encyclopedia of medical concepts
ψ 

Azepines

More information in Books or onNLM PubMed
Definition: Seven membered heterocyclic rings containing a NITROGEN atom.     
See Also Benzazepines; Dibenzazepines
Examples Caprolactam; Dilazep; Meptazinol; Oxazepines; Pentylenetetrazole; Thiazepines; Zolazepam 		Other names Hexamethyleneimines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
maistemonine  0   *Azepines *Spiro Compounds Alkaloids. J Org Chem. 2011 Dec 16;76(24):10173-86
5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-(1,4)diazepino(1,2-a)indole-8-carboxylic acid (1-(3-dimethylamino-propyl)-1H-benzoimidazol-2-yl)amide  0   *Azepines *Benzimidazoles Ribosomal Protein S6 Kinases/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):492-500.
1-(5-chloropyridin-3-yl)-(1,4)diazepane  0   *Azepines *Pyridines Nicotinic Agonists. J Psychopharmacol. 2011 Oct;25(10):1347-56.
darexaban glucuronide  0   *Azepines *Benzamides *Glucuronides. Eur J Pharmacol. 2011 Dec 30;673(1-3):49-55
9-methyl-4-phenyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine  0   *Azepines *Thiophenes. Br J Pharmacol. 2011 Nov;164(6):1642-51.
N-(2-hydroxy-6-(4-methoxybenzamido)phenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide  0   *Azepines *Benzamides Factor Xa/antagonists & inhibitors. Expert Opin Investig Drugs. 2011 Apr;20(4):495-505.
benzo(3,4)azepino(1,2-b)isoquinolin-9-one  0   *Azepines *Isoquinolines. Chem Pharm Bull (Tokyo). 2011;59(9):1169-73
4-amino-3-methyl-2-oxoazepane-4-carboxylate  0   *Azepines *Carboxylic Acids. J Org Chem. 2011 Aug 19;76(16):6592-603
(+)-JQ1 compound  0   *Azepines *Triazoles. Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5801-3
1-(5-ethoxypyridin-3-yl)-1,4-diazepane  0   *Pyridines *Azepines Cholinergic Agonists. J Neurosci 2011 Jul 27;31(30):10759-66
pyrrolo(3,2-e)(1,4)diazepin-2-one  0   *Azepines *Pyrroles. J Org Chem. 2011 Jun 3;76(11):4533-45
PF 3246799  0   *Azepines *Pyrimidines Serotonin Receptor Agonists Receptor, Serotonin, 5-HT2C. Bioorg Med Chem Lett 2011 May 1;21(9):2715-20
MK 2918  0   *Azepines *Imidazoles Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Bioorg Med Chem Lett 2011 May 1;21(9):2683-6
(4-cyclobutyl-(1,4)diazepan-1-yl)-(6-(4-fluorophenoxy)pyridin-3-yl)methanone  0   *Azepines *Pyridines Histamine H3 Antagonists. Bioorg Med Chem Lett 2010 Jul 15;20(14):4210-4
ANA 12 compound  0   *Azepines *Benzamides Receptor, trkB/antagonists & inhibitors. J Clin Invest 2011 May 2;121(5):1846-57
2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1H-chryseno(2,1-c)azepine-12-carboxylic acid amide  0   *Azepines Glycyrrhetinic Acid/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1866-80
benzo(e)indolo(1,2-a)pyrido(2,1-c)(1,4)diazepine-3,9-dione  0   *Azepines *Indoles *Pyridines. J Org Chem. 2011 Mar 4;76(5):1239-49
benzo(e)indolo(1,2-a)pyrrolo(2,1-c)(1,4)diazepine-3,9-dione  0   *Azepines *Indoles *Pyrroles. J Org Chem. 2011 Mar 4;76(5):1239-49
2-(4-(4-methylbenzyl)-(1,4)diazepan-1-yl)-N-(4,5-dihydro-1-methyl-(1,2,4)triazolo(4,3-a)quinolin-7-yl)acetamide  0   *Azepines *Triazoles. Chem Biol Drug Des 2011 Jan;77(1):98-103
4H-pyrazolo(4,5-f)(1,2,4)triazolo(4,3-b)(1,2,4)triazepine  0   *Azepines *Triazoles. Eur J Med Chem. 2011 Feb;46(2):631-5
3-(2-(azepan-1-yl)ethyl)-6-propylbenzo(d)thiazol-2(3H)-one  0   *Azepines *Benzothiazoles Ligands Tritium. Eur J Pharmacol 2011 Feb 25;653(1-3):1-7
1,4-bis(3-methyl-4-pyridinyl)-1,4-diazepane  0   *Azepines *Pyridines Respiratory Syncytial Virus, Human. Antiviral Res. 2010 Dec;88(3):317-24
1H-benzo(e)(1,4)diazepin-2(3H)-one  0   *Azepines. J Org Chem. 2010 Oct 1;75(19):6588-94
2-(dimethylamino)-4-(4-methoxy-3,5-dimethylbenzyl)-6-methylimidazo(4,5-d)azepin-5(6H)-one  0   *Azepines *Imidazoles. J Med Chem 2010 Nov 11;53(21):7843-51
N1-(4,5-dihydro-3H-azepin-2-yl)spermidine  0   *Azepines Spermidine/*analogs & derivatives. J Med Chem 2010 Nov 11;53(21):7647-63
3-fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazolo(4,5-c)azepin-5(6H)-yl)benzonitrile  0   *Azepines *Oxazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2010 Oct 14;53(19):7107-18
1-(2-(4-cyclobutyl-(1,4)diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-yl)-ethanone  0   *Azepines *Pyrrolidines. J Org Chem. 2010 Jul 2;75(13):4344-55
7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine  0   *Azepines *Quinazolines. J Med Chem 2010 Aug 12;53(15):5844-57
(4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone  0   *Azepines *Triazoles. J Med Chem 2010 Jul 22;53(14):5320-32
1-(2-(4-cyclobutyl-(1,4)diazepane-1-carbonyl)-4-(3-fluorophenoxy)pyrrolidin-1-yl)ethanone  0   *Azepines *Pyrrolidines Receptors, Histamine H3. Bioorg Med Chem Lett 2010 May 1;20(9):2755-60
2-((5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-5-(2-hydroxy-3-morpholinopropyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo(3,2-c)azepin-4-ketone  0   *Azepines *Indoles Vascular Endothelial Growth Factors/antagonists & inhibitors. Biomed Chromatogr 2010 Apr;24(4):420-5
5-(3,4-dimethoxybenzyl)-7-isopropyl-1,3,5-triazepane-2,6-dione  0   *Azepines *Benzyl Compounds. Acta Crystallogr C. 2010 Jun;66(Pt 6):o292-4
vabicaserin carbamoyl glucuronide  0   *Azepines *Glucuronides. Drugs Metab Dispos 2010 Apr;38(4):581-90
MLN 8237  0   *Azepines *Pyrimidines. Pediatr Blood Cancer 2010 Jul 15;55(1):26-34
tri-tert-butyl 3-oxo-4-oxa-1,8,11-triazaspiro(5.6)dodecane-1,8,11-triacetate  0   *Acetates *Azepines. Acta Crystallogr C 2010 Apr;66(Pt 4):e174-5
INCB 16562  0   *Azepines *Pyridines Janus Kinases/antagonists & inhibitors. Neoplasia 2010 Jan;12(1):28-38
5,11-dihydro-11-ethyl-5-methyl-8-(2-(1-oxido-4-quinolinyl)ethyl)-6H-dipyrido(3,2-B,2',3'-E)(1,4)diazepin-6-one  0   *Azepines *Pyridines RNA-Directed DNA Polymerase. J Pharm Biomed Anal 2010 Apr 6;51(5):1047-53
A 90289B  0   *Azepines Uracil/*analogs & derivatives. Chembiochem 2010 Jan 25;11(2):184-90
A 90289A  0   *Azepines Uracil/*analogs & derivatives. Chembiochem 2010 Jan 25;11(2):184-90
isopropyl 8-fluoro-1,1-dimethyl-3-(4-(3-morpholin-4-ylpropoxy)benzoyl)-1,2,3,6-tetrahydroazepino(4,5-b)indole-5-carboxylate  0   *Azepines *Indoles. J Med Chem 2010 Feb 25;53(4):1774-87
1,1'-binaphthylazepine  0   *Azepines *Naphthalenes. Chirality. 2010 Jan;22(1):159-64
N(1)-benzyl-2,7-dihydro-1H-azepine  0   *Azepines. Org Lett. 2010 Jan 1;12(1):136-9
S 282430  0   *Azepines *Benzhydryl Compounds. Bioorg Med Chem Lett 2009 Nov 1;19(21):6074-7
S 282429  0   *Azepines *Benzhydryl Compounds. Bioorg Med Chem Lett 2009 Nov 1;19(21):6074-7
1,2,7,8,9,10,11,13-octahydro-4-(3-hydroxyphenylthio)-13-oxo-(1)benzothieno-(2',3'-4,5)pyrimido(1,2-a)azepine-3-carboxaldehyde  0   *Azepines *Thiophenes 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6660-71
indeno-1,4-diazepinone  0   *Azepines *Indenes. J Org Chem. 2009 Oct 2;74(19):7315-21
1,4-diazepane  0   *Azepines. J Org Chem. 2009 Aug 7;74(15):5652-5
A 500359B  0   *Azepines Uridine/*analogs & derivatives. J Antibiot (Tokyo) 2009 Jun;62(6):325-32
(S)-3-benzyl-7-(4-fluorobenzyloxy)-4-(4-methoxyphenethyl)-4,5-dihydro-1H-benzo(e)(1,4)diazepin-2(3H)-one  0   *Azepines. Bioorg Chem. 2009 Jun;37(3):90-5
zoanthamine  0   *Alkaloids *Azepines *Heterocyclic Compounds with 4 or More Rings *Quinolines. Chemistry. 2009 Jul 6;15(27):6626-44
azepino(4,5-b)indolone  0   *Azepines *Indoles. Org Biomol Chem. 2009 Apr 7;7(7):1388-96
3-(3-(6-(4-methyl(1,4)diazepan-1-yl)pyrazin-2-yl)phenyl)acrylic acid  0   *Azepines *Phenylpropionates. J Med Chem 2009 Apr 9;52(7):1814-27
N-(2-(4-(2,3-dihydrobenzo(1,4)dioxin-2-ylmethyl)-(1,4)diazepan-2-yl)ethyl)-2-phenoxynicotinamide  0   *Azepines Niacinamide/*analogs & derivatives Receptors, Adrenergic, alpha-2/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Oct 15;18(20):5689-93
WAY-362450  0   *Azepines *Indoles. Am J Physiol Gastrointest Liver Physiol 2009 Mar;296(3):G543-52
1-(3',3'-diphenylpropyl)-4-(2'-(2'',4''-dichlorophenyl)ethyl)-7-(N-aminocarbonylmethyl-N-(2-(2'',4''-dichlorophenyl)ethyl)aminocarbonyl)perhydro-1,4-diazepine-2,5-dione  0   *Azepines *Peptoids. J Med Chem 2008 Feb 14;51(3):521-9
protostemonamide  0   *Azepines 4-Butyrolactone/*analogs & derivatives. Planta Med 2009 Feb;75(2):174-7
6-(5-chloro-2-methoxybenzyl)-4-alarkylaminocarbonyl-1,4-diazepane-2,5-dione  0   *Azepines. Eur J Pharmacol 2008 Dec 28;601(1-3):186-91
CID755673  0   *Azepines *Benzofurans. J Biol Chem 2008 Nov 28;283(48):33516-26
3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo(3,4-f)(1,2,3,5)tetrazepin-4(3H)-one  0   *Azepines *Pyrazoles. Eur J Med Chem 2008 Nov;43(11):2386-94
diazepino(2,3-h)quinoline  0   *Azepines *Quinolines. Molecules. 2008;13(11) (dup#2):2880-93
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy