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Pyrroles

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Definition: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.     
Examples Cromakalim; Maleimides; Porphobilinogen; Prodigiosin; Pyrrolnitrin; Ryanodine; Tetrapyrroles; Tolmetin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
longmide B  0   *Pyrroles Alkaloids. Org Lett. 2012 Feb 17;14(4):1062-5
kendine 92  0   *Pyrroles Histone Deacetylase Inhibitors. Epigenetics. 2011 Oct 1;6(10):1228-35
7-ethyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine  0   *Pyrazines *Pyrroles. Carcinogenesis. 2012 Mar;33(3):661-9.
cis-4-((3H,3aH,6aH)-3-(4-methoxyphenyl)-4,6-dioxo-2p-tolydihydro-2H-pyrrolo(3,4-d)isoxazol-5(3H,6H,6aH)-yl)benzoic acid  0   *Pyrroles *Benzoic Acids. Bioorg Med Chem. 2012 Jan 1;20(1):521-30
N6022  0   *Benzamides *Pyrroles. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3671-5.
pyrrolo-cytosine  0   *Pyrroles Cytosine/*analogs & derivatives Nucleic Acid Probes. RNA. 2012 Mar;18(3):434-48
fluorohymenidin  0   *Imidazoles *Pyrroles. Org Lett. 2012 Jan 20;14(2):468-71
CR2408  0   *Pyrroles *Sulfonamides Antineoplastic Agents. Br J Haematol. 2012 Mar;156(5):633-42
6-(nitrooxy)hexyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate  0   *Nitrates *Pyrroles. Br J Pharmacol. 2011 Sep;164(2b):570-83.
2-pyrrolecarboxaldehyde  0   *Aldehydes *Pyrroles. J Phys Chem B. 2011 Nov 3;115(43):12549-57
1-methyl-2-pyrrolecarboxaldehyde  0   *Aldehydes *Pyrroles. J Phys Chem B. 2011 Nov 3;115(43):12549-57
2-(2-nitroethyl)pyrrole  0   *Pyrroles. J Org Chem. 2011 Nov 18;76(22):9478-87
3,6-bis(4-1,3-dioxolan-2-ylphenyl)pyrrolo(3,4-c)pyrrole-1,4-dione  0   *Pyrroles. J Org Chem. 2011 Nov 18;76(22):9294-304
terreusinone  0   *Pyrroles *Benzoquinones Sunscreening Agents. Org Lett. 2011 Dec 16;13(24):6444-7
3-(dimethylamino-ethylamino)-8-oxo-8H-acenaphthol(1,2-b)pyrrole-9-carboxylic acid  0   *Acenaphthenes *Pyrroles Antineoplastic Agents Uterine Cervical Neoplasms/drug therapy. Anticancer Drugs. 2011 Oct;22(9):875-85
1-(3,4,5-trimethoxybenzyl)-1H-pyrrole-2-carboxylic acid  0   *Carboxylic Acids *Pyrroles Growth Inhibitors. Cell Cycle. 2011 Sep 15;10(18):3208-9
S35972  0   *Pyrazines *Pyridines *Pyrroles Anticoagulants. J Thromb Haemost. 2011 Jul;9(7):1375-82
poly(3-(pyrrolyl)carboxylic acid)  0   *Carboxylic Acids *Pyrroles. Analyst. 2011 Oct 21;136(20):4211-6
DSE-3 compound  0   *Imidazoles *Pyrroles. Cancer Sci. 2011 Dec;102(12):2221-30.
(-)-7-(3-(cyclopentyloxy)-4-methoxyphenyl)hexahydro-3H-pyrrolizin-3-one  0   *Pyrroles Phosphodiesterase 4 Inhibitors. J Org Chem. 2011 Oct 7;76(19):7893-900
psychotripine  0   *Indoles *Pyrroles. Org Lett. 2011 Nov 4;13(21):5896-9
CS 0777  0   *Amino Alcohols *Pyrroles Receptors, Lysosphingolipid. J Clin Pharmacol. 2009 Jan;49(1):50-62.
langkamide  0   *Pyrroles Alkaloids. Chem Pharm Bull (Tokyo). 2011;59(9):1178-9
pentafluorophenyldipyrrinphenol  0   *Phenols *Pyrroles Ligands. Dalton Trans. 2011 Sep 28;40(36):9090-3
(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride  0   *Benzimidazoles *Pyrroles. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95
2,3-dichloro-N-(1H-pyrrolo(2,3-b)pyridin-5-yl)benzamide  0   *Benzamides *Pyrimidines *Pyrroles. Eur J Pharmacol. 2011 Sep 30;667(1-3):74-9
4-(3-benzoyl-2-methyl-5-phenyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid  0   *Pyrroles *Benzoic Acids. Med Chem. 2011 Jul 1;7(4):309-16
2,5-bisamidopyrrole  0   *Pyrroles. J Org Chem. 2011 Aug 19;76(16):6780-8
1,4,5,6-tetrahydrocyclopenta(b)pyrrole  0   *Cyclopentanes *Pyrroles. J Org Chem. 2011 Jul 15;76(14):5813-20
SEN1176  0   *Pyrroles *Pyrimidines *Triazoles Anti-Inflammatory Agents. Alzheimers Dis. 2011;25(2):219-29
4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine  0   *Pyrimidines *Pyrroles Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Med Chem 2008 Apr 10;51(7):2147-57
lobechine  0   *Butyric Acids *Pyrroles Pancreatic Elastase/antagonists & inhibitors. Arch Pharm Res 2011 May;34(5):715-22
2-((1H-pyrrol-2-ylmethylidene)amino)benzonitrile  0   *Nitriles *Pyrroles. Acta Crystallogr C. 2011 Aug;67(Pt 8):o315-8
pyrrolo(3,2-e)(1,4)diazepin-2-one  0   *Azepines *Pyrroles. J Org Chem. 2011 Jun 3;76(11):4533-45
pyrrolo(2,1-a)isoquinoline  0   *Isoquinolines *Pyrroles. J Org Chem. 2011 May 6;76(9):3296-305
4-((2S)-2-(1H-imidazol-1-ylmethyl)-5-oxotetrahydro-1H-pyrrol-1-yl)methylbenzenecarboxylic acid  0   *Imidazoles *Pyrroles. Bioorg Med Chem. 2011 May 1;19(9):2888-902
1-((2S)-1-(4-(methoxycarbonyl)benzyl)-5-oxotetrahydro-1H-pyrrol-2-ylmethyl)-1H-imidazole-5-carboxylic acid  0   *Imidazoles *Pyrroles. Bioorg Med Chem. 2011 May 1;19(9):2888-902
ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate  0   *Acenaphthenes *Pyrroles Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. J Med Chem 2011 Jun 9;54(11):3732-45
palmyrrolinone  0   *Pyrroles Biomphalaria/drug effects. J Nat Prod. 2011 May 27;74(5):1175-81
marumoside B  0   *Glycosides *Pyrroles Alkaloids. Phytochemistry. 2011 Jun;72(8):791-5
marumoside A  0   *Glycosides *Pyrroles Alkaloids. Phytochemistry. 2011 Jun;72(8):791-5
7-methoxy-8-(5-(4-(1,3-benzothiazol-2-yl)-2-methoxyphenoxy)pentyl)oxy-(11aS)1,2,3,11a-tetra-hydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one  0   *Benzodiazepines *Pyrroles. Bioorg Med Chem. 2010 Jul 1;18(13):4747-61
(Z)-5-(6-(3-(4-methoxyphenyl)-ureido)-2-oxo-1,2-dihydroindol-3-ylidene-methyl)-4-methyl-1H-pyrrole-3-carboxylic acid  0   *Pyrroles Urea/*analogs & derivatives. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86
thieno(3,4-c)pyrrole-4,6-dione  0   *Pyrroles. J Am Chem Soc. 2011 Mar 30;133(12):4250-3
marinoquinoline A  0   *Pyrroles *Quinolines. J Nat Prod. 2011 Apr 25;74(4):603-8
beta-Gal-Py-gamma-Py-Ind  0   *Amides *Indoles *Pyrroles Galactose/*analogs & derivatives. Chemistry. 2011 Apr 11;17(16):4561-70
benzo(e)indolo(1,2-a)pyrrolo(2,1-c)(1,4)diazepine-3,9-dione  0   *Azepines *Indoles *Pyrroles. J Org Chem. 2011 Mar 4;76(5):1239-49
6-ethyl-6-(4-((phenylthio)methyl)phenyl)-6,7-dihydrobenzo(b)pyrrolo(1,2-d)(1,4)oxazepin-7-one  0   *Oxazepines *Pyrroles Adenosine Kinase/antagonists & inhibitors. J Med Chem 2011 Mar 10;54(5):1401-20
cyclooroidin  0   *Pyrroles. Org Lett. 2011 Mar 18;13(6):1382-5
2-formylpyrrole-4-acrylamide  0   *Acrylamides *Pyrroles. Nat Prod Commun. 2011 Mar;6(3):353-5
BC76 compound  0   *Benzimidazoles *Pyrroles Cyclic Nucleotide Phosphodiesterases, Type 5. Cell Signal 2011 Mar;23(3):594-601
8-oxo-3-thiomorpholin-4-yl-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile  0   *Acenaphthenes *Pyrroles. Chembiochem 2007 Jan 2;8(1):113-21
poly(pyrrole-2,6-dimethyl-beta-cyclodextrin)  0   *Pyrroles *beta-Cyclodextrins. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jan;78(1):1-6
1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one  0   *Pyrimidinones *Pyrroles Alkaloids. Fitoterapia. 2010 Dec;81(8):1091-3
3-isopropyl-tetrahydropyrrolo(1,2-a)pyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones *Pyrroles Alkaloids. Fitoterapia. 2010 Dec;81(8):1091-3
wilsoniamine B  0   *Imidazoles *Pyrroles. Org Biomol Chem. 2011 Jan 21;9(2):604-9
wilsoniamine A  0   *Imidazoles *Pyrroles Alkaloids. Org Biomol Chem. 2011 Jan 21;9(2):604-9
polyamide f-IPI  0   *Nylons *Imidazoles *Pyrroles. Biochem Biophys Res Commun. 2011 Jan 21;404(3):848-52
N-pyrrolylketene  0   *Ethylenes *Ketones *Pyrroles. Org Lett. 2011 Feb 4;13(3):494-7
lamellarin R  0   *Heterocyclic Compounds with 4 or More Rings *Pyrroles. Org Lett. 2011 Jan 21;13(2):312-5
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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