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11-beta-Hydroxysteroid Dehydrogenases
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Definition
: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.
Examples
11-beta-Hydroxysteroid Dehydrogenase Type 1
;
11-beta-Hydroxysteroid Dehydrogenase Type 2
Other names
beta-
Hydroxysteroid Dehydrogenase, 11; Dehydrogenases, 11-
beta-
Hydroxysteroid; Dehydrogenase, 11beta-
Hydroxysteroid; Dehydrogenase, 11B-
Hydroxysteroid; Dehydrogenase, 11-
Hydroxysteroid; Dehydrogenase, 11 beta-
Hydroxysteroid; Cortisone 11 Oxoreductase; Corticosteroid 11 Reductase; Corticosteroid 11 Oxidoreductase; 11beta Hydroxysteroid Dehydrogenase; 11B Hydroxysteroid Dehydrogenase; 11-
Reductase, Corticosteroid; 11-
Oxoreductase, Cortisone; 11-
Oxidoreductase, Corticosteroid; 11 beta Hydroxysteroid Dehydrogenases; 11 beta Hydroxysteroid Dehydrogenase; 11 Hydroxysteroid Dehydrogenase; Cortisone 11-
Oxoreductase; Corticosteroid 11-
Reductase; Corticosteroid 11-
Oxidoreductase
Substance
CAS Registry & name
Categories
Source
Drugs
*
2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-
eicosahydro-
5,5,7a,7b,9a,12,15b-
heptamethyl-
3,15-
dioxo-
N-
hydroxy-
N-
methyl-
1H-
chryseno(2,1-
c)azepine-
12-
carboxylic acid amide
0
*Azepines
Glycyrrhetinic Acid/*analogs & derivatives
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Bioorg Med Chem 2011 Mar 15;19(6):1866-80
2-
(3-
benzoyl)-
4-
hydroxy-
1,1-
dioxo-
2H-
1,2-
benzothiazine-
2-
yl-
1-
phenylethanone
0
*Cyclic S-Oxides
*Thiazines
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Biochem Pharmacol 2011 Apr 15;81(8):1028-35
massarinolin C
0
*Sesquiterpenes
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Phytochemistry. 2010 Jan;71(1):100-3
craterellin B
0
*Sesquiterpenes
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Phytochemistry. 2010 Jan;71(1):100-3
craterellin C
0
*Sesquiterpenes
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Phytochemistry. 2010 Jan;71(1):100-3
craterellin A
0
*Sesquiterpenes
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Phytochemistry. 2010 Jan;71(1):100-3
PF 877423
0
*Pyrrolidines
Adamantane/*analogs & derivatives
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Bioorg Med Chem Lett 2010 May 1;20(9):2897-902
Cortisone reductase deficiency
0
*Hirsutism/congenital
*Steroid Metabolism, Inborn Errors
*46, XX Disorders of Sex Development
11-beta-Hydroxysteroid Dehydrogenases/deficiency.
HSD1 protein, Arabidopsis
EC 1.1.1.146
*Arabidopsis Proteins
*11-beta-Hydroxysteroid Dehydrogenases.
Plant Physiol 2007 Sep;145(1):87-97
4-
propyl-
N-
(2-
thiophen-
2-
ylethyl)benzenesulfonamide
0
*Sulfonamides
*Thiophenes
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
3-
chloro-
2-
methyl-
N-
(9-
oxo-
9H-
fluoren-
3-
yl)benzenesulfonamide
0
*Fluorenes
*Sulfonamides
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
3,5-
dichloro-
N-
(2-
methylbenzothiazol-
5-
yl)benzamide
0
*Benzamides
*Benzimidazoles
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9
BVT.14225
0
*Sulfonamides
*Thiazoles
11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Steroid Biochem Mol Biol 2007 May;104(3-5):123-9