encyclopedia of medical concepts
ψ 

Ubiquitin-Protein Ligases

More information in Books or onNLM PubMed
Definition: A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.  UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available   
Examples Fanconi Anemia Complementation Group L Protein; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-mdm2; Receptors, Autocrine Motility Factor; SKP Cullin F-Box Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein 		Other names Ubiquitin Protein Ligases; Ubiquitin Protein Ligase E3; Ubiquitin Protein Ligase; Ubiquitin Ligase, E3; Ligases, Ubiquitin-Protein; Ligase, Ubiquitin-Protein; Ligase, E3 Ubiquitin; Ligase, E3; Ligase E3, Ubiquitin-Protein; Ligase E3, Ubiquitin; E3, Ubiquitin Ligase; Ubiquitin-Protein Ligase E3; Ubiquitin Ligase E3; E3 Ubiquitin Ligase; E3 Ligase; Ubiquitin-Protein Ligase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ring finger protein 180, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Cancer. 2012 Feb 15;118(4):947-59
RNF20 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Genes Dev. 2008 Oct 1;22(19):2664-76.
ubiquitin-conjugating enzyme 7-interacting protein 4, human  EC 6.3.2.19   *Carrier Proteins *Ubiquitin-Protein Ligases RING Finger Domains. J Biol Chem. 2012 Feb 17;287(8):5615-26.
UHRF2 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. J Cell Biochem. 2011 Sep;112(9):2585-93.
HERC6 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40
Rnf2 protein, rat  EC 6.3.2.19   *Ubiquitin-Protein Ligases.
Ring1 protein, rat  EC 6.3.2.-   *Ubiquitin-Protein Ligases.
Trip12 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. PLoS One. 2011;6(10):e25871.
RNF185 protein, human  EC 6.3.2.19   *Mitochondrial Proteins *Ubiquitin-Protein Ligases Membrane Proteins RING Finger Domains. PLoS One. 2011;6(9):e24367.
Nrdp1 protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):18-23
ZNRF1 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Nat Cell Biol. 2011;13(12):1415-23
Qin protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases RING Finger Domains. Mol Cell. 2011 Nov 18;44(4):572-84.
HECW-1 E3 ligase, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *Ubiquitin-Protein Ligases. Nature. 2011 Dec 22;480(7378);525-9
MARCH8 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Eur J Immunol. 2008 May;38(5):1225-30.
Pirh2 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. Mol Cell Biol. 2011 Oct;31(19):3997-4006.
CRL4(Cdt2) protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases. Mol Biol Cell. 2010 Nov 1;21(21):3639-53.
DNF protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. Plant Signal Behav. 2010 Sep;5(9):1105-7.
F-box and leucine-rich repeat protein 4, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases *F-Box Proteins. J Biol Chem 2011 Sep 2;286(35):30462-70
iduna protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases DNA Repair. Proc Natl Acad Sci U S A 2011 Aug 23;108(34):14103-8
KF-1 protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases RING Finger Domains. Cell Biochem Biophys 2011 Jun;60(1-2):69-75
RHA2b protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases Zinc Fingers. Plant Physiol 2011 Jun;156(2):550-63
TRIM-9 protein, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *Ubiquitin-Protein Ligases RING Finger Domains. J Genet Genomics 2011 Jan;38(1):1-11
MSL2 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases RING Finger Domains. Mol Cell 2011 Jul 8;43(1):132-44
Nrdp1 protein, zebrafish  EC 6.3.2.19   *Zebrafish Proteins *Ubiquitin-Protein Ligases. Biochem Biophys Res Commun 2011 Jun 10;409(3):454-8
KPC protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Blood. 2011 Apr 21;117(16):4293-303
c-MIR protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Int Immunol 2011 Mar;23(3):177-83
ATL9 protein, Arabidopsis  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. PLoS One 2010;5(12):e14426
PUB13 protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. Science. 2011 Jun 17;332(6036):1439-42
PUB12 protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. Science. 2011 Jun 17;332(6036):1439-42
San1 protein, S pombe  EC 6.3.2.19   *Schizosaccharomyces pombe Proteins *Ubiquitin-Protein Ligases. J Biol Chem 2011 Apr 15;286(15):13775-90
checkpoint with FHA and RING finger domains protein, mouse  EC 6.3.2.19   *Tumor Suppressor Proteins *Ubiquitin-Protein Ligases. J Cell Sci 2011 Feb 15;124(Pt 4):532-9
degringolade protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases. EMBO J 2011 Apr 6;30(7):1289-301
KPC protein, rat  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Mol Cell Biol 2009 Jan;29(2):547-58
RNF152 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases RING Finger Domains. Protein Cell 2010 Jul;1(7):656-63
RNF213 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases Moyamoya Disease RING Finger Domains. J Hum Genet 2011 Jan;56(1):34-40
ATG10 protein, S cerevisiae  EC 6.3.2.19   *Saccharomyces cerevisiae Proteins *Ubiquitin-Protein Ligases. J Microbiol Biotechnol. 2010 Dec;20(12):1647-52
SAP5 protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. Plant Mol Biol. 2011 Mar;75(4-5):451-66
RNF170 protein, human  0   *Ubiquitin-Protein Ligases Zinc Fingers. Brain 2011 Feb;134(Pt 2):602-7
riplet protein, mouse  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Cell Host Molecule 2010 Dec 16;8(6):496-509
Smurf1 protein, rat  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Neuron 2011 Jan 27;69(2):231-43
NEURL1 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. J Biol Chem 2008 Feb 15;283(7):3846-53
CDT-2 protein, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *Ubiquitin-Protein Ligases. BMC Dev Biol 2010;10:109
BRIZ2 protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. J Biol Chem 2010 Nov 19;285(47):37070-81
BRIZ1 protein, Arabidopsis  EC 6.3.2.19   *Arabidopsis Proteins *Ubiquitin-Protein Ligases. J Biol Chem 2010 Nov 19;285(47):37070-81
UBE3C protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Ann Allergy Asthma Immunol. 2010 Oct;105(4):307-312
NleL protein, E coli  EC 6.3.2.19   *Escherichia coli Proteins *Ubiquitin-Protein Ligases. J Biol Chem 2011 Jan 7;286(1):441-9
Lnx-2b protein, zebrafish  EC 6.3.2.19   *Zebrafish Proteins *Ubiquitin-Protein Ligases RING Finger Domains. Biochem Biophys Res Commun 2010 Nov 26;402(4):626-30
TRIM56 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Immunity 2010 Nov 24;33(5):765-76
TMF protein, mouse  EC 6.3.2.19   *Vesicular Transport Proteins *Ubiquitin-Protein Ligases. Oncogene 2004 Nov 25;23(55):8908-19
Psh1 protein, S cerevisiae  EC 6.3.2.19   *Peptide Elongation Factors *Ubiquitin-Protein Ligases. Mol Cell 2010 Nov 12;40(3):444-54
Rabex-5 protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Protein Ligases Guanine Nucleotide Exchange Factors. Curr Biol 2010 aug 10;20(15):1378-82
ZFP91 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. J Biol Chem 2010 Oct 1;285(40):30539-47
Ltn1 protein, S cerevisiae  EC 6.3.2.19   *Saccharomyces cerevisiae Proteins *Ubiquitin-Protein Ligases. Nature. 2010 Sep 23;467(7314):470-3
POSH2 protein, human  0   *Ubiquitin-Protein Ligases RING Finger Domains. FEBS Lett 2010 Sep 24;584(18):3867-72
RNF-121 protein, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *Ubiquitin-Protein Ligases RING Finger Domains. Mol Biol Cell 2010 Jun;21(11):1788-98
CRL4(Cdt2) protein, Xenopus  EC 6.3.2.19   *Xenopus Proteins *Ubiquitin-Protein Ligases. Mol Cell Biol 2010 Sep;30(17):4120-33
RNF125 protein, human  EC 6.3.2.-   *Ubiquitin-Protein Ligases.
PIR2 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases Zinc Fingers. Proc Natl Acad Sci U S A 2010 Jul 20;107(29):12877-82
arkadia protein, rat  EC 6.3.2.19   *Ubiquitin-Protein Ligases. Lab Invest 2010 Jul;90(7):997-1003
Siah1 protein, Xenopus  EC 6.3.2.19   *Xenopus Proteins *Ubiquitin-Protein Ligases Zinc Fingers. Biochem Biophys Res Commun 2010 May 28;396(2):419-24
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy