encyclopedia of medical concepts
ψ
HSP90 Heat-Shock Proteins
More information
in Books
or on
Definition
: A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.
Other names
Heat-
Shock Proteins, HSP90; Heat Shock Proteins 90; HSP90 Heat Shock Proteins; Heat-
Shock Proteins 90
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
amino-
7-
(4-
fluoro-
2-
(6-
methoxypyridin-
2-
yl)phenyl)-
4-
methyl-
7,8-
dihydropyrido(4,3-
d)pyrimidin-
5(6H)-
one
0
*Pyridones
*Pyrimidines
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Anticancer Res. 2012 Feb;32(2):453-62.
CH5164840
0
*Benzoquinones
*Lactams, Macrocyclic
Biotin
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Cancer Sci. 2012 Feb;103(2):342-9
5-
(2,4-
dihydroxy-
5-
isopropylphenyl)-
4-
(5-
(morpholinomethyl)isoxazole-
3-
carbonylamino)isoxazole-
3-
carboxylic acid ethylamide
0
*Isoxazoles
*Resorcinols
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem. 2011 Dec 22;54(24):8592-604.
N-
(4-
(3H-
imidazo(4,5-
c)pyridin-
2-
yl)-
9H-
fluoren-
9-
yl)-
1H-
pyrrolo(2,3-
b)pyridine-
4-
carboxamide
0
*Fluorenes
*Imidazoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem. 2011 Oct 27;54(20):7206-19.
2-
amino-
4-
(4-
chloro-
2-
(2-
(4-
fluoro-
1H-
pyrazol-
1-
yl)ethoxy)-
6-
methylphenyl)-
N-
(2,2-
difluoropropyl)-
5,7-
dihydro-
6H-
pyrrolo(3,4-
d)pyrimidine-
6-
carboxamide
0
*Pyrazoles
*Pyrimidines
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2011 May 12;54(9):3368-85
2-
(4-
acetyloxycyclohexylamino)-
4-
(3,6,6-
trimethyl-
4-
oxo-
4,5,6,7-
tetrahydro-
1H-
indazol-
1-
yl)-
benzamide
0
*Benzamides
*Indazoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Bioorg Med Chem Lett 2011 Mar 15;21(6):1675-7
XL 888
0
*Phthalic Acids
*Azabicyclo Compounds
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
PLoS One 2011;6(3):e17692
hsp90alpha protein, Xenopus
0
*HSP90 Heat-Shock Proteins
*Xenopus Proteins.
Iran Biomed J. 2010 Oct;14(4):127-35
pochoxime A
0
*Lactones
*Oximes
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Chembiochem 2009 Nov 23;10(17):2753-9
EC 144
0
*Pyrimidines
*Pyrroles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Immunol 2011 Jan 1;186(1):563-75
(4-
(5-
furan-
2-
yl-
3-
methyl-
1H-
pyrazol-
4-
yl)-
butyl)methyl-
(7H-
purin-
6-
yl)amine
0
*Pyrazoles
Adenine/*analogs & derivatives
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
ChemMedChem 2010 Oct 4;5(10):1697-700
(2,4-
dihydroxy-
5-
isopropylphenyl)-
(5-
(4-
methylpiperazin-
1-
ylmethyl)-
1,3-
dihydroisoindol-
2-
yl)methanone
0
*Benzamides
*Isoindoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2010 Aug 26;53(16):5956-69
KW-
2478
0
*Morpholines
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Clin Cancer Res. 2010 May 15;16(10):2792-802
TRAP1 protein, rat
0
*HSP90 Heat-Shock Proteins.
FEBS J. 2010 Apr;277(8):1929-38
2-
fluoro-
6-
(tetrahydrofuran-
3-
ylamino)-
4-
(3,6,6-
trimethyl-
4-
oxo-
4,5,6,7-
tetrahydro-
1H-
indol-
1-
yl)benzamide
0
*Anthranilic Acids
*Indoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Pharmacol Exp Ther 2010 Mar;332(3):849-57
TRAP-
1 protein, mouse
0
*HSP90 Heat-Shock Proteins.
Am J Pathol 2010 Jan;176(1):393-401
NVP-
BEP800
0
*Pyrimidines
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Br J Haematol. 2009 Nov;147(3):319-27
STA-
1474
0
*Triazoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Int J Cancer. 2009 Dec 15;125(12):2792-801
Hsp90-
7 protein, Arabidopsis
0
*HSP90 Heat-Shock Proteins
*Arabidopsis Proteins.
Planta. 2009 Mar;229(4):955-64
Hsp90-
5 protein, Arabidopsis
0
*HSP90 Heat-Shock Proteins
*Arabidopsis Proteins.
Planta. 2009 Mar;229(4):955-64
Hsp90-
2 protein, Arabidopsis
0
*HSP90 Heat-Shock Proteins
*Arabidopsis Proteins.
Planta. 2009 Mar;229(4):955-64
SNX-
7081
0
*Benzamides
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Arthritis Rheum 2008 Dec;58(12):3765-75
SNX 2112
0
*Heterocyclic Compounds with 4 or More Rings
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Blood 2009 Jan 22;113(4):846-55
HSP90alpha protein, human
0
*HSP90 Heat-Shock Proteins.
Cancer Invest 2008 Nov;26(9):900-4
STA 9090
0
*Triazoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Exp Hematol 2008 Oct;36(10):1266-77
5-
(2,4-
dihydroxy-
5-
isopropylphenyl)-
4-
(4-
morpholin-
4-
ylmethylphenyl)isoxazole-
3-
carboxylic acid ethylamide
0
*Isoxazoles
*Resorcinols
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2008 Jan 24;51(2):196-218
PU H71
0
*Purines
*Benzodioxoles
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Cancer Res 2008 Jan 1;68(1):216-26
6-
chloro-
9-
(4-
methoxy-
3,5-
dimethylpyridin-
2-
ylmethyl)-
9H-
purin-
2-
ylamine
0
*Pyridines
Adenine/*analogs & derivatives
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2007 Jun 14;50(12):2767-78
6-
chloro-
9-
(5-
methoxy-
4,6-
dimethylpyridin-
3-
ylmethyl)-
9H-
purin-
2-
ylamine
0
*Pyridines
Adenine/*analogs & derivatives
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2007 Jun 14;50(12):2767-78
2-
amino-
6-
chloro-
9-
(4-
iodo-
3,5-
dimethylpyridin-
2-
ylmethyl)purine
0
*Pyridines
Adenine/*analogs & derivatives
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2007 Jun 14;50(12):2767-78
efungumab
0
*Antibodies, Monoclonal
HSP90 Heat-Shock Proteins.
Curr Opin Investig Drugs 2001 Apr;2(4):472-6
DAF-
21 protein, C elegans
0
*HSP90 Heat-Shock Proteins
*Caenorhabditis elegans Proteins
Cell Cycle Proteins.
Genetics 2000 May;155(1):85-104
9-
(2-
(2,2-
dimethylpropylamino)ethyl)-
8-
(2-
iodo-
5-
methoxyphenylsulfanyl)-
9H-
purin-
6-
ylamine
0
Adenine/*analogs & derivatives
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
J Med Chem 2006 Jan 26;49(2):817-28
8-
(2-
iodo-
5-
methoxyphenylsulfanyl)-
9-
(3-
isopropylaminiopropyl)-
9H-
purin-
6-
ylamine
0