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Organothiophosphorus Compounds

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Definition: Compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as CHOLINERGIC AGENTS and as INSECTICIDES.  includes organothiophosphates; /antag permitted but consider also CHOLINESTERASE REACTIVATORS; DF: ORGANOTHIOPHOSPHORUS CPDS   
Examples Amifostine; Azinphosmethyl; Chlorpyrifos; Coumaphos; Cystaphos; Diazinon; Dimethoate; Disulfoton; Echothiophate Iodide; Fenitrothion; Fenthion; Fonofos; Leptophos; Malathion; Parathion; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Phorate; Phosmet; Temefos; Thiophosphoric Acid Esters; Thiotepa 		Other names Compounds, Organothiophosphorus
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O,O-dimethyl-O-(4-(carboxyl)phenyl)phosphorothiate  0   *Organothiophosphorus Compounds Haptens. J AOAC Int. 2011 Nov-Dec;94(6):1911-7
3-(4-(dimethoxy-O-phosphorothioyl)phenyl)propanoic acid  0   *Organothiophosphorus Compounds Haptens. J AOAC Int. 2011 Nov-Dec;94(6):1911-7
O,O-dimethylthiophosphonosulfenyl bromide-silver triflate  0   *Mesylates *Organothiophosphorus Compounds Silver. Org Biomol Chem. 2011 Jan 21;9(2):616-22
butamifos  0   *Organothiophosphorus Compounds. Chemosphere. 2010 Jan;78(4):482-7
8-thioxodeoxyadenosine  0   *Deoxyadenosines *Organothiophosphorus Compounds. Org Lett 2009 Feb 5;11(3):605-8
6-N-carbamoyl-8-thioxodeoxyadenosine 3'-phosphoramidite  0   *Deoxyadenosines *Organothiophosphorus Compounds. Org Lett 2009 Feb 5;11(3):605-8
GYY 4137  0   *Morpholines *Organothiophosphorus Compounds. Circulation 2008 May 6;117(18):2351-60
BPH-652  0   *Organothiophosphorus Compounds. Science 2008 Mar 7;319(5868):1391-4
2-amino-4-thiophosphonobutyric acid  0   *Aminobutyric Acids *Organothiophosphorus Compounds Receptors, Metabotropic Glutamate/agonists. J Med Chem 2007 Sep 20;50(19):4656-64
O-ethyl-S-2-(N,N-diisopropilamino)ethylmethylthiophosphonate  0   *Organothiophosphorus Compounds Chemical Warfare Agents. Water Sci Technol 2007;55(12):133-8
Cyanex 302  0   *Organothiophosphorus Compounds *Phosphinic Acids. J Hazard Mater 2007 Jun 25;145(1-2):221-6
4-nitrophenyl phosphorothioate  0   *Organothiophosphorus Compounds. Biochemistry 2000 Aug 8;39(31):9451-8
adenosine-5'-O-(N-(tryptophanylamide))phosphoramidothioate  0   *Organothiophosphorus Compounds Adenosine/*analogs & derivatives Tryptophan/*analogs & derivatives. Chem Commun (Camb). 2007 Jun 7;(21):2163-5
O,O-diethyl methylphosphonothioate  0   *Organothiophosphorus Compounds. J Phys Chem A Dyn Kinet Environ Chem Spectrosc Struct Theory 2007 Feb 8;111(5):916-24
bis(2,4,4-trimethylpentyl)dithiophosphinic acid  0   *Organothiophosphorus Compounds. J Chromatogr A. 2006 Aug 4;1123(1):26-30
afugan  0   *Organothiophosphorus Compounds *Xylenes. Mutat Res 2006 Apr 30;604(1-2):53-9
cadusafos  0   *Organothiophosphorus Compounds. Chemosphere 2004 Aug;56(6):549-59
dimethyl thiophosphite  0   *Organothiophosphorus Compounds. J Org Chem 2004 Apr 2;69(7):2322-6
3'-S-(2-Cyanoethyl-N,N-diisopropylphosphorothioamidite)- N4-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine  0   *Organothiophosphorus Compounds *Dideoxynucleotides Zalcitabine/*analogs & derivatives. Nucleic Acids Res 2004;32(2):495-501
3'-S-(2-Cyanoethyl-N,N-diisopropylphosphorothioamidite)- 3'-deoxy-5'-O-(4,4'-dimethoxytrityl)thymidine  0   Organothiophosphorus Compounds Thymidine/*analogs & derivatives. Nucleic Acids Res 2004;32(2):495-501
1-oleoyl-2-O-methylglycerophosphothioate  0   *Organothiophosphorus Compounds *Phosphatidic Acids. J Med Chem 2003 Dec 18;46(26):5575-8
O,S-dimethyl hydrogen phosphorothioate  0   *Organothiophosphorus Compounds. J Agric Food Chem 2003 Oct 8;51(21):6103-9
dithymidine phosphorothioate  0   *Oligodeoxyribonucleotides *Organothiophosphorus Compounds *Thionucleotides. Nucleic Acids Res Suppl 2001:(1):13-4
ethoprophos  0   *Organothiophosphorus Compounds. Bull Environ Contam Toxicol 2003 Mar;70(3):520-6
methylethylphosphoramidothioate  0   *Organothiophosphorus Compounds. Toxicol Lett 2002 Aug 5;134(1-3);115-8
5,5-dimethyl-2-(6-methyl-2-(methylsulfanyl)pyrimidin-4-yloxy)-1,3,2-dioxaphosphorinane-2-thione  0   *Organothiophosphorus Compounds *Pyrimidines. Acta Crystallogr C 2002 May;58(Pt 5):o280-1
adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate  0   *Organothiophosphorus Compounds Cyclic AMP/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. Bioorganic Chem 2002 Feb;30(1):16-31
S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate  0   *Organothiophosphorus Compounds. J Appl Toxicol 2001 Dec;21 Suppl 1():S3-6
TJU 2755  0   *Organothiophosphorus Compounds *Phosphorothioate Oligonucleotides. J Pharmacol Exp Ther 2001 Jun;297(3):1129-36
tolclofos-methyl  0   *Organothiophosphorus Compounds. AIHAJ 2001 Jan-Feb;62(1):87-95
AMTP-3A  0   *Organothiophosphorus Compounds. Antioxid Redox Signal 1999 Fall;1(3):325-38
chlorpyrifos-ethyl  0   *Organothiophosphorus Compounds. Arch Toxicol. 2000 Nov;74(9):533-8
2-diphenylmethylsilylethyldithiophosphorodichloridate  0   *Organothiophosphorus Compounds. Nucleic Acids Res 2000 May 1;28(9):E40
inositol 1,3,6-trisphosphorothioate  0   *Organothiophosphorus Compounds. Mol Pharmacol 2000 Mar;57(3):595-601
flupyrazofos  0   *Organothiophosphorus Compounds *Pyrazoles. J Chromatogr B Biomed Sci Appl 1998 Oct 23;718(1):61-8
N-hydroxymethamidophos  0   *Organothiophosphorus Compounds. Chem Res Toxicol 1998 Jan;11(1):26-34
ethion  563-12-2   *Organothiophosphorus Compounds.
Pharma Action Insecticides 		Rev Elev Med Vet Pays Trop 1980;33(4):399
2-(S-(1-(2-nitrophenyl)ethyl)thiophosphoryloxy)inositol 1,4-bis(dihydrogen phosphate)  165036-14-6   *Inositol Phosphates *Organothiophosphorus Compounds. Biophys J 1995 Jun;68(6):2601-7
2-thiophosphoryloxyinositol 1,4-bis(dihydrogen phosphate)  0   *Inositol Phosphates *Organothiophosphorus Compounds. Biophys J 1995 Jun;68(6):2601-7
fenchlorphos  299-84-3   *Organothiophosphorus Compounds.
adenosine 3',5'-phosphothioate  0   *Organothiophosphorus Compounds Adenosine/*analogs & derivatives. Plant Physiol 1994 Nov;106(3):957-61
inositol 4,5-bisphosphate 1-phosphorothioate  0   *Inositol Phosphates *Organothiophosphorus Compounds. Carbohydr Res 1994 Sep 1;262(1):59-77
inositol 2,3,5-trisphosphorothioate  0   *Organothiophosphorus Compounds Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Bioorg Med Chem 1994 Apr;2(4):253-7
inositol 1,4,6-trisphosphorothioate  0   *Organothiophosphorus Compounds Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Biochem Biophys Res Commun 1994 Apr 15;200(1):8-15
3-dimethylphosphinothioyl-2(3H)-oxazolone  152645-23-3   *Organothiophosphorus Compounds Oxazolone/*analogs & derivatives. Int J Pept Protein Res 1993 Sep;42(3):264-9
O-n-hexyl-S-methylphosphorothioamidate  150641-14-8   *Organothiophosphorus Compounds. Chem Biol Interact 1993 Jun;87(1-3):133-9
fensulfothion  115-90-2   *Organothiophosphorus Compounds.
S 27  21068-51-9   *Organothiophosphorus Compounds. Eur J Pharmacol 1991 Aug 6;200(2-3):331-7
methyl mercaptophos  8022-00-2   *Organothiophosphorus Compounds.
formothion  2540-82-1 phosphorodithioic acid S-(2-(formylmethylamino)-2-oxoethyl) O,O-dimethyl ester  *Organothiophosphorus Compounds.
diisopropylaminoethyl methyl thiolophosphonate  73207-98-4   *Organothiophosphorus Compounds. Xenobiotica 1990;20(7):699
inositol 1,4-bisphosphate 5-phosphorothioate  116778-73-5   *Inositol Phosphates *Organothiophosphorus Compounds. Eur J Biochem 1990;192(2):459
diphenylantimony diphenyldithiophosphinate  106175-35-3   *Organometallic Compounds *Organothiophosphorus Compounds Antimony. Anticancer Res 1990;10(3):803
diphenylantimony diisopropyldithiophosphate  126443-52-5   *Organometallic Compounds *Organothiophosphorus Compounds Antimony. Anticancer Res 1990;10(3):803
pinacolyl S-(2-trimethylaminoethyl)methylphosphonothioate  38770-03-5   *Organothiophosphorus Compounds. Br J Pharmacol 1990;99(4):721
adenosine 3',5'-cyclic methylphosphonothioate  130320-50-2   *Organothiophosphorus Compounds Cyclic AMP/*analogs & derivatives. Yao Hsueh Hsueh Pao 1989;24(11):872
O-ethyl-S-hexyl-methylthiophosphonate  3675-87-4   *Organothiophosphorus Compounds. Vopr Med Khim 1971;17(4):403
methyl-ISP  99675-03-3   *Organothiophosphorus Compounds. J Tongji Med Univ 1988;8(2):78
S-(2-((aminoheptyl)amino)ethyl)phosphorothiate  120182-46-9   *Organothiophosphorus Compounds. Int J Radiat Biol 1989;55(3):463
S-(N-monomethoxytritylaminoethyl)-O-(2-chlorophenyl)phosphorothioate  116454-97-8   *Organothiophosphorus Compounds. Nucleic Acids Symp Ser 1988;(19):21
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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