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Nicotinamide Phosphoribosyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).      Other names Pre B Cell Colony Enhancing Factor; Phosphoribosyltransferase, Nicotinamide; Colony-Enhancing Factor, Pre-B-Cell; NMN Pyrophosphorylase; NAmPRTase; NAMPT Protein; Visfatin; Pre-B-Cell Colony-Enhancing Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TP 201565  0   *Guanidines Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors. BMC Cancer 2010;10:677
nicotinamide phosphoribosyltransferase, rat  EC 2.4.2.12   *Cytokines *Nicotinamide Phosphoribosyltransferase. Biochem Biophys Res Commun 2005 Oct 28;336(3):747-53
nicotinamide phosphoribosyltransferase, mouse  EC 2.4.2.12   *Cytokines *Nicotinamide Phosphoribosyltransferase. Science 2005 Jan 21;307(5708):366-7
CB 30865  0   *Quinazolines Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors. Br J Cancer 1999 Apr;79(11-12):1692-701
nicotinamide phosphoribosyltransferase, human  EC 2.4.2.12   *Cytokines *Nicotinamide Phosphoribosyltransferase. Mol Cell Biol 1994 Feb;14(2):1431-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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