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Reverse Transcriptase Inhibitors

More information in Books or onNLM PubMed
Definition: Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.  DF: REVERSE TRANSCRIPTASE INHIB    Other names Inhibitors, Reverse Transcriptase
Substances having this pharmacologic action: Delavirdine; oltipraz; abacavir; adefovir dipivoxil; Phosphonoacetic Acid; Foscarnet; Stavudine; Zidovudine; Dideoxynucleosides; Lamivudine; Zalcitabine; Didanosine; Nevirapine; sulfoquinovosyl diglyceride; beta-lapachone; lamivudine, zidovudine drug combination; tenofovir disoproxil; efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination; tenofovir; efavirenz; loviride; emivirine; R 82913; (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine; L 697661; 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine; adefovir
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cordysobin protein, Cordyceps sobolifera  EC 3.4.-   *Fungal Proteins *Serine Proteases Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Biosci Bioeng. 2012 Jan;113(1):42-7.
2-(difluoro-((4-ethylpyrimidinyl)thio)methyl)benzoxazole  0   *Benzoxazoles *Pyrimidines Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Med Chem. 2011 Dec 8;54(23):7974-85.
3'-azido-2',3'-dideoxycytidine  0   *Azides Zalcitabine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
3'-azido-2',3'-dideoxyadenosine  0   *Azides Dideoxyadenosine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
2-(sec-butylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones Reverse Transcriptase Inhibitors. J Med Chem. 2011 Aug 25;54(16):5927-36.
DPC 963  0   *Quinolones Reverse Transcriptase Inhibitors. Org Lett 2000 Oct 5;2(20):3119-21
9-(2-methylidene-3-(phosphonomethoxy)propyl)guanine  176434-89-2   Guanine/*analogs & derivatives Reverse Transcriptase Inhibitors. Antimicrob Agents Chemother 1996 May;40(5):1072-7
lobucavir  126062-18-8   Guanine/*analogs & derivatives DNA-Directed DNA Polymerase/antagonists & inhibitors Reverse Transcriptase Inhibitors.
Pharma Action Enzyme Inhibitors ; Anti-HIV Agents 		Antimicrob Agents Chemother 1990;34(2):287
penciclovir  39809-25-1   Acyclovir/*analogs & derivatives Reverse Transcriptase Inhibitors.
Pharma Action Antiviral Agents 		Antimicrob Agents Chemother 1987;31(8):1238DENAVIR

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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