Definition: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Other names Tumor Necrosis Factor alpha; Cachectin Tumor Necrosis Factor; Tumor Necrosis Factor; TNFalpha; TNF Superfamily, Member 2; Cachectin-Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-alpha; Cachectin