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Cyclic Nucleotide Phosphodiesterases, Type 5

More information in Books or onNLM PubMed
Definition: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.      Other names Phosphodiesterases, PDE5; cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotid; Phosphodiesterase-5; Phosphodiesterase V; Phosphodiesterase 5; PDE5 Phosphodiesterases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BC76 compound  0   *Benzimidazoles *Pyrroles Cyclic Nucleotide Phosphodiesterases, Type 5. Cell Signal 2011 Mar;23(3):594-601
1-(6-ethoxy-5-(3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo(4,3-d)pyrimidin-5-yl)-3-pyridyl sulphonyl)-4-ethylpiperazine  0   *Pyrimidinones *Sulfonamides Cyclic Nucleotide Phosphodiesterases, Type 5. BJU Int 2010 Sep;106(5):666-73
4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide  0   *Pyrimidines Cyclic Nucleotide Phosphodiesterases, Type 5. Clin Ther 2010 Jun;32(6):1178-87STENDRA
methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate  0   *Carbamates *Quinazolines Cyclic Nucleotide Phosphodiesterases, Type 5/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jan 1;20(1):383-6
3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido(3,4-b)pyrazin-2(1H)-one  0   *Pyrazines *Pyridines Cyclic Nucleotide Phosphodiesterases, Type 5/antagonists & inhibitors. J Med Chem 2010 Mar 25;53(6):2656-60
N-(6-aminohexyl)-3-(1-ethyl-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-propoxybenzenesulfonamide  0   *Pyrimidinones *Sulfonamides Cyclic Nucleotide Phosphodiesterases, Type 5/antagonists & inhibitors. Mol Biosyst 2009 May;5(5):472-82
PDE5 protein, S cerevisiae  EC 3.1.4.17   *Saccharomyces cerevisiae Proteins *Cyclic Nucleotide Phosphodiesterases, Type 5.
Pde5a protein, rat  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 5.
Pde5a protein, mouse  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 5.
PDE5A protein, human  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 5.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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