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Immunosuppressive Agents 
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.     
See Also Antilymphocyte Serum		Other names Agents, Immunosuppressive; Immunosuppressants
Substances having this pharmacologic action: hypericin; methyl cellosolve; SK&F 105685; Thalidomide; Thioinosine; mycophenolate mofetil; Triamcinolone Acetonide; bis(tri-n-butyltin)oxide; 6-Mercaptopurine; Pentostatin; dan-shen root extract; uterine luminal fluid proteins; didemnins; 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole; leukotoxin; 2-acetyl-4(5)-tetrahydroxybutylimidazole; OM 89; daltroban; Ifosfamide; bis(p-chlorophenyl)acetic acid; N,N'-dimethylnitrosourea; ISIS 2302; Campath 1G; copolymer 1; U 74500A; Azaserine; Azathioprine; fludarabine monophosphate; 8-aminoguanosine; dibutyldichlorotin; traxanox; dimethyl sulfate; triptolide; thermozymocidin; Tacrolimus; BCRF1 protein, Human herpesvirus 4; Cyclosporine; ONO-LB 457; Methotrexate; tanshinone; (T,G)-A-L; deflazacort; Muromonab-CD3; cytotoxic T-lymphocyte antigen 4; enisoprost; CP 55940; cyclolinopeptide A; Cladribine; leucyl-leucine-methyl ester; PAEP protein, human; tobacco tar; doxifluridine; early pregnancy factor; dimethyl fumarate; lisofylline; gemcitabine; methoxyacetic acid; Razoxane; daclizumab; leflunomide; cyclosporin G; glimepiride; immunomycin; Thiamphenicol; Sirolimus; A 771726; trofosfamide; CNI 1493; FTY 720; Antilymphocyte Serum; tepoxalin; KH 1060; U 74389F; saikosaponin; monodansylcadaverine; pristane; Gliotoxin; butenolide; 1,1-azobisformamide; tetrandrine; lobenzarit; wortmannin; Busulfan; Coformycin; Cyclophosphamide; Cytarabine; acteoside; X 910279; FR 167653; Cyclosporins; benzonidazole; bredinin; 9-(2-hydroxy-3-nonyl)adenine; 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine; Fluorouracil; TNFR-Fc fusion protein; everolimus; basiliximab; pimecrolimus; Ellipticines; brequinar; undecylprodigiosin; stepronin; seocalcitol; gallium nitrate; L-glutamic acid-L-tyrosine copolymer; desthiobiotin; repirinast; bestrabucil; gusperimus; pirmagrel; castanospermine; abatacept
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pirarubicin  72496-41-4 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)  Doxorubicin/*analogs & derivatives Immunosuppressive Agents. 
Pharma Action Antineoplastic Agents 		Biotechnol Bioeng 1980;22(suppl 1):83
adefovir  106941-25-7   *Phosphonic Acids Adenine/*analogs & derivatives Immunosuppressive Agents. 
Pharma Action Antineoplastic Agents ; Antiviral Agents ; Reverse Transcriptase Inhibitors 		Antiviral Res 1987;7(3):151
cytolethal distending toxin  0   *Bacterial Toxins Immunosuppressive Agents Escherichia coli Proteins.  Fems Microbiol Lett 1990;59(1-2):193
Tolerogen  0   Organic Chemicals Immunosuppressive Agents.  Vestn Dermatol Venerol 1980;(12):14
suppressive factor of allergy  0   Organic Chemicals Immunosuppressive Agents.  J Immunol 124(2):819;1980
correolide  0   *Triterpenes Immunosuppressive Agents Potassium Channels/antagonists & inhibitors.  Biochemistry 1999 Apr 20;38(16):4922-30
macrophage-derived immunosuppressor factor  0   Proteins Immunosuppressive Agents.  J Leukocyte Biol 1985;38(3):429
SP 100030  0   Organic Chemicals Immunosuppressive Agents.  Transplant Proc 1996 Dec;28(6):3106-9
liver suppressor factor 1  0   Proteins Immunosuppressive Agents.  Transpl Immunol 1996 Dec;4(4):287-92
cell-mediated immune function inhibitor  0   Organic Chemicals Immunosuppressive Agents.  J Clin Lab Immunol 1980;3(3):209
ditritiocorreolide  0   *Triterpenes Immunosuppressive Agents Potassium Channels/antagonists & inhibitors.  Biochemistry 1999 Apr 20;38(16):4922-30
HT29 factor  0   Organic Chemicals Immunosuppressive Agents.  Cancer Res 1990;50(19):6158
Fr.5-B, Bacillus stearothermophilus UK563 component  0   Organic Chemicals Immunosuppressive Agents.  Chem Pharm Bull (Tokyo) 1992 Nov;40(11):3017-20
C4-mycophenolic adenine dinucleotide  0   Mycophenolic Acid/*analogs & derivatives Immunosuppressive Agents.  Curr Med Chem 1999 Jul;6(7):629-34