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DNA-Binding Proteins

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Definition: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.     
See Also DNA Replication; Helix-Loop-Helix Motifs; Helix-Turn-Helix Motifs; Leucine Zippers; Zinc Fingers
Examples Adenovirus E2 Proteins; Basic Helix-Loop-Helix Transcription Factors; Basic-Leucine Zipper Transcription Factors; Butyrate Response Factor 1; Centromere Protein B; Early Growth Response Transcription Factors; Erythroid-Specific DNA-Binding Factors; Factor For Inversion Stimulation Protein; G-Box Binding Factors; GATA Transcription Factors; Hepatocyte Nuclear Factors; Heterogeneous-Nuclear Ribonucleoprotein K; HMGA Proteins; HMGB Proteins; Homeodomain Proteins; I-kappa B Proteins; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Integration Host Factors; Interferon Regulatory Factors; Interferon-Stimulated Gene Factor 3; Kruppel-Like Transcription Factors; Leucine-Responsive Regulatory Protein; LIM-Homeodomain Proteins; Matrix Attachment Region Binding Proteins; Methyl-CpG-Binding Protein 2; MutS DNA Mismatch-Binding Protein; MutS Homolog 2 Protein; Myeloid-Lymphoid Leukemia Protein; NF-kappa B; NFI Transcription Factors; Nuclear Respiratory Factors; Oncogene Protein p55(v-myc); Origin Recognition Complex; Paired Box Transcription Factors; POU Domain Factors; Proto-Oncogene Proteins c-bcl-6; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins c-myb; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-rel; Proto-Oncogene Proteins c-sis; Rad51 Recombinase; Rad52 DNA Repair and Recombination Protein; Receptors, Cytoplasmic and Nuclear; Replication Protein A; Replication Protein C; Repressor Proteins; Retinoblastoma Protein; Smad Proteins; SOX Transcription Factors; T-Box Domain Proteins; TCF Transcription Factors; Telomere-Binding Proteins; Toll-Like Receptor 9; Trans-Activators; Transcription Factor AP-2; Transcription Factors, General; Tristetraprolin; Tumor Suppressor Protein p53; Winged-Helix Transcription Factors; Xeroderma Pigmentosum Group A Protein 		Other names Single-Stranded DNA Binding Proteins; DNA Helix Destabilizing Proteins; Single Stranded DNA Binding Proteins; Single Stranded DNA Binding Protein; DNA-Binding Protein, Single-Stranded; DNA Single Stranded Binding Protein; DNA Binding Proteins; Binding Protein, DNA; Single-Stranded DNA-Binding Protein; SS DNA BP; DNA Single-Stranded Binding Protein; DNA Binding Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NSL1 protein, Drosophila  0   *Transcription Factors *Drosophila Proteins DNA-Binding Proteins. Nucleic Acids Res. 2012 Feb;40(4):1509-22.
BPC6 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins. PLoS One. 2011;6(2):e16070.
Lin28b protein, mouse  0   *DNA-Binding Proteins Zinc Fingers. Science. 2012 Mar 9;335(6073):1195-200
Pcgf1 protein, rat  0   *DNA-Binding Proteins.
Pcgf1 protein, mouse  0   *DNA-Binding Proteins.
Pcgf6 protein, rat  0   *DNA-Binding Proteins.
REM22 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins. Int J Dev Biol. 2011;55(6):657-64.
Creb3l2 protein, zebrafish  0   *Transcription Factors *Zebrafish Proteins DNA-Binding Proteins. Dis Model Mech. 2011 Nov;4(6):763-76.
zinc finger protein 132 protein, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Int J Cancer. 2012 Feb 15;130(4):885-95
Oaz protein, Xenopus  0   *Transcription Factors *Xenopus Proteins DNA-Binding Proteins Zinc Fingers. PLoS One. 2011;6(8):e22621.
Gal80 protein, zebrafish  0   *DNA-Binding Proteins *Transcription Factors *Zebrafish Proteins. Dev Dyn. 2011 Oct;240(10):2324-34
Chd7 protein, Danio rerio  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins *Zebrafish Proteins. Dev Dyn. 2011 Oct;240(10):2272-80
mtSSB protein, Drosophila  0   *DNA-Binding Proteins *Drosophila Proteins. Gene. 1994 Jun 10;143(2):171-7.
zinc finger protein 577, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. J Clin Pathol. 2011 Nov;64(11):1010-3
LZTS2 protein, mouse  0   *DNA-Binding Proteins *Cell Cycle Proteins *Tumor Suppressor Proteins Leucine Zippers. J Biol Chem. 2011 Nov 18;286(46):40331-42
5MP1 protein, human  0   *DNA-Binding Proteins. Nucleic Acids Res. 2011 Oct;39(19):8314-28
Rpa43 protein, S cerevisiae  0   *DNA-Binding Proteins *Saccharomyces cerevisiae Proteins. FEBS Lett. 2011 Nov 4;585(21):3355-9
SOMI-1 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins Nuclear Proteins Zinc Fingers. Genes Dev 2011 Oct 1;25(19):2079-82
MarR-family transcriptional regulatory protein, Mycobacterium  0   *Bacterial Proteins *DNA-Binding Proteins *Transcription Factors. Tuberculosis (Edinb). 2010 Jan;90(1):25-30
zinc finger protein 510, human  0   *DNA-Binding Proteins Zinc Fingers. Clin Chim Acta. 2011 Jul 15;412(15-16):1357-65
BAM8 protein, Arabidopsis  EC 3.2.1.2   *beta-Amylase *Transcription Factors *Arabidopsis Proteins DNA-Binding Proteins. Plant Cell 2011 Apr;23(4):1391-403
BAM7 protein, Arabidopsis  EC 3.2.1.2   *beta-Amylase *Transcription Factors *Arabidopsis Proteins DNA-Binding Proteins. Plant Cell 2011 Apr;23(4):1391-403
ZIFCAT protein, human  0   *DNA-Binding Proteins *Nuclear Proteins Repressor Proteins Zinc Fingers. J Biol Chem 2011 Jul 1;286(26):23178-88
Fezf1 protein, mouse  0   *DNA-Binding Proteins *Nerve Tissue Proteins Zinc Fingers. J Comp Neurol. 2011 Jul 1;519(10):1829-46
YdaL protein, E coli  EC 3.1.-   *Endonucleases *Escherichia coli Proteins DNA-Binding Proteins. J Struct Biol 2011 May;174(2):282-9
SPL5 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins. Plant Mol Biol. 2011 May;76(1-2):35-45
Glis1 protein, mouse  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Nature. 2011;474(7350):225-9
Mms1 protein, S pombe  0   *DNA-Binding Proteins *Schizosaccharomyces pombe Proteins DNA Repair. DNA Repair (Amst) 2011 Mar 7;10(3):283-95
ZNRF4 protein, human  0   *DNA-Binding Proteins Zinc Fingers. J Biol Chem. 2011 Mar 11;286(10):8633-43
Holliday junction recognizing protein, Xenopus  0   *DNA-Binding Proteins *Xenopus Proteins. J Cell Biol. 2011 Feb 21;192(4):569-82
ZAS3 protein, human  0   *DNA-Binding Proteins *Transcription Factors Zinc Fingers. Cell Signal. 2011 Jan;23(1):105-13
ZNF592 protein, human  0   *DNA-Binding Proteins Zinc Fingers. Eur J Hum Genet. 2010 Oct;18(10):1107-13
MqsA protein, E coli  0   *DNA-Binding Proteins *Escherichia coli Proteins. Biomol NMR Assign 2007 Dec;1(2):217-9
GyrB3 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins Nuclear Proteins. PLoS One 2010;5(3):e9899
XPA protein, rat  0   *DNA-Binding Proteins DNA Repair Xeroderma Pigmentosum. J Biol Chem 1997 Mar 7;272(10):6561-6
MMS22L protein, human  0   *DNA-Binding Proteins *Nuclear Proteins DNA Repair. Mol Cell 2010 Nov 24;40(4):619-31
MBD6 protein, human  0   *DNA-Binding Proteins. PLoS One 2010;5(8):e11982
mtss-1 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins. Biochim Biophys Acta. 2010 Sep;1802(9):765-73
ZNF821 protein, human  0   *DNA-Binding Proteins. Biochemistry. 2010 Sep 28;49(38); 8367-75
MSH-5 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins. Genetics 2000 Oct;156(2):617-30
Repin1 protein, mouse  0   *DNA-Binding Proteins Zinc Fingers. Biochem Biophys Res Commun 2010 Sep 17;400(2):246-51
GBF1 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins DNA-Binding Proteins. Plant Physiol 2010 Jul;153(3):1321-31
ZNFD protein, human  0   *DNA-Binding Proteins. Mol Cell Biochem. 2010 Jul;340(1-2):63-71
STRA13 protein, human  0   *DNA-Binding Proteins *Nuclear Proteins.
HIM-19 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins. Mol Biol Cell 2010 Mar;21(6):885-96
Tet3 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. Nature. 2010 Aug 26;466(7310):1129-33
Tet2 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. Nature. 2010 Aug 26;466(7310):1129-33
MORC3 protein, human  EC 3.6.1.-   *Adenosine Triphosphatases *DNA-Binding Proteins Zinc Fingers. J Cell Sci 2010 Jun 15;123(Pt 12):2014-24
MORC3 protein, mouse  EC 3.6.1.-   *Adenosine Triphosphatases *DNA-Binding Proteins Zinc Fingers. J Cell Sci 2010 Jun 15;123(Pt 12):2014-24
Zfp637 protein, mouse  0   *DNA-Binding Proteins Zinc Fingers. J Cell Biochem. 2010 May 15;110(2):352-62
Spps protein, Drosophila  0   *DNA-Binding Proteins *Drosophila Proteins Zinc Fingers. Development 2010 Aug 1;137(15):2597-96
DM-W protein, Xenopus  0   *DNA-Binding Proteins *Xenopus Proteins. Development 2010 Aug 1;137(15):2519-26
PINCH protein, rat  0   *DNA-Binding Proteins. Brain Res. 2010 May 21;1332():100-9
YgiP protein, E coli  0   *DNA-Binding Proteins *Escherichia coli Proteins. Nucleic Acids Res 2010 Jun 1;38(11):3605-18
MBD5 protein, human  0   *DNA-Binding Proteins. Eur J Hum Genet 2010 Apr;18(4):436-41
RDM1 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins. Nature. 2010 May 6;465(7294):106-9
Hop1 protein, S pombe  0   *DNA-Binding Proteins *Schizosaccharomyces pombe Proteins. Mol Cell Biol 2010 Apr;30(7):1570-81
StpA protein, Salmonella typhimurium  0   *Bacterial Proteins *DNA-Binding Proteins *Molecular Chaperones. Mol Microbiol. 2009 Dec;74(5):1169-86
RPA4 protein, human  0   *DNA-Binding Proteins Protein Subunits. Nucleic Acids Res 2010 Jan 1;38(3):846-58
CHD7 protein, Xenopus  EC 5.99.-   *DNA Helicases *DNA-Binding Proteins *Xenopus Proteins. Nature. 2010 Feb 18;463(7283):958-62
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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