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Reverse Transcriptase Inhibitors

More information in Books or onNLM PubMed
Definition: Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.  DF: REVERSE TRANSCRIPTASE INHIB    Other names Inhibitors, Reverse Transcriptase
Substances having this pharmacologic action: Delavirdine; oltipraz; abacavir; adefovir dipivoxil; Phosphonoacetic Acid; Foscarnet; Stavudine; Zidovudine; Dideoxynucleosides; Lamivudine; Zalcitabine; Didanosine; Nevirapine; sulfoquinovosyl diglyceride; beta-lapachone; lamivudine, zidovudine drug combination; tenofovir disoproxil; efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination; tenofovir; efavirenz; loviride; emivirine; R 82913; (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine; L 697661; 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine; adefovir
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cordysobin protein, Cordyceps sobolifera  EC 3.4.-   *Fungal Proteins *Serine Proteases Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Biosci Bioeng. 2012 Jan;113(1):42-7.
2-(difluoro-((4-ethylpyrimidinyl)thio)methyl)benzoxazole  0   *Benzoxazoles *Pyrimidines Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Med Chem. 2011 Dec 8;54(23):7974-85.
3'-azido-2',3'-dideoxycytidine  0   *Azides Zalcitabine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
3'-azido-2',3'-dideoxyadenosine  0   *Azides Dideoxyadenosine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
2-(sec-butylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones Reverse Transcriptase Inhibitors. J Med Chem. 2011 Aug 25;54(16):5927-36.
DPC 963  0   *Quinolones Reverse Transcriptase Inhibitors. Org Lett 2000 Oct 5;2(20):3119-21
9-(2-methylidene-3-(phosphonomethoxy)propyl)guanine  176434-89-2   Guanine/*analogs & derivatives Reverse Transcriptase Inhibitors. Antimicrob Agents Chemother 1996 May;40(5):1072-7
lobucavir  126062-18-8   Guanine/*analogs & derivatives DNA-Directed DNA Polymerase/antagonists & inhibitors Reverse Transcriptase Inhibitors.
Pharma Action Enzyme Inhibitors ; Anti-HIV Agents
Antimicrob Agents Chemother 1990;34(2):287
penciclovir  39809-25-1   Acyclovir/*analogs & derivatives Reverse Transcriptase Inhibitors.
Pharma Action Antiviral Agents
Antimicrob Agents Chemother 1987;31(8):1238DENAVIR

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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