ψ 
Pyrimidines 
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
imatinib  152459-95-5   *Piperazines *Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors. 
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors
Cancer Res 1996 Jan 1;56(1):100-4GLEEVEC
voriconazole  0   *Pyrimidines *Triazoles. 
Pharma Action Antifungal Agents
Antimicrob Agents Chemother 1996 Aug;40(8):1948-9VFEND
pirinixic acid  50892-23-4 acetic acid, ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)  *Pyrimidines Microbodies. 
Pharma Action Anticholesteremic Agents ; Carcinogens ; Mutagens ; Peroxisome Proliferators
Arch Int Pharmacodyn Ther 225(1):51;1977; Arch Int Pharmacodyn Ther 234(1):4;1978; Atherosclerosis 1980;37(4):591; Atherosclerosis 31(2):185;1978; Biochem Biophys Res Commun 77(3):824;1977; Br J Cancer 38(4):537;1978; Cancer Res 1980;40(1):36; Cancer Res 39(1):151;1979; Experientia 30(10):1110;1974; Science 190(4216):787;1975; Science 197(4303):380;1977
pyrimidine  289-95-2   *Pyrimidines.  J Cell Physiol 1981;107(3):335
ipsapirone  92589-98-5   *Pyrimidines. 
Pharma Action Anti-Anxiety Agents ; Serotonin Agonists
Brain 1984;12(6):741
rosuvastatin  287714-41-4 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, (3R,5S,6E)  *Fluorobenzenes *Pyrimidines *Sulfonamides. 
Pharma Action Hydroxymethylglutaryl-CoA Reductase Inhibitors
Am J Cardiol 2001 Mar 8;87(5A):28B-32BCRESTOR
AG 1879  0   src-Family Kinases/antagonists & inhibitors *Pyrimidines.  Proc Natl Acad Sci U S A 2000 Jul 18;97(15):8653-7
gepirone  83928-76-1   *Pyrimidines. 
Pharma Action Antidepressive Agents ; Anti-Anxiety Agents ; Serotonin Agonists
J Neural Transm 1983;57(4):255
ICI D2788  133059-99-1   *Pyrimidines. 
Pharma Action Cardiotonic Agents ; Cardiovascular Agents
J Cardiovasc Pharmacol 1993 Jun;21(6):902-6
LU 135252  0   *Phenylpropionates *Pyrimidines Receptors, Endothelin/antagonists & inhibitors.  Br J Pharmacol 1997;121(5):935-40
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine  0   *Pyrazoles *Pyrimidines Antineoplastic Agents src-Family Kinases/antagonists & inhibitors. 
Pharma Action Enzyme Inhibitors
J Biol Chem 1996 Jan 12;271(2):695-701
zaleplon  151319-34-5 Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl  *Acetamides *Pyrimidines. 
Pharma Action Anticonvulsants ; Hypnotics and Sedatives
Eur J Clin Pharmacol 1993;45(4):313-20SONATA; ZALEPLON
SCH 58261  0   *Pyrimidines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors. 
Pharma Action Neuroprotective Agents
J Med Chem 1996 Mar 1;39(5):1164-71
tandospirone  112457-95-1 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (3aalpha,4beta,7beta,7aalpha)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)  *Piperazines *Pyrimidines. 
Pharma Action Anti-Anxiety Agents ; Serotonin Agonists
Jpn J Pharmacol 1987;45(4):493
piritrexim  72732-56-0 Pyrido(2,3-d)pyrimidine-2,4-diamine, 6-((2,5-dimethoxyphenyl)methyl)-5-methyl  *Pyrimidines. 
Pharma Action Antineoplastic Agents ; Folic Acid Antagonists
J Med Chem 1980;23(3):327
9-hydroxy-risperidone  144598-75-4 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl  *Isoxazoles *Pyrimidines. 
Pharma Action Antipsychotic Agents
J Chromatogr 1992 Dec 2;583(2):223-30
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol  105565-56-8 1-Piperazinebutanol, alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)  *Pyrimidines. 
Pharma Action Anti-Anxiety Agents
J Pharmacol Exp Ther 1986;239(1):124
ST 1571  0   *Pyrimidines.  Am J Hematol 2001 Sep;68(1):63-4
CP 154526  0   *Pyrimidines *Pyrroles Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors.  Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10477-82
isaxonine  4214-72-6 2-Pyrimidinamine, N-(1-methylethyl)  *Pyrimidines.  Br J Clin Pharmacol 1980;9(3):275; Experientia 35(5):626;1979
fenarimol  60168-88-9   *Pyrimidines. 
Pharma Action Fungicides, Industrial
J Gen Microbiol 1981;126(Pt.2):483
antalarmin  0   *Pyrimidines *Pyrroles Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors.  Endocrinology 1996 Dec;137(12):5747-50
pirimicarb  23103-98-2   *Carbamates *Pyrimidines. 
Pharma Action Insecticides
Gig Sanit 11:92;1978; Gig Sanit 1980;(4):11; J Agric Food Chem 24(1):136;1976; Probl Khig 2:45;1976; Scand J Haematol 19:360;1977; Toxicol Appl Pharmacol 1979;49(2):203
5-fluoropyrimidine  675-21-8   *Pyrimidines.  Cancer Res 1980;40(11):4209
monastrol  0   *Pyrimidines *Thiones Kinesin/antagonists & inhibitors.  Science 1999 Oct 29;286(5441):961-4
2,6-diamino-4-hydroxy-5-formamidopyrimidine  133310-38-0   *Pyrimidines.  Cancer Res 1991;51(19):5430
PKI 166  0   Receptor, Epidermal Growth Factor/antagonists & inhibitors *Pyrimidines *Pyrroles.  Cancer Res 2000 Jun 1;60(11):2926-35
DA 8159  0   Phosphodiesterase Inhibitors *Pyrimidines.  Arch Pharm Res 2000 Oct;23(5):471-6; J Pharm Biomed Anal. 2002 Oct 15;30(3):527-33
dasatinib  302962-49-8   Leukemia, Myeloid, Chronic *Pyrimidines *Thiazoles. 
Pharma Action Protein Kinase Inhibitors
Science 2004 Jul 16;305(5682):399-401SPRYCEL
sipatrigine  130800-90-7   *Piperazines *Pyrimidines. 
Pharma Action Neurotransmitter Uptake Inhibitors ; Neuroprotective Agents
Stroke 1993 Jul;24(7):1063-7
azoxystrobin  131860-33-8 Benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (E)  *Methacrylates *Pyrimidines Electron Transport Complex III.  Biochem Soc Trans 1994 Feb;22(1):68S
tetroxoprim  53808-87-0 5-((3,5-dimethoxy-4-(2-methoxyethoxy)phenyl)methyl)pyrimidinediamine  *Pyrimidines. 
Pharma Action Anti-Infective Agents
J Antimicrob Chemother 1979;5( suppl B):19; J Antimicrob Chemother 1979;5(suppl B):37
xymedon  14716-32-6   *Pyrimidines. 
Pharma Action Adjuvants, Immunologic ; Antilipemic Agents ; Antimutagenic Agents
Klin Khir 1991;(1):10
4,6-diamino-5-N-formamidopyrimidine  5122-36-1   *Pyrimidines.  Int J Radiat Biol 1983;44(4):321
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide  0   *Pyrimidines.  Cancer Cell 2005 Feb;7(2):117-9
co-tetroxazin  73173-12-3   *Pyrimidines *Sulfadiazine Drug Combinations. 
Pharma Action Anti-Infective Agents ; Anti-Infective Agents, Urinary
ZFA (Stuttgart) 1980;56(13):949
4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride  0   *Pyrimidines.  J Neurochem 1997 Jun;68(6):2507-13
SB 239063  0   *Imidazoles *Pyrimidines.  J Pharmacol Exp Ther 2000 Apr;293(1):281-8
pyrimethanil  53112-28-0   *Pyrimidines.  J AOAC Int 1997 Jul-Aug;80(4):867-70
2,4-diaminopyrimidine  156-81-0   *Pyrimidines.  Biochem 17(11):2102;1978
Ro 46-2005  150725-87-4   *Pyrimidines *Sulfonamides Receptors, Endothelin/antagonists & inhibitors.  Nature 1993 Oct 21;365(6448):759-61
ormetoprim  6981-18-6   *Pyrimidines. 
T 0201  0   *Pyrimidines *Sulfonamides Receptors, Endothelin/antagonists & inhibitors.  J Pharmacol Exp Ther 1998 Aug;286(2):643-9
R 121919  0   Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors *Pyrimidines.  J Psychiatr Res 2000 May-Jun;34(3):171-81
pirinixil  65089-17-0 2-((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-N-(2-hydroxyethyl)acetamide  *Pyrimidines.  Arch Int Pharmcodyn Ther 234(1):4;1978; Atherosclerosis 30(1):45;1978; Cancer Res 1980;40(1):36; Nature 1980;283(5745):397; Pharmacol Res Commun 1979;11(6):475
CP 31398  0   *Pyrimidines.  Science 1999 Dec 24;286(5449):2507-10
PD 173074  0   *Pyrimidines Receptor Protein-Tyrosine Kinases/antagonists & inhibitors Receptors, Fibroblast Growth Factor/antagonists & inhibitors.  EMBO J 1998 Oct 15;17(20):5896-904
5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate  144425-86-5 Ethanesulfonic acid, compd. with 5-(2,3,5-trichlorophenyl)-2,4-pyrimidinediamine (1:1)  *Pyrimidines.  Neurosci Lett 1992 Aug 31;143(1-2):229-32
LU 224332  0   *Propionic Acids *Pyrimidines Stereoisomerism Receptors, Endothelin/antagonists & inhibitors.  J Cardiovasc Pharmacol 1998;31 Suppl 1:S241-4
RA 642  54093-30-0 2,2'-((4,8-bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)bis((2-methoxyethyl)imino))bisethanol  *Pyrimidines.  Naunyn Schmiedebergs Arch Pharmacol 287 suppl:R23;1975; Naunyn Schmiedebergs Arch Pharmacol 292(2):105;1976; Naunyn Schmiedebergs Arch Pharmacol 292(2):97;1976
RS 8359  119670-32-5   *Nitriles *Pyrimidines.  J Pharm Pharmacol 1989;41(1):32
6-(methylamino)pyrido(3,4-d)pyrimidine  0   *Pyrimidines.  Endocrinology 1997 Sep;138(9):3891-900
U 101033E  0   *Pyrimidines *Pyrrolidines.  Exp Neurol 1996 Oct;141(2):304-9
argpyrimidine  0   *Pyrimidines Ornithine/*analogs & derivatives.  Arch Biochem Biophys 1997 Aug 1;344(1):29-36
chlorimuron ethyl  90982-32-4   *Pyrimidines *Sulfonylurea Compounds.  Biomed Chromatogr 1998 Mar-Apr;12(2):94-6
2,4,6-triaminopyrimidine  1004-38-2 2,4,6-pyrimidinetriamine  *Pyrimidines.  Am J Physiol 236(5):C221;1979; Biochim Biophys Acta 448(3):411;1976; Biochim Biophys Acta 448(3):426;1976; J Membr Biol 49(4):363;1979; J Pharmacol Exp Ther 204(1):175;1978; J Pharmacol Exp Ther 206(1):201;1978; J Physiol 266(1):68P;1977; J Physiol 290:331;1979; J Physiol 290:351;1979; J Physiol 290:367;1979; Pfluegers Arch 379(3):287;1979; Vopr Onkol 21(12):68;1975
pyrazolo(3,4-d)pyrimidine  271-80-7   *Pyrazoles *Pyrimidines.  Pol J Pharmacol Pharm 28:511;1976
5-fluorowillardiine  140187-23-1   *Pyrimidines Alanine/*analogs & derivatives.  Proc Natl Acad Sci U S A 1995 Aug 15;92(17):8083-7
alniditan  155428-00-5   *Benzopyrans *Propylamines *Pyrimidines.  Eur J Pharmacol 1996 Mar 28;299(1-3):127-37
CRA1000  0   *Pyridines *Pyrimidines.  Neurosci Lett 1998 Oct 18;255(2):103-6
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