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Piperazines

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Definition:      
Examples Almitrine; Cinnarizine; Cyclizine; Delavirdine; Diethylcarbamazine; Diketopiperazines; Dimethylphenylpiperazinium Iodide; Flunarizine; Flupenthixol; HEPES; Hydroxyzine; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Itraconazole; Ketoconazole; Lidoflazine; Meclizine; Pipecuronium; Pipemidic Acid; Pipobroman; Piribedil; Prospidium; Quipazine; Thiethylperazine; Trazodone; Trimetazidine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
YQA14  0   *Benzoxazoles *Piperazines Receptors, Dopamine D3/antagonists & inhibitors. Addict Biol. 2012 Mar;17(2):259-73.
4-(2-ethoxyethoxymethyl)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzamide  0   *Benzamides *Piperazines. Bioorg Med Chem. 2012 Jan 1;20(1):455-66
N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-1,2-dihydro-3-H-benzo(e)indole-3-carboxamide  0   *Indoles *Piperazines Adrenergic alpha-2 Receptor Antagonists. J Pharmacol Exp Ther. 2012 Mar;340(3):750-64.
4-(1-(2-(4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo(d)imidazol-6-yl)piperidin-4-yl)piperazine-1-carboxylate  0   *Benzimidazoles *Piperazines Receptor, IGF Type 1/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):688-97.
ERG7.153  0   *Piperazines *Benzofurans. Chem Biol. 2011 Oct 28;18(10):1273-83.
1-(9-iodophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid  0   *Phenanthrenes *Piperazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem. 2012 Jan 12;55(1):327-41.
2-nitro-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazin-6-yl 4-(4-(trifluoromethoxy)phenyl)piperazine-1-carboxylate  0   *Piperazines *Bicyclo Compounds, Heterocyclic. J Med Chem. 2012 Jan 12;55(1):312-26.
5-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2,2-diphenylcyclopentan-1-ol  0   *Cyclopentanes *Piperazines Serotonin Antagonists Receptor, Serotonin, 5-HT1A. J Med Chem. 2012 Jan 12;55(1):23-36.
1-(3-(3-propoxyphenylcarbamoyloxy)-2-hydroxypropyl)-4-(3-trifluoromethylphenyl)piperazinium chloride  0   *Piperazines Antitubercular Agents. Ceska Slov Farm. 2011 Dec;60(6):283-9
1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine  0   *Dioxanes *Piperazines Ligands Receptors, Dopamine D4. J Med Chem. 2011 Dec 22;54(24):8343-52.
thiohomosildenafil  0   *Piperazines *Sulfones. J AOAC Int. 2011 Nov-Dec;94(6):1770-7
3-((4-(3,4-dichlorobenzyl)piperazin-1-yl)methyl)-1H-indole  0   *Indoles *Piperazines. Chem Biol Drug Des. 2011 Nov;78(5):869-75.
N-cyclohexyl-4-(1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl)piperazine-1-carboxamide  0   *Piperazines Receptor, Cannabinoid, CB1/antagonists & inhibitors. Eur J Med Chem. 2010 Mar;45(3):1133-9.
2-amino-N-(2-(4-(3-(2-trifluoromethylphenothiazin-10-yl)propyl)piperazin-1-yl)ethyl)acetamide  0   *Phenothiazines *Piperazines Serotonin 5-HT2 Receptor Antagonists. Eur J Pharmacol. 2011 Nov 16;670(1):195-203.
(2RS,3RS)-5-amino-3-(4-(3-methoxyphenyl)piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Phthalic Acids *Piperazines. Acta Crystallogr C. 2011 Nov;67(Pt 11):o469-72
(R)-1,1,1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol  0   *Piperazines *Propanols. J Org Chem. 2011 Sep 2;76(17):7048-55
(2RS,3RS)-5-amino-3-(4-phenylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Naphthalenes *Piperazines. Acta Crystallogr C. 2011 Oct;67(Pt 10):o378-81
1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one  0   *Piperazines *Thiophenes Thioctic Acid/*analogs & derivatives Cholinesterase Inhibitors. Neurochem Int. 2011 Oct;59(5):722-8
GNF 179  0   *Imidazoles *Piperazines. Science. 2011 Dec 9;334(6061):1372-7.
PF 4840154  0   *Piperazines *Pyrimidines. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9.
N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-3-yl)benzamide  0   *Benzamides *Piperazines Receptors, Dopamine D3/agonists. Neuropharmacology 2011 Feb-Mar;60(2-3):284-94
1-(4-nitro-2-(trifluoromethyl)phenyl)-4-(3-(trifluoromethyl)phenyl)piperazine  0   *Piperazines. J Med Chem 2011 Jan 13;54(1):302-11
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide  0   *Piperazines *Pyrazoles. J Med Chem 2011 Sep 22;54(18):6364-74
9-ethyl-6,6-dimethyl-8-(4-oxetan-3-ylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo(b)carbazole-3-carbonitrile  0   *Carbazoles *Piperazines. J Med Chem 2011 Sep 22;54(18):6286-94
4-(3-(3-chloro-4-fluorophenyl)acryloyl)-1-(3-(4-hydroxy-6-azaspiro(2.5)oct-6-yl)propyl)-3-methylpiperazin-2-one  0   *Cinnamates *Piperazines Receptors, CCR2/antagonists & inhibitors. Kidney Int 2011 Jul;80(1):68-78
fluorescent probe Z1  0   *Heterocyclic Compounds, 3-Ring *Piperazines. Chem Commun (Camb). 2011 Aug 7;47(29):8301-3
2,2'-(piperazine-1,4-diyl)bis(N-(quinolin-8-yl)acetamide)  0   *Piperazines *Aminoquinolines. Dalton Trans 2011 Jun 28;40(24):6367-70
7-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
2-(2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl)-1H-pyrrolo(3,4-b)quinolin-3(2H)-one  0   *Piperazines *Quinolines. Eur J Med Chem 2011 Jun;46(6):2152-6
1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone  0   *Piperazines *Pyridines Receptors, Metabotropic Glutamate/agonists. Eur J Pharmacol 2011 Jun 1;659(2-3):146-54
epicoccin G  0   *Piperazines. J Am Chem Soc. 2011 Jun 1;133(21):8150-3
sildenafil lactate  0   *Piperazines *Sulfones Erectile Dysfunction/drug therapy. Arch Pharm Res. 2011 Mar;34(3):451-4
5-((4-(4-(2-ethoxy-5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)carbonyl)-4,6-dimethylpyrimidine  0   *Piperazines *Pyrimidines Receptors, CCR4/antagonists & inhibitors. J Pharmacol Exp Ther 2011 Jul;338(1):228-39
4-((3-aminophenyl)(4-(4-fluorobenzyl)piperazin-1-yl)methyl)-N,N-diethylbenzamide  0   *Benzamides *Piperazines Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2011 Jul;338(1):195-204
((1-isopropyl-3-(3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone)  0   *Piperazines *Pyridazines Receptors, CCR2/antagonists & inhibitors. Bioorg Med Chem Lett 2011 May 1;21(9):2626-30
PF 00217830  0   *Naphthyridines *Piperazines. Bioorg Med Chem Lett 2011 May 1;21(9):2621-5
pre-aurantiamine  0   *Piperazines. Phytochemistry. 2011 Jun;72(8):816-20
Z 123212  0   *Acetanilides *Piperazines Membrane Transport Modulators. Pain 2011 Apr;152(4):833-43
1,4-bis(9-anthracenylmethyl)piperazine  0   *Anthracenes *Piperazines. J Oleo Sci 2010;59(12):661-6
HHGV678  0   *Piperazines *Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1039-43
piperazine-1,4-diium 4-oxo-4H-pyran-2,6-dicarboxylate monohydrate  0   *Piperazines *Pyrans. Acta Crystallogr C. 2011 Apr;67(Pt 4):o134-8
2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol  0   *Piperazines *Pyridines. Drug Metab Dispos 2011 Jan;39(1):39-46
11-(3-(4-((4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-1H-1,2,3-triazol-1-yl)propoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
11-((1-(3-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
5-piperazin-1-ylindeno(1,2-c)isoquinolin-11-one  0   *Isoquinolines *Piperazines DNA Topoisomerases, Type I. Bioorg Med Chem 2011 Mar 15;19(6):1924-9
N-(3-isopropyl-3-((4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)carbonyl)cyclopentyl)-3-methoxytetrahydro-2H-pyran-4-amine  0   *Piperazines *Pyrans Receptors, CCR5/antagonists & inhibitors Receptors, CCR2/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Mar 1;21(5):1442-6
GSK 525060  0   *Piperazines *Piperidines. Drug Metab Dispos 2011 Mar;39(3):363-72
2-methoxyphenylpiperazine dithiocarbamate  0   *Piperazines *Thiocarbamates. J Biol Inorg Chem. 2011 Jan;16(1):137-55
4-hexadecanoyl-1,1-dimethylpiperazin-1-ium  0   *Piperazines. Carcinogenesis 2011 Mar;32(3):254-61
(3-ethoxyquinoxalin-2-yl)(4-methylpiperazin-1-yl)methanone  0   *Piperazines *Quinoxalines Receptors, Serotonin, 5-HT3. Bioorg Med Chem Lett 2011 Feb 15;21(4):1253-6
4-amino-1-(4-((4-chloro-phenyl)-phenyl-methyl)-piperazin-1-yl)-butan-1-one  0   *Butanones *Piperazines. J Pharm Biomed Anal. 2011 Feb 20;54(3):568-71
2-(2-ethoxy-5-(2-(4-ethylpiperazin-1-yl)acetyl)phenyl)-5-methyl-7-propyl-imidazo(5,1-f)-(1,2,4)triazin-4(3H)-one  0   *Imidazoles *Piperazines *Triazines. J Pharm Biomed Anal. 2011 Feb 20;54(3):491-6
4-(4-ethyl-piperazin-1-yl)-1-(2,3,4-trihydroxyphenyl)butan-1-one  0   *Piperazines Gallic Acid/*analogs & derivatives Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethylpiperazine-1-carbonyl)phenyl ester  0   *Carbamates *Piperazines Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one  0   *Piperazines Dipeptidyl Peptidase 4. Diabetes Res Clin Pract 2011 Jan;91(1):72-9
2-(((2-piperidylmethyl)amino)methyl)-4-bromo-6-((1-methylhomopiperazine-4-yl)methyl)phenol  0   *Phenols *Piperazines. Dalton Trans. 2011 Feb 14;40(6):1372-81
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate  0   *Isoquinolines *Piperazines. Acta Crystallogr C. 2011 Mar;67(Pt 3):o120-4
Lu AA21004  0   *Piperazines *Sulfides Receptor, Serotonin, 5-HT1A Receptors, Serotonin, 5-HT3. IDrugs 2010 Dec;13(12):900-10
6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo(d)oxazol-2(3H)-one  0   *Benzoxazoles *Piperazines Receptors, sigma/antagonists & inhibitors. Biol Psychiatry 2011 Feb 1;69(3):208-17
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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