ψ 
ψ 
ψ 
Thrombin 
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.  /antag permitted: not same as ANTITHROMBINS   
Pharmacological Action Hemostatics
See Also Coagulants
Other names Thrombase; gamma-Thrombin; beta-Thrombin; beta,gamma-Thrombin; alpha-Thrombin; Thrombostat; Thrombinar; Thrombase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
meizothrombin  EC 3.4.21.- Thrombin, meizo  *Enzyme Precursors *Thrombin Esterases.  Thromb Res 1980;18(5):657
thrombin aptamer  145563-68-4   *Aptamers, Nucleotide Thrombin/antagonists & inhibitors.  Blood 1993 Jun 15;81(12):3271-6
tachocomb  0   *Fibrinogen *Aprotinin *Thrombin Drug Combinations Hemostasis, Surgical.  J Cardiovasc Surg (Torino) 1994 Dec;35(6 Suppl 1):169-70
diisopropylphosphoryl-thrombin  0   *Thrombin.  J Clin Invest 1980;66(6):1222
phenylalanyl-prolyl-arginine chloromethyl ketone-thrombin  0   *Amino Acid Chloromethyl Ketones *Thrombin.  J Biol Chem 1986;261(34):15928
TP 508  0   Wound Healing *Peptide Fragments *Thrombin.  Wound Repair Regen 2000 May-June;8(3):204-15
thrombin Quick  0   *Thrombin.  J Clin Invest 1980;66(5):934
DFP-alpha-thrombin  0   *Thrombin Isoflurophate/*analogs & derivatives.  Fiziol Zh SSSR 1980;66(10):1460
CoStasis Surgical Hemostat  0   Plasma *Collagen *Thrombin.  Arch Surg 2000 Oct;135(10) 1200-4; discussion 1205
hylan gel  0   *Cellulose *Hexamethonium Compounds *Tantalum *Thrombin Drug Combinations Hyaluronic Acid/*analogs & derivatives Embolization, Therapeutic.  J Biomed Mater Res 1991;25(6):699
LB 30057  0   *Benzamides Thrombin/antagonists & inhibitors.  Bioorg Med Chem Lett 1998 Mar 17;8(6):631-4
G-T-XIII  0   *Factor XIII *Thrombin.  ASAIO Trans 1986;32(1):609
intimatan  0   Thrombin/antagonists & inhibitors Heparin Cofactor II/agonists Dermatan Sulfate/*analogs & derivatives.  Thromb Res 2000 Sep 15;99(6):603-12
cyclotheonamide A  129033-04-1   *Peptides, Cyclic Thrombin/antagonists & inhibitors.  Thromb Res 1993 Apr 15;70(2):173-90
cerastocytin  EC 3.4.21.-   *Thrombin Viper Venoms.  Biochim Biophys Acta 1995 May 11;1244(1):147-56
RWJ 50353  0   *Guanidines *Thiazoles Thrombin/antagonists & inhibitors.  J Med Chem 1996 Aug 2;39(16):3039-43
dipetalogastin protein, Dipetalogaster maximus  0   Thrombin/analogs & derivatives Triatominae *Insect Proteins.  Haemostasis 1999;29(4):204-11
bio-adhesio-chemo protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Factor XIII Fibrinogen Thrombin.  Am J Clin Oncol 1989;12(2):156
staphylothrombin  EC 3.4.21.-   *Thrombin Coagulase.  Postepy Hig Med Dosw 31(1):17;1977
topostasin  61806-10-8   *Heparin *Thrombin Drug Combinations.  Acta Chir Hung 1983;24(1):37
tosyllysine chloromethyl ketone-thrombin  0   *Thrombin Tosyllysine Chloromethyl Ketone/*analogs & derivatives.  J Biol Chem 1986;261(34):15928
BMS 189090  0   *Nipecotic Acids Serine/*analogs & derivatives Thrombin/antagonists & inhibitors.  Protein Sci 1996 Feb;5(2):221-8
BCH 2763  0   *Oligopeptides Thrombin/antagonists & inhibitors.  Thromb Haemost 1998 Feb;79(2):431-8
L 374087  0   *Pyridones *Sulfonamides Thrombin/antagonists & inhibitors.  Bioorg Med Chem Lett 1998 Apr 7;8(7):817-22
Thrombogen  EC 3.4.21.5   *Thrombin.  J Am Coll Surg 2003 Oct;197(4):580-90
N-acetylthrombin  0   *Thrombin.  Fiziol Zh SSSR 62(4):559;1976
thrombin alpha 2-macroglobulin complex  0   *alpha-Macroglobulins *Thrombin.  Biochim Biophys Acta 1985;845(3):389
FTCH hemostatic  0   *Collagen *Fibrinogen *Aprotinin *Thrombin Drug Combinations.  Ann Surg 1987;205(4):432
t-butyloxycarbonyl-phenylalanyl-prolyl-boroarginine-C10H16  130982-44-4   *Boron Compounds *Oligopeptides Thrombin/antagonists & inhibitors.  J Biol Chem 1990;265(30):18289
synthetic peptide alpha27-50  134998-69-9   *Peptides Thrombin/antagonists & inhibitors.  Thromb Haemost 1991;65(2):165
BMS 186282  0   *Guanidines Serine/*analogs & derivatives Thrombin/antagonists & inhibitors.  Protein Sci 1996 Feb;5(2):221-8
CVS 1578  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors.  Biochemistry 1998 Sep 1;37(35):12094-103
L 375378  0   *Aminopyridines *Pyrazines Thrombin/antagonists & inhibitors.  J Med Chem 1998 Nov 5;41(23):4466-74
thienylamidine  0   *Sulfanilamides Thrombin/antagonists & inhibitors.  Bioorg Med Chem Lett 1998 Jul 7;8(13):1683-6
anophelin protein, Anopheles albimanus  0   *Salivary Proteins *Insect Proteins Thrombin/antagonists & inhibitors.  Biochemistry 1999 Aug 24;38(34):11209-15
savignin protein, Ornithodoros savignyi  0   *Insect Proteins Thrombin/antagonists & inhibitors.  Exp Parasitol 1999 Oct;93(2) 82-91
3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methylenecarboxamidomethylpyridinyl)pyrazinone  0   Thrombin/antagonists & inhibitors *Pyrazines *Pyridines.  J Chromatogr B Biomed Sci Appl 2000 Jan 28;738(1):83-91
thrombin JMI  EC 3.4.21.-   *Thrombin.  Am J Pathol 2001 Nov;159(5):1957-69
dansyl-alpha-thrombin  0   *Thrombin.  THROMB Res 12(1):15;1978
dansyl-gamma-thrombin  0   *Thrombin.  Arch Biochem Biophys 1981;208(2):610
thrombin Metz  90453-22-8 Thrombin Metz  *Thrombin Coagulation Protein Disorders.  Blood 1984;63(4):927
nitro-thrombin  0   *Thrombin.  J Cell Physiol 1984;120(3):289
thrombin Tokushima  93928-47-3   *Thrombin.  Biochemistry 1987;26(4):1117
tetra(pyridoxal phosphate)thrombin  0   *Pyridoxal Phosphate *Thrombin.  J Biol Chem 1989;264(19):11117
phenylalanyl-prolyl-boroarginine  130926-95-3   *Boron Compounds *Oligopeptides Thrombin/antagonists & inhibitors.  J Biol Chem 1990;265(30):18289
succinylthrombin  0   *Thrombin.  Thromb Res 1991;63(1):111
hirulog 3-thrombin complex  0   *Hirudins *Thrombin.  Biochemistry 1992 Dec 1;31(47):11689-97
LY 806303  149725-15-5 (1)Benzothieno(3,2-b)furan-2-carboxylic acid, 3-(2-methyl-1-oxopropoxy)-, methyl ester  *Furans Thrombin/antagonists & inhibitors.  J Med Chem 1993 Aug 6;36(16):2350-5
alpha-(1,7-diaza-5-(alpha-(phenylmethylamino)phenylmethyl)-2,6-dioxobicyclo(5.4.0)undecan-8-yl)glycyl-isoleucyl-argininyl chloromethyl ketone  141650-30-8   *Azepines *Oligopeptides Thrombin/antagonists & inhibitors.  Protein Eng 1993 Jul;6(5):471-8
MDL 73756  0   *Oligopeptides Thrombin/antagonists & inhibitors.  Adv Exp Med Biol 1993;340:185-8
MDL 74063  0   *Oligopeptides Thrombin/antagonists & inhibitors.  Adv Exp Med Biol 1993;340:185-8
grambin  EC 3.4.21.-   *Thrombin Crotalid Venoms.  Toxicon 1995 Aug;33(8):1087-98
thrombin, des(Glu(146)-Thr(147)-Trp(148))  0   *Thrombin.  Biochem J 1996 Apr 1;315( Pt 1):77-83
LY 254603  0   *Naphthalenes *Phenyl Ethers Thrombin/antagonists & inhibitors.  Science 1996 Sep 6;273(5280):1389-91
alpha-((1-aminoiminopiperidin-3-yl)methyl)-N-(2-(3-benzylsulfonamido-2-oxopiperidin-1-yl)-1-oxoethyl)glycinal  0   *Guanidines *Piperidines Thrombin/antagonists & inhibitors.  J Med Chem 1996 Nov 8;39(23):4527-30
RWJ 50215  0   *Dansyl Compounds Thrombin/antagonists & inhibitors.  Biophys J 1996 Nov;71(5):2830-9
N-methylphenylalanyl-prolyl-arginine 1,1-difluorobutyl ketone  0   *Amino Acid Chloromethyl Ketones Thrombin/antagonists & inhibitors.  J Chromatogr B Biomed Appl 1997 Jan 24;688(2):281-9
GR 133686  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors.  Biochemistry 1998 May 12;37(19):6645-57
GR 133687  0   *Lactones *Triterpenes Thrombin/antagonists & inhibitors Serine Proteinase Inhibitors.  Biochemistry 1998 May 12;37(19):6645-57
N-(2-(5-methyl-3-(2-chlorophenylsulfonyloxy)phenoxy)ethyl)-N-methyl-4-aminopyridine  0   *Aminopyridines Thrombin/antagonists & inhibitors.  J Med Chem 1998 Jun 4;41(12):2068-75
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