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Cyclic Nucleotide Phosphodiesterases, Type 6

More information in Books or onNLM PubMed
Definition: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.      Other names gamma Subunit, cGMP-PDE; delta Subunit PDE6; cGMP PDE gamma Subunit; beta Subunit PDE6; alpha Subunit PDE6; Phosphodiesterases, PDE6; Phosphodiesterase 6, Retinal; PDE6 delta Subunit; PDE6 beta Subunit; PDE6 alpha Subunit; gamma Subunit, cGMP Phosphodiesterase; delta Subunit, PDE6; cGMP-PDE gamma Subunit; cGMP Phosphodiesterase delta Subunit; alpha Subunit, PDE6; Rod cGMP Phosphodiesterase, beta Subunit; Retinal Phosphodiesterase, delta Subunit; Retinal Phosphodiesterase, beta Subunit; Retinal Phosphodiesterase, alpha Subunit; Retinal Phosphodiesterase 6
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Pde6g protein, mouse  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 6.
Pde6h protein, rat  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 6.
Pde6b protein, mouse  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 6.
PDE6G protein, human  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 6.
PDE6D protein, human  EC 3.1.4.17   *Cyclic Nucleotide Phosphodiesterases, Type 6.
PDE6B protein, human  EC 3.1.4.35   *Cyclic Nucleotide Phosphodiesterases, Type 6.
Pde6a protein, mouse  EC 3.1.4.35   *Eye Proteins *Cyclic Nucleotide Phosphodiesterases, Type 6.
PDE6A protein, human  EC 3.1.4.35   *Eye Proteins *Cyclic Nucleotide Phosphodiesterases, Type 6. Anim Genet 2000 Apr;31(2):135-9
PDE6C protein, human  EC 3.1.4.35   *Eye Proteins *Cyclic Nucleotide Phosphodiesterases, Type 6. Genomics 1995 Aug 10;28(3):429-35

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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