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Histamine H3 Antagonists

More information in Books or onNLM PubMed
Definition: Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP DISORDERS and MEMORY DISORDERS.      Other names H3 Blockers, Histamine; H3 Antihistaminics; H3 Antagonists, Histamine; Blockers, Histamine H3; Antagonists, Histamine H3; Histamine H3 Blockers; Histamine H3 Receptor Antagonists; Antihistaminics, H3
Substances having this pharmacologic action: ciproxifan; clobenpropit; thioperamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide  0   *Cyclobutanes *Pyrrolidines Histamine H3 Antagonists. J Med Chem. 2011 Nov 10;54(21):7602-20.
N-ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidinylmethyl)phenyl)cyclobutanecarboxamide  0   *Cyclobutanes *Pyrrolidines Histamine H3 Antagonists. J Med Chem. 2011 Nov 10;54(21):7602-20.
(4-cyclobutyl-(1,4)diazepan-1-yl)-(6-(4-fluorophenoxy)pyridin-3-yl)methanone  0   *Azepines *Pyridines Histamine H3 Antagonists. Bioorg Med Chem Lett 2010 Jul 15;20(14):4210-4
GSK 835726  0   *Naphthalenes *Piperidines Histamine H3 Antagonists. Expert Opin Ther Pat 2011 Mar;21(3):425-9
4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol  0   *Naphthols *Pyrrolidines Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors Histamine H3 Antagonists. J Med Chem 2010 Nov 11;53(21):7869-73

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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