ψ 
Azepines 
Seven membered heterocyclic rings containing a NITROGEN atom.     
See Also Dibenzazepines; Benzazepines		Other names Hexamethyleneimines; Hexamethyleneimines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
WEB 2086  105219-56-5   *Azepines *Triazoles. 
Pharma Action Fibrinolytic Agents ; Platelet Aggregation Inhibitors 		Eur J Pharmacol 1987;135(2):117
talipexole  36085-73-1 4H-Thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propenyl)-, dihydrochloride  *Azepines. 
Pharma Action Adrenergic alpha-Agonists ; Antidepressive Agents ; Dopamine Agonists 		Eur J Pharmacol 1980;62(4):278
FR 139317  142375-60-8 D-Alanine, N-(N-(N-((hexahydro-1H-azepin-1-yl)carbonyl)-L-leucyl)-1-methyl-D-tryptophyl)-3-(2-pyridinyl)  *Azepines *Indoles.  Mol Pharmacol 1993 Feb;43(2):127-31
B-HT 933  36067-73-9 4H-oxazolo(4,5-d)azepin-2-amine, 6-ethyl-5,6,7,8-tetrahydro-, dihydrochloride  *Azepines. 
Pharma Action Adrenergic alpha-Agonists ; Antihypertensive Agents ; Vasoconstrictor Agents 		Naunyn Schmiedebergs Arch Pharmacol 300:39;1977
bepafant  114776-28-2   *Azepines *Triazoles. 
Pharma Action Platelet Aggregation Inhibitors 		Br J Pharmacol 1990;99(1):164
laurocapram  59227-89-3   *Azepines.  Arch Dermatol 1982;118(7):474
brotizolam  57801-81-7 2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine  *Azepines. 
Pharma Action Hypnotics and Sedatives 		Arzneim Forsch 29(4):700;1979; EEG EMG 10(2):95;1979
ML 7  109376-83-2 1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)  *Azepines *Naphthalenes Myosin-Light-Chain Kinase/antagonists & inhibitors. 
Pharma Action Enzyme Inhibitors 		FEBS Lett 1991;287(1-2):175
ML 9  105637-50-1   *Azepines Myosin-Light-Chain Kinase/antagonists & inhibitors. 
Pharma Action Enzyme Inhibitors 		Mol Pharmacol 1988;33(6):598
cetiedil  14176-10-4 alpha-cyclohexyl-3-thiopheneacetic acid, 2-(hexahydro-1H-azepin-1-yl)ethyl ester  *Azepines. 
Pharma Action Anti-Arrhythmia Agents ; Antisickling Agents ; Vasodilator Agents 		Arch Ostet Ginecol 1978;83(3-4):127; Blood 1980;55(2):265; Boll Soc Ital Biol Sper 54(3):233;1978; Clin Ter 1979;90(1):11; Eur J Clin Pharmacol 12:205;1977; Int J Clin Pharm Biopharm 16(9):402;1978; J Pharmacol Exp Ther 198(1):176;1976; Kardiologiia 18(8):37;1978; Lille Med 18(10)suppl 5:1303;1973; Nouve Presse Med 5(25):1577;1976
molinate  2212-67-1 S-ethyl hexahydro-1H-azepine-1- carbothioate  *Azepines *Thiocarbamates. 
Pharma Action Antispermatogenic Agents ; Herbicides 		Bull Environ Contam Toxicol 14(3):281;1975; Dokl Acad Nauk SSSR 239(3):717;1978; Farmakol Toksikol 38(1):90;1975; Gig Sanit (1):99;1977; Gig Sanit (6):101;1978; Gig Sanit 10:104;1975; Izv Akad Nauk SSSR (Biol) 1:44;1978; Izv Akad Nauk SSSR (Biol) 5:723;1977; J Agric Food Chem 26(5):1096;1978; Tsitolog Genet 11(4):357;1977; Vrach Delo 9:136;1976; Xenobiotica 1979;9(11):669
BN 50739  128672-07-1 4H-Pyrido(4',3':4,5)thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine, 6-(2-chlorophenyl)-9-(2-((3,4-dimethoxyphenyl)thio)-1-thioxoethyl)-7,8,9,10-tetrahydro-1-methyl  *Azepines *Triazoles. 
Pharma Action Anti-Arrhythmia Agents 		Prostaglandins 1990;39(5):469
BN 50730  132579-32-9   *Azepines *Triazoles. 
Pharma Action Platelet Aggregation Inhibitors 		J Pharmacol Exp Ther 1990;255(3):1320
BQ 485  141594-26-5   *Azepines *Oligopeptides.  Biochem Biophys Res Commun 1993 Sep 15;195(2):969-75
Y 24180  117279-73-9 6H-Thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine, 4-(2-chlorophenyl)-6,9-dimethyl-2-(2-(4-(2-methylpropyl)phenyl)ethyl)  *Azepines *Triazoles.  Agents Actions Suppl 1990;31:251
E 6123  131614-02-3 4H-Pyrido(4',3':4,5)thieno(3,2-f)(1,2,4)triazolol(4,3-a)(1,4)diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-dimethyl-, (S)  *Azepines *Triazoles.  Agents Actions Suppl 1990;31:251
securinine  5610-40-2 (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro(2,3-c)pyrido(1,2-a)azepin-2(6H)-one  *Alkaloids *Azepines *Lactones *Piperidines Heterocyclic Compounds with 4 or More Rings.  Chin Med J Engl 1(3):205;1975; Veterinariia 8:78;1971
5-fluoro-2-methyl-N-(4-(5H-pyrrolo(2,1-c)-(1,4)benzodiazepin-10-(11H)-ylcarbonyl)-3-chlorophenyl)benzamide  0   *Azepines *Benzamides Receptors, Vasopressin/metabolism.  J Med Chem 1998 Jul 2;41(14):2442-4
ophiocordin  63590-19-2 Benzoic acid, 4-(2-(((hexahydro-4-((4-hydroxybenzoyl)oxy)-1H-azepin-3-yl)amino)carbonyl)-6-hydroxybenzoyl)-3,5-dihydroxy  *Azepines *Hydroxybenzoic Acids Protein Kinase C/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.  Arch Microbiol 113(1/2):121;1977
PD 151242  155561-67-4   *Azepines *Oligopeptides Iodine Radioisotopes.  Br J Pharmacol 1994 Jan;111(1):4-6
Ro 19-4603  99632-94-7   *Azepines.  Br J Pharmacol 1988;93(4):965
BN 50727  133686-55-2   *Azepines *Triazoles.  Adv Prostaglandin Thromboxane Leukotriene Res 1991;21B:929
bentazepam  29462-18-8 1,3,6,7,8,9-hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one  *Azepines.  Arzneim Forsch 25(6):926;1975; J Med Chem 17(6):624;1974
B-HT 958  83718-64-3   *Azepines.  Naunyn Schmiedebergs Arch Pharmacol 1982;320(2):110
DMP 450  0   *Azepines Urea/*analogs & derivatives.  J Med Chem 1996 May 24;39(11):2156-69
hymenialdisine  95569-43-0   *Azepines *Pyrroles Interleukin-8/antagonists & inhibitors.  J Pharmacol Exp Ther 1997 Jul;282(1):459-66
MLV 6976  104454-71-9 2-Oxazolidinone, 3-(3-(hexahydro-1H-azepin-1-yl)propyl)-4-(2-methylpropyl)-5-phenyl-, (4S-cis)  *Azepines *Oxazolidinones.  Br J Pharmacol 1986;89(1):219
BN 50726  127279-06-5   *Azepines.  Agents Actions 1989;27(3-4):473
4-methyl-1-homopiperazinedithiocarboxylic acid  26865-04-3 hexahydro-4-methyl-1H-1,4-diazepine-1-carbodithioic acid  *Azepines Dopamine beta-Hydroxylase/antagonists & inhibitors.  Arch Int Pharmacodyn Ther 232:102;1978; Pharmacol Biochem Behav 1979;11(5):545; Pharmacol Biochem Behav 9(5):603;1978; Arch Int Pharmacodyn Ther 230(1):65;1977
debromohymenialdisine  125118-55-0   *Azepines *Pyrroles Protein Kinase C/antagonists & inhibitors.  Inflamm Res 1995 Aug;44 Suppl 2:S123-4
ST 2121  72150-17-5 1,6-Methano-1H-4-benzazonin-10-ol, 2,3,4,5,6,7-hexahydro-1,4-dimethyl-, hydrobromide, (1S)  *Azepines.  Yakugaku Zasshi 1979;99(7):757
premazepam  57435-86-6   *Azepines.  Drug Metab Dispos 1984;12(2):257
setastine  64294-95-7   *Azepines.  Acta Med Hung 1987;44(1):55
clotiazepam  33671-46-4 2H-Thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl  *Azepines. 
L 738167  0   *Azepines *Sulfonamides.  Drug Metab Dispos 1997 Mar;25(3):355-61
hexahydroazepine  111-49-9   *Azepines.  Acta Pol Pharm 1985;42(5):489
norzoanthamine  164991-65-5   *Azepines *Quinolines Alkaloids Heterocyclic Compounds with 4 or More Rings.  Biol Pharm Bull 1999 Sep;22(9):920-4
2-amino-4-oxo-6-acetyl-7,8-dihydro-3H,9H-pyrimidodiazepine  80003-63-0 4H-Pyrimido(4,5-b)(1,4)diazepin-4-one, 6-acetyl-2-amino-1,7,8,9-tetrahydro  *Azepines *Pterins.  J Biol Chem 1981;256(20):10399
azepinomycin  89354-15-4   *Azepines Guanine Deaminase/antagonists & inhibitors.  J Antibiot (Tokyo) 1987;40(10):1461
WEB 2347  114800-19-0   *Azepines *Triazoles.  Agents Actions Suppl 1990;31:251
1-geranylazacycloheptan-2-one  117694-76-5   *Azepines.  J Pharm Sci 1991;80(1)::39
3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride  139592-99-7   *Azepines Receptors, sigma.  Eur J Pharmacol 1993 Feb 16;231(3):465-7
BK 129  105919-73-1   *Azepines.  Arzneimittelforschung 1987 Feb;37(2):149-52
pralnacasan  192755-52-5   *Azepines *Isoquinolines *Pyridazines.  Drugs 2003 Feb;6(2):154-8
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide  0   *Azepines Alanine/*analogs & derivatives.  J Pharmacol Exp Ther. 2004 Apr;309(1):49-55
cyclohexamethylene carbamide  25991-86-0   *Azepines.  Am Ind Hyg Assoc J 39(7):540;1978
hexahydro-1-lauroyl-1H-azepine  18494-60-5   *Azepines.  J Pharm Sci 1986;75(11):1089
DAT 582  141034-42-6 1H-Indazole-3-carboxamide, N-(hexahydro-1-methyl-4-((3-methylphenyl)methyl)-1H-1,4-diazepin-6-yl)-, dihydrochloride, (R)  *Azepines *Indazoles.  J Pharmacol Exp Ther 1992 Mar; 260(3):1159-65
XK 263  0   *Azepines.  J Comput Aided Mol Res 1996 Aug;10(4):293-304
bengamide E  118477-03-5   *Azepines.  J Org Chem 2001 Mar 23;66(6):2118-22
5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide 2-fumarate  0   Receptors, Dopamine D2/antagonists & inhibitors *Azepines *Pyridines.  Br J Pharmacol 2001 May;133(2):253-60
4'-(4,4-difluoro-5-(2-(4-dimethylaminopiperidino)-2-oxoethylidene)-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide  0   Receptors, Vasopressin/antagonists & inhibitors *Azepines *Piperidines.  Br J Pharmacol 2001 Jul;133(5):746-54
ripazepam  26308-28-1 1-ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(lH)-one  *Azepines.  J Clin Pharmacol 16(7):377;1976; J Med Chem 16(12):1346;1973; Pharmacol Ther (B) 2(4):717;1976; Psychopharmacology (Berlin) 48:209;1976
thienodiazepine substance  0   *Azepines.  Arch Psychiatr Nervenkr 224:341;1977; Arzneim Forsch 26(6):1138;1141;1976
norsecurinine  2650-35-3 A-norsecurinan-11-one  *Alkaloids *Azepines *Piperidines.  J Nat Prod 1986;49(4):614
A85 4777  117009-82-2   *Azepines.  Transplant Proc 1990;22(4):1666
5,6,7,8-tetrahydro-4H-isoxazolo(4,3-c)azepin-3-ol  98977-43-6   *Azepines *Isoxazoles.  J Neurosci Res 1991 Oct;30(2):442-6
diazepinone riboside  75421-11-3   *Azepines Cytidine Deaminase/antagonists & inhibitors.  Cancer Chemother Pharmacol 1992;30(1):7-11
MR 16728  147614-21-9   *Acetamides *Acetanilides *Azepines.  Eur J Pharmacol 1993 Feb 16;231(3):407-13
XM 323  152344-10-0 2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-, (4S-(4alpha,5alpha,6beta,7beta))  *Azepines.  Antimicrob Agents Chemother 1993 Dec;37(12):2606-11
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