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Radiopharmaceuticals

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Definition: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)  pharmaceuticals as source of radiation in radiother & radioisotope scanning; D25-26 qualif   
Substances having this pharmacologic action: technetium Tc 99m etidronate; technetium Tc 99m hydroxymethylene diphosphonate; technetium Tc 99m (para-butyl)iminodiacetic acid; technetium phytate; technetium Tc 99m bis(1,2-dimethylphosphino)ethane; technetium Tc 99m diphosphonate; technetium Tc 99m rhenium colloid; 3-iodo-alpha-methyltyrosine; technetium Tc 99m gluconate; technetium Tc 99m tin colloid; technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid; technetium Tc 99m dextran; technetium Tc 99m plasmin; technetium Tc 99m mebrofenin; technetium Tc 99m neogalactoalbumin; technetium Tc 99m pyridoxyl-5-methyltryptophan; technetium Tc 99m sucralfate; Iofetamine; technetium Tc 99m PIPIDA; Technetium Tc 99m Pentetate; Serum Albumin, Radio-Iodinated; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Medronate; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Sulfur Colloid; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sestamibi; Technetium Tc 99m Mertiatide; Technetium Tc 99m Exametazime; Technetium Tc 99m Lidofenin; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Diethyl-iminodiacetic Acid; Technetium Tc 99m Disofenin; Fluorodeoxyglucose F18; 3-Iodobenzylguanidine; Gold Colloid, Radioactive; indium-111-octreotide; technetium Tc 99m gluceptate; gallium citrate; technetium Tc 99m TRODAT-1; (DOTA(0)-Phe(1)-Tyr(3))octreotide; technetium Tc 99m Q12; technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; BMS 181321; carbon-11 methionine; RTI 55; technetium Tc 99m DTPA-galactosyl-human serum albumin; SDZ 215-811; technetium Tc 99m-ethylenedicysteine; technetium Tc 99m bicisate; technetium Tc 99m teboroxime; 3-N-(2-fluoroethyl)spiperone; technetium Tc 99m iminodiacetic acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
technetium Tc 99m N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)  0   *Organotechnetium Compounds Radiopharmaceuticals. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Aug;27(4):811-5
(4S)-4-(3-(18F)fluoropropyl)-L-glutamate  0   *Glutamates Radiopharmaceuticals Positron-Emission Tomography. Clin Cancer Res. 2011 Sep 15;17(18):6000-11
HX4 compound  0   *Imidazoles *Triazoles Radiopharmaceuticals. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14620-5
N-(3-bromo-4-(3-(18F)fluoro-propoxy)benzyl)guanidine  0   *Fluorobenzenes *Guanidines Fluorine Radioisotopes Radiopharmaceuticals. Circ Cardiovasc Imaging. 2011 Jul;4(4):435-43
64Cu-DOTA-conatumumab  0   *Antibodies, Monoclonal *Organometallic Compounds Copper Radiopharmaceuticals. J Nucl Med. 2011 Jun;52(6):942-9
2-(4-aminophenyl)-6-(2-fluoroethoxy)quinoline  0   *Aniline Compounds *Quinolines Radiopharmaceuticals. Brain. 2011 Apr;134(Pt 4):1089-100
4-((3-iodophenyl)amino)-7-(2-(2-(2-(2-(2-(2-(18F)fluoroethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)quinazoline-6-yl-acrylamide  0   *Quinazolines Radiopharmaceuticals. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1603-8
fluoromethyldeoxyspergualin  0   *Guanidines Radiopharmaceuticals. Appl Radiat Isot. 2011 Mar;69(3):609-13
1-(18F)fluoro-3,6-dioxatetracosane  0   *Alkanes Radiopharmaceuticals. Int J Pharm. 2011 Jan 17;403(1-2):170-7
(177)Lu-oxine-lipiodol  0   *Iodized Oil *Oxyquinoline Radiopharmaceuticals. Cancer Biother Radiopharm. 2010 Oct;25(5):539-43
6,7-dimethoxy-2-(6-methoxynaphthalen-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Radiopharmaceuticals. Bioorg Med Chem. 2010 Sep 1;18(17):6489-95
JNJ41510417  0   *Pyrazoles *Quinolines Radiopharmaceuticals. J Nucl Med. 2010 Oct;51(10):1584-91
99mTc-TOR-G  0   *Organotechnetium Compounds Radiopharmaceuticals. Anticancer Res. 2010 Apr;30(4):1243-9
(18F)1-(2'-deoxy-2'-arabinofuranosyl)cytosine  0   Cytarabine/*analogs & derivatives Radiopharmaceuticals. Gastroenterology. 2010 Apr;138(4):1266-75
(166)Ho-oxine-lipiodol  0   *Iodized Oil *Oxyquinoline Radiopharmaceuticals. Nucl Med Commun. 2009 May;30(5):362-7
(18)F-GE067  0   *Benzothiazoles Radiopharmaceuticals. J Nucl Med. 2009 May;50(5):818-22
cFLFLFK-PEG-64Cu  0   *Oligopeptides *Organometallic Compounds *Polyethylene Glycols Copper Radiopharmaceuticals. J Nucl Med. 2009 May;50(5):790-7
(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)  0   *Bombesin *Organometallic Compounds Copper Radiopharmaceuticals. Nucl Med Biol 2009 Feb;36(2):171-81
5-methyl-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (4-morpholin-4-yl-phenyl)amide  0   *Benzopyrans *Morpholines *Piperazines Radiopharmaceuticals. Neuroimage 2008 Jul 1;41(3):1075-85
188Re-DTPA-deoxyglucose  0   Deoxyglucose/*analogs & derivatives Pentetic Acid/*analogs & derivatives Rhenium Radiopharmaceuticals. Cancer Biother Radiopharm 2007 Jun;22(3):400-2
Re-diethylenetriamine pentaacetic acid-glucosamine  0   *Organometallic Compounds Rhenium Radiopharmaceuticals. Cancer Biother Radiopharm. 2007 Aug;22(4):543-50
2beta-carbo-2'-(18F)fluoroethoxy-3beta-(4-bromo-phenyl)tropane  0   *Tropanes Radiopharmaceuticals. Bioorg Med Chem 2007 Jul 1;15(13):4511-9
(123I)INER  0   *Morpholines Radiopharmaceuticals. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7
18F-fluorobenzoyl-lisinopril  0   Lisinopril/*analogs & derivatives Radiopharmaceuticals. J Nucl Med. 2007 Feb;48(2):182-7
(99m)Tc 5-Amino-1,3-bis(ethylamine-(N,N dimethyl diphosphonic acid) acetamido) benzene  0   *Organotechnetium Compounds Radiopharmaceuticals. Bioorg Med Chem. 2007 Jan 15;15(2):1138-45
(R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide  0   *Amides *Isoquinolines Radiopharmaceuticals. Nucl Med Biol. 2005 Apr;32(3):307-12
9-fluoro-3,4-methyleneheptadecanoic acid  0   *Fatty Acids Radiopharmaceuticals. J Nucl Med 2005 Feb;46(2):297-304
technetium Tc 99m CIBCNSH3  0   *Antibodies, Monoclonal *Organotechnetium Compounds Radiopharmaceuticals. Q J Nucl Med 2003 Jun;47(2):139-44
(188)Rhenium tin-colloid  0   *Tin *Rhenium Colloids Radiopharmaceuticals. Nucl Med Commun 2003 Jun;24(6):689-96
technetium Tc 99m interleukin 2  0   *Interleukin-2 *Organotechnetium Compounds Radiopharmaceuticals. Eur J Nucl Med Mol Imaging 2003 Mar;30(3):374-82
pyrithione  1121-30-8 1-hydroxy- 2(1H)-pyridinethione  *Pyridines *Thiones Gallium Radioisotopes Indium Radioisotopes Radiopharmaceuticals.
Pharma Action Antifungal Agents 		Acta Derm Venerol (Stockh) 1979;59(6):521; Antimicrob Ag Chemother 10(2):249;1976; Antimicrob Ag Chemother 14(1):60;1978; Arch Environ Contam Toxicol 1979;8(3):355-; Clin Toxicol 13(1):1;1978; Food Cosmet Toxicol 15(1):43;1977; Prensa Med Mex 42(7-8):319;1977; Toxicol Appl Pharmacol 43:373;1978; Toxicology 5(2):209;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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