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Receptor, Muscarinic M1

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Definition: A specific subtype of muscarinic receptor that has a high affinity for the drug PIRENZEPINE. It is found in the peripheral GANGLIA where it signals a variety of physiological functions such as GASTRIC ACID secretion and BRONCHOCONSTRICTION. This subtype of muscarinic receptor is also found in neuronal tissues including the CEREBRAL CORTEX and HIPPOCAMPUS where it mediates the process of MEMORY and LEARNING.      Other names Receptors M1, Muscarinic; Receptor M1, Muscarinic; Muscarinic M1 Receptors; Muscarinic M1 Receptor; M1, Muscarinic Receptors; M1, Muscarinic Receptor; M1 Receptors, Muscarinic; M1 Receptor, Muscarinic; Receptors, Muscarinic M1; Muscarinic Receptors M1; Muscarinic Receptor M1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine  0   *Oxadiazoles *Pyrimidines Muscarinic Agonists Receptor, Muscarinic M1/agonists. J Pharmacol Exp Ther. 2012 Mar;340(3):588-94.
GSK 1034702  0   *Benzimidazoles Carbon Radioisotopes Receptor, Muscarinic M1/agonists. Appl Radiat Isot. 2011 Oct;69(10):1390-4.
N-(6-((1-((4-fluorobenzyl)(methyl)amino)ethylidene))amino)-2-hydroxy-2,3-dihydro-1H-inden-1-ylbiphenyl-4-carboxamide  0   *Biphenyl Compounds *Indenes Receptor, Muscarinic M1/agonists. J Pharmacol Exp Ther 2011 Aug;338(2):622-32
1-((4-cyano-4-pyridin-2-ylpiperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid  0   *Quinolizines Receptor, Muscarinic M1/agonists. J Med Chem 2011 Jul 14;54(13):4773-80
VU 0405652  0   *Indoles *Sulfones Receptor, Muscarinic M1/agonists. Bioorg Med Chem Lett 2011 May 1;21(9):2697-701
N-(1-(3-(3-oxo-2,3-dihydrobenzo(1,4)oxazin-4-yl)propyl)piperidin-4-yl)-2-phenylacetamide  0   *Benzeneacetamides *Benzoxazines Receptor, Muscarinic M1/agonists. J Med Chem 2010 Sep 9;53(17):6386-97
N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo(c)(1,2,5)thiadiazole-4-sulfonamide  0   *Sulfonamides *Thiadiazoles Receptor, Muscarinic M1/antagonists & inhibitors. Mol Pharmacol 2009 Aug;76(2):356-68
1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one  0   *Benzimidazoles *Piperidines Receptor, Muscarinic M1/agonists. J Neurosci 2008 Oct 8;28(41):10422-33
fluoroxanomeline  0   *Thiadiazoles Fluorine Radioisotopes Receptor, Muscarinic M1/agonists. Nucl Med Biol 2007 Feb;34(2):141-52
4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one  0   *Benzoxazines Receptor, Muscarinic M1/agonists. Mol Pharmacol 2006 Dec;70(6):1974-83

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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