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Receptors, Adrenergic, alpha-2

More information in Books or onNLM PubMed
Definition: A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.      Other names alpha-2 Adrenergic Receptors; Receptors, alpha-2 Adrenergic; Adrenergic alpha-2 Receptors; alpha-2b, Adrenergic Receptor; alpha-2D Receptors, Adrenergic; alpha-2C, Adrenergic Receptor; alpha-2C Receptors, Adrenergic; alpha-2B Receptors, Adrenergic; alpha-2A Receptors, Adrenergic; alpha-2 Receptors, Adrenergic; alpha-2 Adrenergic Receptor; alpha 2D Adrenergic Receptor; alpha 2C Adrenergic Receptor; alpha 2B Adrenergic Receptor; alpha 2A Adrenergic Receptor; Receptors, alpha 2 Adrenergic; Receptors, Adrenergic alpha-2D; Receptors, Adrenergic alpha-2C; Receptors, Adrenergic alpha-2B; Receptors, Adrenergic alpha-2A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-benzoxazin-6-yl)-N-ethyl-N'-methylurea  0   *Methylurea Compounds *Morpholines Receptors, Adrenergic, alpha-2. J Pharmacol Exp Ther 2011 Apr;337(1):256-66
4-(1a,6-dihydro-1H-cyclopropa(a)inden-6a-yl)-1H-imidazole  0   *Imidazoles *Polycyclic Compounds Receptors, Adrenergic, alpha-2. J Med Chem 2010 Oct 14;53(19):6986-95
Adra2c protein, rat  0   *Receptors, Adrenergic, alpha-2.
Adra2c protein, mouse  0   *Receptors, Adrenergic, alpha-2.
ADRA2C protein, human  0   *Receptors, Adrenergic, alpha-2.
Adra2b protein, rat  0   *Receptors, Adrenergic, alpha-2.
Adra2b protein, mouse  0   *Receptors, Adrenergic, alpha-2.
ADRA2B protein, human  0   *Receptors, Adrenergic, alpha-2.
Adra2a protein, rat  0   *Receptors, Adrenergic, alpha-2.
Adra2a protein, mouse  0   *Receptors, Adrenergic, alpha-2.
ADRA2A protein, human  0   *Receptors, Adrenergic, alpha-2.
dibromophakellin  0   *Heterocyclic Compounds with 4 or More Rings Receptors, Adrenergic, alpha-2/agonists. Bioorg Med Chem 2009 Mar 15;17(6):2497-500
N-(2-(4-(2,3-dihydrobenzo(1,4)dioxin-2-ylmethyl)-(1,4)diazepan-2-yl)ethyl)-2-phenoxynicotinamide  0   *Azepines Niacinamide/*analogs & derivatives Receptors, Adrenergic, alpha-2/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Oct 15;18(20):5689-93
1-((imidazolidin-2-yl)imino)-7-methylindazole  0   *Indazoles *Imidazolidines Receptors, Adrenergic, alpha-2/antagonists & inhibitors Imidazoline Receptors/antagonists & inhibitors. J Med Chem 2008 Jun 26;51(12):3599-608
1-((imidazolidin-2-yl)imino)indazole  0   *Indazoles *Imidazolidines Receptors, Adrenergic, alpha-2/antagonists & inhibitors Imidazoline Receptors/antagonists & inhibitors. J Med Chem 2008 Jun 26;51(12):3599-608
3-nitrobiphenyline  0   *Biphenyl Compounds *Imidazoles Receptors, Adrenergic, alpha-2/agonists. J Med Chem 2007 Aug 9;50(16):3964-8
S 18327  0   *Imidazoles *Isoxazoles Receptors, Adrenergic, alpha-1/antagonists & inhibitors Receptors, Adrenergic, alpha-2. J Pharmacol Exp Ther 2000 Jan;292(1):38-53
CP 93393  0   *Pyrazines *Succinimides Receptors, Adrenergic, alpha-2/antagonists & inhibitors. Drug Metab Dispos 1997 Dec;25(12):1395-406
4-(1-(1-naphthyl)ethyl)imidazole  137967-81-8   Medetomidine/*analogs & derivatives Receptors, Adrenergic, alpha-2/agonists. J Med Chem 1992 Feb 21;35(4):750-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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