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Urea
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Definition
: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
See Also
Blood Urea Nitrogen
Examples
Allantoin
;
Biureas
;
Biuret
;
Bromisovalum
;
Hydroxyurea
;
Methylurea Compounds
;
Nitrosourea Compounds
;
Phenylurea Compounds
;
Sulfonylurea Compounds
;
Thiourea
Other names
Carmol; Carbamide; Basodexan
Drugs
*
:
UREAPHIL
;
STERILE UREA
Substance
CAS Registry & name
Categories
Source
Drugs
*
TIR-
203
0
*Peptides, Cyclic
Urea/*analogs & derivatives.
Pharm Biol. 2012 Jan;50(1):25-9
PGI-
02776
0
Urea/*analogs & derivatives.
Brain Res. 2011 Jun 13;1395:62-73.
ethyl 6-
cyclohexylurea-
(1,3)dioxolo(5,4-
g)quinoline-
7-
carboxylate
0
*Quinolines
Urea/*analogs & derivatives.
Pharmacol Rep. 2011;63(4):1029-39.
1-
oxa-
8-
azaspiro(4.5)decane urea
0
*Aza Compounds
*Spiro Compounds
Urea/*analogs & derivatives.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
ScaleA2 solution
0
*Urea
Glycerol
Tissue Fixation/methods.
Nat Neurosci. 2011 Nov;14(11):1481-8
CK 2018448
0
Urea/*analogs & derivatives
Smooth Muscle Myosins/antagonists & inhibitors.
J Pharmacol Exp Ther. 2011 Oct;339(1):307-12.
N-
pyridazin-
3-
yl-
4-
(3-
((5-
(trifluoromethyl)pyridin-
2-
yl)oxy)benzylidene)piperidine-
1-
carboxamide
0
*Pyridazines
Urea/*analogs & derivatives.
J Pharmacol Exp Ther 2011 Jul;338(1):114-24
VS411
0
*Didanosine
Drug Combinations
Urea/*analogs & derivatives.
Expert Opin Investig Drugs. 2011 Apr;20(4):559-65
(Z)-
1-
(2-
oxo-
3-
(1H-
pyrrol-
2-
ylmethylene)-
2,3-
dihydro-
1H-
indol-
6-
yl)-
3-
phenyl-
urea
0
*Indoles
Urea/*analogs & derivatives.
Bioorg Med Chem. 2010 Jul 1;18(13):4674-86
(Z)-
5-
(6-
(3-
(4-
methoxyphenyl)-
ureido)-
2-
oxo-
1,2-
dihydroindol-
3-
ylidene-
methyl)-
4-
methyl-
1H-
pyrrole-
3-
carboxylic acid
0
*Pyrroles
Urea/*analogs & derivatives.
Bioorg Med Chem. 2010 Jul 1;18(13):4674-86
1-
(2-
(morpholin-
4-
yl)ethyl)-
3-
(4-
(-
3-
(6-
(morpholin-
4-
yl)pyridin-
2-
yl)prop-
2-
enoyl)phenyl)urea dihydrochloride
0
*Morpholines
*Pyridines
Urea/*analogs & derivatives.
Neuropharmacology. 2011 May;60(6):991-9
1-
(1-
acetyl-
piperidine-
4-
yl)-
3-
adamantan-
1-
yl-
urea
0
Adamantane/*analogs & derivatives
Urea/*analogs & derivatives
Epoxide Hydrolases/antagonists & inhibitors.
Eur J Pharmacol 2011 Mar 1;654(1):68-74
3-
(1,3-
benzodioxol-
5-
yl)-
3-
((((-
1-
((bis(2-
thienylmethyl)amino)carbonyl)pentyl)amino)carbonyl)amino)propanoic acid
0
*Thiophenes
Urea/*analogs & derivatives
Integrin alpha4beta1/antagonists & inhibitors.
Biochem Biophys Res Commun 2010 Oct 1;400(4):619-24
N,N'-
di-
4-
triazolylurea
0
*Triazoles
Urea/*analogs & derivatives.
Org Lett. 2010 Apr 16;12(8):1776-9
1-
(6-
(4-
fluorophenyl)pyridin-
3-
yl)-
3-
(4-
piperidin-
1-
ylbutyl)urea
0
*Pyridines
Urea/*analogs & derivatives
Receptors, Nicotinic.
J Med Chem 2010 Jun 10;53(11):4379-89
1-
(3,4-
dihydroxystyryl)-
3-
(4-
hydroxyphenethyl)urea
0
*Styrenes
Urea/*analogs & derivatives.
Int Immunopharmacol 2010 Apr;10(4):526-32
N-
(1-
(cyclopropylmethyl)-
2,3-
dioxo-
3-
(2-
propenylamino)propyl)-
3-
(2-
((((1-
((4,4-
dimethyl-
2,6-
dioxo-
1-
piperidinyl)methyl)-
2,2-
dimethylpropyl)amino)carbonyl)amino)-
3,3-
dimethyl-
1-
oxobutyl)-
6,6-
dimethyl-
3-
azabicyclo(3.1.0)hexane-
2-
carboxamide
0
*Piperidones
Urea/*analogs & derivatives.
J Med Chem 2009 Mar 12;52(5):1370-9
N-
(5-
cyclopropyl-
1-
(cyclopropylamino)-
1,2-
dioxopentan-
3-
yl)-
3-
(2-
(3-
(1-
((N-
cyclopropyl-
N-
methylsulfamoyl)methyl)cyclohexyl)ureido)-
3,3-
dimethylbutanoyl)-
6,6-
dimethyl-
3-
azabicyclo(3.1.0)hexane-
2-
carboxamide
0
*Sulfonamides
Urea/*analogs & derivatives.
Bioorg Med Chem 2010 Mar 1;18(5):1854-65
3-
bromoacetamino-
4-
methoxybenzoylurea
0
*Acetanilides
Urea/*analogs & derivatives.
Anticancer Drugs 2010 Apr;21(4):372-80
K 12940
0
*Oligopeptides
Urea/*analogs & derivatives
Receptor, PAR-2/antagonists & inhibitors.
Br J Pharmacol 2009 Sep;158(1):361-71
4-
((5-
(2,4-
dichlorobenzylureido)pentyl)(1-
(4-
chlorophenyl)ethyl)amino)butanoic acid
0
gamma-Aminobutyric Acid/*analogs & derivatives
Urea/*analogs & derivatives
Receptors, CCR3/antagonists & inhibitors.
J Pharmacol Sci 2010;112(2):203-13
ureidoglycine
0
Glycine/*analogs & derivatives
Urea/*analogs & derivatives.
ACS Chem Biol 2010 Feb 19;5(2):203-14
1-
(4-
(4-
(3-
oxa-
8-
azabicyclo(3.2.1)octan-
8-
yl)-
6-
morpholino-
1,3,5-
triazin-
2-
yl)phenyl)-
3-
(pyridin-
4-
yl)urea
0
*Morpholines
Urea/*analogs & derivatives.
J Org Chem. 2010 Mar 5;75(5):1643-51
(E)-
1-
(3,4-
dihydroxyphenethyl)-
3-
styrylurea
0
Urea/*analogs & derivatives.
BMB Rep. 2009 Dec 31;42(12):806-11
1-
(4-
(2-
(4-
bromobenzenesulfonamino) ethyl) phenylsulfonyl)-
3-
(trans-
4-
methylcyclohexyl)urea
0
*Sulfhydryl Compounds
Urea/*analogs & derivatives.
Arzneimittelforschung. 2009;59(11):550-6
omecamtiv mecarbil
0
Urea/*analogs & derivatives.
Heart Fail Rev 2009 Dec;14(4):289-98
N-
(4-
chlorophenyl)-
N'-
(5-