|
| Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.
| /defic = FACTOR X DEFICIENCY
See Also Coagulants | Other names Thrombokinase; Factor X, Activated; Coagulation Factor Xa; Autoprothrombin C; Xa, Coagulation Factor; Factor Xa, Coagulation; Blood Coagulation Factor X, Activated; Activated Factor X; Thrombokinase; Factor X, Activated; Coagulation Factor Xa; Autoprothrombin C
|
| |
| Substance | CAS Registry & name | Categories | Source | Drugs*
|
lipoprotein-associated coagulation inhibitor
| 0
|
*Lipoproteins Factor Xa/antagonists & inhibitors.
Pharma Action Anticoagulants ; Fibrinolytic Agents ; Serine Proteinase Inhibitors
|
Proc Natl Acad Sci USA 1987;84(7):1886
|
| prothrombinase complex
| 0
|
*Factor V *Factor Xa.
|
Chem Biol Thrombin WH 310 C748c; p.291;1977; J Biol Chem 255(1):274;1980
|
| DX 9065a
| 155204-81-2
|
*Naphthalenes *Propionic Acids Factor Xa/antagonists & inhibitors.
Pharma Action Anticoagulants ; Platelet Aggregation Inhibitors ; Serine Proteinase Inhibitors
|
J Med Chem 1994 Apr 15;37(8):1200-7
|
| tick anticoagulant peptide
| 0
|
*Peptides Ticks Factor Xa/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors
|
Science 1990;248(4955):593
|
| YM 60828
| 0
|
*Naphthalenes *Piperidines Factor Xa/antagonists & inhibitors.
|
Eur J Pharmacol 1997 Nov 27;339(2-3):141-6
|
| ZK 807834
| 0
|
*Amidines *Pyridines Stereoisomerism Factor Xa/antagonists & inhibitors.
|
J Med Chem 1998 Sep 10;41(19):3557-62
|
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa
| 0
|
*Amino Acid Chloromethyl Ketones *Factor Xa.
|
Blood 1996 Jan 15;87(2):642-7
|
1-(3-(aminomethyl)phenyl)-N-(3-fluoro-2'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
| 0
|
Factor Xa/antagonists & inhibitors *Pyrazoles *Sulfones.
|
J Med Chem 2001 Feb 15;44(4):566-78
|
2-(3-carbamimidoylbenzyl)-3-(4-(1-oxypyridin-4-yl)benzoylamino)butyric acid methyl ester
| 0
|
Factor Xa/antagonists & inhibitors *Cyclic N-Oxides *Pyridines.
|
Br J Pharmacol 2001 Aug;133(7):1190-8
|
BAY 59-7939
| 0
|
Factor Xa *Morpholines *Thiophenes.
|
J Thromb Haemost 2005 Mar;3(3):514-21
|
4-((2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl)-1-(4-pyridinyl)piperidine-4-carboxylic acid monomethanesulfonate trihydrate
| 0
|
Factor Xa/antagonists & inhibitors *Piperidines *Pyridines *Tetrahydroisoquinolines.
|
Eur J Pharmacol 2001 Oct 5;428(2):163-8
|
| SANORG 34006
| 0
|
*Oligosaccharides Antithrombins Factor Xa/antagonists & inhibitors.
|
Blood 1998 Jun 1;91(11):4197-205
|
| ZK 805412
| 0
|
*Amidines *Benzylidene Compounds Stereoisomerism Factor Xa/antagonists & inhibitors.
|
J Med Chem 1998 Sep 10;41(19):3551-6
|
| RPR 120844
| 0
|
*Sulfonamides *Thiophenes Factor Xa/antagonists & inhibitors.
|
Thromb Haemost 1999 Jan;81(1):157-60
|
| PD0313052
| 0
|
Factor Xa/antagonists & inhibitors *Piperidines.
|
Biochemistry 2005 Jul 5;44(26):9280-9
|
| factor rXai
| 0
|
*Factor Xa Recombinant Proteins.
|
Thromb Haemost 1994 Mar;71(3):57-62
|
| SEL 2711
| 0
|
*Oligopeptides Factor Xa/antagonists & inhibitors.
|
Biochemistry 1998 Jan 27;37(4):1053-9
|
| RPR 130737
| 0
|
*Amidines *Sulfones Factor Xa/antagonists & inhibitors.
|
J Med Chem 1999 Sep 9;42(18):3572-87
|
BnSO(2)-D-Arg-Gly-Arg-ketothiazole
| 0
|
*Oligopeptides *Thiazoles Factor Xa/antagonists & inhibitors.
|
Biochemistry 1999 Nov 2;38(44):14582-91
|
| DPC 602
| 0
|
Factor Xa/antagonists & inhibitors *Pyrazoles.
|
Stroke 2003 Feb;34(2):468-74
|
isoleucyl-glutamyl-glycyl-arginine chloromethyl ketone
| 0
|
*Amino Acid Chloromethyl Ketones Factor Xa/antagonists & inhibitors.
|
J Biol Chem 1981;256(4):1625
|
Factor Xa, des(1-44)
| 0
|
*Peptide Fragments *Factor Xa.
|
J Biol Chem 1984;259(4):2306
|
| ITF 1331
| 144965-07-1
Heparin, compd. with bis(4-(dibutylamino)butyl) carbonate
|
Heparin, Low-Molecular-Weight/*analogs & derivatives Factor Xa/antagonists & inhibitors.
|
Haemostasis 1992;22(3):113-6
|
factor Xa, Glu-Gly-Arg
| 0
|
*Factor Xa Factor Xa/antagonists & inhibitors.
|
Blood 1993 Apr 15;81(8):2059-66
|
Factor Xa, des(1-45)
| 0
|
*Peptide Fragments *Factor Xa.
|
J Mol Biol 1993 Aug 5;232(3):947-66
|
glutamyl-glycyl-arginyl chloromethyl ketone inactivated human factor Xa
| 0
|
*Amino Acid Chloromethyl Ketones *Factor Xa.
|
Thromb Haemost 1994 Mar;71(3):57-62
|
| FX 2212
| 0
|
*Biphenyl Compounds *Pyridines Factor Xa/antagonists & inhibitors.
|
Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6630-5
|
3,3'-(3,5-difluoro-4-methyl-2,6-pyridinediylbis(oxy))bis(benzenecarbox(imide)amide)
| 0
|
*Amidines *Pyridines Factor Xa/antagonists & inhibitors.
|
J Med Chem 1999 May 20;42(10):1749-56
|
3-(3-(aminoiminomethyl)phenyl)-5-(((2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl)amino)carbonyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester
| 0
|
*Acetic Acids *Isoxazoles Factor Xa.
|
J Med Chem 1999 Jul 29;42(15):2752-9
|
| SF 324
| 0
|
*Acetic Acids *Isoxazoles Factor Xa/antagonists & inhibitors.
|
J Med Chem 1999 Jul 29;42(15):2752-9
|
3-(3-(aminoiminomethyl)phenyl)-5-(((5--(2-(aminosulfonyl)phenyl)-2-pyridinyl)amino)carbonyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester
| 0
|
*Acetic Acids *Isoxazoles Factor Xa.
|
J Med Chem 1999 Jul 29;42(15):2752-9
|
| lefaxin
| 0
|
*Salivary Proteins Helminth Proteins Factor Xa/antagonists & inhibitors.
|
Thromb Haemost 1999 Nov;82(5):1469-73
|
N(2)-(4-(dimethylamino)benzoyl)-4-hydroxy-N(1)-(4-methoxybenzoyl)-1,2-benzenediamine
| 0
|
Factor Xa/antagonists & inhibitors *Phenylenediamines *Sulfonamides.
|
J Med Chem 2000 Mar 9;43(5):859-72
|
2-(4-(dimethylamino)benzoylamino)-5-methanesulfonylamino-N'-(4-methoxyphenyl)benzamide
| 0
|
Factor Xa/antagonists & inhibitors *Benzamides *Sulfonamides.
|
J Med Chem 2000 Mar 9;43(5):873-82
|
| RPR 208566
| 0
|
Factor Xa/antagonists & inhibitors *Amidines *Benzamides.
|
Eur J Pharmacol 2000 Feb 18;389(2-3):201-7
|
| therostasin protein, Theromyzon tessulatum
| 0
|
Factor Xa/antagonists & inhibitors *Proteins.
|
J Biol Chem 2000 Oct 20;275(42):32701-7
|
3-(4-(5-(2,6-dimethyltetrahydro-1(2H)-pyridinyl)pentyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-benzenecarboximidamide
| 0
|
Factor Xa/antagonists & inhibitors *Amidines *Oxazines.
|
J Med Chem 2000 Nov 2;43(22):4063-70
|
| SE 170
| 0
|
Factor Xa/antagonists & inhibitors *Amidines *Sulfonamides.
|
J Med Chem 2000 Nov 16;43(23):4398-415
|
alpha-(3-amidinylphenoxy)-2-bromo-N-(5-(pyrrolidin-1-ylcarbonyl)phenyl)phenylacetamide
| 0
|
Factor Xa/antagonists & inhibitors *Acetanilides *Amidines *Phenylacetates.
|
Bioorg Med Chem Lett 2001 Sep 3;11(17):2279-82
|
| ZK 806299
| 0
|
Factor Xa/antagonists & inhibitors *Amidines *Pyridines.
|
J Med Chem 2003 Jan 30;46(3):359-63
|
| RPR 209685
| 0
|
Factor Xa/antagonists & inhibitors *Piperazines *Sulfonamides.
|
J Med Chem 2003 Feb 27;46(5):681-4
|
1-(1-amino-7-isoquinolyl)-N-(2'-(aminosulfonyl)-1,1'-biphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxamide
| 0
|
Factor Xa/antagonists & inhibitors *Isoquinolines *Sulfonamides.
|
J Med Chem 2003 Oct 9;46(21):4405-18
|
3-(4-(5-(2,6-dimethylpiperidin-1-yl)pentyl)-3-oxo-3,4-dihydroxyquinoxalin-2-yl)benzamidine
| 0
|
Factor Xa/antagonists & inhibitors *Benzamidines *Quinoxalines.
|
J Med Chem 2004 Jul 29;47(16):4089-99
|
2-carbamoyl-4-((6-chloronaphthalen-2-yl)sulfonyl)-1-((5-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl)carbonyl)piperazine
| 0
|
Factor Xa/antagonists & inhibitors *Pyridines *Thiazoles.
|
J Med Chem 2004 Oct 7;47(21):5167-82
|
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-(2-fluoro-4-((2'-dimethylaminomethyl)imidazol-1-yl)phenyl)-1H-pyrazole-5-carboxamide
| 0
|
Factor Xa/antagonists & inhibitors *Isoxazoles *Pyrazoles.
|
J Med Chem 2005 Mar 24;48(6):1729-44
|
WX-FX4 compound
| 0
|
Factor Xa/antagonists & inhibitors Adamantane/*analogs & derivatives.
|
Thromb Haemost 2005 Nov;94(5):1084-93
|
| 6-chloromethyl-3-(2,5-dichlorophenoxycarbonyl)-2-benzopyrone
| | | | | | | | | | | | | | | | | | | | | | | | | | |