisotopes Ligands. 
Pharma Action Serotonin Antagonists 		J Med Chem 1994 May 13;37(10):1406-7
suriclone  53813-83-5 (8-(7-chloro(1,8)naphthyridin-2-yl)-7-oxo-2,5-dithia-8-azabicyclo(4.3.0)non-10-en-9-yl) 4-methylpiperazine-1-carboxylate  *Piperazines *Sulfur Compounds. 
Pharma Action Anti-Anxiety Agents 		J Neurochem 1983;40(3):601
sipatrigine  130800-90-7   *Piperazines *Pyrimidines. 
Pharma Action Neurotransmitter Uptake Inhibitors ; Neuroprotective Agents 		Stroke 1993 Jul;24(7):1063-7
sobuzoxane  98631-95-9   *Piperazines DNA Topoisomerases, Type II/antagonists & inhibitors. 
Pharma Action Antineoplastic Agents 		Chung Kuo Yao Li Hsueh Pao 1988;9(4):369
amocarzine  99402-78-5   *Piperazines. 
Pharma Action Anthelmintics ; Filaricides 		Trop Med Parasitol 1986;37(4):375
roquefortine  58735-64-1 2H-pyrazino(1',2':1,5)pyrrolo(2,3-b)indole-1,4(3H,5aH)-dione, 10b-(1,1-dimethyl-2-propenyl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-4-ylmethylene)  *Indoles Heterocyclic Compounds with 4 or More Rings Piperazines Mycotoxins.  Ann Nutr Alim 31(4-6):693;1977; Food Cosmet Toxicol 16(4):369;1978; J Agric Food Chem 24(4):865;1976
BM 15766  86621-92-3   *Piperazines. 
Pharma Action Anticholesteremic Agents ; Enzyme Inhibitors 		Horm Metab Res 1985;17(10):543
BP 897  0   *Piperazines Receptors, Dopamine.  Nature 1999 Jul 22;400(6742):371-5
AR-C239  67339-62-2 1,3(2H,4H)-Isoquinolinedione, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-4,4-dimethyl  *Isoquinolines *Piperazines. 
Pharma Action Adrenergic alpha-Antagonists 		J Cardiovasc Pharmacol 1980;2(2):175
piperazine-N,N'-bis(2-ethanesulfonic acid)  5625-37-6   *Piperazines *Alkanesulfonic Acids Buffers.  Eur J Biochem 1980;103(1):47; J Biol Chem 249(7):2005;1974
3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione  64474-15-3   *Piperazines. 
Pharma Action Antibiotics, Antineoplastic 		Can Treat Rep 62(7):1101;1978; Cancer 40(4):1386;1977; Cancer Chemother Rep 57(1):21;1973; Cancer Res 35(11):5996;1975; Cancer Treat Rep 1979;63(8):1367; Cancer Treat Rep 63(6):939;1979; Cancer Treatment Rep 60(9):1397-25;1976; Cancer Treatment Rep 61(9):1617-1731;1977; Int J Radiat Oncol Biol Phys 1979;5(9):1709; J Chromatogr 152(1):280;1978; J Nat Cancer Inst 57(6):1305;1976; Lancet I(8115):514;1979
zipeprol  34758-83-3 4-(2-methoxy-2-phenylethyl)-alpha-(methoxyphenylmethyl)-1-piperazineethanol  *Piperazines. 
Pharma Action Antitussive Agents 		Arzneim Forsch 26(4):523;1976; Arzneim Forsch 26(5):848;1976; Arzneim Forsch 28(1):64;1978; J Pharm Pharmacol 28 Suppl:57P;1976; J Pharm Pharmacol 29(4):253;1977; J Pharm Pharmacol 29:589;1977; J Pharm Pharmacol 29:645;1977
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