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Receptors, AMPA

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Definition: A class of ionotropic glutamate receptors characterized by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid).      Other names Quisqualate Receptors; AMPA Receptors; Receptors, Quisqualate; Receptor, Quisqualate; Receptor, AMPA; Quisqualate Receptor; AMPA Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(4-amino-3-chlorophenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. Biochemistry. 2012 Feb 28;51(8):1787-95.
1-(4-aminophenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. Biochemistry. 2012 Feb 28;51(8):1787-95.
TARP gamma-4 protein, rat  0   *Calcium Channels Receptors, AMPA. Neuropharmacology. 2011 Dec;61(7):1141-51
TARPgamma-2 protein, rat  0   *Calcium Channels Receptors, AMPA. Neuropharmacology. 2011 Dec;61(7):1141-51
2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid  0   Phenylalanine/*analogs & derivatives Receptors, AMPA/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7289-98.
IKM 159  0   *Benzofurans *Pyrrolidinones Receptors, AMPA/antagonists & inhibitors. Br J Pharmacol 2010 Jul;160(6):1417-29
N-(5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide  0   *Indenes *Sulfonamides Receptors, AMPA. J Med Chem 2010 Aug 12;53(15):5801-12
perampanel  0   *Pyridones Receptors, AMPA/antagonists & inhibitors. Mov Disord 2010 May 15;25(7):896-905
CNIH-3 protein, rat  0   *Receptors, AMPA Protein Subunits. Am J Hematol 2009 Feb;84(2):65-70
CNIH-2 protein, rat  0   *Receptors, AMPA Protein Subunits. Science 2009 Mar 6;323(5919):1313-9
TARP gamma-4 protein, mouse  0   *Membrane Proteins Receptors, AMPA. Mol Cell Neurosci 2008 May;38(1):117-23
TARP gamma-7 protein, rat  0   *Receptors, AMPA Protein Subunits. Neuron 2008 Sep 25;59(6):986-96
TARP gamma-5 protein, rat  0   *Receptors, AMPA Protein Subunits. Neuron 2008 Sep 25;59(6):986-96
tricholomic acid  0   *Isoxazoles Glycine/*analogs & derivatives Receptors, AMPA/agonists Receptors, Kainic Acid/agonists Receptors, Metabotropic Glutamate/agonists. J Med Chem 2008 Apr 10;51(7):2311-5
IEM 1913  0   *Bridged Compounds Putrescine/*analogs & derivatives Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors Receptors, AMPA/antagonists & inhibitors. Eksp Klin Farmakol 2007 Jul-Aug;70(4):15-9
2-amino-3-(3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl)propionic acid  0   *Tetrazoles alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives Receptors, AMPA/agonists. J Med Chem 2007 May 17;50(10):2408-14
TARP gamma-7 protein, mouse  0   *Membrane Proteins Receptors, AMPA. J Neurosci 2007 May 2;27(18):4969-77
3,5-dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-one  0   *Benzodiazepinones Receptors, AMPA/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):575-81
2,3-dimethyl-6-phenyl-12H-(1,3)dioxolo(4,5-h)imidazo(1,2-c)(2,3)benzodiazepine  0   *Benzodiazepines *Dioxoles Receptors, AMPA/antagonists & inhibitors. J Med Chem 2005 Jul 14;48(14):4618-27
GLR-5 protein, C elegans  0   *Receptors, AMPA *Caenorhabditis elegans Proteins. Mol Biol Cell 2004 Nov;15(11):4818-28
GLR-2 protein, C elegans  0   *Receptors, AMPA *Caenorhabditis elegans Proteins. Mol Biol Cell 2004 Nov;15(11):4818-28
KRP 199  0   *Imidazoles *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Oct 18;14(20):5107-11
Grip2 protein, mouse  0   *Carrier Proteins *Nerve Tissue Proteins Receptors, AMPA.
GRIP2 protein, human  0   *Nerve Tissue Proteins *Adaptor Proteins, Signal Transducing Receptors, AMPA.
4,5-dihydro-7-nitro-4-oxo-8-(3-carboxypyrrol-1-yl)-1,2,4-triazolo(1,5-a)quinoxaline-2-carboxylic acid  0   *Quinoxalines *Triazoles Receptors, AMPA/antagonists & inhibitors. J Med Chem 2004 Jan 1;47(1):262-72
ethyl 4,5-dihydro-7-nitro-4-oxo-8-(3-carboxypyrrol-1-yl)-1,2,4-triazolo(1,5-a)quinoxaline-2-carboxylate  0   *Quinoxalines *Triazoles Receptors, AMPA/antagonists & inhibitors. J Med Chem 2004 Jan 1;47(1):262-72
2-(N-(4-chlorophenyl)-N-methylamino)-4H-pyrido(3,2-e)-1,3-thiazin-4-one  0   *Pyridines *Thiazines Receptors, AMPA/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Jul;306(1):66-72
2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Receptors, AMPA/antagonists & inhibitors. J Med Chem 2003 Jan 2;46(1):197-200
2-((4-aminophenyl)-(4-methylsemicarbazono)methyl)-4,5-methylenedioxyphenylacetic acid methyl ester  0   *Dioxoles *Semicarbazones Receptors, AMPA/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2002 Sep 26;45(20):4433-42
CPW 399  0   *Pyrimidinones Alanine/*analogs & derivatives Receptors, AMPA/agonists. J Med Chem 2001 Dec 20;44(26):4501-4
4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one  0   *Azepines Receptors, AMPA. Acta Crystallogr C 2001 Oct;57(Pt 10):1225-7
1,2-bis-nitrooxy-3-thiocyanatopropane  0   *Nitrates Receptors, AMPA. Can J Physiol Pharmacol 2001 May;79(5):422-9
N-2-(4-benzamidophenylpropyl-2-propanesulfonamide)  0   *Benzamides *Sulfonamides Receptors, AMPA. Neuropharmacology 2001 Jun;40(8):1010-8
LY 392098  0   *Sulfonamides *Thiophenes Receptors, AMPA. Neuropharmacology 2001 Jun;40(8):976-83
N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide  0   *Benzamides *Sulfonamides Receptors, AMPA/agonists. J Med Chem 2001 Feb 1;44(3):302-4
LY 404187  0   *Sulfonamides Receptors, AMPA/agonists. J Pharmacol Exp Ther 2001 Jul;298(1):86-102
CP 526,427  0   *Quinazolines Receptors, AMPA/antagonists & inhibitors. Mol Pharmacol. 2000 Dec;58(6):1310-7
CP 465,022  0   *Quinazolines Receptors, AMPA/antagonists & inhibitors. Mol Pharmacol. 2000 Dec;58(6):1310-7
8-methylureido-4,10-dihydro-4-oxo-4H-imidazo(1,2-a)indeno(1,2-e)pyrazin-2-carboxylic acid  0   *Pyrazines Urea/*analogs & derivatives Receptors, AMPA/antagonists & inhibitors. Bioorg Med Chem Lett 2000 May 15;10(10):1133-7
2-amino-3-(3-(2-carboxyethyl)-5-methyl-4-isoxazolyl)propionic acid  0   *Isoxazoles *Propionic Acids Receptors, AMPA/antagonists & inhibitors. Eur J Med Chem 2000 Jan;35(1):69-76
2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid  0   *Isoxazoles Ligands Receptors, AMPA. Eur J Pharmacol 1999 Jun 4;373(2-3):251-62
PD 152247  0   *Quinoxalines Receptors, AMPA. Stroke 1999 Jul;30(7):1472-7
((6-ethyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)methylamino)acetic acid  0   *Quinoxalines Glycine/*analogs & derivatives Receptors, Glycine/antagonists & inhibitors Receptors, AMPA/antagonists & inhibitors. J Med Chem 1999 Jun 17;42(12):2266-71
SPD 502  0   *Pyrroles *Tetrahydroisoquinolines Receptors, AMPA/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Jun;289(3):1492-501
BIIR 561 CL  0   *Oxadiazoles Sodium Channels/antagonists & inhibitors Receptors, AMPA/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Jun;289(3):1343-9
GYKI 53784  0   *Benzodiazepines Receptors, AMPA/antagonists & inhibitors. Brain Res 1999 Feb 13;818(2):421-30
Grip2 protein, rat  0   *Carrier Proteins *Nerve Tissue Proteins Receptors, AMPA. Neuron 1999 Mar;22(3):511-24
LU 136541  0   *Phenylurea Compounds *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Eur J Neurosci 1999 Jan;11(1):250-62
LU 97175  0   *Pyrroles *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Eur J Neurosci 1999 Jan;11(1):250-62
LU 115455  0   *Phenylurea Compounds *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Eur J Neurosci 1999 Jan;11(1):250-62
LU 112313  0   *Pyrroles *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Eur J Neurosci 1999 Jan;11(1):250-62
LU 78919  0   *Pyrroles *Quinoxalines Receptors, AMPA/antagonists & inhibitors. Eur J Neurosci 1999 Jan;11(1):250-62
2-amino-3-(3-(carboxymethoxy)-5-tert-butyl-4-isoxazolyl)propionic acid  0   *Isoxazoles Alanine/*analogs & derivatives Receptors, Glutamate/agonists Receptors, AMPA/antagonists & inhibitors. Neuropharmacology 1998 Oct-Nov;37(10-11):1205-10
glutamate receptor type B  0   *Receptors, AMPA. Proc Natl Acad Sci USA 1998 Nov 10;95(23):13777-82
3a,5,6,6a-tetrahydro-4H-pyrrolo(3,4-d)isoxazole-3,4-dicarboxylic acid  0   *Isoxazoles *Pyrroles Receptors, AMPA/agonists Receptors, Kainic Acid/agonists. J Med Chem 1998 Sep 24;41(20):3759-62
4-ethyl-2,3-dihydro-4H-pyrido(3,2-e)-1,2,4-thiadiazine 1,1-dioxide  0   *Cyclic S-Oxides *Thiadiazines Receptors, AMPA. J Med Chem 1998 Jul 30;41(16):2946-59
1-(4-aminophenyl)-7,8-(methylenedioxy)-3,5-dihdro-4H-2,3-benzodiazepin-4-one  0   *Azepines Receptors, AMPA/antagonists & inhibitors. J Med Chem 1998 Jul 2;41(14):2621-5
2-Fu-AMPA  0   *Furans *Isoxazoles Stereoisomerism Receptors, AMPA/agonists. J Med Chem 1998 Jul 2;41(14):2513-23
2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl)propionic acid  0   *Isoxazoles *Phosphonic Acids Receptors, AMPA/antagonists & inhibitors. Mol Pharmacol 1998 Mar;53(3):590-6
IEM 1460  0   Adamantane/*analogs & derivatives Receptors, AMPA/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Physiol (Lond) 1997 Dec 15;505(Pt3):655-63
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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