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Cholecalciferol

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Definition: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.  deficiency: coordinate CHOLECALCIFEROL /defic (IM) with VITAMIN D DEFICIENCY (IM)   
Pharmacological Action Bone Density Conservation Agents; Vitamins
See Also Receptors, Calcitriol
Examples Hydroxycholecalciferols 		Other names Vitamin D 3; Vitamin D3; Cholecalciferols; Calciol; (3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
19-nor-2-(3-hydroxypropyl)-1,25-dihydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. Steroids. 2011 Dec 11;76(13):1513-9.
1,25-dihydroxy-26-(hydroxymethyl)vitamin D3  0   Cholecalciferol/*analogs & derivatives. J Med Chem 2011 Jun 9;54(11):3950-62
1,25-dihydroxy-26-(hydroxymethyl)-26-methylvitamin D3  0   Cholecalciferol/*analogs & derivatives. J Med Chem 2011 Jun 9;54(11):3950-62
17,20-dihydroxypregnacalciferol-3,17,20-trihydroxy-9,10-secopregna-5,7,10-triene  0   Cholecalciferol/*analogs & derivatives. J Invest Dermatol 2011 May;131(5):1167-9
MF Afragil  0   *Carotenoids *Cholecalciferol *Flavonoids *Xanthophylls Drug Combinations. Panminerva Med 2010 jan;52(2 Suppl 1):49-54
22-butyl-1,24-dihydroxy-24,25,26-trinorvitamin D3  0   Cholecalciferol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors Receptors, Calcitriol/agonists. J Med Chem 2009 Mar 12;52(5):1438-49
SMD-429  0   Cholecalciferol/*analogs & derivatives. Int J Pharm 2008 Apr 2;353(1-2):105-12
HY-11  0   Cholecalciferol/*analogs & derivatives. Int J Oncol 2008 Feb;32(2):387-96
HUM 5007  0   *Cholecalciferol *Ascorbic Acid *Nicotinic Acids *Plant Extracts Dehydroepiandrosterone/*analogs & derivatives. J Nutr Biochem 2007 Sep;18(9):629-34
NT020 formula  0   *Carnosine *Cholecalciferol *Plant Extracts. Rejuvenation Res 2007 Jun;10(2):173-8
2-(3-hydroxypropoxy)-24-propylvitamin D3-26,23-lactone  0   Cholecalciferol/*analogs & derivatives Receptors, Calcitriol. J Med Chem 2006 Nov 30;49(24):7063-75
1,25-dihydroxy-20S-21(3-hydroxy-3-methyl-butyl)-23-yne-26,27-hexafluoro-vitamin D3  0   Cholecalciferol/*analogs & derivatives. J Steroid Biochem Mol Biol 2006 Aug;100(4-5):107-16
C-9,11-bisnor-17-methyl-1, 25-dihydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. Bioorg Med Chem Lett 2002 Jun 17;12(12):1633-6
C-9,11,21-trisnor-17-methyl-1, 25-dihydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. Bioorg Med Chem Lett 2002 Jun 17;12(12):1629-32
4,4-difluoro-1,25-dihydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2002 Apr;50(4):475-83
1,15-dihydroxy-16-ene-19-nor-24-oxovitamin D3  0   Cholecalciferol/*analogs & derivatives. Cancer Res 2002 Feb 1;62(3):741-6
1,25-dihydroxy-22-ene-vitamin D3  0   Cholecalciferol/*analogs & derivatives. J Steroid Biochem Mol Biol 2001 Aug;78(2):167-76
ILX237553  0   Cholecalciferol/*analogs & derivatives. Cancer Chemother Pharmacol 2001 May;47(5):429-36
2-hydroxypropyl-1,25-dihydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. Bioorg Med Chem Lett 2000 May 15;10(10):1129-32
TX 522  0   *Alkynes *Cholecalciferol Stereoisomerism. Cancer Res 2000 May 15;60(10):2673-9
1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3  0   Cholecalciferol/*analogs & derivatives Calcitriol. Biochem Biophys Res Commun 2000 Apr 21;270(3):701-8
1,23-dihydroxy-24-oxovitamin D3  0   Cholecalciferol/*analogs & derivatives. Biochem Pharmacol 1999 Dec 15;58(12):1965-73
1-hydroxy-24-oxovitamin D3  0   Cholecalciferol/*analogs & derivatives. Biochem Pharmacol 1999 Dec 15;58(12):1965-73
1,25-dihydroxy-16,23-diene vitamin D3  0   Cholecalciferol/*analogs & derivatives. Bioorg Med Chem 1998 Nov;6(11):2051-9
25-hydroxy-16,23-diene vitamin D3  0   Cholecalciferol/*analogs & derivatives. Bioorg Med Chem 1998 Nov;6(11):2051-9
Ro 25-6760  0   Cholecalciferol/*analogs & derivatives. Anticancer Res 1998 May-Jun;18(3A):1703-8
1-hydroxy-25,26,27-trinorvitamin D3 24-oic acid  0   Cholecalciferol/*analogs & derivatives Haptens. Biol Pharm Bull 1997 Sep;20(9):948-53
25-hydroxyvitamin D3 3-hemisuccinate  0   *Succinates Cholecalciferol/*analogs & derivatives Haptens. Biol Pharm Bull 1997 Sep;20(9):948-53
19-nor-hexafluoride vitamin D3  0   Cholecalciferol/*analogs & derivatives. J Mol Endocrinol 1997 Aug;19(1):15-27
Ro 24-2090  0   Cholecalciferol/*analogs & derivatives. Anal Biochem 1996 Dec 1;243(1):28-40
2-methoxy-1,26-dihydroxy-27-norvitamin D3  0   Cholecalciferol/*analogs & derivatives. Steroids 1996 Oct;61(10):598-608
1,26-dihydroxy-27-norvitamin D3  0   Cholecalciferol/*analogs & derivatives. Steroids 1996 Oct;61(10):598-608
Ossofortin  0   *Calcium Gluconate *Calcium Phosphates *Cholecalciferol Drug Combinations. Dtsch Med Wochenschr 1996 Mar 15;121(11):356-7
24-oxa-1-hydroxyvitamin D3  0   Cholecalciferol/*analogs & derivatives Cholecalciferol/antagonists & inhibitors. Steroids 1995 Jun;60(6):484-90
24-oxavitamin D3  0   Cholecalciferol/*analogs & derivatives Cholecalciferol/antagonists & inhibitors. Steroids 1995 Jun;60(6):484-90
25-hydroxyvitamin D3-3-(1,2-epoxypropyl)ether  0   Cholecalciferol/*analogs & derivatives Tritium. Arch Biochem Biophys 1995 Jun 1;319(2):504-7
1,25-dihydroxy-19-norprevitamin D3  144699-06-9   *Cholecalciferol. J Bone Miner Res 1993 Aug;8(8):1009-15
22-fluorovitamin D3  110536-31-7 9,10-Secocholesta-5,7,10(19)-trien-3-ol, 22-fluoro-, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Steroids 1987;48(1-2):93
2-fluorovitamin D3  103638-37-5   Cholecalciferol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1986;34(4):1568
3-thiovitamin D3  98353-78-7   Cholecalciferol/*analogs & derivatives. J Steroid Biochem 1985;23(1):81
10-ketovitamin D3  95480-84-5 19-Nor-9,10-secocholesta-5,7-dien-4-one, 1-hydroxy-, (1alpha,5Z,7E)  Cholecalciferol/*analogs & derivatives. Arch Biochem Biophys 1985;236(2):555
6-fluorovitamin D3  91625-75-1 9,10-Secocholesta-5,7,10(19)-trien-3-ol, 6-fluoro-, (3beta,5E,7E)  Cholecalciferol/*analogs & derivatives. Arch Biochem Biophys 1984;233(1):127
19-nor-10-ketovitamin D3  62743-72-0   Cholecalciferol/*analogs & derivatives. Biochemistry 1983;22(15):3636
vitamin D3 butyrate  31316-20-8 9,10-Secocholesta-5,7,10(19)-trien-3-ol, butanoate, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Int J Vitam Nutr Res 1981;51(4):353
vitamin D3 palmitate  13403-10-6   Cholecalciferol/*analogs & derivatives. Int J Vitam Nutr Res 1981;51(4):353
vitamin D3 glucosiduronate  0   Cholecalciferol/*analogs & derivatives. J Clin Invest 1980;66(6):1274
vitamin D3 sulfoconjugate  10529-43-8 9,10-Secocholesta-5,7,10(19)-trien-3-ol, hydrogen sulfate, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Steroids 1980;36(1):21
previtamin D(3)  1173-13-3 (3beta,6Z)-9,10-secocholesta-5(10),6,8-trien-3-ol  Cholecalciferol/*analogs & derivatives. Trans Assoc Am Physicians 1979;92:54
24-dehydrocholecalciferol  63819-59-0 9,10-secocholesta-5,7,10(19),24-tetraen-3-ol, (3 beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Biochem J 182(1):1979; Steroids 1980;35(3):329
25-fluorocholecalciferol  63819-58-9 9,10-Secocholesta-5,7,10(19)-trien-3-ol, 25-fluoro-, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Biochem J 182(1):1;1979
25-dehydrocholecalciferol  63819-60-3 9,10-Secocholesta-5,7,10(19),25-tetraen-3-ol, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. Biochem J 182(1):1;1979
1-fluorovitamin D3  69879-46-5 9,10-Secocholesta-5,7,10(19)-trien-3-ol, 1-fluoro-, (3alpha,5Z,7E)  Cholecalciferol/*analogs & derivatives. Biochemistry 18(9):1641;1979
25-azavitamin D3  63819-61-4 9,10-Secochola-5,7,10(19)-trien-3-ol, 24-(dimethylamino)-, (3beta,5Z,7E)  Cholecalciferol/*analogs & derivatives. J Biol Chem 254(9):3493;1979
3-deoxyvitamin D3  0   Cholecalciferol/*analogs & derivatives. FEBS Lett 97(2):241;1979
3-fluoro-9,10-secocholestatrien-5,7,10(19)  53839-02-4   Cholecalciferol/*analogs & derivatives. Ukr Biochim Zh 46(5):627;1974
cholesta-5,7,24-trien-3 beta-ol  1715-86-2   Cholecalciferol/*analogs & derivatives. J Org Chem 39(14):2018;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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