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Debrisoquin

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Definition: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.     
Pharmacological Action Adrenergic Agents; Antihypertensive Agents; Sympatholytics 		Other names Tendor; Debrisoquine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,4-dehydrodebrisoquine  0   Debrisoquin/*analogs & derivatives. Drug Metab Dispos 2006 Sep;34(9):1563-74
N-hydroxydebrisoquine  0   Debrisoquin/*analogs & derivatives. Drug Metab Dispos 2005 Oct;33(10):1532-7
8-hydroxydebrisoquin  46286-45-7   Debrisoquin/*analogs & derivatives. J Chromatogr 1991 Sep 18;570(1):89-97
4-hydroxydebrisoquin  59333-79-8 Ro 03,7594  Debrisoquin/*analogs & derivatives. Anal Chem 48(6):807;1976; Br Med J 1(6058):423;1977; J Chromatogr 133(1):161;1977; Lancet II (8038):584;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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