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Fluorescent Dyes

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Definition: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.  D25-26 qualif    Other names Fluorochromes; Fluorescent Probes; Substrate, Fluorogenic; Probes, Fluorescent; Dyes, Fluorescent; Agents, Fluorescent; Agents, Fluorescence; Fluorogenic Substrate; Fluorescent Agents; Fluorescence Agents
Substances having this pharmacologic action: lucifer yellow; HOE 33342; 3,3'-dipentyl-2,2'-oxacarbocyanine; dansylarginine N-(3-ethyl-1,5-pentanediyl)amide; N-(7-dimethylamino-4-methylcoumarinyl)maleimide; benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide; 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid; 1-palmitoyl-2-pyrenedecanoylphosphatidylcholine; 6-carboxyfluorescein; 3,3'-dioctadecylindocarbocyanine; bis(1,3-diethylthiobarbiturate)trimethineoxonol; 7-aminoactinomycin D; rhodamine 6G; 1-anilino-8-naphthalenesulfonate; 12-(9-anthroyloxy)stearic acid; dansyl hydrazine; rhodamine isothiocyanate; monobromobimane; 7-nitrobenz-2-oxa-1,3-diazole-phallacidin; N-(1-pyrenyl)iodoacetamide; rhodamine B; dansylglutamyl-glycyl-arginine chloromethyl ketone; N-(4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl)maleimide; pyrene; oxonol VI; diamidino compound 253/50; alpha-aminopyridine; formycin triphosphate; 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole; 1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene; Texas red; 4-methylumbelliferyl glucuronide; 4-(N-(iodoacetoxy)ethyl-N-methyl)amino-7-nitrobenz-2-oxa-1,3-diazole; Quin2-acetoxymethyl ester; Quin2; 5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate); nuclear yellow; 2',3'-(O-(2,4,6-trinitrocyclohexadienylidine))adenosine 5'-diphosphate; fluorescein 5-maleimide; 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate; diamidino yellow; N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine; N-cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide; prodan; acrylodan; true blue; N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine; 3,3'-dihexyl-2,2'-oxacarbocyanine; N-(3-pyrene)maleimide; Rhodamine 123; C.I. Fluorescent Brightening Agent 28; DAPI; merocyanine dye; monodansylcadaverine; Nile Blue; fluorexon; 5-dimethylaminonaphthalene-1-sulfonamide; thioflavin T; dimethyl-4-phenylenediamine; pyranine; tetramethylrhodamine isothiocyanate; 2-(4-toluidino)-6-naphthalenesulfonic acid; HABA; tetramethylrhodaminylphalloidine; tetramethylrhodamine; N-phenyl-1-naphthylamine; procion yellow; anthranilamide; 1,5-I-AEDANS; N-(4-(2-benzimidazolyl)phenyl)maleimide; Fura-2; Eosine I Bluish; Fluoresceins; Quinacrine Mustard; Rhodamines; Rose Bengal; Fluorescein-5-isothiocyanate; Chromomycin A3; Acridine Orange; Acriflavine; Fluorescein; Olivomycins; Diphenylhexatriene; Dithiazanine; Bisbenzimidazole; Eosine Yellowish-(YS); Plicamycin; Erythrosine; Ethidium; Aminacrine; 9-amino-6-chloro-2-methoxyacridine; IAANS; 2-(4-(dimethylamino)styryl)-1-methylpyridinium; 3,3'-dipropyl-2,2'-thiadicarbocyanine; oxonol V; parinaric acid; 1,N(6)-ethenoadenosine diphosphate; 3,3'-dipropyloxadicarbocyanine; xylenol orange; aniline blue; lissamine rhodamine B; 4-methylumbelliferyl-galactopyranoside; NBD-taurine; blue fluorescent protein, Aequorea victoria; Fluo 4; Cyan Fluorescent Protein; enhanced green fluorescent protein; Cy3B N-hydroxysuccinimide ester; 9-diazomethylanthracene; seminaphthorhodaminefluoride; FM 4-64; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; SYBR Green I; CM-DiI; acetyl-aspartyl-glutamyl-valyl-aspartyl-amino-4-methylcoumarin; fura red; zinquin; cyanine dye 5; calcein AM; 5-(6)-carboxyfluorescein diacetate succinimidyl ester; cyanine dye 3; 1-(3-sulfonatopropyl)-4-(beta-(2-(di-n-octylamino)-6-naphthyl)vinyl)pyridinium betaine; Fluoro-Ruby; carboxy-seminaphthorhodaminefluoride; 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine; 5-chloromethylfluorescein; 1,2-dioleoyloxy-3-(trimethylammonium)propane; PKH 26; RH 421; 2-aminoacridone; FM1 43; 1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium; 1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium; 5-cyano-2,3-ditolyltetrazolium; biotinylated dextran amine; monochlorobimane; Fluo-3; sodium-binding benzofuran isophthalate; N-(6-methoxy-8-quinolyl)-4-toluenesulfonamide; aluminum phthalocyanine disulfonate; laurdan; tetramethylrhodamine iodoacetamide; 3,3'-dihexadecylindocarbocyanine; RH 414; 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid; 11-(dansylamino)undecanoic acid; fluorescent Koshland reagent; hydroethidine; 2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid; aluminum tetrasulfophthalocyanine; 1,5-AEDANS; indo-1; 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; fura-2-am; 1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine; thiazole orange; rhodamine dextran; 4-(4-diethylaminostyryl)-N-methylpyridinium; 6-methoxy-N-(3-sulfopropyl)quinolinium; bis(1,3-dibutylbarbiturate)trimethine oxonol; 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein; octadecyl Rhodamine B chloride; 1-palmitoyl-2-(6-(N-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine; nile red; 3'-O-(N-methylanthraniloyl) ATP; 2',3'-O-(2,4,6-trinitro-cyclohexadienylidine)adenosine 5'-triphosphate; 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole; 8-amino-1,3,6-naphthalenetrisulfonic acid; succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dimethylindole red  0   *Carbocyanines *Indoles Fluorescent Dyes. Biochemistry. 2012 Mar 27;51(12):2471-85.
4-methylumbelliferyl-rutinoside  0   *Disaccharides Hymecromone/*analogs & derivatives Fluorescent Dyes. Carbohydr Res. 2012 Jan 10;347(1):69-75.
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl)  0   *Phosphatidylethanolamines Fluorescent Dyes. Biochim Biophys Acta. 2012 Jan;1818(1):19-26
DA364  0   *Carbocyanines *Peptides, Cyclic Fluorescent Dyes. Contrast Media Mol Imaging. 2011 Nov-Dec;6(6):449-58.
Flu-1 compound  0   *Fluoresceins *Oximes Fluorescent Dyes. Chem Commun (Camb). 2011 Nov 21;47(43):11978-80.
Alexa Fluor 647  0   *Carbocyanines Fluorescent Dyes. J Immunol Methods. 2002 Dec 20;271(1-2):17-24
O,O'-di-(3-(2-carboxy-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)allyl)-2',7'-dichlorofluorescein  0   *Fluoresceins *Azabicyclo Compounds Fluorescent Dyes. Anal Biochem. 2011 Dec 1;419(1):9-16.
O,O'-di-(2-oxoethyl)-2',7'-dichlorofluorescein  0   *Fluoresceins Fluorescent Dyes. Anal Biochem. 2011 Dec 1;419(1):9-16.
CDy1 compound  0   *Anthracenes *Morpholines Fluorescent Dyes. Nat Protoc. 2011 Jul;6(7):1044-5
N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide  0   *Boron Compounds Fluorescent Dyes Ligands. J Med Chem. 2011 Oct 13;54(19):6874-87.
F2N12S compound  0   *Flavonoids Fluorescent Dyes. Biotech Histochem. 2011 Aug;86(4):255-61
2,7-bis(1-hydroxyethyl-4-vinylpyridinium iodine)-N-ethylcarbazole  0   *Carbazoles *Pyridinium Compounds Fluorescent Dyes. Org Biomol Chem 2011 May 21;9(10):3615-8
DEAB-TO-3 compound  0   *Quinolines *Thiazoles Fluorescent Dyes. Angew Chem Int Ed Engl. 2011 Apr 26;50(18):4180-3
polymyxin B3, dansyllysyl(1)  0   *Polymyxins Fluorescent Dyes. Anal Biochem 2011 Feb 15;409(2):273-83
8-isoquinolinylboronic acid  0   *Boronic Acids *Isoquinolines Fluorescent Dyes. Chemistry. 2010 Dec 3;16(45):13528-38
FAMX-CTT-54  0   *Fluoresceins *Organophosphorus Compounds Fluorescent Dyes. Prostate 2011 Jan 1;71(1):52-61
7-fluoro-N-(2-(dimethylamino)ethyl)-2,1,3-benzoxadiazole-4-sulfonamide  0   *Oxadiazoles *Sulfonamides Fluorescent Dyes. Analyst. 2010 Aug;135(8):2119-24
10-ethyl-9-oxo-9,10-dihydroacridine-2-sulfonyl chloride  0   *Acridines *Sulfones Fluorescent Dyes. Se Pu. 2009 Mar;27(2):164-8
iodo-dimethyloctadecyl-2-(p-dodecylaminophenyl)-3,3-dimethyl-5-carboethoxy-3H-indole ammonium  0   *Indoles Fluorescent Dyes. Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Sep;25(9):1443-5
iodo-dihexadecylmethyl-2-(p-dodecylaminophenyl)-3,3-dimethyl-5-carboethoxy-3H-indole ammonium  0   *Indoles Fluorescent Dyes. Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Sep;25(9):1443-5
Tichromine  0   *Imines *Naphthalenes Fluorescent Dyes. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Mar;75(3):1057-60
(E)-3-(4-methylaminophenyl)acrylic acid methyl ester  0   *Acrylates Fluorescent Dyes. Chemphyschem. 2009 Jul 13;10(9-10):1664-71
4-(1H-phenanthro(9,10-d)imidazol-2-yl)benzaldehyde  0   *Imidazoles *Phenanthrolines Fluorescent Dyes. Org Lett. 2008 Dec 18;10(24):5577-80
2-amino-deoxyribosylpurine  0   *Purines Fluorescent Dyes. J Phys Chem B 2008 Aug 14;112(32):9736-45
p-cyanophenylalanine  0   *Nitriles Alanine/*analogs & derivatives Fluorescent Dyes. Chembiochem. 2008 Jun 16;9(9):1372-4
vicinal diaminobenzoacridine  0   *Acridines Fluorescent Dyes. Anal Chim Acta. 2008 Jan 7;606(1):57-62
Cy5.5-DTPA-galactosyl-dextran  0   *Carbocyanines *Dextrans *Pentetic Acid Fluorescent Dyes. Nucl Med Biol 2005 Oct;32(7):687-93
SYNYFP protein  0   *Recombinant Fusion Proteins Fluorescent Dyes Luminescent Proteins. J Neurosci 2005 Jul 6;25(27):6379-88
(E,E)-1-bromo-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene-alpha alpha'-(13)C(2)  0   *Styrenes Fluorescent Dyes. Eur J Med Chem. 2004 Jul;39(7):573-8
(E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene  0   *Styrenes Fluorescent Dyes. Eur J Med Chem. 2004 Jul;39(7):573-8
yellow cameleon  0   *Calcium-Binding Proteins Fluorescent Dyes. Circ Res. 2004 Aug 6;95(3):e11-21
green fluorescent protein, Aequorea victoria  0   *Green Fluorescent Proteins Fluorescent Dyes. J Biol Chem. 1988 Jun 5;263(16):7713-6
pityrialactone  0   *Lactones Fluorescent Dyes. Antonie Van Leeuwenhoek. 2003;84(3):185-91
RH1691  0   *Pyrazoles *Thiazoles Fluorescent Dyes. J Neurophysiol 2002 Dec;88(6):3421-38
fluorescent phosphonate IVb  0   *Naphthalenes *Phosphonic Acids Fluorescent Dyes. Biochim Biophys Acta 2002 May 20;1597(1):60-6
fluorescent phosphonate IVa  0   *Naphthalenes *Phosphonic Acids Fluorescent Dyes. Biochim Biophys Acta 2002 May 20;1597(1):60-6
SYTO 13  0   Organic Chemicals Fluorescent Dyes. Cytometry 2002 Apr 1;47(4):226-35
aladan  0   Alanine/*analogs & derivatives 2-Naphthylamine/*analogs & derivatives Fluorescent Dyes. Science 2002 May 31;296(5573):1700-3
4'-cyanostilbene-4-boronic acid  0   *Boronic Acids *Stilbenes Fluorescent Dyes. Anal Biochem 2002 Feb 1;301(1):111-6
PKH67  0   Organic Chemicals Fluorescent Dyes. Cytometry 2002 Feb 1;47(2):111-7
fluoro jade  0   Organic Chemicals Fluorescent Dyes. Brain Res 2001 Jul 13;907(1-2):175-87
NanoOrange  0   Organic Chemicals Fluorescent Dyes Electrophoresis, Capillary. J Chromatogr B Biomed Sci Appl 2001 Apr 25;754(2):345-56
Phen Green SK  0   Organic Chemicals Chelating Agents Fluorescent Dyes. Toxicol Appl Pharmacol 2001 Jul 1;174(1):27-34
SYTO 21  0   Organic Chemicals Fluorescent Dyes. Vet Parasitol. 2001 Feb 26;95(2-4):353-6
fluorescent bezafibrate  0   Bezafibrate/*analogs & derivatives Fluorescent Dyes. Lipids 2000 Dec;35(12):1397-404
thiazin red  0   Organic Chemicals Fluorescent Dyes. Acta Neuropathol (Berl). 2000 Oct;100(4):385-9
fluorescent Tat protein (49-57)  0   *Fluoresceins *Peptide Fragments Fluorescent Dyes Rhodamines Gene Products, tat. Bioorg Med Chem Lett 2000 Aug 21;10(16):1857-61
Alexa594  0   Organic Chemicals Fluorescent Dyes. Biochemistry 2000 Dec 12;39(49):15225-33
SYTOX Orange dye  0   Organic Chemicals Fluorescent Dyes. Anal Biochem 2000 Nov 1;286(1):138-48
fluorescent protein 583  0   *Luminescent Proteins Fluorescent Dyes. FEBS Lett 2000 Aug 18;479(3):127-30
red fluorescent protein  0   *Luminescent Proteins Fluorescent Dyes.
Pharma Action Luminescent Agents 		FEBS Lett 2000 Aug 18;479(3):127-30
1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene  0   *Alkenes *Benzoates Fluorescent Dyes. J Histochem Cytochem 2000 Sep;48(9):1223-32
scFV green fluorescent protein, recombinant  0   *Recombinant Fusion Proteins *Green Fluorescent Proteins *Single-Chain Antibodies Fluorescent Dyes. J Biol Chem 2000 Jun 9;275(23):17556-60
SKM 4-45-1  0   *Lactones Fluorescent Dyes. J Pharmacol Exp Ther 2000 Apr;293(1):289-95
TO-PRO-1  0   Organic Chemicals Fluorescent Dyes. Antimicrob Agents Chemother 2000 Mar;44(3):676-81
bimodal fluorescent protein, Photobacterium phosphoreum  0   *Bacterial Proteins *Luminescent Proteins Fluorescent Dyes. Photochem Photobiol 2000 Feb;71(2):230-6
Oregon Green BAPTA-dextran  0   Organic Chemicals Fluorescent Dyes. Nature 2000 Jan 6;403(6765):93-8
SYTOX Green  0   Organic Chemicals Fluorescent Dyes. Appl Environ Microbiol 1999 Dec;65(12):5451-8
5-(N-octadecanoyl)aminofluorescein  0   *Fluorescein Fluorescent Dyes. Biol Reprod 1998 Dec;59(6):1506-14
NTI4F fluorescent probe  0   *Bridged Compounds *Imides Fluorescent Dyes. Neurosci Lett 1998 Jun 19;249(2-3):83-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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