ψ 
Pyrimethamine 
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.     
Pharmacological Action Antiprotozoal Agents; Antimalarials; Folic Acid Antagonists		Other names Wellcome Brand of Pyrimethamine; Tindurine; Malocide; GlaxoSmithKline Brand of Pyrimethamine; Glaxo Wellcome Brand of Pyrimethamine; Daraprim; Chloridin; Aventis Brand of PyrimethamineDrugs* : DARAPRIM
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
sulfadoxine-pyrimethamine  37338-39-9   *Pyrimethamine *Sulfadoxine Drug Combinations. 
Pharma Action Antimalarials 		Br Med J 1(6058):447;1977; Mil Med 144(3):160;1979; Southeast Asian J Trop Med Public Health 2(1):39;1971FANSIDAR
methodichlorophen  7761-45-7   Pyrimethamine/*analogs & derivatives. 
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Folic Acid Antagonists 		Adv Enzyme Regul 1978;17; Biochem Pharmacol 26(6):543;1977; Br J Cancer 28(3):263;1973; Br Med J 2(5961):20;1975; Cancer 40(Suppl 1):519;1977; Cancer Chemother Pharmacol 1(2):101;1978; Cancer Res 1979;39(9):3441; Cancer Res 1979;39(9):3612; Cancer Treat Rep 61(4):559;1977; Cancer Treat Rep 62(3):341;1978; Cancer Treat Rep 62(5):849;1978; Clin Oncol 3:281;1977; Clin Oncol 5(1):11;1979; Drug Metab Dispos 6(3):329;1978; Eur J Cancer 13:861;1977; Eur J Cancer 1980;16(1):147; Exp Hematol 4:43;1976; J Chromatogr 137(2):449;1977; J Chromatogr 156(1):181;1978; J Clin Pathol 30:1154;1977
Maloprim  37357-69-0   *Dapsone *Pyrimethamine Drug Combinations. 
Pharma Action Antimalarials 		J Chromatogr 1979;163(2):179; Southeast Asian J Trop Med Public Health 2(1):42;1971
mefloquine-sulfadoxine-pyrimethamine  69191-18-0 Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-, mixt. with 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine and (R*,S*)-(+-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride  *Pyrimethamine *Sulfadoxine Drug Combinations Mefloquine/*analogs & derivatives. 
Pharma Action Antimalarials 		Bull WHO 1985;63(3):611
metakelfin  81247-66-7   *Pyrimethamine *Sulfalene Drug Combinations.  Med Parazitol (Mosk) 1986;(4):10
etoprine  18588-57-3 2,4-diamino-5- (3',4'-dichlorophenyl)-6-ethylpyrimidine  Pyrimethamine/*analogs & derivatives.  Biochem Pharmacol 26(6):543;1977; Cancer 40(Suppl 1):519;1977; Cancer Treat Rep 61(4):559;1977; Cancer Treat Rep 62(3):341;1978; Drug Metab Dispos 6(3):329;1978; J Chromatogr 156(1):181;1978; J Invest Dermatol 68:362;1977
3-azidopyrimethamine  95458-40-5   *Azides Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors.  Anticancer Drug Des 1987;2(3):297
M&B 35769  0   Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors.  Am J Trop Med Hyg 1984;33(5):772
pyrimethamine pamoate  85819-86-9   Pyrimethamine/*analogs & derivatives.  Am J Trop Med Hyg 1984;33(4):526
daraprim-sulfamethoxydine combination  0   *Pyrimethamine *Sulfameter Drug Combinations.  Med Parazitol (Mosk) 1980;49(5):27
pyrimethamine 3-N-oxide  67412-31-1   Pyrimethamine/*analogs & derivatives.  J Chromatogr 1984;308:363
M&B 36821  0   Pyrimethamine/*analogs & derivatives.  Parasitology 1987;95 (Pt 1):17
2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine  113494-35-2   Pyrimethamine/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors.  FEBS Lett 1988;240(1-2):201
CC 83  0   Pyrimethamine/*analogs & derivatives.  J Med Chem 1998 Apr 23;41(9):1367-70
2,6-diamino-4-ethyl-5-(3-chlorophenyl)pyrimidine  0   Pyrimethamine/*analogs & derivatives.  J Med Chem 1998 Apr 23;41(9):1367-70
succinyldextranthiomannopyranoside-pyrimethamine  0   *Dextrans Pyrimethamine/*analogs & derivatives.  J Pharm Sci 2003 Oct;92(10):2109-16
carboxymethyldextran-thiomannopyranoside-pyrimethamine  0   *Dextrans Pyrimethamine/*analogs & derivatives.  J Pharm Sci 2003 Oct;92(10):2109-16
2,4-diamino-5-phenyl-6-methylpyrimidine  18588-50-6 6-methyl-5-phenyl-2,4-pyrimidinediamine  Pyrimethamine/*analogs & derivatives.  Arkh Anat Gistol Embriol 63(8):88;1972