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3',5'-Cyclic-GMP Phosphodiesterases

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Definition: Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.  DF: CYCL GMP PHOSPHODIESTERASE   
Examples Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 6 		Other names 3',5'-Cyclic GMP 5'-Nucleotidohydrolase; Phosphodiesterases, 3',5'-Cyclic-GMP; Phosphodiesterase, 3,5-Cyclic GMP; Phosphodiesterase, 3',5'-Cyclic-GMP; Phosphodiesterase, 3',5'-Cyclic GMP; GMP Phosphodiesterase, 3,5-Cyclic; GMP Phosphodiesterase, 3',5'-Cyclic; GMP 5-Nucleotidohydrolase, 3,5-Cyclic; GMP 5'-Nucleotidohydrolase, 3',5'-Cyclic; 5-Nucleotidohydrolase, 3,5-Cyclic GMP; 5'-Nucleotidohydrolase, 3',5'-Cyclic GMP; 3,5 Cyclic GMP 5 Nucleotidohydrolase; 3',5' Cyclic GMP Phosphodiesterases; 3,5 Cyclic GMP Phosphodiesterase; 3',5' Cyclic GMP Phosphodiesterase; 3',5' Cyclic GMP 5' Nucleotidohydrolase; 3,5-Cyclic GMP Phosphodiesterase; 3,5-Cyclic GMP 5-Nucleotidohydrolase; 3',5'-Cyclic-GMP Phosphodiesterase; 3',5'-Cyclic GMP Phosphodiesterase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
YfgF protein, E coli  EC 3.1.4.35   *3',5'-Cyclic-GMP Phosphodiesterases *Escherichia coli Proteins. Microbiology 2010 Sep;156(Pt 9):2873-86
Pde11a protein, mouse  EC 3.1.4.35   *3',5'-Cyclic-GMP Phosphodiesterases.
WIN 65579  0   *Purinones *Pyrimidines 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. Eur J Pharmacol 1998 May 22;349(2-3):263-8
SCH 51866  0   *Imidazoles 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Chromatogr B Biomed Appl 1995 Jul 7;669(1):141-8
A 02011-1  0   *Pyrazoles *Thiophenes 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. Br J Pharmacol 1995 Mar;114(6):1227-35
WIN 58237  0   *Pyrimidines 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Pharmacol Exp Ther 1994 Dec;271(3):1143-9
2'-O-(4-benzoylbenzoyl)guanosine cyclic 3',5'-monophosphate  137154-74-6   Cyclic GMP/*analogs & derivatives 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 1994 Jul 22;37(15):2406-10
6-methoxy-4-((3,4-(methylenedioxy)benzyl)amino)quinazoline  0   *Quinazolines 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 1994 Jun 24;37(13):2106-11
4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline  150450-00-3   *Quinazolines 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 1993 Nov 26;36(24):3765-70
(4-(2-n-butyl-5-chloro-1-(2-chlorobenzyl)imidazolyl)methyl) acetate  131549-86-5   *Imidazoles 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. Biochem Pharmacol 1990;40(10):2315
DTA 35  63162-55-0   *Deoxyadenosines 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Enzym Inhib 1987;1(4):267
zaprinast  37762-06-4 2-o-propoxyphenyl-8-azapurine-6-one  *Purinones 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors 		Cas Lek Res 116(48):1481;1977; Internat Arch Allergy Appl Immunol 49(6):774;1975; Mol Pharm 14(5):848;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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