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Indenes

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Definition: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.  aromatic hydrocarbons   
Examples Dimethindene; Indans; Sulindac
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists. J Med Chem. 2012 Feb 9;55(3):1402-17.
2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists. J Med Chem. 2012 Feb 9;55(3):1402-17.
N-(2,3-dihydro-2,6-dimethyl-1H-inden-1-yl)-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine  0   *Indenes *Triazines. Bull Environ Contam Toxicol. 2012 Mar;88(3):326-32.
3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno(1,2-c)pyrazole-2-carbothioamide  0   *Indenes *Pyrazoles. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5259-61.
N,3-bis(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno(1,2-c)pyrazole-2-carboxamide  0   *Indenes *Pyrazoles. Bioorg Med Chem Lett 2011 Aug 1;21(15):4451-3
2-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Receptor, Adenosine A1 Receptor, Adenosine A2A Purinergic P1 Receptor Antagonists. Chem Res Toxicol 2011 Jul 18;24(7):1012-30
1,3-bis(thiophosphinoyl)indene  0   *Indenes. Inorg Chem. 2011 Jul 4;50(13):6378-83
N-(6-((1-((4-fluorobenzyl)(methyl)amino)ethylidene))amino)-2-hydroxy-2,3-dihydro-1H-inden-1-ylbiphenyl-4-carboxamide  0   *Biphenyl Compounds *Indenes Receptor, Muscarinic M1/agonists. J Pharmacol Exp Ther 2011 Aug;338(2):622-32
3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline  0   *Indenes *Isoquinolines Cyclooxygenase Inhibitors Cyclooxygenase 2. Cancer Prev Res (Phila) 2011 Apr;4(4):592-607
sortin1 compound  0   *Indenes *Pyridines. Chem Biol 2011 Feb 25;18(2):187-97
cajyphenol B  0   *Indenes *Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors. Chem Biodivers 2010 Dec;7(12):2931-40
cajyphenol A  0   *Indenes *Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors. Chem Biodivers 2010 Dec;7(12):2931-40
1,2,3,3a,4,8b-hexahydro-2-benzyl-6-N,N-dimethylamino-1-methylindeno(1,2-b)pyrrole  0   *Indenes *Pyrroles Receptors, Nicotinic. Neuropharmacology 2010 Nov;59(6):511-7
1-butyl-4-(1H-inden-1-ylidene)-1,4-dihydropyridine  0   *Dihydropyridines *Indenes. J Phys Chem A. 2010 Oct 7;114(39):10563-74
2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-indeno(1,2-d)pyrimidin-5-one  0   *Indenes *Pyrimidines Receptor, Adenosine A1 Receptor, Adenosine A2A. J Med Chem 2010 Nov 25;53(22):8104-15
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide  0   *Indenes *Pyrazoles Receptor, Cannabinoid, CB2/agonists. J Neuroimmune Pharmacol 2010 Sep;5(3):456-68
indeno(1,2,3-cd)fluoranthene  0   *Hydrocarbons, Fluorinated *Indenes. Phys Chem Chem Phys. 2010 Jul 28;12(28):7934-41
N-(5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide  0   *Indenes *Sulfonamides Receptors, AMPA. J Med Chem 2010 Aug 12;53(15):5801-12
poly(monomethylnona(ethylene glycol) 1-methylene-3-(4-methylphenyl)-1H-indene-2-carboxylate)  0   *Indenes *Polyethylene Glycols. Int J Pharm 2010 May 10;390(2):183-90
9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile  0   *Indenes *Pyrazines. ChemMedChem 2010 Apr 6;5(4):552-8
cyclododeceno(b)indene  0   *Indenes. Molecules. 2010;15(2):699-708
2-(2,4-dichlorobenzyl)-2,3-dihydro-1H-inden-1-amine  0   *Amines *Indenes. Bioorg Med Chem. 2010 Jan 15;18(2):675-88
1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno(1,2-c)pyrazole-3 carboxamide  0   *Indenes *Pyrazoles Receptor, Cannabinoid, CB2/agonists. Neurobiol Dis 2010 Jan;37(1):177-85
7-(4-(3-(1H-inden-3-yl)propyl)piperazin-1-yl)-1,3-benzoxazol-2(3H)-one  0   *Benzoxazoles *Indenes Receptors, Dopamine D2/agonists. J Pharmacol Exp Ther 2010 Jan;332(1):190-201
HBX 41,108  0   *Indenes *Pyrazines. Mol Cancer Ther 2009 Aug;8(8):2286-95
2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol  0   *Indenes. Bioorg Med Chem Lett 2009 Oct 15;19(20):5927-30
vinylindene  0   *Indenes *Vinyl Compounds. J Org Chem. 2009 Sep 4;74(17):6714-27
indeno-1,4-diazepinone  0   *Azepines *Indenes. J Org Chem. 2009 Oct 2;74(19):7315-21
euplectin  0   *Chromones *Indenes. Org Lett. 2009 Oct 1;11(19):4398-401
5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone  0   *Indenes. Bioorg Med Chem Lett 2009 Sep 1;19(17):5075-7
7-oxoorobanchol  0   *Furans *Indenes. Biosci Biotechnol Biochem. 2009 Jun;73(6):1367-70
7-oxoorobanchyl acetate  0   *Furans *Indenes. Biosci Biotechnol Biochem. 2009 Jun;73(6):1367-70
2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one  0   *Cyclohexylamines *Indenes Dual-Specificity Phosphatases/antagonists & inhibitors. Nat Chem Biol 2009 Sep;5(9):680-7
FR290581  0   *Indenes. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1465-8
2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one  0   *Benzylidene Compounds *Indenes. Eur J Pharmacol 2009 Jun 24;613(1-3):1-9
glycinoeclepin A, tricyclic benzenoid analog  0   *Indenes. Org Lett. 2008 Dec 18;10(24):5617-9
glycinoeclepin A  0   *Indenes. Org Lett. 2008 Dec 18;10(24):5617-9
3-(1,3,4-oxadiazol-5-phenyl-2-yl)-1,4-dihydroindeno(1,2-b)pyrrole  0   *Indenes *Pyrroles. ChemMedChem. 2009 Jun;4(6):998-1009
diindenoperylene  0   *Indenes Perylene/*analogs & derivatives. J Chem Phys. 2009 Mar 28;130(12):124701
1-chloroindene  0   *Indenes. Angew Chem Int Ed Engl. 2009;48(17):3137-40
valone  0   *Butanols *Indenes. J Anal Toxicol. 2009 Mar;33(2):104-8
2-(4-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethan-1-ol  0   *Indenes *Pyrazoles. J Pharmacol Exp Ther 2009 Apr;329(1):360-7
3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8a-decahydrocyclopenta(a)indene-3,3a,7a,8a-tetraol  0   *Indenes *Vinyl Compounds. Bioorg Med Chem Lett. 2009 Feb 1;19(3):959-61
(6-chloro-2,3-dihydro-1H-inden-1-yl)acetic acid  0   *Indenes. Chem Pharm Bull (Tokyo) 2008 May;56(5):626-34
1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno(4,5-h)isochromene-5-yl acetate  0   *Benzopyrans *Indenes Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1319-23
2-(6-methyl-3,4-dioxocyclohexa-1,5-dienyl)-2-phenyl-2H-indene-1,3-dione  0   *Indenes. J Mol Model 2008 Apr;14(4):325-33
2-(4,5-dihydroxy-2-methylphenyl)-2-phenyl-2H-indene-1,3-dione  0   *Indenes. J Mol Model 2008 Apr;14(4):325-33
dispiro(indene-2,5'-indeno(2,1-a)fluorene-6',2''-indene)-1,1'',3,3'',11',12'-hexaone  0   *Fluorenes *Indenes. Acta Crystallogr C 2008 Mar;64(Pt 3):o162-5
trans-2,3,3a,7a-tetrahydro-1H-indene-4-carbaldehyde  0   *Indenes. J Agric Food Chem 2007 Dec 26;55(26):10902-7
5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid  0   *Acetic Acids *Indenes. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6790-6
BYZX compound  0   *Indenes. J Chromatogr B Analyt Technol Biomed Life Sci 2007 Oct 1;857(2):266-74
isoplumericin  0   *Indenes. J Ethnopharmacol 1991 Jul;33(3):289-92
compound 30,640  0   *Indenes. Neuropharmacology 2006 Oct;51(5):993-1003
cyanosporaside B  0   *Glycosides *Indenes. Org Lett 2006 Mar 16;8(6):1021-4
cyanosporaside A  0   *Glycosides *Indenes. Org Lett 2006 Mar 16;8(6):1021-4
2,3-dimethoxy 7-hydroxy 10-methyl 5H 10H indeno(1,2-b)indol-10-one  0   *Indenes *Indoles. Eur J Med Chem. 2006 Mar;41(3):306-20
bis-1,3-((5,6-dihydro-5,11-diketo-11H-indeno(1,2-c)isoquinoline)-6-propylamino)propane  0   *Indenes *Isoquinolines DNA Topoisomerases, Type I/antagonists & inhibitors. Mol Pharmacol 2006 Sep;70(3):1109-20
2-(2,4-difluorophenyl)-2-(3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl)-N,N-dimethylethanamide  0   *Indenes *Piperazines Oxytocin/antagonists & inhibitors. J Med Chem 2006 Jul 13;49(14):4159-70
1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester  0   *Indenes *Morpholines PPAR gamma/agonists. Biochem Pharmacol 2006 Aug 14;72(4):446-54
1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester  0   *Indenes PPAR gamma/agonists. J Med Chem 2006 Jul 27;49(15):4781-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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