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Urea

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Definition: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.     
See Also Blood Urea Nitrogen
Examples Allantoin; Biureas; Biuret; Bromisovalum; Hydroxyurea; Methylurea Compounds; Nitrosourea Compounds; Phenylurea Compounds; Sulfonylurea Compounds; Thiourea 		Other names Carmol; Carbamide; BasodexanDrugs* : UREAPHIL; STERILE UREA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TIR-203  0   *Peptides, Cyclic Urea/*analogs & derivatives. Pharm Biol. 2012 Jan;50(1):25-9
PGI-02776  0   Urea/*analogs & derivatives. Brain Res. 2011 Jun 13;1395:62-73.
ethyl 6-cyclohexylurea-(1,3)dioxolo(5,4-g)quinoline-7-carboxylate  0   *Quinolines Urea/*analogs & derivatives. Pharmacol Rep. 2011;63(4):1029-39.
1-oxa-8-azaspiro(4.5)decane urea  0   *Aza Compounds *Spiro Compounds Urea/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
ScaleA2 solution  0   *Urea Glycerol Tissue Fixation/methods. Nat Neurosci. 2011 Nov;14(11):1481-8
CK 2018448  0   Urea/*analogs & derivatives Smooth Muscle Myosins/antagonists & inhibitors. J Pharmacol Exp Ther. 2011 Oct;339(1):307-12.
N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide  0   *Pyridazines Urea/*analogs & derivatives. J Pharmacol Exp Ther 2011 Jul;338(1):114-24
VS411  0   *Didanosine Drug Combinations Urea/*analogs & derivatives. Expert Opin Investig Drugs. 2011 Apr;20(4):559-65
(Z)-1-(2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl)-3-phenyl-urea  0   *Indoles Urea/*analogs & derivatives. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86
(Z)-5-(6-(3-(4-methoxyphenyl)-ureido)-2-oxo-1,2-dihydroindol-3-ylidene-methyl)-4-methyl-1H-pyrrole-3-carboxylic acid  0   *Pyrroles Urea/*analogs & derivatives. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86
1-(2-(morpholin-4-yl)ethyl)-3-(4-(-3-(6-(morpholin-4-yl)pyridin- 2-yl)prop-2-enoyl)phenyl)urea dihydrochloride  0   *Morpholines *Pyridines Urea/*analogs & derivatives. Neuropharmacology. 2011 May;60(6):991-9
1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea  0   Adamantane/*analogs & derivatives Urea/*analogs & derivatives Epoxide Hydrolases/antagonists & inhibitors. Eur J Pharmacol 2011 Mar 1;654(1):68-74
3-(1,3-benzodioxol-5-yl)-3-((((-1-((bis(2-thienylmethyl)amino)carbonyl)pentyl)amino)carbonyl)amino)propanoic acid  0   *Thiophenes Urea/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. Biochem Biophys Res Commun 2010 Oct 1;400(4):619-24
N,N'-di-4-triazolylurea  0   *Triazoles Urea/*analogs & derivatives. Org Lett. 2010 Apr 16;12(8):1776-9
1-(6-(4-fluorophenyl)pyridin-3-yl)-3-(4-piperidin-1-ylbutyl)urea  0   *Pyridines Urea/*analogs & derivatives Receptors, Nicotinic. J Med Chem 2010 Jun 10;53(11):4379-89
1-(3,4-dihydroxystyryl)-3-(4-hydroxyphenethyl)urea  0   *Styrenes Urea/*analogs & derivatives. Int Immunopharmacol 2010 Apr;10(4):526-32
N-(1-(cyclopropylmethyl)-2,3-dioxo-3-(2-propenylamino)propyl)-3-(2-((((1-((4,4-dimethyl-2,6-dioxo-1-piperidinyl)methyl)-2,2-dimethylpropyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexane-2-carboxamide  0   *Piperidones Urea/*analogs & derivatives. J Med Chem 2009 Mar 12;52(5):1370-9
N-(5-cyclopropyl-1-(cyclopropylamino)-1,2-dioxopentan-3-yl)-3-(2-(3-(1-((N-cyclopropyl-N-methylsulfamoyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexane-2-carboxamide  0   *Sulfonamides Urea/*analogs & derivatives. Bioorg Med Chem 2010 Mar 1;18(5):1854-65
3-bromoacetamino-4-methoxybenzoylurea  0   *Acetanilides Urea/*analogs & derivatives. Anticancer Drugs 2010 Apr;21(4):372-80
K 12940  0   *Oligopeptides Urea/*analogs & derivatives Receptor, PAR-2/antagonists & inhibitors. Br J Pharmacol 2009 Sep;158(1):361-71
4-((5-(2,4-dichlorobenzylureido)pentyl)(1-(4-chlorophenyl)ethyl)amino)butanoic acid  0   gamma-Aminobutyric Acid/*analogs & derivatives Urea/*analogs & derivatives Receptors, CCR3/antagonists & inhibitors. J Pharmacol Sci 2010;112(2):203-13
ureidoglycine  0   Glycine/*analogs & derivatives Urea/*analogs & derivatives. ACS Chem Biol 2010 Feb 19;5(2):203-14
1-(4-(4-(3-oxa-8-azabicyclo(3.2.1)octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea  0   *Morpholines Urea/*analogs & derivatives. J Org Chem. 2010 Mar 5;75(5):1643-51
(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea  0   Urea/*analogs & derivatives. BMB Rep. 2009 Dec 31;42(12):806-11
1-(4-(2-(4-bromobenzenesulfonamino) ethyl) phenylsulfonyl)-3-(trans-4-methylcyclohexyl)urea  0   *Sulfhydryl Compounds Urea/*analogs & derivatives. Arzneimittelforschung. 2009;59(11):550-6
omecamtiv mecarbil  0   Urea/*analogs & derivatives. Heart Fail Rev 2009 Dec;14(4):289-98
N-(4-chlorophenyl)-N'-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea  0   *Pyrazolones Urea/*analogs & derivatives. J Pharmacol Sci. 2009 Nov;111(3):317-21
RGB 286638  0   *Pyrazoles Urea/*analogs & derivatives. J Pharm Biomed Anal 2009 Dec 5;50(5):977-82
YC-27 compound  0   *Glutamates Urea/*analogs & derivatives. Biochem Biophys Res Commun 2009 Dec 18;390(3):624-9
1,4-di(2-(6-ethylamino-3-ethylimino-2,7-dimethyl-3H-xanthen-9-yl)benzoic acid (aminomethyl)-3-phenylthiourea)benzene  0   *Rhodamines Urea/*analogs & derivatives. J Biol Inorg Chem. 2009 Aug;14(6):815-9
2-nitrobenzylurea  0   Urea/*analogs & derivatives. Photochem Photobiol Sci 2009 aug;8(8):1157-63
2-(3-(1-carboxy-5-(3-(4-iodobphenyl)ureido)pentyl)ureido)pentanedioic acid  0   *Glutamates Urea/*analogs & derivatives. Cancer Res 2009 Sep 1;69(17):6932-40
2-(3-(1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid  0   *Glutamates Urea/*analogs & derivatives. Cancer Res 2009 Sep 1;69(17):6932-40
2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid  0   *Glutarates Urea/*analogs & derivatives Ligands. Ann N Y Acad Sci 2009 Sep;1175:32-9
syringolin B  0   *Peptides, Cyclic Urea/*analogs & derivatives. Proc Natl Acad Sci U S A 2009 Apr 21;106(16):6507-12
1-(4-aminoantipyrine)-3-tosylurea  0   Antipyrine/*analogs & derivatives Urea/*analogs & derivatives Ligands. J Fluoresc 2009 Jan;19(1):63-72
1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea  0   *Benzimidazoles Urea/*analogs & derivatives. J Med Chem 2009 Jan 22;52(2):379-88
AMI-1 compound  0   *Naphthalenesulfonates Urea/*analogs & derivatives. J Biol Chem 2004 Jun 4;279(23):23892-9
3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide  0   *Thiophenes Urea/*analogs & derivatives. Mol Cancer Ther 20-08 Sep;7(9):2955-66
hualyzin  0   Urea/*analogs & derivatives. J Nat Prod 2008 Jun;71(6):1068-9
UNBS 5162  0   *Naphthalimides Urea/*analogs & derivatives. Neoplasia 2008 Jun;10(6):573-86
1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea  0   *Pyridines Urea/*analogs & derivatives. Eur J Pharmacol. 2008 Jul 7;588(2-3):309-15
S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea  0   *Organoselenium Compounds Urea/*analogs & derivatives. Mol Cancer Ther 2008 May;7(5):1297-308
3,3-dimethylbutanoylurea  0   Urea/*analogs & derivatives. Epilepsia 2008 Jul;49(7):1202-12
urea nitrate  0   *Nitrates Urea/*analogs & derivatives. Analyst 2008 May;133(5):585-7
6-fluoro-3-(iodoacetamido)benzoylurea  0   *Acetanilides Urea/*analogs & derivatives. J Med Chem 2008 Jun 12;51(11):3094-103
1-cyclohexyl-3-tosylurea  0   Urea/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2008 Apr;56(4):541-6
BMS-639623  0   *Piperidines Urea/*analogs & derivatives. Bioorg Med Chem Lett. 2008 Jan 15;18(2):576-85
2-(4-(2-((3-(5-(Pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1H-imidazol-4-yl)phenoxy)acetic acid  0   *Thiazoles Urea/*analogs & derivatives. J Med Chem 2007 Sep 20;50(19):4710-20
ABT 102  0   *Indazoles Urea/*analogs & derivatives. J Med Chem 2008 Feb 14;51(3):392-5
iodophenyl-chloroethyl urea  0   Urea/*analogs & derivatives. Br J Pharmacol. 2007 Oct;152(4):449-55
cyclohexylphenyl-chloroethyl urea  0   Urea/*analogs & derivatives. Br J Pharmacol. 2007 Oct;152(4):449-55
SA6817  0   *Naphthalenes Urea/*analogs & derivatives. Bioorg Med Chem Lett 2008 Feb 1;18(3):1058-62
4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid  0   *Benzoic Acids Urea/*analogs & derivatives Epoxide Hydrolases/antagonists & inhibitors. J Med Chem 2007 Aug 9;50(16):3825-40
1-(5-tertbutylindan-1-yl)-3-isoquinolin-5-ylurea  0   *Isoquinolines Urea/*analogs & derivatives. J Pharmacol Exp Ther 2007 Oct;323(1):285-93
2,2,2-trichloro-N-((2-(2-(dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-5-yl)carbamoyl)acetamide  0   *Isoquinolines Urea/*analogs & derivatives. J Med Chem 2007 Aug 23;50(17):4122-34
1-((4-(4-(2-(3-(2,6-dichlorobenzyl)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)phenyl)-1H-imidazol-2-yl)methyl)-3-(6-(methylsulfonyl)benzo(d)thiazol-2-yl)urea  0   *Benzothiazoles Urea/*analogs & derivatives Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/antagonists & inhibitors. J Med Chem 2007 Sep 20;50(19):4710-20
N-(3-trichloromethyl-4-(8-azabicyclo(3.2.1)octan-8-yl)benzyl)-N'-(indazol-4-yl)urea  0   *Indazoles Urea/*analogs & derivatives TRPV Cation Channels/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3651-60
KRN383  0   *Quinolines Urea/*analogs & derivatives. Leuk Res 2006 Dec;30(12):1541-6
BX 517  0   *Indoles Urea/*analogs & derivatives. Bioorg Med Chem Lett 2007 Jul 15;17(14):3819-25
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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