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Cyclooxygenase Inhibitors

More information in Books or onNLM PubMed
Definition: Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.  DF: CYCLOOXYGENASE INHIB   
Examples Cyclooxygenase 2 Inhibitors 		Other names Prostaglandin Synthesis Antagonists; Prostaglandin Synthase Inhibitors; Prostaglandin Endoperoxide Synthase Inhibitors; Inhibitors, Prostaglandin Endoperoxide Synthase; Inhibitors, Cyclo Oxygenase; Cyclo Oxygenase Inhibitors; Inhibitors, Prostaglandin-Endoperoxide Synthase; Antagonists, Prostaglandin Synthesis; Inhibitors, Prostaglandin Synthase; Inhibitors, Cyclooxygenase; Inhibitors, Cyclo-Oxygenase; Cyclo-Oxygenase Inhibitors
Substances having this pharmacologic action: fenbufen; indobufen; sulindac sulfone; tenoxicam; Ethonium; Ketorolac; Ketorolac Tromethamine; ursolic acid; salicin; 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole; acetylsalicylic acid lysinate; Piroxicam; Diclofenac; Diflunisal; Aspirin; Naproxen; Niflumic Acid; Salicylates; Sodium Salicylate; Sulindac; Suprofen; Tolmetin; Nordihydroguaiaretic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Meclofenamic Acid; Mefenamic Acid; Flurbiprofen; Ibuprofen; Indomethacin; Indoprofen; Fenoprofen; Ketoprofen; proquazone; nimesulide; phenidone; SC 560; 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; Magnesium Salicylate; L 745337; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; tenidap; DuP 697; meloxicam; mofezolac; flosulide; ebselen
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-acetoxy-7-hydroxyroyleanone  0   *Diterpenes, Abietane Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. J Agric Food Chem. 2011 Oct 26;59(20):11211-8.
4-((2'-O-acetylrhamnosyloxy)benzyl)isothiocyanate  0   *Isothiocyanates Rhamnose/*analogs & derivatives Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Nutr Cancer. 2011;63(6):971-82.
3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole  0   *Triazoles Cyclooxygenase Inhibitors Cyclooxygenase 1. Biochem Pharmacol 2011 Oct 1;82(7):746-54
3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline  0   *Indenes *Isoquinolines Cyclooxygenase Inhibitors Cyclooxygenase 2. Cancer Prev Res (Phila) 2011 Apr;4(4):592-607
ethyl 4-(benzyloxy)-3-((3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methylsulfonamido)benzoate  0   *Benzoates *Sulfonamides Lipoxygenase Inhibitors Cyclooxygenase Inhibitors Cyclooxygenase 1 Cyclooxygenase 2 Inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):2074-83
4'-(bromoacetamido)-N-(2,3-dimethylphenyl)anthranilic acid  0   *Anthranilic Acids Cyclooxygenase Inhibitors. Adv Exp Med Biol 1997;400A:77-84
4'-(bromoacetamido)-benzyl-indomethacin  0   Indomethacin/*analogs & derivatives Cyclooxygenase Inhibitors. Adv Exp Med Biol 1997;400A:77-84
salicylamide  65-45-2   *Salicylamides Cyclooxygenase Inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal 		J Pharm Sci 1981;70(6):641
prostaglandin synthase inhibitor, endogenous  0   Organic Chemicals Cyclooxygenase Inhibitors. Lancet 1981;1(8231):1215

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