encyclopedia of medical concepts
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Thrombin

More information in Books or onNLM PubMed
Definition: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.  /antag permitted: not same as ANTITHROMBINS   
Pharmacological Action Hemostatics
See Also Coagulants 		Other names Thrombase; Thrombin Pfizer Brand; Thrombin Jones Brand; Thrombin Ethicon Brand; JMI, Thrombin; gamma-Thrombin; beta-Thrombin; beta,gamma-Thrombin; alpha-Thrombin; Thrombostat; Thrombinar; Thrombin-JMI; Thrombin JMI; Pfizer Brand of Thrombin; Park Davis Brand of Thrombin; Jones Brand of Thrombin; Ethicon Brand of Thrombin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gloshedobin protein, Gloydius shedaoensis  EC 3.4.21.5   *Thrombin *Viper Venoms. Biotechnol Lett 2003 Apr;25(8):607-10
1-(N-(2-(Amidinoaminooxy)ethyl)amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenylethylamino)pyrazinone  0   *Guanidines *Pyrazines Thrombin. J Med Chem 2010 Feb 25;53(4):1843-56
chitribrisin, Trimeresurus albolabris  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Protein Expr Purif 2009 Sep;67(1):48-52
thrombin-like protein, Agkistrodon acutus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005 Aug;13(4):542-7
leucurobin, Bothrops leucurus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Comp Biochem Physiol A Mol Integr Physiol 2007 Apr;146(4):565-75
TachoSil  0   *Thrombin *Fibrinogen Drug Combinations Surgical Sponges. J Chir (Paris). 2007 Jan-Feb;144(1):82-3
RWJ 445167  0   *Guanidines *Sulfonamides Thrombin/antagonists & inhibitors Factor Xa/antagonists & inhibitors. Chem Biol Drug Des 2006 Jul;68(1):29-36
recombinant human thrombin  0   *Recombinant Proteins *Thrombin Hemorrhage Hemostatics Surgical Procedures, Operative.
acutobin, Deinagkistrodon acutus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Brain Res 2004 Oct 1;1022(1-2):234-43
6-chloromethyl-3-(2,5-dichlorophenoxycarbonyl)-2-benzopyrone  0   *Coumarins Thrombin/antagonists & inhibitors Factor Xa/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7592-603
3-aza-9-hydroxyfluoren-9-ylcarbonyl-prolyl-2-aminomethyl-5-chlorobenzylamide  0   *Fluorenes Proline/*analogs & derivatives Thrombin/antagonists & inhibitors. J Med Chem 2005 Apr 7;48(7):2282-93
amblin protein, Amblyomma hebraeum  0   *Blood Proteins Thrombin/antagonists & inhibitors. Gene 2004 Nov 24;342(2):243-9
Thrombogen  EC 3.4.21.5   *Thrombin. J Am Coll Surg 2003 Oct;197(4):580-90
LU 58463  0   *Hirudins *Peptide Fragments Thrombin. Haematologica. 2002 Oct;87(10):1116-7
thrombin Perija  0   *Thrombin. Thromb Haemost 2002 Feb;87(2):282-7
flavovilase  EC 3.4.21.-   *Thrombin Crotalid Venoms. J Nat Toxins 2001 Aug;10(3):239-48
UK 156406  0   *Peptides Thrombin/antagonists & inhibitors. Am J Pathol 2001 Oct;159(4):1383-95
intimatan  0   Dermatan Sulfate/*analogs & derivatives Thrombin/antagonists & inhibitors Heparin Cofactor II/agonists. Thromb Res 2000 Sep 15;99(6):603-12
theromin  0   *Peptides Thrombin/antagonists & inhibitors. J Biol Chem 2000 Oct 6;275(40):30774-80
CoStasis Surgical Hemostat  0   *Collagen *Thrombin Plasma. Arch Surg 2000 Oct;135(10) 1200-4; discussion 1205
rusalatide acetate  0   *Peptide Fragments *Thrombin Wound Healing. Wound Repair Regen 2000 May-June;8(3):204-15
3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methylenecarboxamidomethylpyridinyl)pyrazinone  0   *Pyrazines *Pyridines Thrombin/antagonists & inhibitors. J Chromatogr B Biomed Sci Appl 2000 Jan 28;738(1):83-91
dipetalogastin protein, Dipetalogaster maximus  0   *Insect Proteins Thrombin/analogs & derivatives Triatominae. Haemostasis 1999;29(4):204-11
1-(2-((5-(6-hydroxy-3-((3-methoxy-4-((1-pyrrolidinyl)methyl)phenyl)methyl)benzo(b)thiophen-2-yl)pyrid-2-yl)oxy)ethyl)pyrrolidine  0   *Pyrrolidines *Thiophenes Thrombin/antagonists & inhibitors. J Med Chem 2000 Feb 24;43(4):649-63
6-hydroxy-3-(3-methoxy-4-((1-pyrrolidinyl)methyl)benzyl)-2-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)benzo(b)thiophene  0   *Pyrrolidines *Thiophenes Thrombin/antagonists & inhibitors. J Med Chem 2000 Feb 24;43(4):649-63
2-amino-3-(1-carbamimidoylpiperidin-3-yl)propanoic acid  0   *Amidines Alanine/*analogs & derivatives Thrombin/antagonists & inhibitors. J Med Chem 2000 Feb 10;43(3):361-8
savignin protein, Ornithodoros savignyi  0   *Insect Proteins Thrombin/antagonists & inhibitors. Exp Parasitol 1999 Oct;93(2) 82-91
anophelin protein, Anopheles albimanus  0   *Salivary Proteins and Peptides *Insect Proteins Thrombin/antagonists & inhibitors. Biochemistry 1999 Aug 24;38(34):11209-15
cyclohexylalanine-prolyl-arginyl-psi(COCH2S)glycyl-glycyl-glycyl-glycyl-glycyl-aspartyl-tyrosyl-glutamyl-prolyl-isoleucyl-prolyl-glutamyl-glutamyl-tyrosyl-cyclohexylalanine-glutamic acid  0   *Peptides Thrombin. J Med Chem 1999 Aug 12;42(16):3109-15
(N-(3-phenylpropionyl)-N-(phenethyl))-glycyl-borolysine  0   *Boron Compounds *Dipeptides Thrombin/antagonists & inhibitors. Acta Crystallogr D Biol Crystallogr 1998 Nov 1;54(2( Pt 6)):1207-15
SEL 2770  0   *Oligopeptides Thrombin/antagonists & inhibitors. Acta Crystallogr D Biol Crystallogr 1999 Apr;55(Pt 4):785-93
bothroalternin  0   *Crotalid Venoms Thrombin/antagonists & inhibitors. Toxicon 1998 Dec;36(12):1903-12
thienylamidine  0   *Sulfanilamides Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jul 7;8(13):1683-6
L 373890  0   *Pyridones *Sulfonamides Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Apr 7;8(7):817-22
L 374087  0   *Pyridones *Sulfonamides Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Apr 7;8(7):817-22
LB 30057  0   *Benzamides Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Mar 17;8(6):631-4
N-cyclopentyl-N-methyl-3-(4-amidrazonophenyl)-2-(2-naphthylsulfonylamino)-propionamide  0   *Amides *Naphthalenes Thrombin/antagonists & inhibitors. J Chromatogr B Biomed Sci Appl 1998 Sep 4;714(2):379-83
L 375378  0   *Aminopyridines *Pyrazines Thrombin/antagonists & inhibitors. J Med Chem 1998 Nov 5;41(23):4466-74
N-(3-((aminoiminomethyl)amino)propyl)-hexahydro-5-oxo-6-(((phenylmethyl)sulfonyl)amino)-5H-thiazolo(3,2-a)pyridine-3-carboxamide  0   *Guanidines *Thiazoles Thrombin/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3664-74
CVS 1694  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors. Biochemistry 1998 Sep 1;37(35):12094-103
CVS 1695  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors. Biochemistry 1998 Sep 1;37(35):12094-103
CVS 1578  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors. Biochemistry 1998 Sep 1;37(35):12094-103
phenylalanyl-prolyl-amidobutylguanidine  0   *Dipeptides *Guanidines Thrombin/antagonists & inhibitors. J Med Chem 1998 Jun 4;41(12):2068-75
N-(2-(5-methyl-3-(2-chlorophenylsulfonyloxy)phenoxy)ethyl)-N-methyl-4-aminopyridine  0   *Aminopyridines Thrombin/antagonists & inhibitors. J Med Chem 1998 Jun 4;41(12):2068-75
GR 133687  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors. Biochemistry 1998 May 12;37(19):6645-57
GR 133686  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors. Biochemistry 1998 May 12;37(19):6645-57
BCH 2763  0   *Oligopeptides Thrombin/antagonists & inhibitors. Thromb Haemost 1998 Feb;79(2):431-8
N-methylphenylalanyl-prolyl-arginine 1,1-difluorobutyl ketone  0   *Amino Acid Chloromethyl Ketones Thrombin/antagonists & inhibitors. J Chromatogr B Biomed Appl 1997 Jan 24;688(2):281-9
RWJ 50215  0   *Dansyl Compounds Thrombin/antagonists & inhibitors. Biophys J 1996 Nov;71(5):2830-9
alpha-((1-aminoiminopiperidin-3-yl)methyl)-N-(2-(3-benzylsulfonamido-2-oxopiperidin-1-yl)-1-oxoethyl)glycinal  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors. J Med Chem 1996 Nov 8;39(23):4527-30
BMS 186282  0   *Guanidines Serine/*analogs & derivatives Thrombin/antagonists & inhibitors. Protein Sci 1996 Feb;5(2):221-8
BMS 189090  0   *Nipecotic Acids Serine/*analogs & derivatives Thrombin/antagonists & inhibitors. Protein Sci 1996 Feb;5(2):221-8
LY 254603  0   *Naphthalenes *Phenyl Ethers Thrombin/antagonists & inhibitors. Science 1996 Sep 6;273(5280):1389-91
RWJ 50353  0   *Guanidines *Thiazoles Thrombin/antagonists & inhibitors. J Med Chem 1996 Aug 2;39(16):3039-43
thrombin, des(Glu(146)-Thr(147)-Trp(148))  0   *Thrombin. Biochem J 1996 Apr 1;315( Pt 1):77-83
grambin  EC 3.4.21.-   *Thrombin Crotalid Venoms. Toxicon 1995 Aug;33(8):1087-98
tachocomb  0   *Fibrinogen *Aprotinin *Thrombin Drug Combinations Hemostasis, Surgical. J Cardiovasc Surg (Torino) 1994 Dec;35(6 Suppl 1):169-70
cerastocytin  EC 3.4.21.-   *Thrombin Viper Venoms. Biochim Biophys Acta 1995 May 11;1244(1):147-56
MDL 74063  0   *Oligopeptides Thrombin/antagonists & inhibitors. Adv Exp Med Biol 1993;340:185-8
MDL 73756  0   *Oligopeptides Thrombin/antagonists & inhibitors. Adv Exp Med Biol 1993;340:185-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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