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Pyrrolidinones

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Definition: A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)  pyrrolidinediones   
Examples Cotinine; Doxapram; Oxotremorine; Piracetam; Povidone; Pyrrolidonecarboxylic Acid; Rolipram; Succinimides; Tenuazonic Acid 		Other names Pyrrolidones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methiosetin  0   *Pyrrolidinones. J Nat Prod. 2012 Mar 23;75(3):420-4
ZL-004  0   *Pyrrolidinones Antineoplastic Agents. Yao Xue Xue Bao. 2010 Jun;45(6):797-800
5-(2,4-dimethylbenzyl)pyrrolidin-2-one  0   *Pyrrolidinones. Interdiscip Sci. 2011 Sep;3(3):198-203
dictamnaindiol  0   *Pyrrolidinones Alkaloids. J Asian Nat Prod Res. 2012 Feb;14(2);105-10
CBS 9106  0   *Aminopyridines *Pyrrolidinones. Blood 2011. 2011 Oct 6;118(14):3922-31.
isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate  0   *Fumarates *Pyrrolidinones NF-kappa B/antagonists & inhibitors. BMB Rep 2011 Jul;44(7):468-72
CAY 10580  0   *Pyrrolidinones Dinoprostone/*analogs & derivatives. Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12949-54
1-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)pyrrolidin-2-one  0   *Pyrrolidinones. Pharmacol Rep. 2011 Mar-Apr;63(2):455-63
excisusin F  0   *Diterpenes *Pyrrolidinones. Bioorg Med Chem Lett 2011 Feb 15;21(4):1279-81
(4R,5S)-4-hydroxy-5-phenylpyrrolidin-2-one  0   *Pyrrolidinones. J Org Chem. 2011 Feb 4;76(3):948-62
sintokamide E  0   *Pyrrolidinones. Angew Chem Int Ed Engl. 2010 Dec 10;49(50):9702-5
sintokamide B  0   *Pyrrolidinones. Angew Chem Int Ed Engl. 2010 Dec 10;49(50):9702-5
sintokamide A  0   *Pyrrolidinones. Angew Chem Int Ed Engl. 2010 Dec 10;49(50):9702-5
5-methylene-1-(prop-2-enoyl)-4-phenyldihydropyrrol-2-one  0   *Pyrrolidinones. Biofouling 2010 Nov;26(8):913-21
5-((3-fluoromethoxy)phenyl)-3-(1-phenylethylamino)-1-(4-trifluoromethylphenyl)pyrrolidin-2-one  0   *Pyrrolidinones Fluorine Radioisotopes Ligands. Eur J Nucl Med Mol Imaging 2010 Aug;37(8):1499-506
3-(3-dimethylaminopropylamino)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile  0   *Acenaphthenes *Pyrrolidinones. Chem Res Toxicol 2009 Mar 16;22(3):483-91
3-(4-methylpiperazin)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile  0   *Acenaphthenes *Pyrrolidinones. Chem Res Toxicol 2009 Mar 16;22(3):483-91
IKM 159  0   *Benzofurans *Pyrrolidinones Receptors, AMPA/antagonists & inhibitors. Br J Pharmacol 2010 Jul;160(6):1417-29
ARQ 197  0   *Pyrrolidinones *Quinolines Proto-Oncogene Proteins c-met/antagonists & inhibitors. IDrugs. 2010 Jun;13(6):404-14
azaspirofuran B  0   *Pyrrolidinones *Spiro Compounds. Arch Pharm Res 2010 Apr;33(4):499-502
azaspirofuran A  0   *Pyrrolidinones *Spiro Compounds. Arch Pharm Res 2010 Apr;33(4):499-502
JBIR-22  0   *Pyrrolidinones *Tetrahydronaphthalenes. J Nat Prod. 2010 Apr 23;73(4):628-31
sintokamide C  0   *Pyrrolidinones. Org Lett 2010 Mar 5;12(5):1100-3
ophiosetin  0   *Pyrrolidinones. J Antibiot (Tokyo). 2010 Apr;63(4):195-8
berkeleyamide A  0   *Pyrrolidinones. Org Lett. 2010 Feb 5;12(3):420-3
poly(1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate)  0   *Polymethacrylic Acids *Pyrrolidinones. Electrophoresis 2009 Nov;30(22):3939-46
1-(4-(2-methoxyisopropyl)phenyl)-3-(2-(4-methylpiperazin-1-yl)benzyl)pyrrolidin-2-one  0   *Piperazines *Pyrrolidinones Receptor, Serotonin, 5-HT1B/antagonists & inhibitors. J Cereb Blood Flow Metab 2010 Jan;30(1):196-210
N- vinyl pyrrolidone  0   *Pyrrolidinones. Chemistry. 2009 Dec 7;15(47):13181-7
melophlin A  0   *Alkanes *Pyrrolidinones. Angew Chem Int Ed Engl. 2009;48(39):7240-5
5-(3-(2-(3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylate  0   *Pyrrolidinones *Thiophenes. J Pharmacol Exp Ther 2009 Nov;331(2):627-35
5-(15-hydroxy(5-(3-pyridyl)(2-thienyl))methyl)-1-methyl-4-phenylpyrrolidin-2-one  0   *Pyrrolidinones *Thiophenes. Bioorg Med Chem Lett 2006 Sep 15;16(18):4965-8
pseurotin E  0   *Pyrrolidinones 4-Butyrolactone/*analogs & derivatives. J Antibiot (Tokyo) 2008 Nov;61(11):692-5
virgineone  0   *Glycosides *Pyrrolidinones. J Nat Prod 2009 Jan;72(1):136-41
2-(5-chlorothien-2-yl)-N-(1-(1-methyl-2-(morpholin-4-yl)-2-oxoethyl)-2-oxopyrrolidin-3-yl)ethenesulfonamide  0   *Pyrrolidinones *Sulfonamides Factor Xa/antagonists & inhibitors. J Cardiovasc Pharmacol 2008 Jul;52(1):66-71
((3)H)(S)-2-((S)-3-acetylamino-3-sec-butyl-2-oxo-pyrrolidin-1-yl)-N-((1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxy-benzylamino)-propyl)-4-phenyl-butyramide  0   *Pyrrolidinones. Eur J Pharmacol 2008 Sep 28;593(1-3):10-5
2-isopropoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol(2,1-a)pyrrolo(3,4-c)carbazole-5-one  0   *Carbazoles *Pyrrolidinones. J Med Chem 2008 Sep 25;51(18):5680-9
2-methoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol(2,1-a)pyrrolo(3,4-c)carbazole-5-one  0   *Carbazoles *Pyrrolidinones. J Med Chem 2008 Sep 25;51(18):5680-9
5-(3-methoxyphenyl)-3-(1-phenylethylamino)-1-(4-trifluoromethylphenyl)pyrrolidin-2-one  0   *Pyrrolidinones Carbon Radioisotopes. Neuropsychopharmacology 2008 Jan;33(2):259-69
epicoccamide D  0   *Mannosides *Pyrrolidinones. J Nat Prod 2007 Nov;70(11):1800-3
epicoccamide C  0   *Mannosides *Pyrrolidinones. J Nat Prod 2007 Nov;70(11):1800-3
epicoccamide B  0   *Mannosides *Pyrrolidinones. J Nat Prod 2007 Nov;70(11):1800-3
11-O-methylpseurotin A  0   *Pyrrolidinones. J Nat Prod 2007 Oct;70(10):1672-5
SMTP-0 compound  0   *Benzopyrans *Pyrrolidinones. J Antibiot (Tokyo) 2007 Jul;60(7):463-8
N-ethyl-2-pyrrolidone  0   *Pyrrolidinones. J Appl Toxicol 2007 Sep-Oct;27(5):491-7
epicoccarine A  0   *Pyrrolidinones. Org Biomol Chem 2007 Jun 7;5(11):1702-5
epicoccarine B  0   *Pyrrolidinones. Org Biomol Chem 2007 Jun 7;5(11):1702-5
1-(1-naphthalenethoxy)-2-(3-ketopyrrolidinyl)cyclohexane  0   *Cyclohexanes *Pyrrolidinones. J Med Chem 2007 Jun 14;50(12):2818-41
quinolactacin B2  0   *Pyrrolidinones *Quinolones. Org Biomol Chem 2006 Apr 21;4(8):1512-9
1-octyl-2-pyrrolidone  0   *Pyrrolidinones. J Pharm Sci 1995 Mar;84(3):312-7
3-amino-1-(1-boronic-ethyl)pyrrolidine-2-one  0   *Boronic Acids *Pyrrolidinones.
Pharma Action Dipeptidyl-Peptidase IV Inhibitors 		J Med Chem 2007 May 17;50(10):2391-8
malyngamide X  0   *Amides *Pyrrolidinones. Chem Asian J 2007 Jan 8;2(1):114-22
Seletracetam  0   *Pyrrolidinones. Neurotherapeutics 2007 Jan;4(1):117-22
gliocladin C  0   *Piperazines *Pyrrolidinones Alkaloids. Org Lett. 2007 Jan 18;9(2):339-41
2-methoxycarbonylmethyl-5-oxo-2,5-dihydropyrrole-1-carboxylic acid  0   *Pyrrolidinones. J Org Chem 2006 Mar 3;71(5):2173-6
1-(4-iodophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide  0   *Pyrrolidinones *Sulfones. J Med Chem 2006 Aug 24;49(17):5282-90
1-(4-nitrophenylsulfonyl)-N-(1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide  0   *Pyrrolidinones *Sulfones. J Med Chem 2006 Aug 24;49(17):5282-90
N-tert-butyloxycarbonyl-4-(4-chlorophenyl)-2-pyrrolidone  0   *Pyrrolidinones. J Chromatogr A 2006 Jun 30;1119(1-2):156-62
3-hydroxy-2-pyrrolidinone  0   *Pyrrolidinones. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3205-8
sarmentamide A  0   *Pyrrolidinones. Chem Pharm Bull (Tokyo) 2006 Feb;54(2):149-51
piperazine-1-pyrrolidine-2,5-dione  0   *Piperazines *Pyrrolidinones. Bioorg Med Chem Lett. 2006 Feb1;16(3):525-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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