ψ
| DNA Topoisomerases, Type II |
| DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
| GEN or unspecified; prefer specifics
| Other names DNA Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing); Type II DNA Topoisomerase; Topoisomerase II; DNA Type 2 Topoisomerase; DNA Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing)
| |
| Substance | CAS Registry & name | Categories | Source | Drugs*
|
| baicalein
| 491-67-8
5,6,7-trihydroxyflavone
*Flavanones DNA Topoisomerases, Type II/antagonists & inhibitors Dinoprostone/antagonists & inhibitors.
Pharma Action Antioxidants ; Enzyme Inhibitors ; Prostaglandin Antagonists
|
Jap J Pharmacol 25:763;1975
|
| microcin
| 1403-96-9
|
*Bacteriocins Anti-Bacterial Agents DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Biochem Biophys Res Commun 88(1):297;1979
|
| coumermycins
| 4434-05-3
|
Aminocoumarins DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Antibiotics, Antineoplastic ; Enzyme Inhibitors
|
Biochemistry 15(17):3769-78;1976; J Mol Biol 120:145;1978; J Mol Biol 1979;131(3):637; MGG 1979;176(1):25; MGG 1979;176(2):171; MGG 1979;177(1):169; MGG 1980;177(2):301; Mol Biol (Mosk) 1979;13(6):1341; Proc Nat Acad Sci USA 73(12):4474;1976; Proc Nat Acad Sci USA 75(10):4838;1978; Proc Nat Acad Sci USA 75(9):4125;1978
|
| DNA topoisomerase II beta
| EC 5.99.1.3
|
*DNA Topoisomerases, Type II *DNA-Binding Proteins.
|
Neurosci Res 1994 Feb;19(1):51-7
|
| ICRF 193
| 21416-68-2
|
*Piperazines DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors
|
Cancer Res 1991;51(18):4903
|
| marbofloxacin
| 115550-35-1
|
*Quinolones *Fluoroquinolones DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
Zentralbl Veterinarmed (A) 1993 Feb;40(1):73-9
|
| NSC 336628
| 97534-21-9
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo
*Thiobarbiturates DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors
|
Biochem Pharmacol 1985;34(11):2047
|
| NSC 601316
| 89459-25-6
4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)
*Acridines DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Intercalating Agents
|
Eur J Cancer Clin Oncol 1988;24(11):1783
|
| cryptolepine
| 480-26-2
5H-Quindoline, 5-methyl
*Alkaloids *Indoles *Quinolines DNA Topoisomerases, Type II/antagonists & inhibitors Asclepiadaceae.
Pharma Action Adrenergic alpha-Antagonists ; Antimalarials ; Antineoplastic Agents, Phytogenic ; Enzyme Inhibitors ; Hypoglycemic Agents ; Intercalating Agents ; Vasodilator Agents
|
J Pharm Sci 68(12):1510;1979
|
| sobuzoxane
| 98631-95-9
|
*Piperazines DNA Topoisomerases, Type II/antagonists & inhibitors.
Pharma Action Antineoplastic Agents
|
Chung Kuo Yao Li Hsueh Pao 1988;9(4):369
|
| TAS 103
| 0
|
*Aminoquinolines *Indenes DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors.
|
J Chromatogr B Biomed Appl 1997 Mar 28;691(1):179-85
|
| bakuchiol
| 10309-37-2
4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
|
*Phenols DNA Topoisomerases, Type II/antagonists & inhibitors DNA-Directed DNA Polymerase/antagonists & inhibitors.
|
Arzneim Forsch(Drug Res)26(4):486;1976
|
| serpentine (alkaloid)
| 18786-24-8
(19 alpha)-3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyloxayohimbanium
|
*Secologanin Tryptamine Alkaloids DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Exp Cell Biol 1982;50(2):79; J Chromatogr 100(1):231;1974
|
| intoplicine
| 125974-72-3
7H-Benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl
|
*Indoles *Pyridines DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors.
|
J Chromatogr 1993 May 5;614(2):299-306
|
| pixantrone
| 144510-96-3
|
*Isoquinolines DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Med Chem 1994 Mar 18;37(6):828-37
|
| psammaplin A
| 110659-91-1
|
*Disulfides Tyrosine/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Arch Pharm Res 1999 Feb;22(1):25-9; J Nat Prod 1995 Nov;58(11):1722-6
|
| F 11782
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors *Naphthalenes *Pyrans.
|
Biochem Pharmacol 2000 Apr 1;59(7):807-19
|
| phenoxodiol
| 0
2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)
|
DNA Topoisomerases, Type II/antagonists & inhibitors *Isoflavones.
|
Anticancer Res 2002 Sep-Oct;22(5):2581-5
|
| cyclothialidine
| 147214-63-9
L-Alanine, N-(S-((2-carboxy-4,6-dihydroxy-3-methylphenyl)methyl)-N-(N-(cis-3-hydroxy-1-L-seryl-L-prolyl)-L-seryl)-L-cysteinyl)-, kappa-lactone
|
*Peptides, Cyclic DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Antimicrob Agents Chemother 1993 Dec;37(12):2656-61
|
3'-deamino-3'-hydroxydoxorubicin
73113-90-3
5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)
|
Epirubicin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1984;37(8):853
|
| azatoxin
| 129564-92-7
|
*Indoles DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Cancer Res 1992 Aug 15;52(16):4478-83
|
| SbmC protein, E coli
| 0
|
*Repressor Proteins *Escherichia coli Proteins DNA Topoisomerases, Type II.
|
J Biol Chem 1998 Jan 23;273(4):1933-8
|
| neocryptolepine
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors Asclepiadaceae *Alkaloids *Quinolines.
|
Anticancer Drug Des 2000 Jun;15(3):191-201
|
| NSC 659687
| 0
|
*Carbazoles *Pyridines DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Natl Cancer Inst 1999 Feb 3;91(3):236-44
|
2,3-benzo-1,4-dimethyl-alpha-iso-carboline
| 114414-79-8
|
*Carbolines DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Arch Immunol Ther Exp (Warsz) 1987;35(2):143
|
| PD 138312
| 107334-06-5
|
*Naphthyridines *Fluoroquinolones DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Antimicrob Agents Chemother 1993 Dec;37(12):2563-70
|
| A 62176
| 148201-53-0
|
*Oxazines *Quinolones DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Med Chem 1995 Feb 3;38(3):408-24
|
| BN 80927
| 0
|
Camptothecin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors.
|
Bioorg Med Chem Lett 1999 Sep 6;9(17):2599-602
|
alpha-lapachone
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors *Naphthoquinones.
|
Biochem Pharmacol. 2000 Nov 1;60(9):1367-79
|
4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors *Phenazines.
|
J Med Chem 2002 Jan 31;45(3):721-39
|
| BE 13793C
| 133805-03-5
|
*Carbazoles *Indoles DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1991;44(7):723
|
| GR 122222X
| 161161-54-2
|
*Peptides, Cyclic DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Mol Biol 1994 Aug 5;241(1):128-30
|
| isoaurostatin
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors *Benzofurans.
|
J Nat Prod 2001 Feb;64(2):204-7
|
| BE 10988
| 135261-89-1
4-Thiazolecarboxamide, 2-(5-amino-4,7-dihydro-1-methyl-4,7-dioxo-1H-indol-3-yl)
|
*Thiazoles DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1991;44(5):486
|
| BE 22179
| 147816-33-9
Alanine, N-((3-hydroxy-2-quinolinyl)carbonyl)cysteinylglycyl-N-methylcysteinyl-2,3-didehydro-N-methylthio-, bimol. (4-1'),(4'-1)-(thio lactone), cyclic (3-3')-disulfide
|
*Peptides DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1994 Feb;47(2):129-35
|
| PD 161148
| 0
|
Ciprofloxacin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13991-6
|
Ro 47-3359
| 155144-64-2
|
*Benzimidazoles *Pyrimidines DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Antimicrob Agents Chemother 1993 Dec;37(12):2599-605
|
| makaluvamine N
| 0
|
*Pyrroles *Quinolones DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Nat Prod 1997 Apr;60(4):408-10
|
| PD 160793
| 0
|
Ciprofloxacin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13991-6
|
| Ruthenium Ben
| 0
|
*Organometallic Compounds Dimethyl Sulfoxide DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Biochemistry 1999 Apr 6;38(14):4382-8
|
2,3-dihydroindolizino(7,6,5-kl)acridinium chloride
| 0
|
*Acridines *Indoles DNA Topoisomerases, Type II/antagonists & inhibitors.
|
Biochemistry 1999 May 25;38(21):6723-31
|
4-methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one
| 0
|
DNA Topoisomerases, Type II/antagonists & inhibitors *Coumarins.
|
Parasitol Res 2004 Feb;92(3):177-82
|
| carbobenzoxycoumarin
| 93729-75-0
|
*Coumarins DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1988;41(3):373
|
| chlorobiocic acid
| 114515-20-7
Benzamide, N-(8-chloro-4,7-dihydroxy-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)
|
*Coumarins DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1988;41(3):373
|
9'-fluoro-10'-(4-methyl-1-piperazinyl)-7'-oxospiro(cyclopropane-1,3'(2'H)-(7H)pyrido(1,2,3-de)(1,4)benzoxazine)-6'-carboxylic acid
| 113211-53-3
|
*Oxazines DNA Topoisomerases, Type II/antagonists & inhibitors.
|
J Med Chem 1988;31(9):1694
|
2-(4-methoxyphenyl)-5-((4-methylpiperazin-1-yl)-3H-imidazo(4,5-b)pyridin-2-yl)-3H-imidazo(4,5-b)pyridine
| 142764-75-8
|
Bisbenzimide/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors Ligands.
|
Chem Res Toxicol 1992 Sep-Oct;5(5):597-607
|
| bastadin 14
| 146345-73-5
2,18-Dioxa-10,27-diazapentacyclo(28.2.2.214,17.13,7.119,23)octatriaconta-3,5,7(38),14,16,19,21,23(35),28,30,32,33,36-tridecaene-11,12,25,26-tetrone, 5,16,21,32,33-pentabromo-4,20-dihydroxy-, 12,15-bis(O-methyloxime), (E,E,?)
|
*Phenyl Ethers DNA Topoisomerases, Type II/antagonists & inhibitors Tetrahydrofolate Dehydrogenase/antagonists & inhibitors.
|
J Nat Prod 1993 Jan;56(1):153-7
|
| 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10- | | | | | | | | | | | | | | | | | | | | | | | | | |