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ψ
ψ
Spiro Compounds
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Definition
: A group of compounds consisting in part of two rings sharing one carbon atom in common.
DF: SPIRO CPDS
Examples
Buspirone
;
Fluorescamine
;
Fluoresceins
;
Fluspirilene
;
Leucogenenol
;
Prospidium
;
Spiperone
Other names
Compounds, Spiro
Substance
CAS Registry & name
Categories
Source
Drugs
*
6-
(1,2,6,7-
tetraoxaspiro(7.11)nonadec-
4-
yl)hexan-
1-
ol
0
*Hexanols
*Spiro Compounds
Antimalarials.
Parasitol Int. 2011 Sep;60(3):270-3
maistemonine
0
*Azepines
*Spiro Compounds
Alkaloids.
J Org Chem. 2011 Dec 16;76(24):10173-86
cycloelatanene B
0
*Furans
*Spiro Compounds.
Phytochemistry. 2011 Nov;72(16):2081-9
cycloelatanene A
0
*Furans
*Spiro Compounds.
Phytochemistry. 2011 Nov;72(16):2081-9
tenuipyrone
0
*Pyrones
*Spiro Compounds.
Org Lett. 2012 Jan 20;14(2):513-5
portentol
0
*Pyrans
*Spiro Compounds.
Org Lett. 2012 Jan 6;14(1):58-61
2'-
(tert-
butyl)-
1-
(1H-
indazole-
5-
carbonyl)-
2'H-
spiro(piperidine-
4,5'-
pyrano(3,2-
c)pyrazol)-
7'(6'H)-
one
0
*Indazoles
*Spiro Compounds
Acetyl-CoA Carboxylase.
J Med Chem. 2012 Jan 26;55(2):935-42.
spirotetramat
0
*Aza Compounds
*Spiro Compounds
Insecticides.
Bull Environ Contam Toxicol. 2012 Feb;88(2):124-8
(2'R,3R,4R,4aS,7aR)-
methyl-
3-
hydroxy-
4'-
((S)-
1-
hydroxyethyl)-
5'-
oxo-
3,4,4a,7a-
tetrahydro-
1H,5'H-
spiro(cyclopenta(c)pyran-
7,2'-
furan)-
4-
carboxylate
0
*Furans
*Pyrans
*Spiro Compounds.
Acta Crystallogr C. 2011 Oct;67(Pt 10):o409-12
1-
oxa-
8-
azaspiro(4.5)decane urea
0
*Aza Compounds
*Spiro Compounds
Urea/*analogs & derivatives.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
PF-
04862853
0
*Spiro Compounds
Aza Compounds.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
1-
oxa-
8-
azaspiro(4.5)decane
0
*Aza Compounds
*Spiro Compounds.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44
7-
azaspiro(3.5)nonane
0
*Aza Compounds
*Spiro Compounds.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44
1',3'-
dihydrospiro(fluorene-
9,2'-
perimidine)
0
*Fluorenes
*Spiro Compounds.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):56-62
1-
(2-
chlorobenzyl)-
5'-
phenyl-
3'H-
spiro(indoline-
3,2'-
(1,3,4)thiadiazol)-
2-
one
0
*Spiro Compounds
*Thiadiazoles.
J Biol Chem. 2011 Nov 4;286(44):38000-17.
pestalospirane B
0
*Benzoxepins
*Spiro Compounds.
J Nat Prod. 2011 Oct 28;74(10):2206-15
pestalospirane A
0
*Benzoxepins
*Spiro Compounds.
J Nat Prod. 2011 Oct 28;74(10):2206-15
massarigenin A
0
*Lactones
*Spiro Compounds.
Chirality. 2011 Sep;23(8):617-23
14,15,18,20-
diepoxyturbinarin
0
*Spiro Compounds
Stigmasterol/*analogs & derivatives.
Nat Prod Res. 2011 Apr;25(7):723-9
3-
(2'-
fluoro-
6',7'-
dihydrospiro(piperidine-
4,4'-
thieno(3,2-
c)pyran)-
1-
yl)-
2-
(2-
fluorobenzyl)-
N-
methylpropanamide
0
*Spiro Compounds
*Bicyclo Compounds, Heterocyclic
Carbon Radioisotopes
Ligands.
J Nucl Med 2011 Oct;52(10):1638-45
sequosempervirin A
0
*Spiro Compounds.
Org Lett. 2011 Sep 2;13(17):4640-3
4-
(6-
amino-
9H-
purin-
9-
yl)-
7-
(hydroxymethyl)spiro(2.4)heptane-
5,6-
diol
0
*Spiro Compounds
Adenosine/*analogs & derivatives.
Bioorg Med Chem Lett 2011 Jul 1;21(13):3982-5
XEN 907
0
*Indoles
*Spiro Compounds.
Bioorg Med Chem Lett 2011 Jun 15;21(12):3676-81
maldoxin
0
*Lactones
*Spiro Compounds.
Org Lett. 2011 Aug 19;13(16):4224-7
97-
63 compound
0
*Heterocyclic Compounds, 1-Ring
*Spiro Compounds
Antimalarials.
Arzneimittelforschung. 2011;61(7):425-32
8-
(3-
(4-
chlorophenyl)prop-
2-
enoyl)-
3-
((3,4-
dichlorophenyl)methyl)-
1-
oxa-
3,8-
diazaspiro(4.5)decan-
2-
one
0
*Oxazoles
*Spiro Compounds.
J Biol Chem 2011 Aug 19;286(33):29292-302
spiro-
prorocentrimine
0
*Lactones
*Spiro Compounds.
Org Lett. 2011 Jul 15;13(14):3758-61
filifolinol acetate
0
*Benzofurans
*Spiro Compounds.
Nat Prod Commun. 2011 Jun;6(6):759-62
3,4-
dehydrotheaspirone
0
*Spiro Compounds.
Fitoterapia. 2011 Mar;82(2):225-9
spironaphthoxazine
0
*Oxazines
*Spiro Compounds.
Bioorg Med Chem 2011 Feb 1;19(3):1030-40
3-
methoxy-
1-
oxa-
2,7-
diaza-
7,10-
ethanospiro(4.5)dec-
2-
ene
0
*Aza Compounds
*Spiro Compounds.
ChemMedChem. 2011 May 2;6(5):889-903
pinnarine
0
*Alkaloids
*Spiro Compounds.
J Nat Prod. 2011 May 27;74(5):1323-6
virgatolide B
0
*Furans
*Spiro Compounds.
Org Lett. 2011 May 20;13(10):2670-3
virgatolide C
0
*Furans
*Spiro Compounds.
Org Lett. 2011 May 20;13(10):2670-3
virgatolide A
0
*Furans
*Spiro Compounds.
Org Lett. 2011 May 20;13(10):2670-3
coixspiroenone
0
*Spiro Compounds.
J Agric Food Chem 2011 Feb 23;59(4):1185-94
97-
78 compound
0
*Heterocyclic Compounds, 1-Ring
*Spiro Compounds
Antimalarials.
Arzneimittelforschung. 2011;61(2):120-5
1'-
benzyl-
3-
(3-
fluoropropyl)-
3H-
spiro((2)benzofuran-
1,4'-
piperidine)
0
*Piperidines
*Spiro Compounds.
Chirality. 2011 Feb;23(2):148-54
27-
hydroxy-
13-
desmethyl spirolide C
0
*Spiro Compounds.
Toxicon. 2010 Dec;56(8):1327-33
27-
oxo-
13,19-
didesmethyl spirolide C
0
*Spiro Compounds.
Toxicon. 2010 Dec;56(8):1327-33
5'-
(2-
fluorophenyl)-
spiro(1-
azabicyclo(2.2.2)octane-
3,2'(3'H)-
furo(2,3-
b)pyridine)
0
*Spiro Compounds
*Azabicyclo Compounds
Receptors, Nicotinic.
Eur J Pharmacol 2010 Oct 25;645(1-3):63-9
1',3'-
dihydro-
1'-
ethanol-
3',3'-
dimethyl-
8-
methoxy-
6-
nitro-
spiro(2H-
1-
benzopyran-
2,2'-
(2H)-
indole)
0
*Benzopyrans
*Spiro Compounds.
Chem Res Toxicol 2010 Sep 20;23(9):1459-66
didemnaketal C
0
*Spiro Compounds
*Terpenes.
Org Lett. 2010 Nov 19;12(22):5354-7
didemnaketal A
0
*Spiro Compounds
*Terpenes.
Org Lett. 2010 Nov 19;12(22):5354-7
didemnaketal B
0
*Spiro Compounds
*Terpenes.
Org Lett. 2010 Nov 19;12(22):5354-7
dihypoestoxide
0
*Chromans
*Spiro Compounds.
Org Lett. 2010 Nov 19;12(22):5294-7
RKA 182
0
*Spiro Compounds
*Tetraoxanes.
Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7
2'-
deoxy-
2'-
spirocyclopropylcytidine
0
*Spiro Compounds
Cytidine/*analogs & derivatives
RNA Replicase/antagonists & inhibitors.
J Med Chem 2010 Nov 25;53(22):8150-60
JB-
788
0
*Pyridines
*Spiro Compounds.
Neuroscience. 2010 Sep 1;169(3):1337-46
spliceostatin A
0
*Pyrans
*Spiro Compounds.
Cancer Sci 2010 Nov;101(11):2483-9
2-
((2,6-
dichlorophenyl)carbonylamino)-
3-
((2,4,8-
triaza-
2-
methyl-
1-
oxo-
4-
phenylspiro(4.5)dec-
8-
yl)carbonylamino)propanoic acid
0
*Spiro Compounds
beta-Alanine/*analogs & derivatives
Integrin alpha4beta1/antagonists & inhibitors.
J Pharm Sci 2010 Sep;99(9):3986-4004
MK-
0489
0
*Pyrrolidines
*Spiro Compounds.
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4399-405
(3,3')spiro((hexahydropyrrolo(1,2-
a)pyrazine-
1,4-
dione)-
6,3'-
(2',3'-
dihydrothieno(2,3-
b)naphtho-
4',9'-
dione))
0
*Quinolines
*Spiro Compounds.
Br J Pharmacol 2010 Jun;160(4):931-40
pinnatoxin G
0
*Alkaloids
*Spiro Compounds.
J Agric Food Chem 2010 May 26;58(10):6532-42
pinnatoxin F
0
*Alkaloids
*Spiro Compounds.
J Agric Food Chem 2010 May 26;58(10):6532-42
pinnatoxin E
0
*Alkaloids
*Spiro Compounds.
J Agric Food Chem 2010 May 26;58(10):6532-42
N-
(2-
(1-
(3-
fluorophenyl)-
4-
oxo-
1,3,8-
triazaspiro(4.5)decan-
8-
yl)ethyl)-
2-
naphthamide
0
*Naphthalenes
*Spiro Compounds
Phospholipase D/antagonists & inhibitors.
J Med Chem 2010 Sep 23;53(18):6706-19
linderaspirone A
0
*Lactones
*Spiro Compounds.
Org Lett. 2010 Jul 16;12(14):3196-9
longianone
0
*Lactones
*Spiro Compounds.
J Org Chem. 2009 Aug 21;74(16):6339-42
7,9-
diamino-
10-