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Drug Combinations 
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.  IM for general only; NIM with specific drugs; differentiate from DRUG THERAPY, COMBINATION: drug combinations = 2 or more drugs in a single dosage form; combination ther = 2 or more drugs separately for a combined eff;   
See Also Drug Synergism; Drug Therapy, Combination		Other names Combinations, Drug
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
matrigel  119978-18-6 Matrigel  *Collagen *Laminin *Proteoglycans Drug Combinations Extracellular Matrix. 
Pharma Action Biocompatible Materials 		Prog Brain Res 1988;78:427
sulfadoxine-pyrimethamine  37338-39-9   *Pyrimethamine *Sulfadoxine Drug Combinations. 
Pharma Action Antimalarials 		Br Med J 1(6058):447;1977; Mil Med 144(3):160;1979; Southeast Asian J Trop Med Public Health 2(1):39;1971FANSIDAR
S 1 (combination)  150863-82-4   *Tegafur *Oxonic Acid Drug Combinations. 
Pharma Action Antimetabolites, Antineoplastic 		Gan To Kagaku Ryoho 1993 Jan; 20(1):10-18
carbamide peroxide  124-43-6 Urea, compd. with hydrogen peroxide (H2O2) (1:1)  *Peroxides Drug Combinations Urea/*analogs & derivatives Tooth Bleaching.  Am J Ment Defic 78(4):502;1974; J Natl Cancer Inst 1975;55(6):1359; J Periodontol 1976;47(10):607; Pharmacol Ther Dent 1974;1(2):83
Fluosol-DA  75216-20-5 Fluosol DA  *Fluorocarbons Drug Combinations Blood Substitutes Plasma Substitutes. 
Pharma Action Contrast Media ; Radiation-Sensitizing Agents 		JAMA 1980;243(8):719; JAMA 1980;243(8):721; Jpn J Anesthesiol 27(7):717;1978; Kokyu To Junkan 1979;27(8):869; Masui 1979;28(9):929
Sinemet  57308-51-7   *Carbidopa *Levodopa Drug Combinations Delayed-Action Preparations. 
Pharma Action Adjuvants, Immunologic ; Antiparkinson Agents ; Dopamine Agonists 		Ann Neurol 3(3):267;1978; Cesk Neurol Neurochir 42(3):195;1979; Harefuah 87(5):208;1974; Neurol Neurochir Pol 10(3):345;1976; Neurol Neurochir Pol 9(5):611;1975SINEMET; SINEMET CR
mineral trioxide aggregate  0   *Oxides *Aluminum Compounds *Calcium Compounds *Silicates Drug Combinations Dental Cements Root Canal Filling Materials.  J Endod 1993 Nov;19(11):541-4
urovision  8064-12-8   *Diatrizoate *Diatrizoate Meglumine Drug Combinations. 
Pharma Action Contrast Media 		Clin Radiol 1980;31(3):291; Lancet 1(8063):556;1978ANGIOVIST 292; ANGIOVIST 370; DIATRIZOATE-60; GASTROVIST; HYPAQUE-76; HYPAQUE-M,75%; HYPAQUE-M,90%; MD-60; MD-76; MD-76R; MD-GASTROVIEW; RENOCAL-76; RENOGRAFIN-60; RENOGRAFIN-76; RENOVIST; RENOVIST II
UFT(R) drug  0   *Tegafur *Uracil Drug Combinations. 
Pharma Action Antineoplastic Agents 		Dig Dis Sci 1995 Nov;40(11):2434-7
AH 26  55599-25-2   *Bismuth *Epoxy Resins *Silver *Titanium Drug Combinations Root Canal Filling Materials.  J Endodont 1980;6(10):784
Exosurf  99732-49-7 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxohexadecyl)oxy)-, hydroxide, inner salt, 4-oxide, (R)-, mixt. with formaldehyde polymer with oxirane and 4-(1,1,3,3-tetramethylbutyl)phenol, and 1-hexadecanol  *Fatty Alcohols *Phosphorylcholine *Polyethylene Glycols Drug Combinations.  J Pediatr 1985;107(5):775EXOSURF NEONATAL
Abelcet  0   *Amphotericin B *Phosphatidylcholines *Phosphatidylglycerols Drug Combinations. 
Pharma Action Antifungal Agents 		Eur J Haematol Suppl 1996;57:18-23ABELCET
aluminum magnesium hydroxide  37317-08-1   *Aluminum Hydroxide *Magnesium Hydroxide Drug Combinations. 
Pharma Action Antacids 		Am J Hosp Pharm 33(11):1127;1976; Clin Pharmacol Ther 24(3):308;1978
alcoholic prolamine solution  91196-33-7   *Diatrizoate *Fatty Acids *Propylene Glycols *Zein Drug Combinations. 
Pharma Action Sclerosing Solutions 		Radiologe 1980 Jun;20(6):308-18
bendectin  8064-77-5   *Doxylamine *Pyridoxine Drug Combinations Dicyclomine. 
Pharma Action Antiemetics ; Teratogens 		Brit Med J 1(6119):1055;1978; Can Med Assoc J 117(7):721;1977; JAMA 1979;242(23):2518; Nature 1980;283(5748):609; Nurs Mirror 1980;150(8):8BENDECTIN
Listerine  51273-66-6   *Salicylates *Terpenes Drug Combinations. 
Pharma Action Anti-Infective Agents, Local ; Mouthwashes 		J Am Dent Assoc 1988;117(3):515
madopar  37270-69-2   *Benserazide *Levodopa Drug Combinations Dopa Decarboxylase/antagonists & inhibitors. 
Pharma Action Enzyme Inhibitors ; Dopamine Agents 		Acta Neurol 28(2):208;1973; Acta Neurol Scand 53(3):189;1976; Br Med J 1(5957):573;1975; Wien Med Wochenschr 123(26):433;1973
amphotericin B-deoxycholate  87687-70-5   *Amphotericin B *Deoxycholic Acid Drug Combinations. 
Pharma Action Antifungal Agents 		Antimicrob Agents Chemother 1989;33(3):362
gelatin-resorcinol-formaldehyde tissue adhesive  0   *Formaldehyde *Gelatin *Resorcinols Drug Combinations. 
Pharma Action Tissue Adhesives 		Z Exp Chir 1980;13(1):43
Maxepa  0   *Docosahexaenoic Acids *Eicosapentaenoic Acid Drug Combinations Dietary Fats, Unsaturated Fish Oils.  Atherosclerosis 1985;54(1):75
co-trimazine  39474-58-3 benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine  *Sulfadiazine *Trimethoprim Drug Combinations. 
Pharma Action Anti-Infective Agents, Urinary 		NZ Med J 1980;91(652):43
Salazopyrine  31363-03-8   *Sulfasalazine Drug Combinations Glucosamine/*analogs & derivatives.  Union Med Can 1980;109(9):1326
N2 Dental Cement  8068-83-5 2-methoxy-4-(2-propenyl)phenol, mixt. with zinc oxide  *Eugenol *Formaldehyde *Zinc Oxide Drug Combinations Dental Cements Root Canal Filling Materials. 
spinosad  0   *Macrolides Drug Combinations. 
Pharma Action Insecticides 		J Agric Food Chem 2000 Sep;48(9):4428-31
Maloprim  37357-69-0   *Dapsone *Pyrimethamine Drug Combinations. 
Pharma Action Antimalarials 		J Chromatogr 1979;163(2):179; Southeast Asian J Trop Med Public Health 2(1):42;1971
Berodual  115112-73-7   *Fenoterol *Ipratropium Drug Combinations Aerosols. 
Pharma Action Bronchodilator Agents 		Med Klin 1981;76(11):324
acetaminophen-propoxyphene combination  39400-85-6   *Acetaminophen *Propoxyphene Drug Combinations.  Br Med J 1(6007):460;1976; Br Med J 1(6162):551;1979; Therapie 1982;37(3):321DARVOCET; DARVOCET A500; DARVOCET-N 100; DARVOCET-N 50; DOLENE AP-65; PROPACET 100; PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN; PROPOXYPHENE NAPSYLATE AND ACETAMINOPHEN; WYGESIC
corticosteroid methanetriol mixture  0   *Dexamethasone *Formaldehyde *Hydrocortisone Drug Combinations Thymol/*analogs & derivatives Root Canal Filling Materials. 
Pharma Action Dental Materials 		Czas Stomatol 28(11):1051;1975; ZWR 85(20):937;1976; ZWR 86(3):116;1977
terrilytin  37338-91-3   *Amylases *Peptide Hydrolases Drug Combinations Enzymes, Immobilized. 
Pharma Action Adjuvants, Immunologic ; Anti-Infective Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Fibrinolytic Agents ; Hemostatics 		Antibiotiki 23(7):622;1978; Antibiotiki 23(8):720;1978; Biokhimiia 1979;44(12):2134; Biokhimiia 43(12):2143;1978; Biull Eksp Biol Med 82(8):936;1976; Biull Eksp Biol Med 87(3):214;1979; Mycopathologia 56(3):153;1975; Probl Gematol Pereliv Krovi 17(9):21;1972; Probl Tuberk 1979;(ll):51; Vestn Oftalmol 1:41;1977; Veterinariia 9:79;1976
Viscoat  123352-36-3   *Chondroitin *Hyaluronic Acid Drug Combinations.  Am J Ophthalmol 1985;100(3):377
Cavit  66458-08-0   *Calcium Sulfate *Polyvinyls *Zinc Oxide Drug Combinations Dental Cements Root Canal Filling Materials.  Oral Surg 48(3):250;1979
Diane  60528-19-0   *Ethinyl Estradiol *Cyproterone Acetate Drug Combinations. 
Pharma Action Androgen Antagonists 		Orv Hetil 1981;122(30):1821
BSS solution  0   *Acetates *Minerals *Sodium Chloride Drug Combinations.  Nippon Ganka Gakkai Zasshi 1980;84(10):1777
Fluor Protector  64441-49-2   *Fluorides, Topical *Polyurethanes *Silanes Drug Combinations.  Caries Res 14(2):103;1980; Wiad Lek 1980;33(1):19
heparin-dihydergot  0   *Dihydroergotamine *Heparin, Low-Molecular-Weight Drug Combinations.  Med Welt 1981;32(25):1021EMBOLEX
camphorated parachlorophenol  8003-18-7   *Camphor *Chlorophenols Drug Combinations. 
Pharma Action Anti-Infective Agents, Local ; Disinfectants 		Odontostomatol Proodos 1980;34(5):237
co-amilozide  68529-45-3   *Amiloride *Hydrochlorothiazide Drug Combinations.  J Med Assoc Thai 58(4):186;1975; Pol Tyg Lek 32(8):1253;1977AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE; HYDRO-RIDE; MODURETIC 5-50
Lorenzo's oil  0   *Erucic Acids *Triolein Drug Combinations Adrenoleukodystrophy Dietary Fats, Unsaturated.  Brain Dev 1992 Nov;14(6):409-12
alginic acid compound  66220-44-8 alginic acid, mixt. with aluminum hydroxide, silicic acid (H4Si3O8) magnesium salt (1:2) and sodium hydrogen carbonate  *Alginates *Aluminum Hydroxide *Silicic Acid *Sodium Bicarbonate Drug Combinations. 
Pharma Action Antacids 		Aust Paediatr J 1979;15(4):263; Brit Med J 1(6115):787;1978; Harefuah 89(7):327;1975; J Kansas Med Soc 74(11):423;1973; J Nucl Med 1980;20(10):1023; Southern Med J 71(Suppl 1):16;1978; Southern Med J 71(Suppl 1):26;1978GAVISCON
bone wax  8021-48-5   *Palmitates *Waxes Drug Combinations. 
Pharma Action Hemostatics 		J Foot Surg 1987;26(6):496
Lipofundin  11096-66-5   *Phospholipids *Sorbitol Drug Combinations Fat Emulsions, Intravenous.  Probl Gematol Pereliv Krovi 17(9):27;1972
reproterol  54063-54-6   Drug Combinations Orciprenaline/*analogs & derivatives Theophylline/*analogs & derivatives. 
Pharma Action Adrenergic beta-Agonists ; Bronchodilator Agents 		Arzneim Forsch 28(1):765;1978; Birth Defects 1979;15(4):541; Curr Med Res Opin 1979;6(5):364; Dtsch Med Wochenschr 102(16):619;1977; Dtsch Med Wochenschr 104(29):1041;1979; Med Welt 30(23):897;1979; Respiration 1979;38(5):280
CI 744  37291-85-3   *Tiletamine *Zolazepam Drug Combinations. 
Pharma Action Anesthetics ; Anesthetics, Dissociative 		Am J Vet Res 36(5):695;1975; Invest Ophthalmol Vis Sci 18(8):8780;1979; J Am Vet Med Assoc 173(9):1127;1978; J Med Primatol 7(4):193;1978; Lab Animal Sci 22(6):878;1972; Vet Med Small Anim Clin 69(4):479;1974; Vet Med Small Anim Clin 71(6):764;1976; Vet Med Small Anim Clin 72(11):1722;1977
malarone  0   *Chloroguanide *Atovaquone Drug Combinations. 
Pharma Action Antimalarials 		Lancet 1997 Nov 29;350(9091):1624-5MALARONE; MALARONE PEDIATRIC
leukinferon  0   *Interferon Type I *Cytokines Drug Combinations. 
Pharma Action Adjuvants, Immunologic 		Antibiotic Khimoter 1989;34(9):657
hydrochlorothiazide-triamterene  14124-50-6 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine- 7-sulfonamide, 1,1-dioxide, mixt. with 6-phenyl- 2,4,7-pteridinetriamine  *Hydrochlorothiazide *Triamterene Drug Combinations. 
Pharma Action Antihypertensive Agents 		Kardiologiia 4:57;1973; Otolaryngology 86(4):668;1979DYAZIDE; MAXZIDE; MAXZIDE-25; TRIAMTERENE AND HYDROCHLOROTHIAZIDE
Trisequens  66100-41-2   *Estradiol *Estriol Drug Combinations Norethindrone/*analogs & derivatives Estrogen Replacement Therapy.  Drug Ther Bull 1981;19(16):63
Ledermix  8059-68-5   *Demeclocycline *Triamcinolone Acetonide Drug Combinations.  J Br Endod Soc 6(1):8;1972
Diaket  56509-77-4   *Zinc Oxide Drug Combinations *Bismuth *Polyvinyls Root Canal Filling Materials.  Czas Stomatol 30(4):290;1977
Cervitec  0   *Chlorhexidine *Thymol Drug Combinations Dental Cavity Lining. 
Pharma Action Anti-Infective Agents, Local 		Swed Dent J 1992;16(5):183-9
glutathione-bicarbonate-Ringer solution  0   *Bicarbonates *Glutathione Drug Combinations Adenosine Ophthalmic Solutions.  Am J Ophthalmol 82(4):594;1976BSS PLUS
trimethoprim sulfamethizole  79735-35-6 Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine  *Sulfamethizole *Trimethoprim Drug Combinations.  J Chir (Paris) 1981;116(11):637
Carbicarb  72227-05-5   *Carbonates *Sodium Bicarbonate Drug Combinations.  Trans Am Clin Climatol Assoc 1984;96:141
bacitracin zinc, neomycin sulfate, polymyxin B, drug combination  8057-37-2 Bacitracin zinc, mixture with neomycin sulfate (salt) & polymyxin B sulfate (salt)  *Bacitracin *Neomycin *Polymyxin B Drug Combinations.  Arch Dermatol 1979;115(11):1311; Chemotherapy 1980;26(1):64; Lancet 2(8030):196;1977; Laryngoscope 87(9):1533;1977; South Med J 65(9):1083;1972; Ther Gegenwart 115(5):879;1976BACITRACIN ZINC-NEOMYCIN SULFATE-POLYMYXIN B SULFATE; BACITRACIN-NEOMYCIN-POLYMYXIN; LANABIOTIC; MYCITRACIN; NEO-POLYCIN; NEOMYCIN AND POLYMYXIN B SULFATE AND BACITRACIN ZINC; NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC; NEOSPORIN
Cortisporin  8024-64-4   *Hydrocortisone *Neomycin *Polymyxin B Drug Combinations.  J R Coll Gen Pract 1981;31(226):291CORTISPORIN; NEOMYCIN AND POLYMYXIN B SULFATES AND HYDROCORTISONE; NEOMYCIN SULFATE, POLYMYXIN B SULFATE & HYDROCORTISONE; NEOMYCIN SULFATE-POLYMYXIN B SULFATE-HYDROCORTISONE; OTICAIR; OTOBIONE; OTOCORT; PEDIOTIC
Mylanta  39322-42-4   *Aluminum Hydroxide *Magnesium Hydroxide *Simethicone Drug Combinations. 
Pharma Action Antacids 		N Engl J Med 1980;302(8):426; N Engl J Med 297(7):342;1977; West J Med 120(2):157;1974
shengmaisan  0   *Drugs, Chinese Herbal Drug Combinations Panax Schisandraceae.  Chin Med J 4(0):246(68):1974
Wobenzym  72506-65-1 Wobenzym  *Hydrolases *Rutin Drug Combinations. 
Pharma Action Adjuvants, Immunologic 		Acta Med Austriaca 6(1):13;1979
diucifon  34941-71-4 5-Pyrimidinesulfonamide, N,N'-(sulfonyldi-4,1-phenylene)bis(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo)  *Sulfones Drug Combinations Uracil/*analogs & derivatives. 
Pharma Action Adjuvants, Immunologic ; Anti-Inflammatory Agents, Non-Steroidal ; Antifungal Agents ; Dermatologic Agents ; Leprostatic Agents 		Vestn Dermatol Venerol 1980;(2):41
mefloquine-sulfadoxine-pyrimethamine  69191-18-0 Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-, mixt. with 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine and (R*,S*)-(+-)-alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride  *Pyrimethamine *Sulfadoxine Drug Combinations Mefloquine/*analogs & derivatives. 
Pharma Action Antimalarials 		Bull WHO 1985;63(3):611
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