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Ribonucleotide Reductases
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Definition
:
Examples
Ribonucleoside Diphosphate Reductase
Other names
Reductases, Ribonucleotide; Reductase, Ribonucleotide; Ribonucleotide Reductase
Substance
CAS Registry & name
Categories
Source
Drugs
*
NrdB protein, E coli
EC 1.17.4.-
*Ribonucleotide Reductases
*Escherichia coli Proteins.
J Bacteriol. 1976 Dec;128(3):810-4.
RNR2 protein, S cerevisiae
EC 1.17.4.-
*Ribonucleotide Reductases
*Saccharomyces cerevisiae Proteins.
Biochem Cell Biol. 1989 Jul;67(7):352-7.
p53R2 protein, zebrafish
EC 1.17.4.-
*Ribonucleotide Reductases
*Zebrafish Proteins
Protein Subunits.
Gene 2011 Apr 1;475(1):30-8
Rnr1 protein, S cerevisiae
EC 1.17.4.-
*Ribonucleotide Reductases
*Saccharomyces cerevisiae Proteins.
Nucleic Acids Res 2010 Jul 1;38(12):3975-83
2'-
(2-
hydroxyethyl)-
2'-
deoxyadenosine 5'-
phosphate
0
Adenosine Triphosphate/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
ChemMedChem 2009 Oct;4(10):1649-56
2'-
(2-
hydroxyethyl)-
2'-
deoxyadenosine
0
*Deoxyadenosines
Ribonucleotide Reductases/antagonists & inhibitors.
ChemMedChem 2009 Oct;4(10):1649-56
NrdF protein, E coli
EC 1.17.4.-
*Ribonucleotide Reductases
*Escherichia coli Proteins
Protein Subunits.
Proc Natl Acad Sci U S A 2008 Sep 23;105(38):14383-8
NrdE protein, E coli
EC 1.17.4.-
*Ribonucleotide Reductases
*Escherichia coli Proteins
Protein Subunits.
Proc Natl Acad Sci U S A 2008 Sep 23;105(38):14383-8
ribonucleotide reductase 2B, Arabidopsis
EC 1.17.4.-
*Ribonucleotide Reductases
*Arabidopsis Proteins
Protein Subunits.
Plant Cell 2006 Feb;18(2):350-65
ribonucleotide reductase 2A, Arabidopsis
EC 1.17.4.-
*Ribonucleotide Reductases
*Arabidopsis Proteins
Protein Subunits.
Plant Cell 2006 Feb;18(2):350-65
TSO2 protein, Arabidopsis
EC 1.17.4.-
*Ribonucleotide Reductases
*Arabidopsis Proteins
Protein Subunits.
Plant Cell 2006 Feb;18(2):350-65
3'-
C-
methyladenosine
0
Adenosine/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
J Med Chem 2005 Jul 28;48(15):4983-9
NrdJb protein, Pseudomonas aeruginosa
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
J Biol Chem 2005 Apr 29;280(17):16571-8
NrdJa protein, Pseudomonas aeruginosa
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
J Biol Chem 2005 Apr 29;280(17):16571-8
RRR1 protein, Xenopus
EC 1.17.4.-
*Ribonucleotide Reductases
*Xenopus Proteins.
Rrm1 protein, mouse
EC 1.17.4.1
*Ribonucleotide Reductases.
NrdG protein, E coli
EC 1.17.4.-
*Ribonucleotide Reductases
*Escherichia coli Proteins.
nrdG protein, Enterobacteria phage T4
EC 1.17.4.-
*Ribonucleotide Reductases
*Viral Proteins.
Rrm2b protein, mouse
EC 1.17.4.-
*Ribonucleotide Reductases
*Cell Cycle Proteins
DNA Repair.
m45 protein, Mouse cytomegalovirus 1
EC 1.17.4.-
*Ribonucleotide Reductases
*Viral Proteins.
Science 2001 Jan 12;291(5502):303-5
ADP-
S-
HBES-
S-
dGTP
0
*Nucleotides
Ribonucleotide Reductases/antagonists & inhibitors.
Bioorg Med Chem Lett 2000 Oct 16;10(20):2387-9
acetyl-
phenylalanyl-
threonyl-
leucyl-
aspartyl-
alanyl-
aspartyl-
phenylalanine
0
*Peptide Fragments
*Ribonucleotide Reductases
Ribonucleotide Reductases/antagonists & inhibitors.
J Med Chem 2001 Jan 4;44(1):36-46
nrdG protein, Lactococcus lactis
0
*Bacterial Proteins
*Iron-Sulfur Proteins
Ribonucleotide Reductases.
J Biol Chem 2000 Apr 28;12367-73
RRM2B protein, human
EC 1.17.4.-
*Ribonucleotide Reductases
*Cell Cycle Proteins
DNA Repair.
Nature 2000 Mar 2;404(6773):42-9
U28 protein, Human herpesvirus
EC 1.17.4.1
*Ribonucleotide Reductases
*Viral Proteins.
J Gen Virol 1999 Oct;80 ( Pt 10):2713-8
6-
methyl-
2-
isopropylsulfonyloxy-
1(H)-
isoindole-
1,3-
dione
0
*Isoindoles
Ribonucleotide Reductases/antagonists & inhibitors.
Anticancer Res 1999 May-Jun;19(3A):1625-34
2-
hydroxy-
1(H)-
isoindole-
1,3-
dione
0
*Isoindoles
Ribonucleotide Reductases/antagonists & inhibitors.
Anticancer Res 1999 May-Jun;19(3A):1625-34
NrdG protein, Alcaligenes
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
J Bacteriol 1999 Aug;181(16):4919-28
NrdD protein, Alcaligenes
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
J Bacteriol 1999 Aug;;181(16):4919-28
NrdF protein, bacteria
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
Biochemistry 1998 Sep 22;37(38):13359-69
BILD 1633 SE
0
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors.
Antimicrob Agents Chemother 1998 Jul;42(7):1629-35
2'-
azido-
2'-
deoxyuridine
26929-65-7
*Azides
Deoxyuridine/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
Nucleosides Nucleotides 1998 Jun;17(6):1077-88
ribonucleotide reductase R2 subunit
EC 1.17.4.-
*Ribonucleotide Reductases.
FEBS Lett 1997 Sep 8;414(2):449-53
BILD 1357
0
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors.
J Med Chem 1996 Oct 11;39(21):4173-80
BILD 1351
0
*Dipeptides
Urea/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
J Med Chem 1996 Oct 11;39(21):4173-80
anaerobic ribonucleotide reductase
EC 1.17.4.-
*Ribonucleotide Reductases
Bacterial Proteins
Viral Proteins
Escherichia coli Proteins.
J Biol Chem 1996 Aug 23;271(34):20770-5
ICP10 protein, herpes simplex virus type 2
EC 1.17.4-
*Ribonucleotide Reductases
*Protein-Serine-Threonine Kinases.
J Biol Chem 1996 Jul 19;271(29):17021-7
BILD 733
0
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors.
J Virol 1996 Feb;70(2):787-93
cladribine triphosphate
0
Adenosine Triphosphate/*analogs & derivatives
Cladribine/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
Blood 1996 Jan 1;87(1):256-64
N-
acetyltyrosyl-
threonyl-
leucyl-
aspartyl-
alanyl-
aspartyl-
phenylalanine
0
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors.
Struct Biol 1995 Nov;2(11):951-5
BILD 1263
0
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors.
Nature 1993 Dec 15;372(6507):695-8
nrdG protein, bacteria
EC 1.17.4.-
*Bacterial Proteins
*Ribonucleotide Reductases.
J Biol Chem 1994 Nov 11;269(45):27815-8
SUC22 protein, S pombe
EC 1.17.4.1
*Ribonucleotide Reductases
*Schizosaccharomyces pombe Proteins
Schizosaccharomyces.
Mol Gen Genet 1993 Apr;238(1-2):241-51
cdc22 protein, S pombe
0
*Cell Cycle Proteins
*Schizosaccharomyces pombe Proteins
Ribonucleotide Reductases
Schizosaccharomyces.
Mol Gen Genet 1993 Apr;238(1-2):241-51
3,4,5-
trihydroxybenzamidoxime
0
*Benzamidines
Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
;
Free Radical Scavengers
Ann Thorac Surg 1992 Jun;53(6):1091-5
compound 348U87
127142-14-7
*Hydrazones
*Pyridines
Ribonucleotide Reductases/antagonists & inhibitors.
Biochem Pharmacol 1991;42(1):91
resveratrol
501-36-0
*Stilbenes
Phenols
Ribonucleotide Reductases/antagonists & inhibitors
Vasodilator Agents
Angiogenesis Inhibitors.
Pharma Action
Anti-Inflammatory Agents, Non-Steroidal
;
Antineoplastic Agents, Phytogenic
;
Antioxidants
;
Enzyme Inhibitors
;
Platelet Aggregation Inhibitors
;
Antimutagenic Agents
;
Anticarcinogenic Agents
Pharmacol Res Commun 1988;20 Suppl 5:79
A 1110U
96860-23-0
*Hydrazones
*Pyridines
Ribonucleotide Reductases/antagonists & inhibitors.
Proc Natl Acad Sci USA 1989;86(3):1051
herpes simplex virus H2 (6-
15), 4'-
azido-
Phe(6)
0
*Azides
*Oligopeptides
Ribonucleotide Reductases/antagonists & inhibitors
Immunodominant Epitopes.
J Biol Chem 1988;263(31):16045
ribonucleoside-
triphosphate reductase
EC 1.17.4.2
*Ribonucleotide Reductases.
Biochemistry 1988;27(12):4305
gemcitabine
103882-84-4
Deoxycytidine/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action
Antimetabolites, Antineoplastic
;
Antiviral Agents
;
Enzyme Inhibitors
;
Immunosuppressive Agents
;
Radiation-Sensitizing Agents
Cancer Res 1988;48(14):4024
GEMCITABINE
;
GEMCITABINE HYDROCHLORIDE
;
GEMZAR
herpes simplex virus type 1-
protein ICP6
0
*Viral Proteins
Ribonucleotide Reductases
Simplexvirus.
J Virol 1987;62(1):196
2'-
chloro-
2'-
deoxyuridine 5'-
diphosphate
40111-66-8 Uridine 5'-
(trihydrogen diphosphate), 2'-
chloro-
2'-
deoxy
*Deoxyuracil Nucleotides
Ribonucleotide Reductases/antagonists & inhibitors.
Biochemistry 1985;24(25):7214
alpha beta, beta gamma-
dimethylenedeoxythymidine 5'-
triphosphate
90094-77-2 Thymidine, 5'-
(hydrogen ((hydroxy(phosphonomethyl)phosphinyl)methyl)phosphonate)
*Thymine Nucleotides
Ribonucleotide Reductases/antagonists & inhibitors.
Adv Exp Med Biol 1984;165(pt B):371
beta, gamma-
methylenedeoxythymidine 5'-
triphosphate
59957-94-7 5'-
Thymidylic acid, monoanhydride with (phosphonomethyl)phosphonic acid
*Thymine Nucleotides
Ribonucleotide Reductases/antagonists & inhibitors.
Adv Exp Med Biol 1984;165(pt B):371
1-
formylisoquinoline-
thiosemicarbazone iron chelate
0
*Isoquinolines
Ribonucleotide Reductases/antagonists & inhibitors.
J Biol Chem 1983;258(7):4063
3,4-
dihydroxybenzohydroxamic acid
69839-83-4 Benzamide, N,3,4-
trihydroxy
*Hydroxamic Acids
Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Enzyme Inhibitors
Cancer Res 1982;42(8):2963
tobacco tar
0
*Tars
Ribonucleotide Reductases/antagonists & inhibitors
Tobacco.
Pharma Action
Enzyme Inhibitors
;
Immunosuppressive Agents
Oral Surg 1980;49(5):435
2'-
azidocytidine
51034-68-5
Cytidine/*analogs & derivatives
Ribonucleotide Reductases/antagonists & inhibitors.
Eur J Biochem 72(2):371;1977; J Virol 24(1):22;1977; Proc Natl Acad Sci USA 74(12):5310;1977
4-
methyl-
5-
amino-
1-
formylisoquinoline thiosemicarbazone
59261-39-1
*Isoquinolines
Ribonucleotide Reductases/antagonists & inhibitors.
Cancer Res 1979;39(11):4600; Cancer Res 37:1692;1977; Cancer Treat Rep 63(3):449;1979; J Med Chem 19(7):970;1976
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