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Receptors, Metabotropic Glutamate

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Definition: Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.  metabotropic refers to action via the second messenger system; DF: RECEPT METAB GLUTAMATE    Other names Receptors, Glutamate, Metabotropic; Metabotropic Glutamate Receptors; Glutamate Receptors, Metabotropic; Receptor, Metabotropic Glutamate; Glutamate Receptor, Metabotropic; Metabotropic Glutamate Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one  0   *Quinolones Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Neural Transm. 2011 Dec;118(12):1703-18.
3-chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo(d)isothiazol-6-yloxy)methyl)biphenyl-4-carboxylic acid  0   *Chlorobenzoates *Benzothiazoles Receptors, Metabotropic Glutamate/agonists. J Med Chem 2011 Jan 13;54(1):342-53
1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone  0   *Piperazines *Pyridines Receptors, Metabotropic Glutamate/agonists. Eur J Pharmacol 2011 Jun 1;659(2-3):146-54
1-methyl-2-((3-methyl-4-(4-trifluoromethyl-2-fluoro)phenyl)piperidin-1-ylmethyl)-1H-imidazo(4,5-b)pyridine  0   *Piperidines *Bicyclo Compounds, Heterocyclic Receptors, Metabotropic Glutamate/agonists. J Med Chem 2011 Mar 24;54(6):1724-39
LSP1 2111  0   *Aminobutyric Acids *Phosphinic Acids Receptors, Metabotropic Glutamate/agonists. FASEB J 2009 Oct;23(10):3619-28
4-styrylpyrimidin-2-ylamine  0   *Pyrimidines *Styrenes Receptors, Metabotropic Glutamate/agonists. Bioorg Med Chem Lett 2010 Aug 15;20(16):4901-5
3-fluoro-5-(2-(pyridin-2-yl)-7,8-dihydro-4H-oxazolo(4,5-c)azepin-5(6H)-yl)benzonitrile  0   *Azepines *Oxazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2010 Oct 14;53(19):7107-18
6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo(4,5-c)pyridin-4(5H)-one  0   *Pyridones Receptors, Metabotropic Glutamate/antagonists & inhibitors. Eur J Pharmacol 2010 Aug 10;639(1-3):106-14
AZ 12216052  0   *Acetanilides *Thioglycolates Receptors, Metabotropic Glutamate. Behav Brain Res 2010 Oct 15;212(2):168-73
VU 0155041  0   *Anilides *Cyclohexanecarboxylic Acids Receptors, Metabotropic Glutamate. Bioorg Med Chem Lett 2009 Sep 1;19(17):4967-70
3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one  0   *Chromones *Morpholines Receptors, Metabotropic Glutamate. Neuropharmacology 2009 Sep;57(4):438-45
tricholomic acid  0   *Isoxazoles Glycine/*analogs & derivatives Receptors, AMPA/agonists Receptors, Kainic Acid/agonists Receptors, Metabotropic Glutamate/agonists. J Med Chem 2008 Apr 10;51(7):2311-5
9-dimethylamino-3-(4-methylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one  0   *Pyrimidinones *Thiophenes Receptors, Metabotropic Glutamate/antagonists & inhibitors. Eur J Pharmacol 2008 Feb 12;580(3):314-21
9-dimethylamino-3-cycloheptyl-3H-5-thia-1,3,6-triazafluoren-4-one  0   *Pyrimidinones *Thiophenes Receptors, Metabotropic Glutamate/antagonists & inhibitors. Eur J Pharmacol 2008 Feb 12;580(3):314-21
N-cyclohexyl-6-(((2-methoxyethyl)(methyl)amino)methyl)-N-methylthiazolo(3,2-a)benzimidazole-2-carboxamide  0   *Benzimidazoles *Thiazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. Brain Res 2008 Jan 29;1191:168-79
2-amino-4-thiophosphonobutyric acid  0   *Aminobutyric Acids *Organothiophosphorus Compounds Receptors, Metabotropic Glutamate/agonists. J Med Chem 2007 Sep 20;50(19):4656-64
1-amino-2-phosphonomethylcyclopropanecarboxylic acid  0   *Amino Acids *Phosphonic Acids Cyclopropanes Receptors, Metabotropic Glutamate/agonists. J Med Chem 2007 Jul 26;50(15):3585-95
biphenyl-indanone A  0   *Biphenyl Compounds *Indans Receptors, Metabotropic Glutamate/agonists. J Pharmacol Exp Ther 2006 Jul;318(1):173-85
4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3,-triazol-4-yl)-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide  0   *Triazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Pharmacol Exp Ther 2007 Jun;321(3):1144-53
A-841720  0   *Heterocyclic Compounds, 3-Ring Receptors, Metabotropic Glutamate/antagonists & inhibitors. Br J Pharmacol 2006 Nov;149(6):761-74
3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime  0   *Oximes *Pyridines Carbon Radioisotopes Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Nucl Med 2006 Apr;47(4):698-705
9-dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one  0   *Heterocyclic Compounds, 3-Ring Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7374-88
6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide  0   *Benzimidazoles *Thiazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Oct;315(1):163-9
2-((2'-amino)propionyl)aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid  0   *Bicyclo Compounds Alanine/*analogs & derivatives Receptors, Metabotropic Glutamate/agonists. J Med Chem 2005 Aug 11;48(16):5305-20
(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate  0   *Quinolines Receptors, Metabotropic Glutamate/antagonists & inhibitors. Behav Pharmacol 2005 Mar;16(2):113-21
mGluRA protein, Drosophila  0   *Receptors, Metabotropic Glutamate *Drosophila Proteins Neuromuscular Junction. J Neurosci 2004 Oct 13;24(41):9105-16
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide  0   *Benzamides *Pyrazoles Receptors, Metabotropic Glutamate. J Med Chem 2004 Nov 18;47(24):5825-8
2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid  0   *Bicyclo Compounds *Dicarboxylic Acids Receptors, Metabotropic Glutamate/antagonists & inhibitors. Biochem Biophys Res Commun 2004 Mar 5;315(2):493-6
2-(2'-carboxy-3'-hydroxymethylcyclopropyl)glycine  0   Glycine/*analogs & derivatives Receptors, Metabotropic Glutamate/agonists. J Med Chem 2004 Jan 15;47(2):456-66
N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide  0   *Benzamides *Phthalimides Receptors, Metabotropic Glutamate/antagonists & inhibitors. Ann N Y Acad Sci 2003 Nov;1003:481-4
3,3'-difluorobenzaldazine  0   *Hydrazines Receptors, Metabotropic Glutamate/antagonists & inhibitors. Ann N Y Acad Sci 2003 Nov;1003:481-4
methoxymethyl-3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine  0   *Pyridines *Thiazoles Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Dec;303(3):1044-51
2-(2'-carboxy-3'-methylcyclopropyl)glycine  0   *Cyclopropanes Glycine/*analogs & derivatives Receptors, Metabotropic Glutamate/agonists. J Med Chem 2002 Aug 15;45(17):3619-29
N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide  0   *Benzopyrans Receptors, Metabotropic Glutamate/antagonists & inhibitors. Brain Res Mol Brain Res 2001 Oct 19;94(1-2):75-84
alpha-methylserine-O-phosphate monophenyl ester  0   Phosphoserine/*analogs & derivatives Receptors, Metabotropic Glutamate/antagonists & inhibitors. Brain Res Mol Brain Res 2001 Oct 19;94(1-2):75-84
2-amino-3-(4-hexyl-3-hydroxy-5-isoxazolyl)propionic acid  0   *Isoxazoles *Propionic Acids Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2001 Mar 29;44(7):1051-9
LY 344545  0   *Amino Acids *Xanthenes Receptors, Metabotropic Glutamate/antagonists & inhibitors. Br J Pharmacol 2000 Sep;131(2):239-44
MGS 0028  0   *Bicyclo Compounds *Dicarboxylic Acids Receptors, Metabotropic Glutamate/agonists. J Med Chem 2000 Dec 14;43(25):4893-909
MGS 0008  0   *Bicyclo Compounds *Dicarboxylic Acids Receptors, Metabotropic Glutamate/agonists. J Med Chem 2000 Dec 14;43(25):4893-909
bis(glutar-2-ylmethyl)phosphinic acid  0   *Glutarates *Phosphinic Acids Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):769-71
3,4-dihydroxyglutamic acid  0   Glutamic Acid/*analogs & derivatives Receptors, Metabotropic Glutamate/agonists. Bioorg Med Chem Lett 2000 Jan 17;10(2):129-33
LY393053  0   *Propionic Acids Receptors, Metabotropic Glutamate/antagonists & inhibitors. Neuroscience 2000 ;95(3):787-93
6-methyl-2-(phenylethynyl)pyridine  0   *Pyridines Receptors, Metabotropic Glutamate/antagonists & inhibitors.
Pharma Action Anti-Anxiety Agents ; Excitatory Amino Acid Antagonists 		Br J Pharmacol 1999 Jul;127(5):1057-9
4-phosphonophenylglycine  0   Glycine/*analogs & derivatives Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Jun;289(3):1678-87
LY 389795  0   *Amino Acids *Bicyclo Compounds, Heterocyclic Receptors, Metabotropic Glutamate/agonists. J Med Chem 1999 Mar 25;42(6):1027-40
LY 379268  0   *Amino Acids *Bicyclo Compounds, Heterocyclic Receptors, Metabotropic Glutamate/agonists. J Med Chem 1999 Mar 25;42(6):1027-40
2-amino-4-(2,2-diphenylethyl)pentanedioic acid  0   *Glutamates Receptors, Metabotropic Glutamate/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Apr 7;8(7):765-70
metabotropic glutamate receptor 6  0   *Receptors, Metabotropic Glutamate. Brain Res Brain Res Rev 1998 May;26(2-3):230-5
7-aminobicyclo(2.2.1)heptane-2,7-dicarboxyxlic acid  0   *Dicarboxylic Acids *Norbornanes Receptors, Metabotropic Glutamate/agonists. J Med Chem 1998 May 7;41(10):1641-50
2-aminobycyclo(2.1.1)hexane-2,5-dicarboxylic acid  0   *Bicyclo Compounds *Dicarboxylic Acids Receptors, Metabotropic Glutamate. J Med Chem 1998 May 7;41(10):1641-50
metabotropic glutamate receptor 8  0   *Receptors, Metabotropic Glutamate. Brain Res Mol Brain Res 1998 Jan;53(1-2):88-97
metabotropic glutamate receptor 4  0   *Receptors, Metabotropic Glutamate. J Neurosci 1997 Nov 1;17(21):8588-95
metabotropic glutamate receptor 2  0   *Receptors, Metabotropic Glutamate. J Neurosci 1997 Nov 1;17(21):8588-95
metabotropic glutamate receptor 4b  0   *Receptors, Metabotropic Glutamate. Neuropharmacology 1997 Jan;36(1):21-30
cyclopropyl-4-phosphonophenylglycine  0   Glycine/*analogs & derivatives Receptors, Metabotropic Glutamate/antagonists & inhibitors. Br J Pharmacol 1996 Nov;119(5):851-4
metabotropic glutamate receptor type 1  0   *Receptors, Metabotropic Glutamate. Neuron 1997 Jan;18(1):71-9
alpha-methyl-3-carboxyphenylalanine  171031-50-8   Phenylalanine/*analogs & derivatives Receptors, Metabotropic Glutamate/antagonists & inhibitors. Eur J Pharmacol 1996 Aug 22;310(1):61-6
metabotropic glutamate receptor 7  0   *Receptors, Metabotropic Glutamate. Brain Res Mol Brain Res 1996 Aug;40(1):165-70
metabotropic glutamate receptor 3  0   *Receptors, Metabotropic Glutamate. Brain Res Mol Brain Res 1996 Aug;40(1):55-63
metabotropic glutamate receptor 5  0   *Receptors, Metabotropic Glutamate. J Neurochem 1996 Oct;67(4):1435-47
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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