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Phthalazines

More information in Books or onNLM PubMed
Definition:      
Examples Hydralazine; Todralazine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-aminophthalazin-1(2H)-one  0   *Phthalazines. Org Lett. 2011 Dec 16;13(24):6496-9
10-((4-hydroxypiperidin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one  0   *Benzopyrans *Phthalazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Drug Metab Dispos 2011 Jan;39(1):61-70
GSK 1004723  0   *Phthalazines *Piperidines Histamine H1 Antagonists. Expert Opin Ther Pat 2011 Mar;21(3):425-9
3-(4-(3-methylbut-2-enyloxy)styryl)-(1,2,4)triazolo(3,4-a)phthalazine  0   *Phthalazines *Triazoles. J Med Chem 2011 Mar 10;54(5):1449-61
helioxanthin 8-1  0   *Phthalazines *Benzodioxoles. Antivir Chem Chemother 2010;21(2):97-103
N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl(1,2,4)triazolo(3,4-a)phthalazin-3-yl)benzenesulfonamide  0   *Phthalazines *Sulfonamides Respiratory Syncytial Virus, Human. Antiviral Res. 2010 Dec;88(3):317-24
N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine  0   *Phthalazines. Cancer Res 2010 Dec 1;70(23):9846-54
3-(5-methylisoxazol-3-yl)-6-((1-methyl-1,2,3-triazol-4-yl)methyloxy)-1,2,4-triazolo(3,4-a)phthalazine  0   *Phthalazines *Triazoles. Neuropharmacology 2010 Dec;59(7-8):635-9
4-(4-phenylphthalazine-1-yl)piperazine amide  0   *Phthalazines *Piperazines. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4607-10
1,4-bis(9-O dihydroquinidinyl)phthalazine hydroquinidine 1,4-phathalazinediyl diether  0   *Phthalazines. Radiat Res. 2010 Oct;174(4):526-31
4-(4-fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)phthalazin-1-amine  0   *Phthalazines *Pyrimidines. J Med Chem 2010 Sep 9;53(17):6368-77
6-(4-chlorophenoxy)tetrazolo(5,1-a)phthalazine  0   *Phthalazines *Tetrazoles. Pharmacol Rep 2010 Mar-Apr;62(2):273-7
2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxophthalazin-4-yl)-N-(2,6-dimethylphenyl)acetamide  0   *Acetamides *Phthalazines. Chem Biol Drug Des. 2010 Apr;75(4):381-91
BAL 0030545  0   *Phthalazines. Antimicrob Agents Chemother 2009 Nov;53(11):4949-52
BAL 0030544  0   *Phthalazines. Antimicrob Agents Chemother 2009 Nov;53(11):4949-52
BAL 0030543  0   *Phthalazines. Antimicrob Agents Chemother 2009 Nov;53(11):4949-52
6-heptyloxy-(1,2,4)triazolo(3,4-a)phthalazine  0   *Phthalazines. Chem Biol Drug Des 2009 Mar;73(3):313-9
6-(4-chlorophenoxyl)-(1,2,4)triazolo(3,4-a)phthalazine  0   *Phthalazines. Chem Biol Drug Des 2009 Mar;73(3):313-9
IM-094482 57  0   *Isoquinolines *Phthalazines. Bioorg Med Chem. 2009 Jan 15;17(2):731-40
4-(3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl)-2H-phthalazin-1-one  0   *Phthalazines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. J Med Chem 2008 Oct 23;51(20):6581-91
AZD 2281  0   *Phthalazines *Piperazines Poly(ADP-ribose) Polymerases/antagonists & inhibitors. Clin Cancer Res 2008 Jun 15;14(12):3916-25
4,4'-dihydroxy-3,3'-dimethoxy-5,5'-biphenyl-1,1'-(diphthalazin-1-yl)methylhydrazone  0   *Hydrazones *Phthalazines. J Med Chem 2008 Jun 12;51(11):3171-81
poly(phthalazine ether sulfone ketone)  0   *Ketones *Phthalazines Polymers. J Chromatogr A 2008 Jan 4;1177(1):28-35
N-(4-(1-methylethyl)phenyl)-4-(2-(3-pyridinyl)ethyl)-1-phthalazinamine  0   *Aniline Compounds *Phthalazines Protein-Tyrosine Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Jan 18;365(3):515-20
8-1 compound  0   *Phthalazines *Benzodioxoles. Proc Natl Acad Sci U S A 2007 May 15;104(20):8526-31
1,2-dihydrophthalazine  0   *Phthalazines. Angew Chem Int Ed Engl. 2005 Sep 19;44(37):6058-63
1-(1-cyclohexylethylamino)-4-phenylphthalazine  0   *Phthalazines. Drug Metab Dispos 2006 Jun;34(6):950-4
KU0058948  0   *Fluorobenzenes *Phthalazines. Cancer Res 2005 Nov 15;65(22):10145-8
formelschema  0   *Phthalazines *Triazoles. Pharmazie. 2005 May;60(5):359-63
4-((3-chloro-4-methoxybenzyl)amino)-1-(2-hydroxy-7-azaspiro(3.5)non-7-yl)-6-phthalazinecarbonitrile monohydrochloride  0   *Phthalazines *Spiro Compounds. Biol Pharm Bull. 2003 Dec;26(12):1661-7
N-(3-(4-Oxo-3,4-dihydro-phthalazin-1-yl)phenyl)-4-(morpholin-4-yl) butanamide methanesulfonate monohydrate  0   *Morpholines *Phthalazines. Life Sci. 2004 Nov 26;76(2):151-62
6,7-dichloro-5,8-phthalazinedione  0   *Phthalazines. Bioorg Med Chem. 2004 Apr 1;12(7):1623-8
3-(1(2H)-phthalazinon-2-yl)propanamide  0   *Phthalazines Propane/*analogs & derivatives. Arch Pharm (Weinheim). 2004 Jun;337(6):303-10
2-(1(2H)-phthalazinon-2-yl)acetamide  0   *Acetamides *Phthalazines. Arch Pharm (Weinheim). 2004 Jun;337(6):303-10
3-(5-methylisoxazol-3-yl)-6-(2-pyridyl)methyloxy-1,2,4-triazolo(3,4-a)phthalazine  0   *Isoxazoles *Phthalazines. J Med Chem 2004 Jul 1;47(14):3642-57
4-aminophenyl-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine  0   *Phthalazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Endocrinology 2004 Jun;145(6):2775-83
3-phenyl-6-(2-pyridyl)methoxy-7,8,9,10-tetrahydro(7,10-ethano)-1,2,4-triazolo(3,4-a)phthalazine  0   *Phthalazines *Triazoles Receptors, GABA-A/agonists. J Med Chem 2004 Mar 25;47(7):1807-22
s-triazolo(3,4-a)phthalazine  0   *Triazoles *Phthalazines. Life Sci. 2003 Nov 21;74(1):29-36
4-(3-chloro-4-methoxyphenyl)-2-(4-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy)butyl)4a,5,8,8a-tetrahydro-2H-phthalazin-1-one  0   *Phthalazines. J Med Chem 2003 May 8;46(10):2008-16
4-(3,4-diethoxyphenyl)-2-(4-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy)butyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one  0   *Phthalazines. J Med Chem 2003 May 8;46(10):2008-16
4-(4-(3,4-diethoxyphenyl)-1oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl)benzoic acid  0   *Phthalazines *Benzoic Acids 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2526-33
2-adamantan-2-yl-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one  0   *Phthalazines Adamantane/*analogs & derivatives 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2526-33
2-benzyl-4-(3,4--dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1one  0   *Phthalazines. J Med Chem 2001 Aug 2;44(16):2511-22
2-benzyl-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one  0   *Phthalazines. J Med Chem 2001 Aug 2;44(16):2511-22
4-aminophthalhydrazide  0   *Phthalazines. J Mol Biol 2001 Feb 23;306(3):455-67
1-(3,5-dichloropyrid-4-ylmethyl)-5-cyclopentoxy-6-methoxyphthalazine  0   *Phthalazines. Bioorg Med Chem Lett 2000 Oct 2;10(19):2235-8
N-2-(3'-phthalide-yl)phthalazin-1-one  0   *Phthalazines. Spectrochim Acta A Mol Biomol Spectrosc 2000 May;56(6):1045-9
(4-(3-chloro-4-methoxybenzyl)amino-1-(4-hydroxy)piperidino)-6-phthalazinecarbonitrile  0   *Phthalazines *Piperidines. J Med Chem 2000 Jun 29;43(13):2523-9
vatalanib  0   *Phthalazines *Pyridines.
Pharma Action Protein Kinase Inhibitors 		Am J Pathol 2000 Feb;156(2):697-707
T 2585  0   *Phthalazines *Pyridines Phosphoric Diester Hydrolases/antagonists & inhibitors. J Med Chem 1999 Mar 25;42(6):1088-99
3,4-dihydro-2(H)-phthalazine carboxylic acid  0   *Carboxylic Acids *Phthalazines. Amino Acids 1998;14(4):301-9
phthalhydrazidylazoacetylacetone  0   *Hydrazines *Phthalazines. Anal Biochem 1998 Nov 1;264(1):47-52
1-chloro-4-((3-chloro-4-methoxybenzyl-)amino)-6-nitrophthalazine  0   *Phthalazines. J Med Chem 1998 Aug 27;41(18):3367-72
1-chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrile  0   *Phthalazines. J Med Chem 1998 Aug 27;41(18):3367-72
MRZ 2-576  0   *Phthalazines. Eur J Pharmacol 1998 Jan 19;342(1):39-46
N-dephenethylflezelastine  0   *Azepines *Phthalazines. J Chromatogr B Biomed Appl 1997 Apr 11;691(2):463-71
flezelastine N-oxide  0   *Azepines *Phthalazines. J Chromatogr B Biomed Appl 1997 Apr 11;691(2):463-71
1,2,3,4-tetrahydrophthalazine  13152-89-1   *Phthalazines. Int J Pept Protein Res 1996 Mar;47(3):142-7
flezelastine  135381-77-0   *Azepines *Phthalazines. Agents Actions 1994 Mar;41(1-2):99-100
2-(4-(4-(3-(1,2-benzisothiazolyl))-1-piperazinyl)butyl)-4a,5,6,7,8,8a-hexahydro-1(2H)-phthalazinone  155289-55-7   *Phthalazines *Thiazoles. J Med Chem 1994 Aug 5;37(16):2552-63
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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