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Oximes

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Definition: Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.     
Examples Fluvoxamine; Obidoxime Chloride; Pralidoxime Compounds; Technetium Tc 99m Exametazime; Trimedoxime 		Other names Compounds, Hydroxyimino; Ketoximes; Hydroxyimino Compounds; Aldoximes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
UVI5008  0   *Disulfides *Oximes. Mol Cancer Ther. 2011 Dec;10(12):2394-404.
coprismycin A  0   *Oximes *Pyridines. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5715-8.
N-((2-chloro-6-methylquinolin-3-yl)methylene)-2-methylpropan-2-amine oxide  0   *Oximes *Quinolines. J Med Chem. 2012 Jan 12;55(1):153-68.
N-((2-chloro-6-methylquinolin-3-yl)methylene)-1-phenylmethanamine oxide  0   *Oximes *Quinolines. J Med Chem. 2012 Jan 12;55(1):153-68.
Flu-1 compound  0   *Fluoresceins *Oximes Fluorescent Dyes. Chem Commun (Camb). 2011 Nov 21;47(43):11978-80.
6-bromoindirubin-3'-(O-(2-morpholin-1-ylethyl)oxime)  0   *Indoles *Oximes Glycogen Synthase Kinase 3/antagonists & inhibitors. J Neurosci Res. 2011 Nov;89(11):1802-11.
6-bromoindirubin-3'-(O-(N,N-diethylcarbamyl)oxime)  0   *Indoles *Oximes Glycogen Synthase Kinase 3/antagonists & inhibitors. J Neurosci Res. 2011 Nov;89(11):1802-11.
isonitrosoacetone  0   *Oximes Cholinesterase Reactivators. Chem Biol Interact. 2011 Nov 15;194(2-3):91-6.
cordioxime  0   *Oximes *Lactams. Nat Prod Commun. 2011 Aug;6(8):1135-6
GSK 2118436  0   *Imidazoles *Oximes. Arch Pharm Res 2011 May;34(5):699-701
dodecylamidoxime  0   *Oximes. Talanta 2011 Jun 15;84(5):1209-14
1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone O-2-aminoethyloxime  0   *Oximes *Quinolines. J Med Chem 2011 Jul 14;54(13):4446-61
A 967079  0   *Oximes Analgesics, Non-Narcotic Transient Receptor Potential Channels/antagonists & inhibitors. Pain 2011 May;152(5):1165-72
2-pyridylcyanoxime  0   *Oximes *Pyridines. Inorg Chem. 2011 Mar 21;50(6):2468-78
1-(4-carbamoylpyridinium)-3-(4-hydroxyiminomethylpyridinium)-2-oxapropane  0   *Oximes *Pyridinium Compounds. Toxicol Mech Methods 2011 Mar;21(3):241-5
1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one oxime  0   *Oximes *Diarylheptanoids Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Am J Chin Med 2010;38)6):1207-22
1,12-bis(N,N'-hydroxyacetamidinyl)dodecane  0   *Amidines *Oximes. Eur J Pharm Sci 2011 Jan 18;42(1-2):81-90
pochoxime A  0   *Lactones *Oximes HSP90 Heat-Shock Proteins/antagonists & inhibitors. Chembiochem 2009 Nov 23;10(17):2753-9
4,4'-bis(hydroxyiminomethyl)-1,10-(1,2-phenylenedimethyl)bispyridinium  0   *Oximes *Pyridinium Compounds. Biomed Pharmacother 2010 Oct;64(8):541-5
1-(4-(1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime  0   *Oximes *Imidazoles. J Med Chem 2010 Dec 23;53(24):8650-62
pyrrole-2-carbaldehyde oxime  0   *Oximes *Pyrroles. Magn Reson Chem 2010 Sep;48(9):685-92
1-(2-hydroxy-5-methylphenyl)ethanone oxime  0   *Oximes *Phenols. Magn Reson Chem 2010 Sep;48(9):671-7
paeonol oxime  0   *Oximes. PLoS One 2010;5(8):e12358
2-(4-bromophenyl)-1-(3,4-dihydroxyphenyl)ethanone oxime  0   *Oximes Benzoin/*analogs & derivatives. ChemMedChem 2010 Jul 5;5(7):1117-22
6-hydroxy-9-methoxy-11H-indeno(1,2-c)quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl oxime  0   *Hydroxyquinolines *Oximes. J Med Chem 2010 Aug 26;53(16):6164-79
tepraloxydim  0   *Oximes *Cyclohexanones Acetyl-CoA Carboxylase. Proc Natl Acad Sci U S A 2009 Dec 8;106(49):20723-7
3-(2-(4-methylquinolin-2-yl)hydrazono)butan-2-one oxime  0   *Hydrazones *Oximes. Spectrochim Acta A Mol Biomol Spectrosc 2010 May;75(5):1446-51
3-(pyridin-2-ylethynyl)cyclohex-2-enone-O-2-(2-fluoroethoxy)ethyloxime  0   *Oximes *Pyridines Fluorine Radioisotopes Ligands. J Med Chem 2010 May 27;53(10):4009-17
fluoxastrobin  0   *Oximes *Pyrimidines. BMC Microbiol 2010;10:112
3,5-seco-4-norcholestan-5-one oxime-3-ol  0   *Oximes *Secosteroids. J Pharmacol Exp Ther 2010 Jun;333(3):696-706
ethyl 2-cyano-2-(hydroxyimino)acetate  0   *Acetates *Oximes. J Pept Sci 2010 Jan;16(1):6-9
1-(4-hydroxyiminomethylpyridinium)-4-(4-methylcarbonylpyridinium)-but-2-ene  0   *Oximes *Pyridinium Compounds. J Enzyme Inhib Med Chem 2009 Aug;24(4):1040-4
1-(4-carboxypyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene  0   *Oximes *Pyridinium Compounds. J Enzyme Inhib Med Chem 2009 Aug;24(4):1040-4
1-(4-(6-amino-5-(methoxyiminomethyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea  0   *Oximes *Phenylurea Compounds Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Angiogenesis 2009;12(3):287-96
2-propenal,2-methyl-,O-((methylamino)carbonyl)oxime  0   *Methylamines *Oximes. J Chromatogr A. 2009 Sep 4;1216(36):6394-9
3-((6-Fluoropyridin-2-yl)ethynyl)cyclohex-2-enone O-methyl oxime  0   *Oximes *Pyridines Fluorine Radioisotopes. Nucl Med Biol 2009 Aug;36(6):613-22
17-hydroxyprogesterone-3-O-carboxymethyloxime  0   *Oximes Progesterone/*analogs & derivatives. J Immunoassay Immunochem 2009;30(2):186-96
2-methyl-5-isopropenylcyclohex-2-enone oxime  0   *Oximes *Cyclohexanones. Chem Res Toxicol. 2009 Feb;22(2):399-405
4-fluorobenzaldehyde-O-(2-(2-(2-(pyrrol-2,5-dione-1-yl)ethoxy)ethoxy)ethyl)oxime  0   *Maleimides *Oximes Fluorine Radioisotopes. Amino Acids 2009 Feb;36(2):283-95
tiloronoxim  0   *Oximes Tilorone/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2008 Nov 15;875(2):349-57
5'-nitroindirubinoxime  0   *Indoles *Oximes. Cancer Lett 2009 Feb 8;274(1):72-7
KR 62776  0   *Indans *Oximes PPAR gamma/agonists. Biochem Biophys Res Commun 2009 Jan 16;378(3):645-9
1-(4-(1-aminohydroxyiminomethyl)pyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene  0   *Oximes *Pyridinium Compounds. J Enzyme Inhib Med Chem 2008 Dec;23(6):776-80
1-(3-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene  0   *Oximes *Pyridinium Compounds. J Enzyme Inhib Med Chem 2008 Dec;23(6):776-80
methyl 2-pyridyl ketone oxime  0   *Oximes *Pyridines. Spectrochim Acta A Mol Biomol Spectrosc 2008 Nov 15;71(2):655-62
3-(phenylhydrazono) butan-2-one oxime  0   *Oximes. Arch Toxicol 2008 Oct;82(10):755-62
5alpha-androst-3-en-17-one oxime  0   *Oximes *17-Ketosteroids Aromatase Inhibitors. Acta Crystallogr C. 2008 Sep;64(Pt 9):o508-10
1-((4-(aminocarbonyl)pyridinio)trimethylene)-2-((hydroxyimino)methyl)pyridinium  0   *Oximes *Pyridinium Compounds. Toxicol Appl Pharmacol 2008 Sep 1;231(2):157-64
K117 compound  0   *Oximes *Pyridinium Compounds. Drug Chem Toxicol. 2008;31(3):371-81
K127 compound  0   *Oximes *Pyridinium Compounds. Drug Chem Toxicol. 2008;31(3):371-81
fluorodeoxyglucose F18-maleimidehexyloxime  0   *Oximes *Maleimides. Bioconjug Chem. 2008 Jun;19(6):1202-10
pentafluorobenzyloxime  0   *Fluorobenzenes *Oximes. J Am Chem Soc. 2008 Jun 18;130(24):7554-5
3-chloro-4-(4-hydroxyphenyl)salicylaldoxime  0   *Oximes *Phenols Ligands. J Med Chem 2008 Mar 13;51(5):1344-51
darapladib  0   *Benzaldehydes *Oximes. J Am Coll Cardiol. 2008 Apr 29;51(17):1632-41
phenyl 2-pyridyl ketone oxime  0   *Oximes. J Hazard Mater 2008 Feb 28;151(1):26-32
fluoroethyl-desmethyl-ABP688  0   *Oximes *Pyridines Fluorine Radioisotopes Ligands. Nucl Med Biol 2007 Nov;34(8):973-80
1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride  0   *Oximes *Pyridinium Compounds. Bioorg Med Chem. 2007 Dec 15;15(24):7704-10
LDN 57444  0   *Indoles *Oximes. Chem Biol 2003 Sep;10(9):837-46
1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene  0   *Oximes *Pyridinium Compounds. J Med Chem 2007 Nov 1;50(22):5514-8
1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane  0   *Oximes *Pyridinium Compounds. Molecules 2007;12(8):1964-72
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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