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3',5'-Cyclic-AMP Phosphodiesterases

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Definition: Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.  general; prefer specifics; DF: 3 5 CYCL NPD   
Examples Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 6; Cyclic Nucleotide Phosphodiesterases, Type 7 		Other names CAMP Phosphodiesterase; 3',5'-Cyclic-Nucleotide Phosphodiesterase; 3',5'-Cyclic AMP 5'-Nucleotidohydrolase; Phosphodiesterases, 3',5'-Cyclic-AMP; Phosphodiesterase, CAMP; Phosphodiesterase, 3,5-Cyclic AMP; Phosphodiesterase, 3',5'-Nucleotide; Phosphodiesterase, 3',5'-Cyclic-Nucleotide; Phosphodiesterase, 3',5'-Cyclic-AMP; Phosphodiesterase, 3',5'-Cyclic Nucleotide; Phosphodiesterase, 3',5'-Cyclic AMP; Nucleotide Phosphodiesterase, 3',5'-Cyclic; AMP Phosphodiesterase, 3,5-Cyclic; AMP Phosphodiesterase, 3',5'-Cyclic; AMP 5-Nucleotidohydrolase, 3,5-Cyclic; AMP 5'-Nucleotidohydrolase, 3',5'-Cyclic; 5-Nucleotidohydrolase, 3,5-Cyclic AMP; 5'-Nucleotidohydrolase, 3',5'-Cyclic AMP; 3,5 Cyclic AMP Phosphodiesterase; 3,5 Cyclic AMP 5 Nucleotidohydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2-fluorobenzamido)benzoate ethyl ester  0   *Benzamides *Benzoates 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Free Radic Biol Med 2011 Jun 15;50(12):1737-48
PDE8A protein, rat  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. Endocrinology. 2008 Feb;149(2):741-8
Pde4a protein, rat  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases.
Pde8a protein, mouse  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases.
Pde9a protein, mouse  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. Mol Pharmacol. 2005 Dec;68(6):1775-81
BAY 19-8004  0   *Sulfonic Acids Urea/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Chest 2002 May;121(5 Suppl):192S-196S
Pde9a protein, rat  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. J Neurocytol. 2002 Sep-Nov;31(8-9):729-41
PDE8B protein, human  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. Biochem Biophys Res Commun 2002 Oct 11;297(5):1253-8
4-(4-(3,4-diethoxyphenyl)-1oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl)benzoic acid  0   *Phthalazines *Benzoic Acids 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2526-33
2-adamantan-2-yl-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one  0   *Phthalazines Adamantane/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2526-33
adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate  0   *Organothiophosphorus Compounds Cyclic AMP/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Bioorganic Chem 2002 Feb;30(1):16-31
tyrphostin 51  0   *Tyrphostins Protein-Tyrosine Kinases/antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Mol Cell Cardiol 1998 Dec;30(12):2577-90
PDE9A protein, human  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. Hum Genet 1998 Oct;103(4):386-92
PDE8A protein, human  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases. Biochem Biophys Res Commun 1998 May 29;246(3):570-7
regA protein, Dictyostelium  EC 3.1.4.17   *3',5'-Cyclic-AMP Phosphodiesterases *Protozoan Proteins. EMBO J 1998 May 15;17(10):2838-45
2-trifluoromethyl-9-(2-fluorophenylmethyl)-N-methyladenine  0   Adenine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1768-70
1-(3-(cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime  141184-34-1 Ethanone, 1-(3-(cyclopentyloxy)-4-methoxyphenyl)-, O-(aminocarbonyl)oxime, (E)  *Oximes 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Pharmacol Exp Ther 1994 Feb;268(2):888-96
BMY 21190  154512-24-0   *Imidazoles *Quinolines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Jpn Circ J 1993 Oct;57(10):979-92
U 84569  130736-25-3   *Chromones *Morpholines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Pharmacol Exp Ther 1993 April;265(1):457-62
inchinko-to  0   *Drugs, Chinese Herbal Cholagogues and Choleretics 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Hepatol. 2004 Aug;41(2):242-50; Yakugaku Zasshi 1992 Aug;112(8):534-43
longestin  131774-53-3 beta-D-Glucopyranosiduronic acid, 1-carboxy-2,3,4,4a,4b,5,6,6a,6b,7,8,8a,8b,9,10,10a,14,16,17,17a,17b,18,19,19a,19b,20,21,21a,21b,22,23,23a-dotriacontahydro-14-hydroxy-8a,10a-bis(hydroxymethyl)-14-(3-methoxy-3-oxopropyl)-1,4,4a,6,6a,17b,19b,21b-octameth  *Methylglucosides *Terpenes Streptomyces 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Mar;45(3):341-7
CK 2289  101183-99-7   *Imidazoles 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Arch Int Pharmacodyn Ther 1991;309:103
8-aminohexylamino cAMP  39824-30-1   Cyclic AMP/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Int J Biochem 1990;22(9):1047
KS 504e  122006-32-0 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)  *Cyclopentanes 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(12):1775
KS 504d  122005-23-6 1,3-Cyclopentanediol, 2,2,4,4-tetrachloro-1-(dichloromethyl)-5-(dichloromethylene)-, (+)  *Cyclopentanes 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(12):1775
KS 504a  122022-77-9 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)  *Cyclopentanes 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(12):1775
DTA 35  63162-55-0   *Deoxyadenosines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Enzym Inhib 1987;1(4):267
penta-O-ethylquercetin  82547-07-7   Quercetin/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Prog Clin Biol Res 1988;280:151
griseolic acid C  100242-49-7 beta-D-allo-Octofuranuronic acid, 1-(6-amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy  Adenosine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1988;41(5):705
griseolic acid B  98890-01-8 beta-D-ribo-Oct-4-enofuranuronic acid, 1-(6-amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy  Adenosine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1988;41(5):705
4-(3,4-dibutoxybenzyl)-2-imidazolidinone  123774-76-5   *Imidazoles 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Urol 1986;135(6):1293
griseolic acid  79030-08-3 alpha-L-talo-Oct-4-enofuranuronic acid, 1-(6-amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5-dideoxy  Adenosine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1985;38(7):824
2,4-diamino-5-cyano-6-iodopyridine  70172-54-2   4-Aminopyridine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Biochem Pharmacol 1984;33(13):2109
2,4-diamino-5-cyano-6-bromopyridine  42530-03-0   4-Aminopyridine/*analogs & derivatives Bronchodilator Agents 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Biochem Pharmacol 1984;33(13):2109
terferol  20958-04-7   *Terphenyl Compounds 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 1984;37(1):10; J Antibiot (Tokyo) 1984;37(1):6
7-chloro-5-propyl-1,2,4-triazolo(4,3-a)quinoxaline-1,4(2H,5H)-dione  80708-33-4 (1,2,4)Triazolo(4,3-a)quinoxaline-1,4(2H,5H)-dione, 7-chloro-5-propyl  *Triazoles 2',3'-Cyclic-Nucleotide Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Int Arch Allergy Appl Immunol 1984;73(1):56
RX-RA 69  77749-49-6 Pyrimido(5,4-d)pyrimidine, 4-(4-morpholinyl)-8-((phenylmethyl)thio)-2-(1-piperazinyl)  *Pyrimidines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Prog Clin Biol Res 1982;89:131
9-cyclohexyl-2-n-propoxy-9H-adenine  73535-50-9 9H-Purin-6-amine, 9-cyclohexyl-2-propoxy  Adenine/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Jpn J Pharmacol 1981;31(3):333
phthalazinol  56611-65-5   *Phthalazines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors 		Arch Int Pharmacodyn 228:23;1977; Exp Mol Pathol 30(3):449;1979; Int Symp:State of Prev Ther Hum Arteriosclerosis Animal; Jpn J Pharmacol 27:97;1977; Jpn J Pharmacol 29(1):49;1979; Mech Ageing Dev 5(4):241;1976; Models; WG 550 I6222i:139;1977; Mol Pharmacol 13:400;1977; Prostaglandins 17(2):235;1979; Stroke 1979;10(6):638; Thromb Diath Haemorrh 34(1):344;1975
zaprinast  37762-06-4 2-o-propoxyphenyl-8-azapurine-6-one  *Purinones 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors 		Cas Lek Res 116(48):1481;1977; Internat Arch Allergy Appl Immunol 49(6):774;1975; Mol Pharm 14(5):848;1978
reticulol  26246-41-3   *Coumarins 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Antibiot (Tokyo) 28(7):558;1975

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