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Glycyrrhetinic Acid
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Definition
: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
Pharmacological Action
Anti-Inflammatory Agents
Examples
Carbenoxolone
Other names
Uralenic Acid; Rhetinic Acid; Glycyrrhetic Acid; Enoxolone; Acid, Uralenic; Acid, Rhetinic; Acid, Glycyrrhetinic; Acid, Glycyrrhetic; Plantes et M+Źdecines Brand of Glycyrrhetinic Acid; Glycyram; Dexo Brand of Glycyrrhetinic Acid; Arthrodont; Po 12; Glyciram; Jintan
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(2-
(3-
(3,5-
bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide
0
*Phenylurea Compounds
Glycyrrhetinic Acid/*analogs & derivatives.
J Med Chem. 2011 Oct 13;54(19):6501-13.
2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-
eicosahydro-
5,5,7a,7b,9a,12,15b-
heptamethyl-
3,15-
dioxo-
N-
hydroxy-
N-
methyl-
1H-
chryseno(2,1-
c)azepine-
12-
carboxylic acid amide
0
*Azepines
Glycyrrhetinic Acid/*analogs & derivatives
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Bioorg Med Chem 2011 Mar 15;19(6):1866-80
methyl 2-
cyano-
3,12-
dioxooleana-
1, 12-
dien-
30-
oate
0
Glycyrrhetinic Acid/*analogs & derivatives.
Cancer Biol Ther 2010 Jan;9(2):96-108
methyl 2-
cyano-
3,11-
dioxooleana-
1,12-
dien-
30-
oate
0
Glycyrrhetinic Acid/*analogs & derivatives.
Cancer Biol Ther 2010 Jan;9(2):96-108
27-
hydroxyglycyrrhentic acid
0
Glycyrrhetinic Acid/*analogs & derivatives.
Magn Reson Chem 2010 Feb;48(2):164-7
6,7-
dihydroxyglycyrrhentic acid
0
Glycyrrhetinic Acid/*analogs & derivatives.
Magn Reson Chem 2010 Feb;48(2):164-7
methyl 2-
cyano-
3,11-
dioxo-
18beta-
olean-
1,12-
dien-
30-
oate
0
Glycyrrhetinic Acid/*analogs & derivatives.
Int J Cancer. 2009 Oct 15;125(8):1965-74
MAS063DP
0
*Dietary Fats
*Glycyrrhetinic Acid
*Plant Extracts
Dermatitis, Atopic/drug therapy.
J Pediatr 2008 Jun;152(6):854-9
enoxolone, hyaluronic acid, levomenol, telmesteine, vitis vinifera drug combination
0
*Glycyrrhetinic Acid
*Hyaluronic Acid
Drug Combinations.
Cutan Ocul Toxicol 2006;25(3):165-71
18beta-
glycyrrhetinic acid-
3-
O-
beta-
D-
glucuronide
0
*Glucuronides
Glycyrrhetinic Acid/*analogs & derivatives.
Arch Pharm Res. 2004 Jan;27(1):5760
3-
alpha-
hydroxyglycyrrhetic acid
0
Glycyrrhetinic Acid/*analogs & derivatives.
Biol Pharm Bull. 2003 May;26(5):658-61
glycyrrhetic acid mono-
glucuronide
0
Glycyrrhetinic Acid/*analogs & derivatives.
Biol Pharm Bull. 2003 May;26(5):658-61
18alpha-
glycyrrhetinic acid
1449-05-4
Glycyrrhetinic Acid/*analogs & derivatives
Gap Junctions.
Gastroenterology 1999 May;116(5):1176-83
18-
dehydroglycyrrhetic acid
0
Glycyrrhetinic Acid/*analogs & derivatives.
Eksp Klin Farmakol 1996 Sep-Oct;59(5):53-5
benzocaine, chlorhexidine, enoxolone drug combination
0
*Benzocaine
*Chlorhexidine
*Glycyrrhetinic Acid
Drug Combinations.
Contact Dermatitis 1994 Feb;30(2):124
ascorbic acid 2-
(11-
oxoolean-
12-
en-
29-
oic acid ethyl ester 3-
yl-
phosphate)
145079-98-7
Ascorbic Acid/*analogs & derivatives
Glycyrrhetinic Acid/*analogs & derivatives.
Res Commun Chem Pathol Pharmacol 1993 Nov;82(2):151-66
apioglycyrrhizin
121709-66-8
Glycyrrhetinic Acid/*analogs & derivatives
Plant Extracts
Saponins.
Chem Pharm Bull (Tokyo) 1993 Aug;41(8):1350-7
araboglycyrrhizin
121687-83-0
Glycyrrhetinic Acid/*analogs & derivatives
Glycyrrhiza
Plant Extracts
Saponins.
Chem Pharm Bull (Tokyo) 1993 Aug;41(8):1350-7
stronger neominophagen C
88863-96-1 alpha-
D-
Glucopyranosiduronic acid, (3beta,20beta)-
20-
carboxy-
11-
oxo-
30-
norolean-
12-
en-
3-
yl 2-
O-
beta-
D-
glucopyranuronosyl-
, mixt. with L-
cysteine, glycine and DL-
methionine
*Cysteine
*Glycine
Drug Combinations
Glycyrrhetinic Acid/*analogs & derivatives.
Liver 1993 Aug;13(4):227-31
licorice extract -
magnesium aluminometasilicate
0
*Plant Extracts
*Silicic Acid
Glycyrrhetinic Acid/*analogs & derivatives
Glycyrrhiza
Plant Extracts.
J Electrocardiol 1992 Apr;25(2):163-6
olean-
9(11),12-
diene-
3,30-
diol 3-
O-
hemisuccinate
0
Glycyrrhetinic Acid/*analogs & derivatives.
Am J Chin Med 1991;19(2):115-20
olean-
11,13(18)-
diene-
3,30-
diol dihemiphthalate, disodium salt
102416-29-5
Glycyrrhetinic Acid/*analogs & derivatives.
J Pharm Pharmacol 1990;42(3):199
18-
olean-
9(11),12-
diene-
3,30-
diol dihemiphthalate
102416-28-4
Glycyrrhetinic Acid/*analogs & derivatives.
J Pharm Pharmacol 1990;42(3):199
deoxoglycyrrhetol dihemiphthalate
102416-27-3
Glycyrrhetinic Acid/*analogs & derivatives.
J Pharm Pharmacol 1990;42(3):199
glycyrrhetinic acid 3-
O-
hemiphthalate
66067-20-7
Glycyrrhetinic Acid/*analogs & derivatives.
Masui 1990;39(4):473
glycyrrhizin sulfate
111196-54-4
Glycyrrhetinic Acid/*analogs & derivatives
Glycyrrhiza.
J Acquir Immune Defic Syndr 1989;2(5):441
glyderinine
95507-60-1
Glycyrrhetinic Acid/*analogs & derivatives.
Farmakol Tosikol 1988;51(4):90
methyl 18-
hydroxyglycyrrhetate
0
Glycyrrhetinic Acid/*analogs & derivatives
Drugs, Chinese Herbal.
Yao Hsueh Hsueh Pao 1987;22(7):512
uralenolide
111150-27-7
Glycyrrhetinic Acid/*analogs & derivatives
Drugs, Chinese Herbal
Glycyrrhiza.
Yao Hsueh Hsueh Pao 1987;22(7):512
licorice acid
85441-51-6
Glycyrrhetinic Acid/*analogs & derivatives
Zinc
Drugs, Chinese Herbal.
Chin Med J 1987;100(8):669
glycyrrhetyl 3-
monoglucuronide
34096-83-8
Glycyrrhetinic Acid/*analogs & derivatives
Glycyrrhiza
Sweetening Agents.
Chem Pharm Bull (Tokyo) 1986;34(12):4978
glycyrrhetyl 30-
monoglucuronide
111510-20-4
Glycyrrhetinic Acid/*analogs & derivatives.
Chem Pharm Bull (Tokyo) 1986;34(12):4978
LPD gingival message agent
0
*Chlorhexidine
*Glycyrrhetinic Acid
*Plant Extracts
Adrenochrome/*analogs & derivatives
Drug Combinations.
Nippon Shishubyo Gakkai Kaishi 1984;26(2):397
glycyrrhetinyl-
glycine conjugate
82824-02-0 Glycine, N-
((3beta,20beta)-
3-
hydroxy-
11,29-
dioxoolean-
12-
en-
29-
yl)-
, calcium salt
*Glycine
*Glycyrrhetinic Acid.
Jpn Heart J 1982;23(2):201
stearyl glycyrrhetinate
13832-70-7
Glycyrrhetinic Acid/*analogs & derivatives.
J Dent Health (Jpn) 24(4):332;1976
acetylglycyrrhetinic acid
6277-14-1
Glycyrrhetinic Acid/*analogs & derivatives.
Arzneim Forsch (Drug Res) 1680;1976
lauroylglycyrrhetinic acid
5356-59-2
Glycyrrhetinic Acid/*analogs & derivatives.
Gut 13(6):459;1972