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Guanidines

More information in Books or onNLM PubMed
Definition: A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.  do not confuse with GUANINE   
Examples Agmatine; Bethanidine; Biguanides; Cimetidine; Creatine; Gabexate; Guanabenz; Guanethidine; Guanfacine; Guanidine; Impromidine; 3-Iodobenzylguanidine; Methylguanidine; Mitoguazone; Nitrosoguanidines; Pinacidil; Robenidine; Sulfaguanidine; Zanamivir
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(5-(1-methyl-1H-pyrazol-4-yl)-napthalene-2-carbonyl)guanidine  0   *Guanidines *Pyrazoles. PLoS One. 2011;6(11):27660.
DB1127  0   *Guanidines *Thiophenes. Antimicrob Agents Chemother. 2011 Oct;55(10):4866-72.
pyridin-2-yl guanidine  0   *Guanidines. J Org Chem. 2011 Nov 18;76(22):9216-27
alpha-keto-delta-(NG,NG-dimethylguanidino)valeric acid  0   *Guanidines *Keto Acids. Anal Biochem. 2011 Dec 15;419(2):234-40.
KR33426  0   *Guanidines *Oxazoles Lupus Erythematosus, Systemic/drug therapy. Eur J Pharmacol. 2011 Oct 15;668(3):459-66
CMP Y compound  0   *Guanidines *Sulfonamides Serotonin Antagonists. Neurobiol Learn Mem. 2011 Sep;96(2):392-402.
CMP X compound  0   *Guanidines *Sulfonamides Serotonin Antagonists. Neurobiol Learn Mem. 2011 Sep;96(2):392-402.
N-(3,4-dichlorophenyl)-N'-isopropyl-N'-(1-isopropyl-1H-imidazol-2-yl)guanidine  0   *Guanidines *Imidazoles. J Med Chem. 2011 Oct 13;54(19):6634-46.
N-(3-bromo-4-(3-(18F)fluoro-propoxy)benzyl)guanidine  0   *Fluorobenzenes *Guanidines Fluorine Radioisotopes Radiopharmaceuticals. Circ Cardiovasc Imaging. 2011 Jul;4(4):435-43
N-(tert-butoxycarbonyl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine  0   *Guanidines *Imidazolidines. J Med Chem 2011 Jul 14;54(13):4523-35
aperidine  0   *Benzofurans *Guanidines. Org Lett. 2011 May 20;13(10):2789-91
N-(4-fluorobenzoyl)-N'-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro(1,3,5)triazin-2-ylamino)ethyl)guanidine  0   *Guanidines *Triazines Fluorine Radioisotopes. J Nucl Med 2011 Apr;52(4):600-7
BPR-DC-2 compound  0   *Guanidines P-Glycoprotein/antagonists & inhibitors. Invest New Drugs. 2011 Apr;29(2):195-206
gamitrinib-G4  0   *Guanidines *Lactams, Macrocyclic. J Clin Invest 2009 Mar;119(3):454-64
fluoromethyldeoxyspergualin  0   *Guanidines Radiopharmaceuticals. Appl Radiat Isot. 2011 Mar;69(3):609-13
N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide  0   *Benzamides *Guanidines. Mol Pharmacol 2011 Mar;79(3):453-60
TP 201565  0   *Guanidines Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors. BMC Cancer 2010;10:677
pterogynine  0   *Alkaloids *Guanidines. Tumour Biol. 2010 Oct;31(5):513-22
clavatadine E  0   *Guanidines. J Nat Prod. 2009 May 22;72(5):973-5
clavatadine D  0   *Guanidines. J Nat Prod. 2009 May 22;72(5):973-5
clavatadine C  0   *Guanidines. J Nat Prod. 2009 May 22;72(5):973-5
N-(imino(4-morpholyl)methyl)guanidine  0   *Guanidines *Morpholines. Bull Exp Biol Med 2009 Oct;148(4):619-22
pyridoxylidene aminoguanidine  0   *Guanidines *Pyridoxal. Gen Physiol Biophys. 2009 Dec;28(4):347-55
N,N',N''-triphenylguanidinium carboxylate  0   *Guanidines. J Phys Chem A. 2010 Feb 25;114(7):2607-17
nitensidine E  0   *Guanidines. J Nat Prod. 2009 Mar 27;72(3):473-6
nitensidine D  0   *Guanidines. J Nat Prod. 2009 Mar 27;72(3):473-6
1-(N-(2-(Amidinoaminooxy)ethyl)amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenylethylamino)pyrazinone  0   *Guanidines *Pyrazines Thrombin. J Med Chem 2010 Feb 25;53(4):1843-56
bistellettadine A  0   *Guanidines. Org Lett. 2010 Feb 19;12(4):828-31
batzelladine C methyl ester  0   *Guanidines *Heterocyclic Compounds, 3-Ring. Org Biomol Chem 2009 Dec 7;7(23):5001-9
N2-(2-amino-3-(3,5-bis((2-acetamido-3-(1H-imidazol-4-yl)propanamido)methyl)-2,4,6-triethylbenzylamino)-3-oxopropyl)-N5-carbamimidoyl-1H-pyrrole-2,5-dicarboxamide  0   *Guanidines Histidine/*analogs & derivatives. Org Biomol Chem 2009 Dec 7;7(23):4895-903
6-(dimethylcarbamoyl)nicotinoyl guanidine  0   *Guanidines Factor Xa/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 15;19(24):6882-9
KMN-21 compound  0   *Guanidines Naltrexone/*analogs & derivatives. Bioorg Med Chem Lett 2009 Dec 15;19(24):6978-80
7-nitro-1H-indole-2-carboxylic acid (4-(1-(guanidinohydrazone)ethyl)phenyl)amide  0   *Guanidines *Hydrazones. J Pharmacol Exp Ther 2009 Dec;331(3):816-26
scytoscalarol  0   *Guanidines *Sesterterpenes. J Nat Prod. 2009 Nov;72(11):2043-5
merobatzelladine A  0   *Guanidines. Org Lett. 2009 Jun 18;11(12):2655-8
merobatzelladine B  0   *Guanidines. Org Lett. 2009 Jun 18;11(12):2655-8
pterogynidine  0   *Alkaloids *Guanidines. Complement Altern Med. 2009;9() (dup#9):15
1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium  0   *Guanidines. Bioorg Med Chem Lett 2005 May 16;15(10):2491-4
(2-(2,5-dimethoxyphenylthio)-6-methoxybenzylideneamino)guanidine  0   *Benzylidene Compounds *Guanidines. Bioorg Med Chem. 2009 Apr 1;17(7):2852-8
N1-acetyl-N2-(3-(1H-imidazol-4-yl)propyl)guanidine  0   *Guanidines *Imidazoles Receptors, Histamine. J Med Chem 2009 Apr 23;52(8):2623-7
N(1)-(3-(1H-imidazol-4-yl)propyl)-N(2)-propionylguanidine  0   *Guanidines *Imidazoles. ChemMedChem 2009 Feb;4(2):225-31
2-cyano-1-((1S)-1-phenylethyl)-3-quinolin-5-ylguanidine  0   *Guanidines *Quinolines. Neuropharmacology 2009 Jan;56(1):223-9
N-(3-(1-(2-(benzylamino)-1-methylethyl)-3-(2-(3-fluorophenyl)ethyl)-2-thioxoimidazolidin-4-yl)propyl)guanidine  0   *Guanidines Ethylenethiourea/*analogs & derivatives. Eur J Pharmacol 2009 Jan 14;602(2-3):194-202
N-cyano-N'-(2-((8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido(2,3-d)pyrimidin-2-yl)amino)ethyl)guanidine  0   *Guanidines *Pyrimidinones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Feb;328(2):458-68
1,1,3,3-tetramethylguanidium lactate  0   *Guanidines *Lactates. Phys Chem Chem Phys. 2008 Oct 21;10(39):5976-82
1,2-bis(N,N,N',N'-tetramethylguanidino)benzene  0   *Benzene Derivatives *Guanidines. Chemistry. 2008;14(26):7813-21
N-succinimidyl 3-astato-5-guanidinomethylbenzoate  0   *Guanidines Astatine. Int J Radiat Oncol Biol Phys 2008 Sep 1;72(1):193-200
clavatadine A  0   *Guanidines *Phenylacetates Factor XIa/antagonists & inhibitors. 3583-7J Med Chem 2008 Jun 26;51(12):
N-(5,6,7,8-tetrahydronaphthalen-2-yl)guanidine  0   *Guanidines *Tetrahydronaphthalenes. J Med Chem 2008 Jun 12;51(11):3304-12
N-(cyclopropylmethyl)-N'-(4-(aminomethyl)cyclohexylmethyl)guanidine  0   *Guanidines. J Med Chem 2008 Jun 12;51(11):3073-6
hordatine B  0   *Benzofurans *Guanidines. Genes Genet Syst 2007 Dec;82(6):455-64
hordatine A  0   *Benzofurans *Guanidines. Alcohol Clin Exp Res 2007 Jan;31(1 Suppl):S9-14
lysianadioic acid  0   *Guanidines *Succinic Acids. Bioorg Med Chem Lett 2008 Feb 15;18(4):1495-7
2-(4-guanidynephenyl)-1-phenyl-ethanone  0   *Guanidines. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5
methyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
N-(2-(2,5-diphenyl-pyrrol-1-yl)-acetyl)guanidine  0   *Guanidines. Bioorg Med Chem Lett 2008 Feb 1;18(3):1063-6
NeoG6 compound  0   *Guanidines Framycetin/*analogs & derivatives. Nucleic Acids Res 2008 Feb;36(2):697-704
ptilomycalin D  0   *Guanidines. J Nat Prod 2007 Dec;70(12):2033-5
4-chloro-N-(2,2-dichloro-1-(N'-(6-chloropyridin-3-yl)-N''-cyanoguanidino)propyl)benzamide  0   *Benzamides *Guanidines. J Med Chem 2007 Nov 29;50(24):6265-73
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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