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Muscarinic Agonists

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Definition: Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.  GEN or unspecified; prefer specifics; DF: MUSCARINIC AGON or MUSCARINIC AG    Other names Muscarinic Cholinergic Agonists; Muscarinic Cholinergic Agonist; Agonists, Muscarinic Cholinergic; Agonists, Muscarinic; Agonist, Muscarinic Cholinergic; Agonist, Muscarinic; Muscarinic Agonist; Cholinergic Agonist, Muscarinic; Cholinergic Agonists, Muscarinic
Substances having this pharmacologic action: Methacholine Chloride; Pilocarpine; Muscarine; Bethanechol; Oxotremorine; (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; xanomeline; cevimeline; oxotremorine M
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine  0   *Oxadiazoles *Pyrimidines Muscarinic Agonists Receptor, Muscarinic M1/agonists. J Pharmacol Exp Ther. 2012 Mar;340(3):588-94.
(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one  0 (S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one  *Piperidines *Spiro Compounds *Thiazoles Muscarinic Agonists. J Mol Neurosci 2002 Aug-Oct;19(1-2):145-53
1-methylpiperidine-4-spiro-(2'-methylthiazoline)  0   *Piperidines *Thiazoles Muscarinic Agonists. J Neurochem 1998 May;70(5):1991-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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