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Factor Xa

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Definition: Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.  /defic   
See Also Coagulants 		Other names Thrombokinase; Factor X, Activated; Coagulation Factor Xa; Autoprothrombin C; Xa, Coagulation Factor; Factor Xa, Coagulation; Blood Coagulation Factor X, Activated; Activated Factor X
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-hydroxy-6-(4-methoxybenzamido)phenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide  0   *Azepines *Benzamides Factor Xa/antagonists & inhibitors. Expert Opin Investig Drugs. 2011 Apr;20(4):495-505.
Amblyomin-X protein, Amblyomma cajennense  0   *Salivary Proteins and Peptides Factor Xa/antagonists & inhibitors. Toxicon. 2010 Dec 15;56(7):1145-54
1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one  0   *Pyrimidinones *Sulfones Factor Xa/antagonists & inhibitors. J Med Chem 2010 May 13;53(9):3517-31
edoxaban  480449-70-5   *Pyridines *Thiazoles Factor Xa/antagonists & inhibitors. J Clin Pharmacol. 2010 Jul;50(7):743-53
6-(dimethylcarbamoyl)nicotinoyl guanidine  0   *Guanidines Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 15;19(24):6882-9
BMS 269223  0   *Benzofurans *Lactams Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Aug 1;19(15):4034-41
N-(4-(1-(acetimidoyl)piperidin-4-yloxy)-3-carbamoylphenyl)-N-(3-(3-amidinophenyl)-2-fluoro-2-propenyl)sulfamoylacetic acid  0   *Amidines *Sulfonamides Factor Xa/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2009 Jan;57(1):22-33
eisenstasin  0   *Invertebrate Hormones Factor Xa/antagonists & inhibitors. Biol Pharm Bull 2009 Feb;32(2):253-8
2-(5-chlorothien-2-yl)-N-(1-(1-methyl-2-(morpholin-4-yl)-2-oxoethyl)-2-oxopyrrolidin-3-yl)ethenesulfonamide  0   *Pyrrolidinones *Sulfonamides Factor Xa/antagonists & inhibitors. J Cardiovasc Pharmacol 2008 Jul;52(1):66-71
2-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)propanoyl)piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo(1,5-c)imidazol-3-one  0   *Imidazoles *Sulfones Factor Xa/antagonists & inhibitors. J Med Chem 2008 Jun 26;51(12):3422-36
3-chloro-N-(4-chloro-2-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-methoxyphenyl)-4-(((4,5-dihydro-2-oxazolyl)methylamino)methyl)-2-thiophenecarboxamide  0   *Aminopyridines *Thiophenes Factor Xa/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):2967-80
3-chloro-N-(4-chloro-2-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-methoxyphenyl)-4-((methylamino)methyl)-2-thiophenecarboxamide  0   *Aminopyridines *Thiophenes Factor Xa/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):2967-80
N-(4-chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide  0   *Pyridones *Pyrrolidines Factor Xa/antagonists & inhibitors. Chem Biol Drug Des 2007 Aug;70(2):100-12
RWJ 445167  0   *Guanidines *Sulfonamides Thrombin/antagonists & inhibitors Factor Xa/antagonists & inhibitors. Chem Biol Drug Des 2006 Jul;68(1):29-36
1-(3-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-6-(2'-(3-hydroxy-N-pyrrolidinyl)methyl-(1,1')-biphen-4-yl)-1,4,5,6-tetrahydropyrazolo-(3,4-c)-pyridin-7-one  0   *Pyrazoles *Pyridones Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 1;16(15):4141-7
6-chloromethyl-3-(2,5-dichlorophenoxycarbonyl)-2-benzopyrone  0   *Coumarins Thrombin/antagonists & inhibitors Factor Xa/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7592-603
WX-FX4 compound  0   Adamantane/*analogs & derivatives Factor Xa/antagonists & inhibitors. Thromb Haemost 2005 Nov;94(5):1084-93
rivaroxaban  0   *Morpholines *Thiophenes Factor Xa/antagonists & inhibitors.
Pharma Action Anticoagulants 		J Thromb Haemost 2005 Mar;3(3):514-21XARELTO
PD0313052  0   *Piperidines Factor Xa/antagonists & inhibitors. Biochemistry 2005 Jul 5;44(26):9280-9
razaxaban hydrochloride  0   *Isoxazoles *Pyrazoles Factor Xa/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1729-44
2-carbamoyl-4-((6-chloronaphthalen-2-yl)sulfonyl)-1-((5-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl)carbonyl)piperazine  0   *Pyridines *Thiazoles Factor Xa/antagonists & inhibitors. J Med Chem 2004 Oct 7;47(21):5167-82
3-(4-(5-(2,6-dimethylpiperidin-1-yl)pentyl)-3-oxo-3,4-dihydroxyquinoxalin-2-yl)benzamidine  0   *Benzamidines *Quinoxalines Factor Xa/antagonists & inhibitors. J Med Chem 2004 Jul 29;47(16):4089-99
1-(1-amino-7-isoquinolyl)-N-(2'-(aminosulfonyl)-1,1'-biphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxamide  0   *Isoquinolines *Sulfonamides Factor Xa/antagonists & inhibitors. J Med Chem 2003 Oct 9;46(21):4405-18
RPR 209685  0   *Piperazines *Sulfonamides Factor Xa/antagonists & inhibitors. J Med Chem 2003 Feb 27;46(5):681-4
DPC 602  0   *Pyrazoles Factor Xa/antagonists & inhibitors. Stroke 2003 Feb;34(2):468-74
ZK 806299  0   *Amidines *Pyridines Factor Xa/antagonists & inhibitors. J Med Chem 2003 Jan 30;46(3):359-63
4-((2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl)-1-(4-pyridinyl)piperidine-4-carboxylic acid monomethanesulfonate trihydrate  0   *Piperidines *Pyridines *Tetrahydroisoquinolines Factor Xa/antagonists & inhibitors. Eur J Pharmacol 2001 Oct 5;428(2):163-8
alpha-(3-amidinylphenoxy)-2-bromo-N-(5-(pyrrolidin-1-ylcarbonyl)phenyl)phenylacetamide  0   *Acetanilides *Amidines *Phenylacetates Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2279-82
2-(3-carbamimidoylbenzyl)-3-(4-(1-oxypyridin-4-yl)benzoylamino)butyric acid methyl ester  0   *Cyclic N-Oxides *Pyridines Factor Xa/antagonists & inhibitors. Br J Pharmacol 2001 Aug;133(7):1190-8
1-(3-(aminomethyl)phenyl)-N-(3-fluoro-2'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide  0   *Pyrazoles *Sulfones Factor Xa/antagonists & inhibitors. J Med Chem 2001 Feb 15;44(4):566-78
SE 170  0   *Amidines *Sulfonamides Factor Xa/antagonists & inhibitors. J Med Chem 2000 Nov 16;43(23):4398-415
3-(4-(5-(2,6-dimethyltetrahydro-1(2H)-pyridinyl)pentyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-benzenecarboximidamide  0   *Amidines *Benzoxazines Factor Xa/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4063-70
therostasin protein, Theromyzon tessulatum  0   *Proteins Factor Xa/antagonists & inhibitors. J Biol Chem 2000 Oct 20;275(42):32701-7
RPR 208566  0   *Amidines *Benzamides Factor Xa/antagonists & inhibitors. Eur J Pharmacol 2000 Feb 18;389(2-3):201-7
2-(4-(dimethylamino)benzoylamino)-5-methanesulfonylamino-N'-(4-methoxyphenyl)benzamide  0   *Benzamides *Sulfonamides Factor Xa/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):873-82
N(2)-(4-(dimethylamino)benzoyl)-4-hydroxy-N(1)-(4-methoxybenzoyl)-1,2-benzenediamine  0   *Phenylenediamines *Sulfonamides Factor Xa/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):859-72
lefaxin  0   *Salivary Proteins and Peptides Helminth Proteins Factor Xa/antagonists & inhibitors. Thromb Haemost 1999 Nov;82(5):1469-73
BnSO(2)-D-Arg-Gly-Arg-ketothiazole  0   *Oligopeptides *Thiazoles Factor Xa/antagonists & inhibitors. Biochemistry 1999 Nov 2;38(44):14582-91
RPR 130737  0   *Amidines *Sulfones Factor Xa/antagonists & inhibitors. J Med Chem 1999 Sep 9;42(18):3572-87
3-(3-(aminoiminomethyl)phenyl)-5-(((5--(2-(aminosulfonyl)phenyl)-2-pyridinyl)amino)carbonyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester  0   *Acetic Acids *Isoxazoles Factor Xa. J Med Chem 1999 Jul 29;42(15):2752-9
SF 324  0   *Acetic Acids *Isoxazoles Factor Xa/antagonists & inhibitors. J Med Chem 1999 Jul 29;42(15):2752-9
3-(3-(aminoiminomethyl)phenyl)-5-(((2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl)amino)carbonyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester  0   *Acetic Acids *Isoxazoles Factor Xa. J Med Chem 1999 Jul 29;42(15):2752-9
3,3'-(3,5-difluoro-4-methyl-2,6-pyridinediylbis(oxy))bis(benzenecarbox(imide)amide)  0   *Amidines *Pyridines Factor Xa/antagonists & inhibitors. J Med Chem 1999 May 20;42(10):1749-56
RPR 120844  0   *Sulfonamides *Thiophenes Factor Xa/antagonists & inhibitors. Thromb Haemost 1999 Jan;81(1):157-60
ZK 807834  0   *Amidines *Pyridines Stereoisomerism Factor Xa/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3557-62
ZK 805412  0   *Amidines *Benzylidene Compounds Stereoisomerism Factor Xa/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3551-6
FX 2212  0   *Biphenyl Compounds *Pyridines Factor Xa/antagonists & inhibitors. Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6630-5
SANORG 34006  0   *Oligosaccharides Antithrombins Factor Xa/antagonists & inhibitors. Blood 1998 Jun 1;91(11):4197-205
YM 60828  0   *Naphthalenes *Piperidines Factor Xa/antagonists & inhibitors. Eur J Pharmacol 1997 Nov 27;339(2-3):141-6
SEL 2711  0   *Oligopeptides Factor Xa/antagonists & inhibitors. Biochemistry 1998 Jan 27;37(4):1053-9
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa  0   *Amino Acid Chloromethyl Ketones *Factor Xa. Blood 1996 Jan 15;87(2):642-7
glutamyl-glycyl-arginyl chloromethyl ketone inactivated human factor Xa  0   *Amino Acid Chloromethyl Ketones *Factor Xa. Thromb Haemost 1994 Mar;71(3):57-62
factor rXai  0   *Factor Xa Recombinant Proteins. Thromb Haemost 1994 Mar;71(3):57-62
DX 9065a  155204-81-2   *Naphthalenes *Propionic Acids Factor Xa/antagonists & inhibitors.
Pharma Action Anticoagulants ; Platelet Aggregation Inhibitors ; Serine Proteinase Inhibitors 		J Med Chem 1994 Apr 15;37(8):1200-7
Factor Xa, des(1-45)  0   *Peptide Fragments *Factor Xa. J Mol Biol 1993 Aug 5;232(3):947-66
factor Xa, Glu-Gly-Arg  0   *Factor Xa Factor Xa/antagonists & inhibitors. Blood 1993 Apr 15;81(8):2059-66
ITF 1331  144965-07-1 Heparin, compd. with bis(4-(dibutylamino)butyl) carbonate  Heparin, Low-Molecular-Weight/*analogs & derivatives Factor Xa/antagonists & inhibitors. Haemostasis 1992;22(3):113-6
tick anticoagulant peptide  0   *Peptides *Arthropod Proteins Factor Xa/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors 		Science 1990;248(4955):593
lipoprotein-associated coagulation inhibitor  0   *Lipoproteins Factor Xa/antagonists & inhibitors.
Pharma Action Anticoagulants ; Fibrinolytic Agents ; Serine Proteinase Inhibitors 		Proc Natl Acad Sci USA 1987;84(7):1886
Factor Xa, des(1-44)  0   *Peptide Fragments *Factor Xa. J Biol Chem 1984;259(4):2306
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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