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Pinacidil
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Definition
: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Pharmacological Action
Antihypertensive Agents
;
Membrane Transport Modulators
;
Vasodilator Agents
Other names
Anhydrous, Pinacidil; Pindac; Pinacidil Anhydrous
Drugs
*
:
PINDAC
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(4-
difluoromethoxyphenyl)-
N'-
pinacolyl-
N''-
cyanoguanidine
0
Pinacidil/*analogs & derivatives.
Br J Pharmacol 2011 Feb;162(3):701-11
flokalin
0
Pinacidil/*analogs & derivatives.
Fiziol Zh. 2005;51(6):18-24
Washington University solution
0
*Organ Preservation Solutions
*Pinacidil.
Ann Thorac Surg 2004 Aug;78(2):620-6
3-
pyridyl pinacidil
60560-07-8
Pinacidil/*analogs & derivatives.
J Cardiovasc Pharmacol 1993 Nov;22(5):731-43
pinacidil pyridine N-
oxide
83285-82-9
Pinacidil/*analogs & derivatives.
Br J Clin Pharmacol 1985;19(1):91