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Urokinase-Type Plasminogen Activator

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Definition: A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.      Other names Urokinase; Urinary Plasminogen Activator; U-Plasminogen Activator; Plasminogen Activator, Urokinase-Type; Urokinase Type Plasminogen Activator; U Plasminogen Activator; Single Chain Urokinase Type Plasminogen Activator; Single-Chain Urokinase-Type Plasminogen Activator; Renokinase; Kidney Plasminogen Activator; Abbokinase; U-PADrugs* : KINLYTIC
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5,14-dioxo-12-(2-phenylalanine-N-ylethyl-1-yl)-1,2,3,5,5a,6,11,12,14,14a-decahydro-5H,14H-pyrolo(1,2-4,5)pyrazino(1,2-1,6)pyrido(3,4-b)indole  0   *Heterocyclic Compounds with 4 or More Rings Phenylalanine/*analogs & derivatives Urokinase-Type Plasminogen Activator/antagonists & inhibitors. ChemMedChem. 2011 Dec 9;6(12):2312-22.
SLURP-1 protein, mouse  0   *Antigens, Ly *Urokinase-Type Plasminogen Activator. Neurosci Res. 2009 Aug;64(4):403-12
SLURP-1 protein, rat  0   *Antigens, Ly *Urokinase-Type Plasminogen Activator. Neurosci Res. 2009 Aug;64(4):403-12
mupain-1  0   *Peptides, Cyclic Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Biochem J 2008 Jun 15;412(3):447-57
methyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid  0   *Guanidines *Sulfonamides Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 May 17;50(10):2341-51
upain-1 peptide  0   *Peptides, Cyclic Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Biol Chem 2005 Nov 18;280(46):38424-37
acetyl-lysyl-prolyl-seryl-seryl-prolyl-prolyl-glutamyl-glutamic acid amide  0   *Peptide Fragments *Urokinase-Type Plasminogen Activator. Am J Pathol 2003 Feb;162(2):619-26
amediplase  151912-11-7   *Tissue Plasminogen Activator *Urokinase-Type Plasminogen Activator. BioDrugs 2002;16(5):378-9
cyclo(19,31)-urokinase-type plasminogen activator (19-31)  0   *Peptide Fragments *Urokinase-Type Plasminogen Activator Peptides, Cyclic Plasminogen Activators/antagonists & inhibitors. Biol Chem 2001 Aug;382(8):1197-205
2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine  0   *Amidines *Indoles Factor XI/antagonists & inhibitors Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2753-71
2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine  0   *Amidines *Indoles Factor XI/antagonists & inhibitors Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2753-71
B 623  0   *Amidines *Thiophenes Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Oncol Rep 1999 May-Jun;6(3):523-6
urokinase-fibrinogen conjugate  0   *Urokinase-Type Plasminogen Activator Fibrinogen/*analogs & derivatives. Bioorg Khim 1998 May;24(5):376-8
urokinase-ATF-SAP-3, recombinant  0   *N-Glycosyl Hydrolases *Plant Proteins *Recombinant Fusion Proteins *Urokinase-Type Plasminogen Activator Immunotoxins. Faseb J 1997 Nov;11(13):1169-76
M23 urokinase  0   *Hirudins *Urokinase-Type Plasminogen Activator Recombinant Proteins. Eur J Pharmacol 1996 Apr 29;302(1-3):69-77
4-iodine-benzo(b)thiophene-2-carboxamidine  0   *Amidines *Thiophenes Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Int J Cancer 1995 Dec 11;63(6):840-5
nasaruplase  99821-44-0   *Urokinase-Type Plasminogen Activator. Jpn Heart J 1995 Jan;36(1):61-79
urokinase-type plasminogen activator (6-135)  0   *Peptide Fragments *Urokinase-Type Plasminogen Activator. Biochemistry 1994 Apr 26;33(16):4847-64
urokinase A chain 149-157  0   *Peptide Fragments *Urokinase-Type Plasminogen Activator. Sci China B 1992 Aug;35(8):966-73
urokinase-type plasminogen activator (17-34)  0   *Peptide Fragments *Urokinase-Type Plasminogen Activator. Semin Thromb Hemost 1991 Jul;17(3):291-302
saruplase  99149-95-8   *Urokinase-Type Plasminogen Activator Recombinant Proteins Enzyme Precursors.
Pharma Action Fibrinolytic Agents 		Arzneimittelforschung 1990;40(10):1180
plasmin heavy chain-urokinase conjugate  0   *Fibrinolysin *Urokinase-Type Plasminogen Activator. Thromb Haemost 1986;56(3):364
glutamyl-glycyl-arginine chloromethyl ketone  65113-67-9   *Amino Acid Chloromethyl Ketones Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Eur J Biochem 1987;162(2):351
preprourokinase  EC 3.4.21.-   *Enzyme Precursors *Urokinase-Type Plasminogen Activator. Gene 1985;36(1-2):183
ARS protein, human  0   *Antigens, Ly *Urokinase-Type Plasminogen Activator. Biochem J 1986;234(2):355; Protein Sci 1999 Apr;8(4):810-9
epigallocatechin gallate  989-51-5   Catechin/*analogs & derivatives Protease Inhibitors Radiation-Protective Agents Urokinase-Type Plasminogen Activator/antagonists & inhibitors.
Pharma Action Antioxidants ; Antimutagenic Agents ; Anticarcinogenic Agents ; Neuroprotective Agents 		Mutat Res 1985;150(1-2):127
N(alpha)-benzoylarginineamide  965-03-7 Benzamide, N-(1-(aminocarbonyl)-4-((aminoiminomethyl)amino)butyl)-, (S)  Arginine/*analogs & derivatives Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Biochem Biophys Res Commun 1983;112(2):754; J Am Chem Soc 94(2):665;1972; Lab Invest 75(32):86;1975
3,4-dihydro-3,4-dibromo-6-bromomethylcoumarin  50465-97-9 2H-1-Benzopyran-2-one, 3,4-dibromo-6-(bromomethyl)-3,4-dihydro  *Coumarins Urokinase-Type Plasminogen Activator/antagonists & inhibitors. Febs Lett 1982;14191):58
urokinase inhibitor  0   *Blood Proteins Urokinase-Type Plasminogen Activator/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Serine Proteinase Inhibitors 		Mol Cell Biochem 1981;36(3):129
Antagosan  9050-74-2   *Aprotinin *Urokinase-Type Plasminogen Activator. Arzneimittelforsch 21(10):1430;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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