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Immunoconjugates

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Definition: Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.     
Pharmacological Action Immunologic Factors
Examples Immunotoxins 		Other names Radioimmunoconjugate; Immunoconjugate; Radioimmunoconjugates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
huB3F6-SPDB-DM4 immunoconjugate  0   *Antibodies, Monoclonal *Immunoconjugates. Eur J Cancer 2011 Jul;47(11):1736-46
hI-con1  0   *Immunoconjugates. BMC Cancer 2011;11:263
PsL-EGFmAb-BSA4-(Gd-DTPA)n  0   *Antibodies, Monoclonal *Serum Albumin, Bovine *Gadolinium DTPA Immunoconjugates. Clin Appl Thromb Hemost. 2010 Apr;16(2):177-83
cAC10-vcMMAE  0   *Immunoconjugates. Blood 2003 Aug 15;102(4):1458-65ADCETRIS
CMD 195  0   *Immunoconjugates. Clin Cancer Res 2009 Nov 1;15(21):6709-15
naptumomab estafenatox  676258-98-3   *Antibodies, Monoclonal *Enterotoxins *Immunoconjugates. J Clin Oncol. 2009 Sep 1;27(25):4116-23
MLN2704 antibody  0   *Immunoconjugates. J Clin Oncol. 2008 May 1;26(13):2147-54
Erb-hcAb  0   *Immunoconjugates. Br J Cancer 2007 Nov 19;97(10):1354-60
chFRP5-ZZ-PE38  0   *Immunoconjugates. Cancer Lett 2007 Nov 8;257(1):124-35
hdsFv25, human  0   *Immunoconjugates. Pharmazie. 2006 Aug;61(8):685-8
IMMU-110  0   *Antibodies, Monoclonal *Doxorubicin *Immunoconjugates. Clin Cancer Res 2005 Jul 15;11(14):5257-64
cpIL-4(13D)-PE38KDEL immunotoxin  0   *Recombinant Fusion Proteins *Immunoconjugates. Biochemistry (Mosc) 2005 Jan;70(1):62-8
ETI104  0   *Immunoconjugates. Ann Rheum Dis 2004 Sep;63(9):1104-12
copper-64-DOTA-NR-LU-10  0   *Organometallic Compounds *Immunoconjugates Copper. J Nucl Med 2003 Aug;44(8):1284-92
genistein-17.1A immunoconjugate  0   *Antibodies, Monoclonal *Immunoconjugates Genistein/*analogs & derivatives. Int J Oncol 2003 May;22(5):955-9
abatacept  0   *Immunoconjugates Arthritis, Rheumatoid Tumor Necrosis Factor-alpha.
Pharma Action Immunosuppressive Agents ; Antirheumatic Agents 		Nat Immunol 2002 Nov;3(11):1056-7ORENCIA; NULOJIX
BACH 250-rGel  0   *Antibodies, Monoclonal *Recombinant Fusion Proteins *Immunoconjugates.
Pharma Action Immunotoxins 		Clin Cancer Res 1999 Apr;5(4):865-74
anti-B4 blocked ricin immunoconjugate  0   *Ricin *Immunoconjugates. Clin Cancer Res 1998 Nov;4(11):2599-604
RFT5-SMPT-dgA immunotoxin  0   *Ricin *Antibodies, Monoclonal *Immunoconjugates. Leukemia Lymphoma 1998 Aug;30(5-6):525-37
lead-203 DOTA-B72.3  0   *Antibodies, Monoclonal *Heterocyclic Compounds Lead Radioisotopes Immunoconjugates. Eur J Nucl Med 1998 May;25(5):471-80
TXU-pokeweed antiviral protein, Phytolacca  0   *Immunoconjugates *Ribosome Inactivating Proteins, Type 1. Antimicrob Agents Chemother 1998 Feb;42(2):383-8
technetium Tc 99m-monoclonal antibody-170H.82  0   *Antibodies, Monoclonal *Organotechnetium Compounds Immunoconjugates. Breast Cancer Res Treat 1997 Aug;45(1):29-37
OST7-(1-(4-(4-(2-maleimidoethoxy)succinamido)benzyl)ethylenediamine-N,N,N',N'-tetraacetic acid)  0   *Antibodies, Monoclonal *Immunoconjugates Edetic Acid/*analogs & derivatives Immunoconjugates. Nucl Med Biol 1996 Feb;23(2):129-36
OX7-saporin  0   *Antibodies, Monoclonal *Immunoconjugates *Ribosome Inactivating Proteins, Type 1.
Pharma Action Immunotoxins 		Exp Neurol 1993 Dec;124(2):242-52
N901 MoAb-blocked ricin conjugate  0   *Ricin *Antibodies, Monoclonal *Immunoconjugates Immunotoxins. Chest 1993 Apr;103(4 Suppl):436S-39S
Oncolysin B  0   *Ricin *Antibodies, Monoclonal *Immunoconjugates Immunotoxins. Oncology (Williston Park) 1992 Sep;6(9):94

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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