Definition: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Other names DNA Untwisting Protein; DNA Untwisting Enzyme; DNA Topoisomerase I; DNA Topoisomerase; DNA Relaxing Protein; DNA Relaxing Enzyme; DNA Nicking-Closing Protein; Type I DNA Topoisomerase; Topoisomerase I; DNA Untwisting Proteins; DNA Untwisting Enzymes; DNA Type 1 Topoisomerase; DNA Relaxing Enzymes; DNA Nicking-Closing Proteins